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Protein Page:
FASN (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FASN a multifunctional enzyme. Catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. Note: This description may include information from UniProtKB.
Protein type: EC 4.2.1.61; EC 1.1.1.100; Acetyltransferase; EC 2.3.1.39; EC 3.1.2.14; Oxidoreductase; EC 2.3.1.85; EC 2.3.1.41; EC 2.3.1.38; Lyase; EC 1.3.1.10; Hydrolase; Lipid Metabolism - fatty acid biosynthesis
Cellular Component: Golgi apparatus; membrane; glycogen granule; mitochondrion; cytoplasm; plasma membrane; melanosome; cytosol
Molecular Function: fatty-acid synthase activity; protein homodimerization activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; zinc ion binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; [acyl-carrier-protein] S-acetyltransferase activity; drug binding; 3-oxoacyl-[acyl-carrier-protein] reductase activity; protein binding; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; [acyl-carrier-protein] S-malonyltransferase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
Biological Process: osteoblast differentiation; vitamin metabolic process; acetyl-CoA metabolic process; pantothenate metabolic process; energy reserve metabolic process; positive regulation of cellular metabolic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid metabolic process; fatty acid biosynthetic process; water-soluble vitamin metabolic process
Reference #:  P49327 (UniProtKB)
Alt. Names/Synonyms: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; Enoyl-[acyl-carrier-protein] reductase; FAS; FASN; Fatty acid synthase; MGC14367; MGC15706; OA-519; Oleoyl-[acyl-carrier-protein] hydrolase; SDR27X1; short chain dehydrogenase/reductase family 27X, member 1
Gene Symbols: FASN
Molecular weight: 273,427 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FASN

Protein Structure Not Found.


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Sites Implicated In
