Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Interacts with FNBP3. Interacts with CDKL5. Present in all adult somatic tissues tested. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Cellular Component: heterochromatin; protein complex; nuclear chromatin; nucleus; cytosol
Molecular Function: protein domain specific binding; siRNA binding; methyl-CpG binding; unmethylated CpG binding; chromatin DNA binding; protein N-terminus binding; transcription factor binding; mRNA binding; protein binding; enzyme binding; four-way junction DNA binding; DNA binding; double-stranded methylated DNA binding; transcription factor activity; transcription corepressor activity
Biological Process: catecholamine secretion; startle response; behavioral fear response; genetic imprinting; adult locomotory behavior; positive regulation of transcription, DNA-dependent; chromatin silencing; pathogenesis; neurological control of breathing; proprioception; negative regulation of transcription from RNA polymerase II promoter; sensory perception of pain; neuron maturation; negative regulation of histone methylation; post-embryonic development; negative regulation of histone acetylation; phosphatidylcholine metabolic process; protein localization; synaptogenesis; positive regulation of cell proliferation; dendrite development; visual learning; cerebellum development; negative regulation of neuron apoptosis; histone acetylation; mitochondrial electron transport, ubiquinol to cytochrome c; transcription, DNA-dependent; ventricular system development; glutamine metabolic process; respiratory gaseous exchange; social behavior; cardiolipin metabolic process; histone methylation; glucocorticoid metabolic process; positive regulation of synaptogenesis; embryonic development; regulation of systemic arterial blood pressure by neurological process; long-term memory; inositol metabolic process; response to hypoxia; negative regulation of transcription, DNA-dependent; regulation of excitatory postsynaptic membrane potential
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.