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Protein Page:
BAT3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BAT3 Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Acts in part by regulating stability of proteins and their degradation by the proteasome. Participates in endoplasmic reticulum stress-induced apoptosis via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and preventing its degradation. Also required during spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2. Required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response. Key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane. Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET3/TRC35. Interacts with AIFM1, CTCFL, HSPA2 and p300/EP300. Interacts with ricin A chain. Interacts with L.pneumophila proteins Lpg2160 and LegU1. Interacts with NCR3. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Ubiquitin conjugating system; Chaperone; Apoptosis
Cellular Component: cytosol; nucleus
Molecular Function: protein binding; ribosome binding; Hsp70 protein binding; polyubiquitin binding
Biological Process: negative regulation of proteolysis; ubiquitin-dependent protein catabolic process; synaptonemal complex assembly; internal peptidyl-lysine acetylation; protein stabilization; immune system process; chromatin modification; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of cell proliferation; embryonic development; transport; spermatogenesis; brain development; cell differentiation; kidney development; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; lung development
Reference #:  P46379 (UniProtKB)
Alt. Names/Synonyms: BAG-6; BAG6; BAT3; D6S52E; G3; HLA-B associated transcript 3; HLA-B associated transcript-3; HLA-B-associated transcript 3; Large proline-rich protein BAT3; Protein G3; scythe
Gene Symbols: BAG6
Molecular weight: 119,409 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BAT3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S6-p __MEPNDsTSTAVEE
0 1 K22-ub DSLEVLVkTLDsQTR
1 1 S26-p VLVkTLDsQTRTFIV
0 4 K40-ub VGAQMNVkEFKEHIA
0 69 K56-ub SVSIPSEkQRLIYQG
0 1 K56-ac SVSIPSEkQRLIYQG
0 1 K70-ub GRVLQDDkKLQEYNV
0 1 K71 RVLQDDkKLQEYNVG
0 9 K80-ub QEYNVGGkVIHLVER
0 1 S96-p PPQTHLPsGASSGTG
0 1 S106-p SSGTGSAsATHGGGs
0 11 S113-p sATHGGGsPPGtRGP
0 2 T117-p GGGsPPGtRGPGASV
0 1 T178-p HMIRDIQtLLsRMET
0 1 S181-p RDIQtLLsRMETLPY
1 1 S218-p PEPVALSsQTSEPVE
0 27 T350-p LRCNLACtPPRHLHV
0 1 S450 VIRISHQSVEPVVMM
0 1 S464 MHMNIQDSGTQPGGV
0 1 S473 TQPGGVPSAPTGPLG
0 1 S697-p GLGLESLsPEFFTSV
0 2 Y818-p LITGLEEyVRESFSL
0 2 T915-p PSLVSWLtTMMGLRL
0 1 T916 SLVSWLtTMMGLRLQ
0 2 P949 RVGDPPQPLPEEPME
0 2 A963 EVQGAERAsPEPQRE
0 24 S964-p VQGAERAsPEPQREN
0 39 S973-p EPQRENAsPAPGttA
0 2 T978-p NAsPAPGttAEEAMs
0 1 T979-p AsPAPGttAEEAMsR
0 2 S985-p ttAEEAMsRGPPPAP
0 1 D1001-ca GGSRDEQdGASAETE