transcription, inhibited: S1028‑p, T1032‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T34-p IGGVDMVtDDDRRWk
0 6 K41-ub tDDDRRWkAGLyGLP
0 93 Y45-p RRWkAGLyGLPRRSG
0 4 R49 AGLyGLPRRSGKLKD
0 2 R59 GKLKDLSRFDAsFFG
0 1 R59 GKLKDLSRFDAsFFG
0 2 S63-p DLSRFDAsFFGVHPk
0 11 K70-ac sFFGVHPkQAHTMDP
0 3 K70-ub sFFGVHPkQAHTMDP
0 1 K193 GGINVLLKPNTSVQF
0 26 S207-p FLRLGMLsPEGTCkA
0 28 K213-ac LsPEGTCkAFDTAGN
0 17 K213-ub LsPEGTCkAFDTAGN
0 57 Y222-p FDTAGNGyCRsEGVV
0 1 S225-p AGNGyCRsEGVVAVL
0 9 K235-ac VVAVLLTkKSLARRV
0 3 K235-ub VVAVLLTkKSLARRV
0 2 K257-ac GTNTDGFkEQGVTFP
0 1 K257-ub GTNTDGFkEQGVTFP
0 1 Y277-p EQLIRSLyQSAGVAP
0 11 K298-ac EAHGTGTkVGDPQEL
0 3 K298-ub EAHGTGTkVGDPQEL
0 3 K326-ub PLLIGSTkSNMGHPE
0 2 S361-p APNLHFHsPNPEIPA
0 17 K436-ac RTPEAVQkLLEQGLR
0 17 K436-ub RTPEAVQkLLEQGLR
0 2 E489 VQQVPAGERPLWFIC
0 1 S509 QWRGMGLSLMRLDRF
0 1 R515 LSLMRLDRFRDSILR
0 2 K528-ac LRSDEAVkPFGLKVS
0 5 K528-ub LRSDEAVkPFGLKVS
0 1 K533 AVkPFGLKVSQLLLS
0 1 S535 kPFGLKVSQLLLSTD
0 1 S540 KVSQLLLSTDESTFD
0 4 K631-ac GLSWEECkQRCPPGV
0 1 K646-ac VPACHNSkDTVTISG
0 2 K667-ub EFVEQLRkEGVFAkE
0 15 K673-ac RkEGVFAkEVRTGGM
0 5 K673-ub RkEGVFAkEVRTGGM
0 1 K673 RkEGVFAKEVRTGGM
0 1 S724 IPEAQWHSsLARTSS
0 7 S725-p PEAQWHSsLARTSSA
0 1 K776-ac AVLKRGLkPSCTIIP
0 1 K776 AVLKRGLKPSCTIIP
0 1 P777 VLKRGLkPSCTIIPL
0 1 S778 LKRGLkPSCTIIPLM
0 30 K786-ac CTIIPLMkkDHRDNL
0 1 K786 CTIIPLMKkDHRDNL
0 1 K786-sc CTIIPLMkkDHRDNL
0 2 K787-ac TIIPLMkkDHRDNLE
0 1 R790 PLMkkDHRDNLEFFL
0 2 S831-p PRGTPLIsPLIKWDH
0 3 K897-ub GYLSIVWktLARALG
0 1 T898-p YLSIVWktLARALGL
0 1 K927-ub HQATILPktGtVSLE
0 1 T928-p QATILPktGtVSLEV
0 1 T930-p TILPktGtVSLEVRL
0 1 R967 QWDDPDPRLFDHPEs
0 1 R967 QWDDPDPRLFDHPEs
0 11 S974-p RLFDHPEsPtPNPTE
0 4 T976-p FDHPEsPtPNPTEPL
0 2 K992-ac LAQAEVYkELRLRGY
0 5 K992-ub LAQAEVYkELRLRGY
0 1 K992 LAQAEVYKELRLRGY
0 1 R1019 SLEGDSGRLLWKDNW
1 1 S1028-p LWKDNWVsFMDtMLQ
1 1 T1032-p NWVsFMDtMLQMSIL
0 28 Y1047-p GSAKHGLyLPTRVTA
0 6 H1056 PTRVTAIHIDPATHR
