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Protein Page:
SMARCA2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SMARCA2 an enzyme with ATP-dependent DNA helicase activity. A transcriptional coactivator that cooperates with nuclear hormone receptors to potentiate transcriptional activation. Binds TOPBP1. Belongs to the SNF2/RAD54 helicase family. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; EC 3.6.4.-; Helicase; EC 3.6.1.-; Nuclear receptor co-regulator
Cellular Component: nucleoplasm; SWI/SNF complex; intermediate filament cytoskeleton; intracellular membrane-bound organelle; nuclear chromatin; nucleolus; nucleus
Molecular Function: DNA-dependent ATPase activity; protein binding; transcription coactivator activity; helicase activity; ATP binding
Biological Process: chromatin remodeling; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; nervous system development; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Reference #:  P51531 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase SMARCA2; BAF190; BAF190B; BRG1-associated factor 190B; BRM; FLJ36757; global transcription activator homologous sequence; hBRM; hSNF2a; MGC74511; Probable global transcription activator SNF2L2; Protein brahma homolog; SMARCA2; SMCA2; SNF2; SNF2-alpha; SNF2-like 2; SNF2/SWI2-like protein 2; SNF2A; SNF2L2; SNF2LA; Sth1p; sucrose nonfermenting 2-like protein 2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; SWI2
Gene Symbols: SMARCA2
Molecular weight: 181,279 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SMARCA2
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 S93-p VEDIHCGsMKGTGMR
0 1 S172-p SQPNRGPsPFsPVQL
0 2 S175-p NRGPsPFsPVQLHQL
0 1 G284 KLPVPAPGGRPSPAP
0 1 S288 PAPGGRPSPAPPAAA
0 1 S316 QPAPGQPSPVLQLQQ
0 9 S329-p QQKQSRIsPIQKPQG
0 2 K333 SRIsPIQKPQGLDPV
0 1 T408-p RRDTTLEtALNSkAy
0 2 K413-u LEtALNSkAyKRSKR
0 1 Y415-p tALNSkAyKRSKRQT
0 1 K437-a EKLEKQQkIEQERKR
0 1 S468 DFKEYHRSVAGKIQK
0 1 S477 AGKIQKLSKAVATWH
0 1 K563 KKKRRRRKKKAEENA
0 1 K565 KRRRRKKKAEENAEG
