an enzyme with ATP-dependent DNA helicase activity. Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Interacts with glucocorticoid receptor (GR), TOPBP1 and progesterone receptor (PR). Component of the BAF53 complex which acetylates histone H4 and H2A within nucleosomes. Belongs to the SNF2/RAD54 helicase family. Note: This description may include information from UniProtKB.
Molecular Function: DNA-dependent ATPase activity; protein binding; androgen receptor binding; DNA binding; Tat protein binding; p53 binding; transcription coactivator activity; protein N-terminus binding; transcription corepressor activity; helicase activity; ATP binding
Biological Process: chromatin remodeling; regulation of transcription from RNA polymerase II promoter; nervous system development; transcription, DNA-dependent; negative regulation of S phase of mitotic cell cycle; nucleosome disassembly; positive regulation of transcription, DNA-dependent; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; negative regulation of transcription, DNA-dependent
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.