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Protein Page:
SMARCA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SMARCA2 an enzyme with ATP-dependent DNA helicase activity. A transcriptional coactivator that cooperates with nuclear hormone receptors to potentiate transcriptional activation. Binds TOPBP1. Belongs to the SNF2/RAD54 helicase family. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.-; Transcription, coactivator/corepressor; EC 3.6.1.-; Helicase; Nuclear receptor co-regulator
Cellular Component: nucleoplasm; SWI/SNF complex; intermediate filament cytoskeleton; intracellular membrane-bound organelle; nuclear chromatin; nucleolus; nucleus
Molecular Function: DNA-dependent ATPase activity; protein binding; histone binding; transcription coactivator activity; helicase activity; ATP binding
Biological Process: ATP catabolic process; regulation of transcription from RNA polymerase II promoter; chromatin remodeling; nervous system development; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; negative regulation of transcription, DNA-dependent
Reference #:  P51531 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase SMARCA2; BAF190; BAF190B; BRG1-associated factor 190B; BRM; FLJ36757; hBRM; hSNF2a; MGC74511; Probable global transcription activator SNF2L2; Protein brahma homolog; SMARCA2; SMCA2; SNF2; SNF2-alpha; SNF2-like 2; SNF2/SWI2-like protein 2; SNF2A; SNF2L2; SNF2LA; Sth1p; sucrose nonfermenting 2-like protein 2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; SWI2
Gene Symbols: SMARCA2
Molecular weight: 181,279 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SMARCA2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S93-p VEDIHCGsMKGTGMR
0 3 S172-p SQPNRGPsPFsPVQL
0 5 S175-p NRGPsPFsPVQLHQL
0 1 G284 KLPVPAPGGRPSPAP
0 1 S288 PAPGGRPSPAPPAAA
0 1 S316 QPAPGQPSPVLQLQQ
0 17 S329-p QQKQSRIsPIQKPQG
0 2 K333 SRIsPIQKPQGLDPV
0 1 T408-p RRDTTLEtALNSkAy
0 2 K413-ub LEtALNSkAyKRSKR
0 1 Y415-p tALNSkAyKRSKRQT
0 1 K437-ac EKLEKQQkIEQERKR
0 1 S468 DFKEYHRSVAGKIQK
0 1 S477 AGKIQKLSKAVATWH
0 1 T541-p DEYVANLtNLVWEHK
0 1 K563 KKKRRRRKKKAEENA
0 1 K565 KRRRRKKKAEENAEG
0 7 S587-p DGEPIDEssQMsDLP