0 7 S587-p DGEPIDEssQMsDLP
0 10 S588-p GEPIDEssQMsDLPV
0 10 S591-p IDEssQMsDLPVKVT
0 1 K596 QMsDLPVKVTHTETG
0 1 K604-a VTHTETGkVLFGPEA
0 1 K604-u VTHTETGkVLFGPEA
0 2 S666-p KILLDPNsEEVsEKD
0 1 S670-p DPNsEEVsEKDAKQI
0 1 Y689-p KQDVDDEysMQYSAR
0 1 S690-p QDVDDEysMQYSARG
0 1 S956-p RLKKEVEsQLPEKVE
0 1 S971-p YVIKCDMsALQKILy
0 1 Y978-p sALQKILyRHMQAKG
0 16 K996-a TDGSEKDkkGkGGAk
0 133 K997-a DGSEKDkkGkGGAkt
0 134 K999-a SEKDkkGkGGAktLM
0 122 K1003-a kkGkGGAktLMNtIM
0 1 T1004-p kGkGGAktLMNtIMQ
0 2 T1008-p GAktLMNtIMQLRKI
0 2 Y1020-p RKICNHPyMFQHIEE
0 1 Y1035-p SFAEHLGySNGVING
0 1 Y1046-p VINGAELyRASGkFE
0 16 K1051-u ELyRASGkFELLDRI
0 1 K1189-a EKILAAAkyKLNVDQ
0 1 Y1190-p KILAAAkyKLNVDQk
0 2 K1197-u yKLNVDQkVIQAGMF
0 2 K1271-a DARNPKRkPRLMEED
0 4 K1286-u ELPSWIIkDDAEVER
0 1 Y1316-p RQRRDVDySDALTEk
0 1 K1323-u ySDALTEkQWLRAIE
0 8 S1377-p RPPAEKLsPNPPKLT
0 1 T1393 QMNAIIDTVINYKDR
0 1 Y1397 IIDTVINYKDRCNVE
0 1 R1400 TVINYKDRCNVEKVP
0 3 S1408-p CNVEKVPsNsQLEIE
0 9 S1410-p VEKVPsNsQLEIEGN
0 1 S1418-p QLEIEGNssGRQLSE
0 1 S1419-p LEIEGNssGRQLSEV
0 7 S1512-p KIAKEEEsEDEsNEE
0 7 S1516-p EEEsEDEsNEEEEEE
0 4 S1528-p EEEDEEEsESEAKSV
0 1 S1530 EDEEEsESEAKSVKV
0 10 K1547-a KLNKKDDkGRDkGkG
1 68 K1551-a KDDkGRDkGkGkkRP
2 68 K1553-a DkGRDkGkGkkRPNR
1 3 K1555-a GRDkGkGkkRPNRGK
1 66 K1556-a RDkGkGkkRPNRGKA
1 0 K1562 kkRPNRGKAKPVVsD
1 0 K1564 RPNRGKAKPVVsDFD
0 33 S1568-p GKAKPVVsDFDsDEE
0 33 S1572-p PVVsDFDsDEEQDER
0 5 S1582-p EQDEREQsEGsGtDD
0 3 S1585-p EREQsEGsGtDDE__
0 3 T1587-p EQsEGsGtDDE____
  SMARCA2 iso2  
S93 VEDIHCGSMKGTGMR
S172 SQPNRGPSPFSPVQL
S175 NRGPSPFSPVQLHQL
G284 KLPVPAPGGRPSPAP
S288 PAPGGRPSPAPPAAA
S316 QPAPGQPSPVLQLQQ
S329 QQKQSRISPIQKPQG
K333 SRISPIQKPQGLDPV
T408 RRDTTLETALNSKAY
K413 LETALNSKAYKRSKR
Y415 TALNSKAYKRSKRQT
K437 EKLEKQQKIEQERKR
S468 DFKEYHRSVAGKIQK
S477 AGKIQKLSKAVATWH
K563 KKKRRRRKKKAEENA
K565 KRRRRKKKAEENAEG
S587 DGEPIDESSQMSDLP
S588 GEPIDESSQMSDLPV
S591 IDESSQMSDLPVKVT
K596 QMSDLPVKVTHTETG
K604 VTHTETGKVLFGPEA
K604 VTHTETGKVLFGPEA
S666 KILLDPNSEEVSEKD
S670 DPNSEEVSEKDAKQI
Y689 KQDVDDEYSMQYSAR