0 1 K1065-ub DPATHRQkLYTLQDk
0 1 Q1070 RQkLYTLQDkAQVAD
0 2 Q1070 RQkLYTLQDkAQVAD
0 1 Q1070 RQkLYTLQDkAQVAD
0 1 K1072-ac kLYTLQDkAQVADVV
0 11 K1072-ub kLYTLQDkAQVADVV
0 1 S1081-p QVADVVVsRWLRVTV
0 1 I1113 QQEQQVPILEkFCFT
0 1 K1116-ac QQVPILEkFCFTPHT
0 2 K1116-ub QQVPILEkFCFTPHT
0 1 E1136 SERAALQEELQLCkG
0 87 K1142-ub QEELQLCkGLVQALQ
0 1 K1151-ac LVQALQTkVTQQGLk
0 27 K1151-ub LVQALQTkVTQQGLk
0 43 K1158-ub kVTQQGLkMVVPGLD
0 29 S1174-p AQIPRDPsQQELPRL
0 1 S1221-p LLSGLLDsPALKACL
0 4 K1239-ac VENMPSLkMkVVEVL
0 3 K1239-ub VENMPSLkMkVVEVL
0 3 K1241-ub NMPSLkMkVVEVLAG
0 4 Y1253 LAGHGHLYSRIPGLL
0 1 T1273-p LQLSYTAtDRHPQAL
0 1 E1281 DRHPQALEAAQAELQ
0 1 E1281 DRHPQALEAAQAELQ
0 1 Y1367-p LTSTEPQyGQGILsQ
0 1 S1373-p QyGQGILsQDAWEsL
0 1 S1379-p LsQDAWEsLFsRVSL
0 1 S1382-p DAWEsLFsRVSLRLV
0 1 V1384 WEsLFsRVSLRLVGL
0 1 K1393-ub LRLVGLKkSFYGSTL
0 2 T1407-p LFLCRRPtPQDsPIF
0 6 S1411-p RRPtPQDsPIFLPVD
0 1 S1411 RRPtPQDSPIFLPVD
0 1 S1421-p FLPVDDTsFRWVESL
0 1 K1429-ac FRWVESLkGILADED
0 5 K1429-ub FRWVESLkGILADED
0 1 K1444-ub SSRPVWLkAINCATS
0 1 S1479-p VLLSNLSsTSHVPEV
0 1 E1485 SsTSHVPEVDPGSAE
0 1 Q1498 AELQKVLQGDLVMNV
0 1 Q1498 AELQKVLQGDLVMNV
0 2 Y1506-p GDLVMNVyRDGAWGA
0 2 K1523-ac HFLLEEDkPEEPTAH
0 1 K1523-ub HFLLEEDkPEEPTAH
0 1 R1552-m1 RWVCSSLrHAQPTCP
0 5 K1582-ac DIMLATGkLsPDAIP
0 3 K1582-ub DIMLATGkLsPDAIP
0 5 S1584-p MLATGkLsPDAIPGk
0 1 K1591-ac sPDAIPGkWTsQDSL
0 3 K1591-ub sPDAIPGkWTsQDSL
0 2 S1594-p AIPGkWTsQDSLLGM
0 96 K1704-ac TTVGSAEkRAYLQAR
0 8 K1704-ub TTVGSAEkRAYLQAR
0 1 S1723-p DSTSFANsRDTSFEQ
0 2 K1739-ub VLWHTGGkGVDLVLN
0 1 S1747-p GVDLVLNsLAEEkLQ
0 6 K1752-ac LNsLAEEkLQASVRC
0 2 K1752-ub LNsLAEEkLQASVRC
0 12 K1771-ac GRFLEIGkFDLSQNH
0 1 R1824 GIRDGVVRPLKCTVF
0 1 K1827 DGVVRPLKCTVFHGA
0 1 G1833 LKCTVFHGAQVEDAF
0 1 K1847-ac FRYMAQGkHIGkVVV
0 1 K1847-ub FRYMAQGkHIGkVVV
0 4 K1851-ub AQGkHIGkVVVQVLA
0 68 K1866-ub EEPEAVLkGAkPkLM
0 25 K1869-ub EAVLkGAkPkLMSAI
0 16 K1871-ub VLkGAkPkLMSAISk
0 6 K1878-ac kLMSAISkTFCPAHK
0 2 K1878-ub kLMSAISkTFCPAHK