0 2 K1033-ub IQSQRKVkPQPPLSD
0 1 K1049-ub YLSGMPAkRRktMQG
0 3 K1052-ub GMPAkRRktMQGEGP
0 5 T1053-p MPAkRRktMQGEGPQ
0 1 S1064-p EGPQLLLsEAVSRAA
0 2 T1080-p AAGARPLtsPESLSR
0 25 S1081-p AGARPLtsPESLSRD
0 64 Y1116-p RLQEDPNysPQRFPN
0 22 S1117-p LQEDPNysPQRFPNA
  BAT3 iso5  
S6 __MEPNDSTSTAVEE
K22 DSLEVLVKTLDSQTR
S26 VLVKTLDSQTRTFIV
K40 VGAQMNVKEFKEHIA
K56 SVSIPSEKQRLIYQG
K56 SVSIPSEKQRLIYQG
K70 GRVLQDDKKLQEYNV
K71 RVLQDDKKLQEYNVG
K80 QEYNVGGKVIHLVER
S96 PPQTHLPSGASSGTG
S106 SSGTGSASATHGGGS
S113 SATHGGGSPPGTRGP
T117 GGGSPPGTRGPGASV
T178 HMIRDIQTLLSRMEC
S181 RDIQTLLSRMECRGG
S212 PEPVALSSQTSEPVE
T344 LRCNLACTPPRHLHV
S444 VIRISHQSVEPVVMM
S458 MHMNIQDSGTQPGGV
S467 TQPGGVPSAPTGPLG
S565 GLGLESLSPEFFTSV
Y686 LITGLEEYVRESFSL
T783 PSLVSWLTTMMGLRL
T784 SLVSWLTTMMGLRLQ
P817 RVGDPPQPLPEEPME
A831 EVQGAERAsPEPQEW
S832-p VQGAERAsPEPQEWV
- gap
- gap
- gap
- gap
- gap
K853 IQSQRKVKPQPPLSD
K869 YLSGMPAKRRKLRSD
K872 GMPAKRRKLRSDIQK
- gap
- gap
- gap
- gap
Y887 RLQEDPNYSPQRFPN
S888 LQEDPNYSPQRFPNA
  mouse

 
S6 __MEPSDSASTAMEE
K22 DSLEVLVKTLDSQTR
S26 VLVKTLDSQTRTFIV
K40-ub VGAQMNVkEFKEHIA
K56-ub SVSIPSEkQRLIYQG
K56 SVSIPSEKQRLIYQG
K70 GRVLQDDKkLQEYNV
K71-ub RVLQDDKkLQEYNVG
K80-ub QEYNVGGkVIHLVER
S96 PPQTQLPSGASSGTG
S106 SSGTGSASATHGGAP
P113 SATHGGAPLPGTRGP
T117 GGAPLPGTRGPGASV
T178 HMIRDIQTLLSRMEC
S181 RDIQTLLSRMECRGG
S213 SETVALNSQTSEPVE
A351 LRCNLACAPPRHLHV
S451-p VIRISHQsVEPVVMM
S465-p MHMNIQDsGAQPGGV
S474-p AQPGGVPsAPTGPLG
P719 GLGPESLPPEFFTSV
Y840 LITGLEEYVRESFSL
T937-p PSLVSWLttMMGLRL
T938-p SLVSWLttMMGLRLQ
T971-p RVGDPPQtLPEEPME
T985-p EVQGAERtsPEPQRE
S986-p VQGAERtsPEPQREN
S995-p EPQRENAsPAPGttA
T1000-p NAsPAPGttAEEAMS
T1001-p AsPAPGttAEEAMSR
S1007 ttAEEAMSRGPPPAP
D1023 GGSRDEQDGASADAE
K1055-ub IQSQRKVkPQPPLSD
K1071 YLSGMPAKRRktMQG
K1074-ub GMPAKRRktMQGEGP
T1075-p MPAKRRktMQGEGPQ
S1086 EGPQLLLSEAVSRAA
T1102 AAGARPLTsPESLSR
S1103-p AGARPLTsPESLSRD
Y1138-p RLQEDPNysPQRFPN
S1139-p LQEDPNysPQRFPNA
  rat

 
S6 __MEPSDSTSTAMEE
K22 DSLEVLVKTLDSQTR
S26 VLVKTLDSQTRTFIV
K40 VGAQMNVKEFKEHIA
K56 SVSIPSEKQRLIYQG
K56 SVSIPSEKQRLIYQG
K70 GRVLQDDKKLQDYNV
K71 RVLQDDKKLQDYNVG
K80 QDYNVGGKVIHLVER
S96 PPQTQLPSGASSGTG
S106 SSGTGSASATHGGGP
P113 SATHGGGPLPGTRGP
T117 GGGPLPGTRGPGASG
T178 HMIRDIQTLLSRMEC
S181 RDIQTLLSRMECRGG
S212 SETVALNSQTSEPVE
A345 LRCNLACAPPRHLHV
S445 VIRISHQSVEPVVMM
S459 MHMNIQDSGAQPGGV
S468 AQPGGVPSAPTGPLG
P711 GLGPESLPPEFFTSV
Y832 LITGLEEYVRESFSL
T929 PSLVSWLTTMMGLRL
T930 SLVSWLTTMMGLRLQ
A963 RIGDPPQALPEEPME
T977-p EVQGAERtSPEPQRE
S978 VQGAERtSPEPQRED
S987-p EPQREDAsPAPGTTA
T992 DAsPAPGTTAEEAMS
T993 AsPAPGTTAEEAMSR
S999 TTAEEAMSRGPPPAP
D1015 GGSRDEQDGASADAE
K1047 IQSQRKVKPQPPLSD
K1063 YLSGMPAKRRKTMQG
K1066 GMPAKRRKTMQGEGP
T1067 MPAKRRKTMQGEGPQ
S1078 EGPQLLLSEAVSRAA
T1094 AAGARPLTSPESLSR
S1095 AGARPLTSPESLSRD
Y1130 RLQEDPNYSPQRFPN
S1131 LQEDPNYSPQRFPNA
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