0 11 S588-p GEPIDEssQMsDLPV
0 13 S591-p IDEssQMsDLPVKVT
0 1 K596 QMsDLPVKVTHTETG
0 2 K604-ac VTHTETGkVLFGPEA
0 1 K604-ub VTHTETGkVLFGPEA
0 1 Y642-p SEESDSDyEEEDEEE
0 1 S651-p EEDEEEEsSRQETEE
0 4 S666-p KILLDPNsEEVsEKD
0 1 S670-p DPNsEEVsEKDAKQI
0 1 Y689-p KQDVDDEysMQYSAR
0 1 S690-p QDVDDEysMQYSARG
0 2 S820-p SLVPQLRsGKFNVLL
0 1 S956-p RLKKEVEsQLPEKVE
0 1 S971-p YVIKCDMsALQKILy
0 1 Y978-p sALQKILyRHMQAKG
0 16 K996-ac TDGSEKDkkGkGGAk
0 133 K997-ac DGSEKDkkGkGGAkt
0 134 K999-ac SEKDkkGkGGAktLM
0 122 K1003-ac kkGkGGAktLMNtIM
0 1 T1004-p kGkGGAktLMNtIMQ
0 2 T1008-p GAktLMNtIMQLRKI
0 2 Y1020-p RKICNHPyMFQHIEE
0 1 Y1035-p SFAEHLGySNGVING
0 1 Y1046-p VINGAELyRASGkFE
0 16 K1051-ub ELyRASGkFELLDRI
0 1 K1189-ac EKILAAAkyKLNVDQ
0 1 Y1190-p KILAAAkyKLNVDQk
0 2 K1197-ub yKLNVDQkVIQAGMF
0 2 K1271-ac DARNPKRkPRLMEED
0 4 K1286-ub ELPSWIIkDDAEVER
0 2 T1295-p DAEVERLtCEEEEEK
0 1 Y1316-p RQRRDVDySDALTEk
0 1 K1323-ub ySDALTEkQWLRAIE
0 13 S1377-p RPPAEKLsPNPPKLT
0 1 T1393 QMNAIIDTVINYKDR
0 1 Y1397 IIDTVINYKDRCNVE
0 3 S1408-p CNVEKVPsNsQLEIE
0 9 S1410-p VEKVPsNsQLEIEGN
0 1 S1418-p QLEIEGNssGRQLSE
0 1 S1419-p LEIEGNssGRQLSEV
0 9 S1512-p KIAKEEEsEDEsNEE
0 9 S1516-p EEEsEDEsNEEEEEE
0 5 S1528-p EEEDEEEsESEAKSV
0 1 S1530 EDEEEsESEAKSVKV
0 10 K1547-ac KLNKKDDkGRDkGkG
0 68 K1551-ac KDDkGRDkGkGkkRP
1 68 K1553-ac DkGRDkGkGkkRPNR
1 3 K1555-ac GRDkGkGkkRPNRGK
0 66 K1556-ac RDkGkGkkRPNRGKA
1 0 K1562 kkRPNRGKAKPVVsD
1 0 K1564 RPNRGKAKPVVsDFD
0 45 S1568-p GKAKPVVsDFDsDEE
0 46 S1572-p PVVsDFDsDEEQDER
0 5 S1582-p EQDEREQsEGsGtDD
0 3 S1585-p EREQsEGsGtDDE__
0 3 T1587-p EQsEGsGtDDE____
  SMARCA2 iso2  
S93 VEDIHCGSMKGTGMR
S172 SQPNRGPSPFSPVQL
S175 NRGPSPFSPVQLHQL
G284 KLPVPAPGGRPSPAP
S288 PAPGGRPSPAPPAAA
S316 QPAPGQPSPVLQLQQ
S329 QQKQSRISPIQKPQG
K333 SRISPIQKPQGLDPV
T408 RRDTTLETALNSKAY
K413 LETALNSKAYKRSKR
Y415 TALNSKAYKRSKRQT
K437 EKLEKQQKIEQERKR
S468 DFKEYHRSVAGKIQK
S477 AGKIQKLSKAVATWH
T541 DEYVANLTNLVWEHK
K563 KKKRRRRKKKAEENA
K565 KRRRRKKKAEENAEG
S587 DGEPIDESSQMSDLP
S588 GEPIDESSQMSDLPV
S591 IDESSQMSDLPVKVT
K596 QMSDLPVKVTHTETG
K604 VTHTETGKVLFGPEA
K604 VTHTETGKVLFGPEA
Y642 SEESDSDYEEEDEEE
S651 EEDEEEESSRQETEE
S666 KILLDPNSEEVSEKD
S670 DPNSEEVSEKDAKQI