0 6 K1911-ub LIQRGVQkLVLTSRS
0 1 Y1924 RSGIRTGYQAkQVRR
0 3 K1927-ac IRTGYQAkQVRRWRR
0 11 K1927-ub IRTGYQAkQVRRWRR
0 1 S1947-p QVSTSNIssLEGARG
0 1 S1948-p VSTSNIssLEGARGL
0 5 K1993-ac EFFQDVCkPkYSGtL
0 9 K1993-ub EFFQDVCkPkYSGtL
0 7 K1995-ac FQDVCkPkYSGtLNL
0 10 K1995-ub FQDVCkPkYSGtLNL
0 1 T1999-p CkPkYSGtLNLDRVT
0 8 Y2034-p GNAGQSNyGFANSAM
0 1 K2047-ub AMERICEkRRHEGLP
0 2 S2123-p AAYRDRDsQRDLVEA
0 1 E2129 DsQRDLVEAVAHILG
0 1 S2175-p RELNLVLsVREVRQL
0 1 K2186-ub VRQLTLRkLQELSsK
0 1 S2192-p RkLQELSsKADEAsE
0 1 K2193 kLQELSsKADEAsEL
0 3 E2196 ELSsKADEAsELACP
0 5 S2198-p SsKADEAsELACPtP
0 19 T2204-p AsELACPtPkEDGLA
0 1 T2204 AsELACPTPkEDGLA
0 6 K2206-ac ELACPtPkEDGLAQQ
0 1 E2207 LACPtPkEDGLAQQQ
0 2 T2215-p DGLAQQQtQLNLRSL
0 4 S2236-p PTLMRLNsVQSSERP
0 1 S2265-p HSLASRLsIPtyGLQ
0 1 T2268-p ASRLsIPtyGLQCTR
0 1 Y2269-p SRLsIPtyGLQCTRA
0 1 N2381 QFTDMEHNRVLEALL
0 1 R2382 FTDMEHNRVLEALLP
0 2 K2391-ac LEALLPLkGLEERVA
0 24 K2391-ub LEALLPLkGLEERVA
0 1 I2405 AAAVDLIIKSHQGLD
0 1 Y2424-p SFAARSFyykLRAAE
0 3 Y2425-p FAARSFyykLRAAEQ
0 2 K2426-ac AARSFyykLRAAEQy
0 1 K2426-ub AARSFyykLRAAEQy
0 1 Y2433-p kLRAAEQyTPkAkyH
0 1 T2434 LRAAEQyTPkAkyHG
0 5 K2436-ub AAEQyTPkAkyHGNV
0 6 K2438-ac EQyTPkAkyHGNVML
0 1 K2438 EQyTPkAKyHGNVML
0 1 Y2439-p QyTPkAkyHGNVMLL
0 1 M2444 AkyHGNVMLLRAkTG
0 82 K2449-ub NVMLLRAkTGGAYGE
0 1 T2450 VMLLRAkTGGAYGED
0 1 K2471-ac LSQVCDGkVSVHVIE
  mouse

 
T34 IGGVDMVTDDDRRWk
K41-ub TDDDRRWkAGLYGLP
Y45 RRWkAGLYGLPkRSG
K49-ac AGLYGLPkRSGKLKD
K59-ac GKLKDLSkFDAsFFG
K59-ub GKLKDLSkFDAsFFG
S63-p DLSkFDAsFFGVHPk
K70-ac sFFGVHPkQAHTMDP
K70-ub sFFGVHPkQAHTMDP
K193-ub GGINLLLkPNTSVQF
S207-p FMKLGMLsPDGTCRS
R213 LsPDGTCRSFDDSGS
R213 LsPDGTCRSFDDSGS
Y222 FDDSGSGYCRSEAVV
S225 SGSGYCRSEAVVAVL
K235 VVAVLLTKKSLARRV
K235 VVAVLLTKKSLARRV
K257 GTNTDGSKEQGVTFP
K257 GTNTDGSKEQGVTFP
Y277 EQLICSLYQPAGLAP
K298 EAHGTGTKVGDPQEL
K298 EAHGTGTKVGDPQEL
K326-ub PLLIGSTkSNMGHPE
N361 APNLHFHNPNPEIPA
D436 RTLEAVQDLLEQGRQ
D436 RTLEAVQDLLEQGRQ
K489-ac VQQVSTNkRPLWFIC