S690 QDVDDEYSMQYSARG
S956 RLKKEVESQLPEKVE
S971 YVIKCDMSALQKILY
Y978 SALQKILYRHMQAKG
K996 TDGSEKDKKGKGGAK
K997 DGSEKDKKGKGGAKT
K999 SEKDKKGKGGAKTLM
K1003 KKGKGGAKTLMNTIM
T1004 KGKGGAKTLMNTIMQ
T1008 GAKTLMNTIMQLRKI
Y1020 RKICNHPYMFQHIEE
Y1035 SFAEHLGYSNGVING
Y1046 VINGAELYRASGKFE
K1051 ELYRASGKFELLDRI
K1189 EKILAAAKYKLNVDQ
Y1190 KILAAAKYKLNVDQK
K1197 YKLNVDQKVIQAGMF
K1271 DARNPKRKPRLMEED
K1286 ELPSWIIKDDAEVER
Y1316 RQRRDVDYSDALTEK
K1323 YSDALTEKQWLRAIE
S1377 RPPAEKLSPNPPKLT
T1393 QMNAIIDTVINYKDS
Y1397 IIDTVINYKDSSGRQ
- gap
- gap
- gap
S1400 TVINYKDSSGRQLSE
S1401 VINYKDSSGRQLSEV
S1494 KIAKEEESEDESNEE
S1498 EEESEDESNEEEEEE
S1510 EEEDEEESESEAKSV
S1512 EDEEESESEAKSVKV
K1529 KLNKKDDKGRDKGKG
K1533 KDDKGRDKGKGKKRP
K1535 DKGRDKGKGKKRPNR
K1537 GRDKGKGKKRPNRGK
K1538 RDKGKGKKRPNRGKA
K1544 KKRPNRGKAKPVVSD
K1546 RPNRGKAKPVVSDFD
S1550 GKAKPVVSDFDSDEE
S1554 PVVSDFDSDEEQDER
S1564 EQDEREQSEGSGTDD
S1567 EREQSEGSGTDDE__
T1569 EQSEGSGTDDE____
  SMARCA2 iso5  
S93 VEDIHCGSMKGTGMR
S172 SQPNRGPSPFSPVQL
S175 NRGPSPFSPVQLHQL
G280 KLPVPAPGGRPSPAP
S284 PAPGGRPSPAPPAAA
S312 QPAPGQPSPVLQLQQ
S325 QQKQSRISPIQKPQG
K329 SRISPIQKPQGLDPV
T404 RRDTTLETALNSKAY
K409 LETALNSKAYKRSKR
Y411 TALNSKAYKRSKRQT
K433 EKLEKQQKIEQERKR
S464 DFKEYHRSVAGKIQK
S473 AGKIQKLSKAVATWH
K559 KKKRRRRKKKAEENA
K561 KRRRRKKKAEENAEG
S583 DGEPIDESSQMSDLP
S584 GEPIDESSQMSDLPV
S587 IDESSQMSDLPVKVT
K592 QMSDLPVKVTHTETG
K600 VTHTETGKVLFGPEA
K600 VTHTETGKVLFGPEA
S662 KILLDPNSEEVSEKD
S666 DPNSEEVSEKDAKQI
Y685 KQDVDDEYSMQYSAR
S686 QDVDDEYSMQYSARG
S952 RLKKEVESQLPEKVE
S967 YVIKCDMSALQKILY
Y974 SALQKILYRHMQAKG
K992 TDGSEKDKKGKGGAK
K993 DGSEKDKKGKGGAKT
K995 SEKDKKGKGGAKTLM
K999 KKGKGGAKTLMNTIM
T1000 KGKGGAKTLMNTIMQ
T1004 GAKTLMNTIMQLRKI
Y1016 RKICNHPYMFQHIEE
Y1031 SFAEHLGYSNGVING
Y1042 VINGAELYRASGKFE
K1047 ELYRASGKFELLDRI
K1185 EKILAAAKYKLNVDQ
Y1186 KILAAAKYKLNVDQK
K1193 YKLNVDQKVIQAGMF
K1267 DARNPKRKPRLMEED
K1282 ELPSWIIKDDAEVER
Y1312 RQRRDVDYSDALTEK
K1319 YSDALTEKQWLRAIE
S1373 RPPAEKLSPNPPKLT
T1389 QMNAIIDTCINYKDs
Y1393 IIDTCINYKDsCNVE
S1396-p TCINYKDsCNVEKVP
