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Protein Page:
SMARCA4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SMARCA4 an enzyme with ATP-dependent DNA helicase activity. Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Interacts with glucocorticoid receptor (GR), TOPBP1 and progesterone receptor (PR). Component of the BAF53 complex which acetylates histone H4 and H2A within nucleosomes. Belongs to the SNF2/RAD54 helicase family. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; Cell cycle regulation; Transcription, coactivator/corepressor; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: heterochromatin; SWI/SNF complex; extracellular space; protein complex; perichromatin fibrils; membrane; nuclear chromatin; nucleolus; nucleus
Molecular Function: DNA-dependent ATPase activity; protein binding; nucleosomal DNA binding; androgen receptor binding; Tat protein binding; p53 binding; transcription coactivator activity; protein N-terminus binding; helicase activity; transcription corepressor activity; ATP binding
Biological Process: extracellular matrix organization and biogenesis; glial cell fate determination; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter, mitotic; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; embryonic organ morphogenesis; epidermis morphogenesis; forebrain development; blastocyst hatching; blastocyst growth; vasculogenesis; hindbrain development; positive regulation of DNA binding; ATP catabolic process; transcription, DNA-dependent; stem cell maintenance; liver development; keratinocyte differentiation; chromatin remodeling; regulation of transcription from RNA polymerase II promoter; cytosine methylation within a CG sequence; nucleosome disassembly; methylation-dependent chromatin silencing; ATP-dependent chromatin remodeling; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; negative regulation of transcription, DNA-dependent
Reference #:  P51532 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase SMARCA4; BAF190; BAF190A; brahma protein-like 1; BRG1; BRG1-associated factor 190A; BRM/SWI2-related gene 1; FLJ39786; homeotic gene regulator; hSNF2b; Mitotic growth and transcription activator; nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; RTPS2; SMARCA4; SMCA4; SNF2; SNF2-beta; SNF2-like 4; SNF2B; SNF2L4; SNF2LB; sucrose nonfermenting-like 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SWI2; Transcription activator BRG1
Gene Symbols: SMARCA4
Molecular weight: 184,646 Da
Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SMARCA4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T3-p _____MStPDPPLGG