S509-p QWRGMGLsLMRLDsF
S515-p LsLMRLDsFRESILR
K528-ac LRSDEAVkPLGVkVs
K528-ub LRSDEAVkPLGVkVs
K533-ub AVkPLGVkVsDLLLs
S535-p kPLGVkVsDLLLsTD
S540-p kVsDLLLsTDERTFD
K631 GLSWEECKQRCPAGV
E646 VPACHNSEDTVTISG
Q667 EFVEQLKQEGVFAkE
K673-ac KQEGVFAkEVRTGGL
K673-ub KQEGVFAkEVRTGGL
K673-sc KQEGVFAkEVRTGGL
S724-p IPEAQWQssLARTSS
S725-p PEAQWQssLARTSSA
K776 AVLKRGVKssCTIIP
K776-ub AVLKRGVkssCTIIP
S777-p VLKRGVkssCTIIPL
S778-p LKRGVkssCTIIPLM
K786-ac CTIIPLMkRDHkDNL
K786-ub CTIIPLMkRDHkDNL
K786 CTIIPLMKRDHkDNL
R787 TIIPLMkRDHkDNLE
K790-ub PLMkRDHkDNLEFFL
S831 PRGTPLISPHIKWDH
K897 GYLCLVWKTLARSLG
T898 YLCLVWKTLARSLGL
K927 HQATILPKTGtVALE
T928 QATILPKTGtVALEV
T930-p TILPKTGtVALEVRL
K967-ac LWEDPNSkLFDHPEV
K967-ub LWEDPNSkLFDHPEV
V974 kLFDHPEVPtPPESA
T976-p FDHPEVPtPPESASV
K993-ac LTQGEVYkELRLRGY
K993-ub LTQGEVYkELRLRGY
K993-sc LTQGEVYkELRLRGY
K1020-ub TLEGEQGkLLWKDNW
T1029-p LWKDNWVtFMDtMLQ
T1033-p NWVtFMDtMLQVSIL
Q1048 GSSQQSLQLPTRVTA
Y1057-p PTRVTAIyIDPATHR
K1066 DPATHRQKVYRLkED
K1071-ac RQKVYRLkEDTQVAD
K1071-ub RQKVYRLkEDTQVAD
K1071-sc RQKVYRLkEDTQVAD
D1073 KVYRLkEDTQVADVT
D1073 KVYRLkEDTQVADVT
S1082 QVADVTTSRCLGITV
T1114-p QQEQLVPtLEkFVFT
K1117 QLVPtLEKFVFTPHM
K1117-ub QLVPtLEkFVFTPHM
K1137-ub SESTALQkELQLCkG
K1143-ub QkELQLCkGLARALQ
K1152 LARALQTKATQQGLk
K1152-ub LARALQTkATQQGLk
K1159-ub kATQQGLkAAMLGQE
P1169 MLGQEDPPQHGLPRL
S1216 LISGLLNSQALKACV
K1234-ac LENLSTLkMkVAEVL
K1234-ub LENLSTLkMkVAEVL
K1236-ub NLSTLkMkVAEVLAG
Y1248-p LAGEGHLySRIPALL
T1268 LQLEYTATDRHPQAL
K1276-ac DRHPQALkDVQTKLQ
K1276-ub DRHPQALkDVQTKLQ
P1361 CLPSEVQPAPSLLSQ
S1367 QPAPSLLSQEEWESL
S1373 LSQEEWESLFSRkAL
S1376 EEWESLFSRkALHLV
K1378-ub WESLFSRkALHLVGL
R1387 LHLVGLKRSFYGTAL
I1401 LFLCRRAIPQEkPIF
K1405 RRAIPQEKPIFLSVE
K1405-ac RRAIPQEkPIFLSVE
S1415 FLSVEDTSFQWVDSL
K1423 FQWVDSLKSTLATSS
K1423 FQWVDSLKSTLATSS
T1437 SSQPVWLTAMDCPTS
N1472 ILLSNLSNTSHAPkL
K1478-ub SNTSHAPkLDPGSPE
K1491-ac PELQQVLkHDLVMNV
K1491-ub PELQQVLkHDLVMNV
Y1499-p HDLVMNVyRDGAWGA
K1516-ac HFQLEQDkPKEQTAH
