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Protein Page:
CDK4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDK4 a protein kinase of the CDK family that is important for cell cycle G1 phase progression. Its activity is restricted to the G1-S phase. Controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). Phosphorylates the retinoblastoma gene product (Rb). Point mutations found in somatic and familial melanoma. Amplified in sarcomas, glioma and lymphoma. Amplified, methylated or deleted in head and neck squamous cell carcinoma. Overexpression drives epithelial tumors in mice. Disruption makes mice resistant to cancer. Inhibitor: PD332991. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.22; Kinase, protein; CMGC group; CDK family; CDK/CDK4 subfamily; CDK4 subfamily
Cellular Component: nucleoplasm; transcription factor complex; nuclear membrane; tight junction; perinuclear region of cytoplasm; nucleolus; cyclin-dependent protein kinase holoenzyme complex; chromatin; nucleus; cytosol
Molecular Function: cyclin binding; protein binding; cyclin-dependent protein kinase activity; protein complex binding; ATP binding
Biological Process: circadian rhythm; response to drug; organ regeneration; positive regulation of translation; positive regulation of cell size; positive regulation of apoptosis; response to toxin; response to testosterone stimulus; signal transduction; protein amino acid phosphorylation; positive regulation of fibroblast proliferation; response to hyperoxia; cell division; regulation of gene expression; positive regulation of cell proliferation; response to lead ion; mitotic cell cycle; G1/S transition of mitotic cell cycle
Reference #:  P11802 (UniProtKB)
Alt. Names/Synonyms: CDK4; cell division kinase 4; Cell division protein kinase 4; CMM3; Cyclin-dependent kinase 4; melanoma cutaneous malignant, 3; MGC14458; PSK-J3
Gene Symbols: CDK4
Molecular weight: 33,730 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDK4

Protein Structure Not Found.

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Sites Implicated In
enzymatic activity, induced: T172‑p

Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 3 Y17-p AEIGVGAyGTVYkAR
0 1 K22-ub GAyGTVYkARDPHSG
0 1 K35-ub SGHFVALkSVRVPNG
0 1 K106-ub DLRTYLDkAPPPGLP
0 1 K118-ub GLPAETIkDLMRQFL
0 1 K142-ub CIVHRDLkPENILVT
0 1 K155-ub VTSGGTVkLADFGLA
6 4 T172-p YSYQMALtPVVVTLW
0 11 G300 SYLHKDEGNPE____
  mouse

 
Y17 AEIGVGAYGTVYKAR
K22 GAYGTVYKARDPHSG
K35 SGHFVALKSVRVPNG
K106 DLRTYLDKAPPPGLP
K118 GLPVETIKDLMRQFL
K142 CIVHRDLKPENILVT
K155 VTSNGTVKLADFGLA
T172-p YSYQMALtPVVVTLW
S300-p SYLHKEEsDAE____
  rat

 
Y17 AEIGVGAYGTVYKAR
K22 GAYGTVYKARDPHSG
K35 SGHFVALKSVRVPNG
K106 DLRTYLDKAPPPGLP
K118 GLPVETIKDLMRQFL
K142 CIVHRDLKPENILVT
K155 VTSNGTVKLADFGLA
T172 YSYQMALTPVVVTLW
S300-p SYLHKEEsDPE____
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