0 2 T11-p PDPPLGGtPRPGPSP
0 1 R181-m1 QNQLHQLrAQIMAYk
0 1 K188-ac rAQIMAYkMLARGQP
0 1 T298-p NAAAPTStPQKLIPP
0 1 S312 PQPTGRPSPAPPAVP
0 2 S323-p PAVPPAAsPVMPPQT
0 1 S332-p VMPPQTQsPGQPAQP
0 3 T353-p HQKQSRItPIQkPRG
0 2 K357-ub SRItPIQkPRGLDPV
0 3 K399-ub LAGDLRTkATIELkA
0 24 K405-ub TkATIELkALRLLNF
0 2 K437-ub LETALNAkAYKRSKR
0 11 S446-p YKRSKRQsLREARIT
0 1 K455-ac REARITEkLEKQQkI
0 1 K461-ac EkLEKQQkIEQERKR
0 1 Y475 RRQKHQEYLNSILQH
0 1 S492 DFKEYHRSVTGKIQK
0 1 T494 KEYHRSVTGKIQKLT
0 1 T596-p AENAEGQtPAIGPDG
0 33 T609-p DGEPLDEtsQMsDLP
1 48 S610-p GEPLDEtsQMsDLPV
0 54 S613-p LDEtsQMsDLPVKVI
0 1 S624-p VKVIHVEsGkILTGT
0 1 K626-ac VIHVEsGkILTGTDA
0 1 K626-ub VIHVEsGkILTGTDA
0 32 S695-p KKIPDPDsDDVsEVD
0 21 S699-p DPDsDDVsEVDARHI
0 4 K711-ub RHIIENAkQDVDDEy
0 6 Y718-p kQDVDDEyGVsQALA
1 5 S721-p VDDEyGVsQALARGL
0 6 Y732-p ARGLQSYyAVAHAVT
0 1 K835-ub SVVKVSYkGSPAARR
0 1 T1032 DKKGKGGTkTLMNTI
0 1 K1033-ac KKGKGGTkTLMNTIM
0 16 K1081-ub DLYRASGkFELLDRI
0 23 Y1123-p FAYRGFKyLRLDGTT
0 3 K1131-ub LRLDGTTkAEDRGML
0 1 K1219-ac EKILAAAkyKLNVDQ
0 1 Y1220-p KILAAAkyKLNVDQk
0 2 K1227-ub yKLNVDQkVIQAGMF
0 4 K1349-ub ELPSWIIkDDAEVER
0 2 T1358-p DAEVERLtCEEEEEK
0 1 S1371-p EKMFGRGsRHRKEVD
0 1 Y1379-p RHRKEVDysDsLTEK
0 3 S1380-p HRKEVDysDsLTEKQ
0 18 S1382-p KEVDysDsLTEKQWL
0 2 T1396-p LKAIEEGtLEEIEEE
0 1 S1410-p EVRQKKSsRKRKRDs
0 27 S1417-p sRKRKRDsDAGsstP
0 6 S1421-p KRDsDAGsstPttSt
0 9 S1422-p RDsDAGsstPttStR
0 40 T1423-p DsDAGsstPttStRS
0 3 T1425-p DAGsstPttStRSRD
0 2 T1426-p AGsstPttStRSRDK
0 4 T1428-p sstPttStRSRDKDD
1 33 S1452-p RPPAEKLsPNPPNLT
0 1 T1459 sPNPPNLTKKMKKIV
0 1 K1518 KERIRNHKYRSLNDL
0 1 S1550 GSLIYEDSIVLQSVF
0 1 S1555 EDSIVLQSVFTSVRQ
0 21 S1570-p KIEKEDDsEGEEsEE
0 21 S1575-p DDsEGEEsEEEEEGE
0 13 S1586-p EEGEEEGsESESRsV
0 1 S1592-p GsESESRsVKVKIKL
0 14 S1627-p SRAKPVVsDDDsEEE
0 16 S1631-p PVVsDDDsEEEQEED
0 1 R1639 EEEQEEDRsGsGsEE
0 4 S1640-p EEQEEDRsGsGsEED
0 5 S1642-p QEEDRsGsGsEED__
0 4 S1644-p EDRsGsGsEED____
  mouse

 
T3 _____MSTPDPPLGG
T11 PDPPLGGTPRPGPSP
R181 QNQLHQLRAQIMAYK
K188 RAQIMAYKMLARGQP
T298 NAAAPTSTPQKLIPP
S312-p PQPTGRPsPAPPAVP
S323-p PAVPPAAsPVMPPQT
S332-p VMPPQTQsPGQPAQP
T353 HQKQSRITPIQKPRG
K357 SRITPIQKPRGLDPV
K399 LAGDLRTKATIELkA
K405-ub TKATIELkALRLLNF
K437 LETALNAKAYKRSKR
S446 YKRSKRQSLREARIT
K455 REARITEKLEKQQKI
K461 EKLEKQQKIEQERKR
Y475 RRQKHQEYLNSILQH
S492-p DFREYHRsVtGKLQK
T494-p REYHRsVtGKLQKLT
T596 AENAEGQTPAIGPDG
T609-p DGEPLDEtsQMsDLP
S610-p GEPLDEtsQMsDLPV
S613-p LDEtsQMsDLPVKVI
S624-p VKVIHVEsGKILTGT
K626 VIHVEsGKILTGTDA
K626 VIHVEsGKILTGTDA
S695-p KKIPDPDsDDVsEVD
S699-p DPDsDDVsEVDARHI