Y689 KQDVDDEYSMQYSAR
S690 QDVDDEYSMQYSARG
S820 SLVPQLRSGKFNVLL
S956 RLKKEVESQLPEKVE
S971 YVIKCDMSALQKILY
Y978 SALQKILYRHMQAKG
K996 TDGSEKDKKGKGGAK
K997 DGSEKDKKGKGGAKT
K999 SEKDKKGKGGAKTLM
K1003 KKGKGGAKTLMNTIM
T1004 KGKGGAKTLMNTIMQ
T1008 GAKTLMNTIMQLRKI
Y1020 RKICNHPYMFQHIEE
Y1035 SFAEHLGYSNGVING
Y1046 VINGAELYRASGKFE
K1051 ELYRASGKFELLDRI
K1189 EKILAAAKYKLNVDQ
Y1190 KILAAAKYKLNVDQK
K1197 YKLNVDQKVIQAGMF
K1271 DARNPKRKPRLMEED
K1286 ELPSWIIKDDAEVER
T1295 DAEVERLTCEEEEEK
Y1316 RQRRDVDYSDALTEK
K1323 YSDALTEKQWLRAIE
S1377 RPPAEKLSPNPPKLT
T1393 QMNAIIDTVINYKDS
Y1397 IIDTVINYKDSSGRQ
- gap
- gap
S1400 TVINYKDSSGRQLSE
S1401 VINYKDSSGRQLSEV
S1494 KIAKEEESEDESNEE
S1498 EEESEDESNEEEEEE
S1510 EEEDEEESESEAKSV
S1512 EDEEESESEAKSVKV
K1529 KLNKKDDKGRDKGKG
K1533 KDDKGRDKGKGKKRP
K1535 DKGRDKGKGKKRPNR
K1537 GRDKGKGKKRPNRGK
K1538 RDKGKGKKRPNRGKA
K1544 KKRPNRGKAKPVVSD
K1546 RPNRGKAKPVVSDFD
S1550 GKAKPVVSDFDSDEE
S1554 PVVSDFDSDEEQDER
S1564 EQDEREQSEGSGTDD
S1567 EREQSEGSGTDDE__
T1569 EQSEGSGTDDE____
  mouse

 
S93 VEDVHCGSMKGTSMR
S166-p NQPNRGPsPFSPVQL
S169 NRGPsPFSPVQLHQL
S289-p KLSAPAPsGRPsPAP
S293-p PAPsGRPsPAPQAAV
S321-p QPAPGQPsPVLQLQQ
S334-p QQKQSRIsPIQkPQG
K338-ub SRIsPIQkPQGLDPV
T413 RRDTTLETALNSkAY
K418-ub LETALNSkAYKRSKR
Y420 TALNSkAYKRSKRQT
K442 EKLEKQQKIEQERKR
S473-p DFKEYHRsVAGKIQK
S482-p AGKIQKLsKAVATWH
T546 DEYVANLTNLVWEHK
K568-ac KKKRRRRkKkAEENA
K570-ac KRRRRkKkAEENAEG
S592-p DGEPIDEssQMsDLP
S593-p GEPIDEssQMsDLPV
S596-p IDEssQMsDLPVkVT
K601-ac QMsDLPVkVTHTETG
K609-ac VTHTETGkVLFGPEA
K609 VTHTETGKVLFGPEA
Y647 SEESESDYEEEDEEE
S656 EEDEEEESSRQETEE
S671 KILLDPNSEEVSEKD
S675 DPNSEEVSEKDAKQI
Y694 KQDVDDEYSMQYSAR
S695 QDVDDEYSMQYSARG
S825 SLVPQLRSGKFNVLL
S961 RLKKEVESQLPEKVE
S976 YVIKCDMSALQKILY
Y983 SALQKILYRHMQAKG
K1001 TDGSEKDKkGkGGAk
K1002-ac DGSEKDKkGkGGAkT
K1004-ac SEKDKkGkGGAkTLM
K1008-ac KkGkGGAkTLMNTIM
T1009 kGkGGAkTLMNTIMQ
T1013 GAkTLMNTIMQLRKI
Y1025 RKICNHPYMFQHIEE
Y1040 SFAEHLGYSNGVING
Y1051 VINGAELYRASGKFE
K1056 ELYRASGKFELLDRI
K1194 EKILAAAKYKLNVDQ
Y1195 KILAAAKYKLNVDQK
K1202 YKLNVDQKVIQAGMF
K1276 DARNPKRKPRLMEED
K1291 ELPSWIIKDDAEVER
T1300 DAEVERLTCEEEEEK
Y1321 RQRRDVDYSDALTEK
K1328 YSDALTEKQWLRAIE
S1382-p RPPAEKLsPNPPKLT