K1516 HFQLEQDKPKEQTAH
K1545 RWVSSPLKHTQPSSS
K1575-ac DIMLATGkLsPDAIP
K1575-ub DIMLATGkLsPDAIP
S1577-p MLATGkLsPDAIPGk
K1584-ac sPDAIPGkWAsRDCM
K1584-ub sPDAIPGkWAsRDCM
S1587-p AIPGkWAsRDCMLGM
K1697-ac TTVGSAEkRAYLQAR
K1697 TTVGSAEKRAYLQAR
S1716 DDTSFANSRDTSFEQ
K1732 VLLHTGGKGVDLVLN
S1740 GVDLVLNSLAEEkLQ
K1745-ac LNSLAEEkLQASVRC
K1745-ub LNSLAEEkLQASVRC
K1764-ac GRFLEIGkFDLSNNH
K1817-ub GIRDGVVkPLkCTVF
K1820-ub DGVVkPLkCTVFPkA
K1826-ub LkCTVFPkAQVEDAF
K1840 FRYMAQGKHIGKVLV
K1840 FRYMAQGKHIGKVLV
K1844 AQGKHIGKVLVQVRE
P1859 EEPEAVLPGAQPTLI
Q1862 EAVLPGAQPTLISAI
T1864 VLPGAQPTLISAISk
K1871 TLISAISKTFCPAHK
K1871-ub TLISAISkTFCPAHK
R1904 LVLRGAQRLVLTSRS
Y1917-p RSGIRTGyQAKHIRE
K1920 IRTGyQAKHIREWRR
K1920 IRTGyQAKHIREWRR
S1940 LVSTSNVSSLEGARA
S1941 VSTSNVSSLEGARAL
K1986-ac ELFQDVNkPkYNGTL
K1986-ub ELFQDVNkPkYNGTL
K1988-ac FQDVNkPkYNGTLNL
K1988-ub FQDVNkPkYNGTLNL
T1992 NkPkYNGTLNLDRAT
Y2027 GNAGQTNYGFANSTM
Q2040 TMERICEQRRHDGLP
T2117 VAHGDGDTQRDLVkA
K2123-ub DTQRDLVkAVAHILG
P2169 REHDLVLPMREVRQL
K2180 VRQLTLRKLQEMSSk
S2186 RKLQEMSSkTDsATD
K2187-ub KLQEMSSkTDsATDT
S2190-p EMSSkTDsATDTTAP
T2192 SSkTDsATDTTAPkS
K2198 ATDTTAPKSRsDTSL
K2198-ub ATDTTAPkSRsDTSL
R2200 DTTAPkSRsDTSLKQ
S2201-p TTAPkSRsDTSLKQN
N2208 sDTSLKQNQLNLSTL
S2229 PTLTQLNSVQSSERP
S2258 HSLAAKLSVPTYGLQ
T2261 AAKLSVPTYGLQCTQ
Y2262 AKLSVPTYGLQCTQA
S2374-p QFLDVEHskVLEALL
K2375-ub FLDVEHskVLEALLP
K2384-ac LEALLPLkSLEDRVA
K2384-ub LEALLPLkSLEDRVA
T2398-p AASVDLItKSHHSLD
Y2417 SFAAVSFYHkLRAAD
H2418 FAAVSFYHkLRAADQ
K2419-ac AAVSFYHkLRAADQY
K2419 AAVSFYHKLRAADQY
Y2426 kLRAADQYkPKAkyH
K2427-sc LRAADQYkPKAkyHG
K2429 AADQYkPKAkyHGNV
K2431 DQYkPKAKyHGNVtL
K2431-ub DQYkPKAkyHGNVtL
Y2432-p QYkPKAkyHGNVtLL
T2437-p AkyHGNVtLLRAktG
K2442-ub NVtLLRAktGGTYGE
T2443-p VtLLRAktGGTYGED
K2464 LSQVCDGKVSVHIIE
  rat

 
T34 IGGVDMVTDDDRRWK
K41 TDDDRRWKAGLYGLP
Y45 RRWKAGLYGLPKRSG
K49 AGLYGLPKRSGKLKD
K59 GKLKDLSKFDASFFG
K59 GKLKDLSKFDASFFG
S63 DLSKFDASFFGVHPK
K70 SFFGVHPKQAHTMDP
K70 SFFGVHPKQAHTMDP
