an enzyme with ATP-dependent DNA helicase activity. Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Interacts with glucocorticoid receptor (GR), TOPBP1 and progesterone receptor (PR). Component of the BAF53 complex which acetylates histone H4 and H2A within nucleosomes. Belongs to the SNF2/RAD54 helicase family. Note: This description may include information from UniProtKB.
Molecular Function: DNA-dependent ATPase activity; protein binding; androgen receptor binding; p53 binding; Tat protein binding; transcription coactivator activity; protein N-terminus binding; chromatin binding; helicase activity; transcription corepressor activity; ATP binding
Biological Process: ATP catabolic process; extracellular matrix organization and biogenesis; glial cell fate determination; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter, mitotic; stem cell maintenance; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; liver development; embryonic hindlimb morphogenesis; chromatin remodeling; regulation of transcription from RNA polymerase II promoter; keratinocyte differentiation; embryonic organ morphogenesis; cytosine methylation within a CG sequence; methylation-dependent chromatin silencing; nucleosome disassembly; epidermis morphogenesis; forebrain development; blastocyst hatching; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; blastocyst growth; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; vasculogenesis; hindbrain development; positive regulation of DNA binding
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.