K711 RHIIENAKQDVDDEY
Y718 KQDVDDEYGVSQALA
S721 VDDEYGVSQALARGL
Y732 ARGLQSYYAVAHAVT
K835 SVVKVSYKGSPAARR
T1032-p DKKGKGGtKTLMNTI
K1033 KKGKGGtKTLMNTIM
K1081 DLYRASGKFELLDRI
Y1123 FAYRGFKYLRLDGTT
K1131 LRLDGTTKAEDRGML
K1219 EKILAAAKYKLNVDQ
Y1220 KILAAAKYKLNVDQK
K1227 YKLNVDQKVIQAGMF
K1316 ELPSWIIKDDAEVER
T1325 DAEVERLTCEEEEEK
S1338 EKMFGRGSRHRKEVD
Y1346 RHRKEVDYSDsLTEK
S1347 HRKEVDYSDsLTEKQ
S1349-p KEVDYSDsLTEKQWL
T1363 LKAIEEGTLEEIEEE
S1377 EVRQKKSSRKRKRDs
S1384-p SRKRKRDsEAGSStP
S1388 KRDsEAGSStPtTST
S1389 RDsEAGSStPtTSTR
T1390-p DsEAGSStPtTSTRS
T1392-p EAGSStPtTSTRSRD
T1393 AGSStPtTSTRSRDK
T1395 SStPtTSTRSRDKDE
S1419-p RPPAEKLsPNPPNLt
T1426-p sPNPPNLtKKMKKIV
K1484-ub KERIRNHkYRSLNDL
S1516-p GSLIYEDsIVLQsVF
S1521-p EDsIVLQsVFTSVRQ
S1536-p KIEKEDDsEGEEsEE
S1541-p DDsEGEEsEEEEEGE
S1552-p EEGEEEGsESESRSV
S1558 GsESESRSVKVKIKL
S1593-p SRAKPVVsDDDsEEE
S1597-p PVVsDDDsEEEQEED
R1605-m1 EEEQEEDrsGsGsEE
S1606-p EEQEEDrsGsGsEED
S1608-p QEEDrsGsGsEED__
S1610-p EDrsGsGsEED____
  rat

 
T3 _____MSTPDPPLGG
T11 PDPPLGGTPRPGPSP
R181 QNQLHQLRAQIMAYK
K188 RAQIMAYKMLARGQP
T298 NAAAPTSTPQKLIPP
S312 PQPTGRPSPAPPAVP
S323 PAVPPAASPVMPPQT
S332 VMPPQTQSPGQPAQP
T353 HQKQSRITPIQKPRG
K357 SRITPIQKPRGLDPV
K399 LAGDLRTKATIELKA
K405 TKATIELKALRLLNF
K437 LETALNAKAYKRSKR
S446 YKRSKRQSLREARIT
K455-ac REARITEkLEKQQkI
K461-ac EkLEKQQkIEQERKR
Y475-p RRQKHQEyLNSILQH
S492 DFREYHRSVTGKLQK
T494 REYHRSVTGKLQKLT
T596 AENAEGQTPAIGPDG
T609 DGEPLDETSQMsDLP
S610 GEPLDETSQMsDLPV
S613-p LDETSQMsDLPVKVI
S624 VKVIHVESGKILTGT
K626 VIHVESGKILTGTDA
K626 VIHVESGKILTGTDA
S695-p KKIPDPDsDDVsEVD
S699-p DPDsDDVsEVDARHI
K711 RHIIENAKQDVDDEY
Y718 KQDVDDEYGVSQALA
S721 VDDEYGVSQALARGL
Y732 ARGLQSYYAVAHAVT
K835 SVVKVSYKGSPAARR
T1032 DKKGKGGTKTLMNTI
K1033 KKGKGGTKTLMNTIM
K1081 DLYRASGKFELLDRI
Y1123 FAYRGFKYLRLDGTT
K1131 LRLDGTTKAEDRGML
K1219 EKILAAAKYKLNVDQ
Y1220 KILAAAKYKLNVDQK
K1227 YKLNVDQKVIQAGMF
K1316 ELPSWIIKDDAEVER
T1325 DAEVERLTCEEEEEK
S1338 EKMFGRGSRHRKEVD
Y1346 RHRKEVDYSDsLTEK
S1347 HRKEVDYSDsLTEKQ
S1349-p KEVDYSDsLTEKQWL
T1363 LKAIEEGTLEEIEEE
S1377 EVRQKKSSRKRKRDS
S1384 SRKRKRDSEAGSStP
S1388 KRDSEAGSStPTTST
S1389 RDSEAGSStPTTSTR
T1390-p DSEAGSStPTTSTRS
T1392 EAGSStPTTSTRSRD
T1393 AGSStPTTSTRSRDK
T1395 SStPTTSTRSRDKDE
S1419-p RPPAEKLsPNPPNLT
T1426 sPNPPNLTKKMKKIV
K1484 KERIRNHKYRSLNDL
S1516 GSLIYEDSIVLQSVF
S1521 EDSIVLQSVFTSVRQ
S1536-p KIEKEDDsEGEEsEE
S1541-p DDsEGEEsEEEEEGE
S1552-p EEGEEEGsESESRSV
S1558 GsESESRSVKVKIKL
S1593-p SRAKPVVsDDDsDEE
S1597-p PVVsDDDsDEEQEED
R1605 DEEQEEDRSGSGSEE
S1606 EEQEEDRSGSGSEED
S1608 QEEDRSGSGSEED__
S1610 EDRSGSGSEED____
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