K193 GGINLLLKPNTSVQF
S207 FMKLGMLSPDGTCRS
R213 LSPDGTCRSFDDSGN
R213 LSPDGTCRSFDDSGN
Y222 FDDSGNGYCRAEAVV
A225 SGNGYCRAEAVVAVL
K235 VVAVLLTKKSLARRV
K235 VVAVLLTKKSLARRV
K257 GTNTDGCKEQGVTFP
K257 GTNTDGCKEQGVTFP
Y277 EQLIRSLYQPGGVAP
K298 EAHGTGTKVGDPQEL
K298 EAHGTGTKVGDPQEL
K326 PLLIGSTKSNMGHPE
N361 APNLHFHNPNPEIPA
G436 RTMEAVQGLLEQGRQ
G436 RTMEAVQGLLEQGRQ
Q489 VQQVPASQRPLWFIC
S509 QWRGMGLSLMRLDSF
S515 LSLMRLDSFRESILR
K528 LRSDEALKPLGVKVS
K528 LRSDEALKPLGVKVS
K533 ALKPLGVKVSDLLLS
S535 KPLGVKVSDLLLSTD
S540 KVSDLLLSTDEHTFD
K631 GLSWEECKQRCPPGV
E646 VPACHNSEDTVTISG
Q667 EFVEQLKQEGVFAKE
K673 KQEGVFAKEVRTGGL
K673 KQEGVFAKEVRTGGL
K673 KQEGVFAKEVRTGGL
S724 IPEAQWQSSLARTSS
S725 PEAQWQSSLARTSSA
K776 AVLKRGVKPSCTIIP
K776 AVLKRGVKPSCTIIP
P777 VLKRGVKPSCTIIPL
S778 LKRGVKPSCTIIPLM
K786 CTIIPLMKRDHKDNL
K786 CTIIPLMKRDHKDNL
K786 CTIIPLMKRDHKDNL
R787 TIIPLMKRDHKDNLE
K790 PLMKRDHKDNLEFFL
S831 PRGTPLISPHIKWDH
K897 GYLYLVWKTLARSLS
T898 YLYLVWKTLARSLSL
R927 HQATILPRTGTVPLE
T928 QATILPRTGTVPLEV
T930 TILPRTGTVPLEVRL
K967 QWEDPDSKLFDHPEV
K967 QWEDPDSKLFDHPEV
V974 KLFDHPEVPIPAESE
I976 FDHPEVPIPAESESV
K993 LTQGEVYKELRLRGY
K993 LTQGEVYKELRLRGY
K993 LTQGEVYKELRLRGY
K1020 TLEGEQGKLLWKDNW
T1029 LWKDNWVTFMDTMLQ
T1033 NWVTFMDTMLQISIL
Q1048 GFSKQSLQLPTRVTA
Y1057 PTRVTAIYIDPATHL
K1066 DPATHLQKVYMLEGD
E1071 LQKVYMLEGDTQVAD
E1071 LQKVYMLEGDTQVAD
E1071 LQKVYMLEGDTQVAD
D1073 KVYMLEGDTQVADVT
D1073 KVYMLEGDTQVADVT
S1082 QVADVTTSRCLGVTV
T1114 QQEQLVPTLEKFVFT
K1117 QLVPTLEKFVFTPHV
K1117 QLVPTLEKFVFTPHV
K1137 SESAILQKELQLCKG
K1143 QKELQLCKGLAKALQ
K1152 LAKALQTKATQQGLK
K1152 LAKALQTKATQQGLK
K1159 KATQQGLKMTVPGLE
P1169 VPGLEDLPQHGLPRL
S1216 LISGLLNSQALKACI
K1234 LENLSTLKMKVVEVL
K1234 LENLSTLKMKVVEVL
K1236 NLSTLKMKVVEVLAG
Y1248 LAGEGHLYSHISALL
T1268 LQLEYTATDRHPQAL
K1276 DRHPQALKDVQTKLQ
K1276 DRHPQALKDVQTKLQ
P1361 CLPSEVQPGPSFLSQ
S1367 QPGPSFLSQEEWESL
S1373 LSQEEWESLFSRKAL
S1376 EEWESLFSRKALHLV
K1378 WESLFSRKALHLVGL
K1387 LHLVGLKKSFYGTAL
S1401 LFLCRRLSPQDKPIF
K1405 RRLSPQDKPIFLPVE