S1404 CNVEKVPSNSQLEIE
S1406 VEKVPSNSQLEIEGN
S1414 QLEIEGNSSGRQLSE
S1415 LEIEGNSSGRQLSEV
S1508 KIAKEEESEDESNEE
S1512 EEESEDESNEEEEEE
S1524 EEEDEEESESEAKSV
S1526 EDEEESESEAKSVKV
K1543 KLNKKDDKGRDKGKG
K1547 KDDKGRDKGKGKKRP
K1549 DKGRDKGKGKKRPNR
K1551 GRDKGKGKKRPNRGK
K1552 RDKGKGKKRPNRGKA
K1558 KKRPNRGKAKPVVSD
K1560 RPNRGKAKPVVSDFD
S1564 GKAKPVVSDFDSDEE
S1568 PVVSDFDSDEEQDER
S1578 EQDEREQSEGSGTDD
S1581 EREQSEGSGTDDE__
T1583 EQSEGSGTDDE____
  mouse

 
S93 VEDVHCGSMKGTSMR
S166-p NQPNRGPsPFSPVQL
S169 NRGPsPFSPVQLHQL
S289-p KLSAPAPsGRPsPAP
S293-p PAPsGRPsPAPQAAV
S321-p QPAPGQPsPVLQLQQ
S334-p QQKQSRIsPIQkPQG
K338-u SRIsPIQkPQGLDPV
T413 RRDTTLETALNSkAY
K418-u LETALNSkAYKRSKR
Y420 TALNSkAYKRSKRQT
K442 EKLEKQQKIEQERKR
S473-p DFKEYHRsVAGKIQK
S482-p AGKIQKLsKAVATWH
K568-a KKKRRRRkKkAEENA
K570-a KRRRRkKkAEENAEG
S592-p DGEPIDEssQMsDLP
S593-p GEPIDEssQMsDLPV
S596-p IDEssQMsDLPVkVT
K601-a QMsDLPVkVTHTETG
K609 VTHTETGKVLFGPEA
K609 VTHTETGKVLFGPEA
S671 KILLDPNSEEVSEKD
S675 DPNSEEVSEKDAKQI
Y694 KQDVDDEYSMQYSAR
S695 QDVDDEYSMQYSARG
S961 RLKKEVESQLPEKVE
S976 YVIKCDMSALQKILY
Y983 SALQKILYRHMQAKG
K1001 TDGSEKDKkGkGGAk
K1002-a DGSEKDKkGkGGAkT
K1004-a SEKDKkGkGGAkTLM
K1008-a KkGkGGAkTLMNTIM
T1009 kGkGGAkTLMNTIMQ
T1013 GAkTLMNTIMQLRKI
Y1025 RKICNHPYMFQHIEE
Y1040 SFAEHLGYSNGVING
Y1051 VINGAELYRASGKFE
K1056 ELYRASGKFELLDRI
K1194 EKILAAAKYKLNVDQ
Y1195 KILAAAKYKLNVDQK
K1202 YKLNVDQKVIQAGMF
K1276 DARNPKRKPRLMEED
K1291 ELPSWIIKDDAEVER
Y1321 RQRRDVDYSDALTEK
K1328 YSDALTEKQWLRAIE
S1382-p RPPAEKLsPNPPKLT
T1398-p QMNAIIDtVINyKDS
Y1402-p IIDtVINyKDSSGRQ
- gap
- gap
- gap
S1405 tVINyKDSSGRQLSE
S1406 VINyKDSSGRQLSEV
S1499-p KIAKEEEsEEEsNEE
S1503-p EEEsEEEsNEEEEED
S1515-p EEDDEEEsEsEAKSV
S1517-p DDEEEsEsEAKSVKV
K1534 KLNKKEEKGRDTGkG
T1538 KEEKGRDTGkGkKRP
K1540-a EKGRDTGkGkKRPNR
K1542-a GRDTGkGkKRPNRGk
K1543 RDTGkGkKRPNRGkA
K1549-a kKRPNRGkAkPVVsD
K1551-a RPNRGkAkPVVsDFD
S1555-p GkAkPVVsDFDsDEE
S1559-p PVVsDFDsDEEQEEN
S1569-p EQEENEQsEAsGtDN
S1572-p ENEQsEAsGtDNE__
T1574-p EQsEAsGtDNE____
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