T1398-p QMNAIIDtVINyKDS
Y1402-p IIDtVINyKDSSGRQ
- gap
- gap
S1405 tVINyKDSSGRQLSE
S1406 VINyKDSSGRQLSEV
S1499-p KIAKEEEsEEEsNEE
S1503-p EEEsEEEsNEEEEED
S1515-p EEDDEEEsEsEAKSV
S1517-p DDEEEsEsEAKSVKV
K1534 KLNKKEEKGRDTGkG
T1538 KEEKGRDTGkGkKRP
K1540-ac EKGRDTGkGkKRPNR
K1542-ac GRDTGkGkKRPNRGk
K1543 RDTGkGkKRPNRGkA
K1549-ac kKRPNRGkAkPVVsD
K1551-ac RPNRGkAkPVVsDFD
S1555-p GkAkPVVsDFDsDEE
S1559-p PVVsDFDsDEEQEEN
S1569-p EQEENEQsEAsGtDN
S1572-p ENEQsEAsGtDNE__
T1574-p EQsEAsGtDNE____
  rat

 
S93 VEGVHCGSMKGTSMR
S172 NQPDRGPSPFSPVQL
S175 DRGPSPFSPVQLHQL
S291 KLSAPAPSGRPSPAP
S295 PAPSGRPSPAPPAAT
S323 EPAPGQPSPVLQLQQ
S336 QQKQSRISPIQKPQG
K340 SRISPIQKPQGLDPV
T415 RRDTTLETALNSKAY
K420 LETALNSKAYKRSKR
Y422 TALNSKAYKRSKRQT
K444-ac EKLEKQQkIEQERKR
S475 DFKEYHRSVAGKIQK
S484 AGKIQKLSKAVATWH
T548 DEYVANLTNLVWEHK
R570 KKKRRRRRKKAEENA
K572 KRRRRRKKAEENAEG
S594 DGEPIDESSQMSDLP
S595 GEPIDESSQMSDLPV
S598 IDESSQMSDLPVKVT
K603 QMSDLPVKVTHTETG
K611-ac VTHTETGkVLFGPEA
K611 VTHTETGKVLFGPEA
Y649 SEESESDYEEEDEEE
S658 EEDEEEESSRQETEE
S673 KILLDPNSKEVSEKD
S677 DPNSKEVSEKDARQI
Y696 KQDVDDEYSMQYSAR
S697 QDVDDEYSMQYSARG
S827-p SLVPQLRsGKFNALL
S963 RLKKEVESQLPEKVE
S978 YVIKCDMSALQKILY
Y985 SALQKILYRHMQAKG
K1003 TDGSEKDKkGkGGAK
K1004-ac DGSEKDKkGkGGAKT
K1006-ac SEKDKkGkGGAKTLM
K1010 KkGkGGAKTLMNTIM
T1011 kGkGGAKTLMNTIMQ
T1015 GAKTLMNTIMQLRKI
Y1027 RKICNHPYMFQHIEE
Y1042 SFAEHLGYSNGVING
Y1053 VINGAELYRASGKFE
K1058 ELYRASGKFELLDRI
K1196 EKILAAAKYKLNVDQ
Y1197 KILAAAKYKLNVDQK
K1204 YKLNVDQKVIQAGMF
K1278 DARNPKRKPRLMEED
K1293 ELPSWIIKDDAEVER
T1302 DAEVERLTCEEEEEK
Y1323 RQRRDVDYSDALTEK
K1330 YSDALTEKQWLRAIE
S1384-p RPPAEKLsPNPPKLT
T1400 QMNAIIDTVINYKDR
Y1404 IIDTVINYKDRCNVE
C1415 CNVEKVPCNSQLEIE
S1417 VEKVPCNSQLEIEGN
S1425 QLEIEGNSSGRQLSE
S1426 LEIEGNSSGRQLSEV
S1519-p KIAKEEEsEEEsNEE
S1523-p EEEsEEEsNEEEEEE
S1535-p EEEDEEEsEAEAKSV
A1537 EDEEEsEAEAKSVKV
K1554 KLNKKEEKGRDTGKG
T1558 KEEKGRDTGKGKKRP
K1560 EKGRDTGKGKKRPNR
K1562 GRDTGKGKKRPNRGK
K1563 RDTGKGKKRPNRGKA
K1569 KKRPNRGKAKPVVSD
K1571 RPNRGKAKPVVSDFD
S1575 GKAKPVVSDFDSDEE
S1579 PVVSDFDSDEEQDEN
S1589-p EQDENEQsEAsGtDD
S1592-p ENEQsEAsGtDDE__
T1594-p EQsEAsGtDDE____
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