K1405 RRLSPQDKPIFLPVE
S1415 FLPVEDTSFQWVDSL
K1423 FQWVDSLKSILATSS
K1423 FQWVDSLKSILATSS
T1437 SSQPVWLTAMNCPTS
S1472 ILLSNLSSTSHVPKL
K1478 SSTSHVPKLDPGSSE
E1491 SELQKVLESDLVMNV
E1491 SELQKVLESDLVMNV
Y1499 SDLVMNVYRDGAWGA
K1516 HFQLEQDKPEEQTAH
K1516 HFQLEQDKPEEQTAH
K1545 RWVSSPLKHMQPPSS
K1576 DIMLATGKLSPDAIP
K1576 DIMLATGKLSPDAIP
S1578 MLATGKLSPDAIPGK
K1585 SPDAIPGKWASRDCM
K1585 SPDAIPGKWASRDCM
S1588 AIPGKWASRDCMLGM
K1698 TTVGSAEKRAYLQAR
K1698 TTVGSAEKRAYLQAR
S1717 DDTSFANSRDTSFEQ
K1733 VLLHTGGKGVDLVLN
S1741 GVDLVLNSLAEEKLQ
K1746 LNSLAEEKLQASVRC
K1746 LNSLAEEKLQASVRC
K1765 GRFLEIGKFDLSNNH
K1818 GIRDGVVKPLKCTVF
K1821 DGVVKPLKCTVFPKA
K1827 LKCTVFPKAQVEDAF
K1841 FRYMAQGKHIGKVLV
K1841 FRYMAQGKHIGKVLV
K1845 AQGKHIGKVLVQVRE
P1860 EEPEAMLPGAQPTLI
Q1863 EAMLPGAQPTLISAI
T1865 MLPGAQPTLISAISK
K1872 TLISAISKTFCPEHK
K1872 TLISAISKTFCPEHK
R1905 LVLRGAQRLVLTSRS
Y1918 RSGIRTGYQAKHVRE
K1921 IRTGYQAKHVREWRR
K1921 IRTGYQAKHVREWRR
S1941 LVSTSNVSSLEGARA
S1942 VSTSNVSSLEGARAL
K1987 ELFQDVNKPKYNGTL
K1987 ELFQDVNKPKYNGTL
K1989 FQDVNKPKYNGTLNL
K1989 FQDVNKPKYNGTLNL
T1993 NKPKYNGTLNLDRAT
Y2028 GNAGQSNYGFANSTM
Q2041 TMERICEQRRHDGLP
A2118 VAHGDGEAQRDLVKA
K2124 EAQRDLVKAVAHILG
P2170 REHDLVLPIREVRQL
K2181 VRQLTLRKLQEMSSK
S2187 RKLQEMSSKAGsDTE
K2188 KLQEMSSKAGsDTEL
S2191-p EMSSKAGsDTELAAP
T2193 SSKAGsDTELAAPKS
K2199 DTELAAPKSKNDTSL
K2199 DTELAAPKSKNDTSL
K2201 ELAAPKSKNDTSLKQ
N2202 LAAPKSKNDTSLKQA
A2209 NDTSLKQAQLNLSIL
S2230 PTLTRLNSVQSSERP
S2259 HSLAAKLSVPTYGLQ
T2262 AAKLSVPTYGLQCTQ
Y2263 AKLSVPTYGLQCTQA
S2375 QFVDAEHSKVLEALL
K2376 FVDAEHSKVLEALLP
K2385 LEALLPLKSLEDRVA
K2385 LEALLPLKSLEDRVA
T2399 AAAVDLITRSHQSLD
Y2418 SFAAVSFYYKLRAAD
Y2419 FAAVSFYYKLRAADQ
K2420 AAVSFYYKLRAADQY
K2420 AAVSFYYKLRAADQY
Y2427 KLRAADQYKPKAKYH
K2428 LRAADQYKPKAKYHG
K2430 AADQYKPKAKYHGNV
K2432 DQYKPKAKYHGNVIL
K2432 DQYKPKAKYHGNVIL
Y2433 QYKPKAKYHGNVILL
I2438 AKYHGNVILLRAKTG
K2443 NVILLRAKTGGTYGE
T2444 VILLRAKTGGTYGED
K2465 LSQVCDGKVSVHIIE
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