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CDK4 (human)

Overview CDK4 a protein kinase of the CDK family that is important for cell cycle G1 phase progression. Its activity is restricted to the G1-S phase. Controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). Phosphorylates the retinoblastoma gene product (Rb). Point mutations found in somatic and familial melanoma. Amplified in sarcomas, glioma and lymphoma. Amplified, methylated or deleted in head and neck squamous cell carcinoma. Overexpression drives epithelial tumors in mice. Disruption makes mice resistant to cancer. Inhibitor: PD332991. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; CMGC group; CDK family; CDK4 subfamily; CDK/CDK4 subfamily Cellular Component: nucleoplasm; transcription factor complex; nuclear membrane; nucleolus; cyclin-dependent protein kinase holoenzyme complex; nucleus; cytosol; chromatin Molecular Function: protein binding; cyclin-dependent protein kinase activity; ATP binding Biological Process: response to drug; positive regulation of fibroblast proliferation; cell division; regulation of gene expression; regulation of cell cycle; positive regulation of cell proliferation; mitotic cell cycle; S phase of mitotic cell cycle; G1 phase of mitotic cell cycle; signal transduction; protein amino acid phosphorylation; G1/S transition of mitotic cell cycle Reference #:  P11802 (UniProtKB) Alt. Names/Synonyms: CDK4; cell division kinase 4; Cell division protein kinase 4; CMM3; Cyclin-dependent kinase 4; melanoma cutaneous malignant, 3; MGC14458; PSK-J3 Gene Symbols: CDK4 Molecular weight: 33,730 Da Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CDK4 1LD2 - A=1-303 (human) 2W96 - B=48-303 (human) 2W99 - B=48-303 (human) 2W9F - B=48-303 (human) 2W9Z - B=48-303 (human) 3G33 - A/C=1-303 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1LD2 2W96 2W99 2W9F 2W9Z 3G33  |  ENZYME  |  Phospho3D  |  DISEASE 123829 609048  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: T172‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	3		Y17-p	AEIGVGAyGTVYkAR
0	1		K22-u	GAyGTVYkARDPHSG
0	1		K35-u	SGHFVALkSVRVPNG
0	1		K106-u	DLRTYLDkAPPPGLP
0	1		K118-u	GLPAETIkDLMRQFL
0	1		K142-u	CIVHRDLkPENILVT
0	1		K155-u	VTSGGTVkLADFGLA
5	4		T172-p	YSYQMALtPVVVTLW
0	8		G300	SYLHKDEGNPE____

	mouse
Y17	AEIGVGAYGTVYKAR
K22	GAYGTVYKARDPHSG
K35	SGHFVALKSVRVPNG
K106	DLRTYLDKAPPPGLP
K118	GLPVETIKDLMRQFL
K142	CIVHRDLKPENILVT
K155	VTSNGTVKLADFGLA
T172-p	YSYQMALtPVVVTLW
S300-p	SYLHKEEsDAE____

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