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Protein Page:
matrin 3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
matrin 3 an acidic protein that is a component of the nuclear matrix. May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA binding protein
Cellular Component: nuclear matrix; nucleolus; nuclear inner membrane; nucleus
Molecular Function: protein binding; zinc ion binding; nucleotide binding; structural molecule activity
Reference #:  P43243 (UniProtKB)
Alt. Names/Synonyms: DKFZp686K0542; DKFZp686K23100; KIAA0723; MATR3; matrin 3; Matrin-3; MGC9105; MPD2
Gene Symbols: MATR3
Molecular weight: 94,623 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Select Structure to View Below

matrin 3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K3-a _____MSksFQQssL
1 6 S4-p ____MSksFQQssLs
0 2 S8-p MSksFQQssLsRDsQ
0 8 S9-p SksFQQssLsRDsQG
0 2 S11-p sFQQssLsRDsQGHG
0 11 S14-p QssLsRDsQGHGRDL
0 4 S22-p QGHGRDLsAAGIGLL
0 1 S41-p QSLSMPAsLGRMNQG
0 4 S54-p QGTARLAsLMNLGMS
0 1 R92-m1 SIFNIGSrGPLPLSs
0 2 S99-p rGPLPLSsQHRGDAD
0 3 S118-p ILASFGLsARDLDEL
0 1 S126-p ARDLDELsRyPEDkI
0 2 Y128-p DLDELsRyPEDkItP
0 32 K132-u LsRyPEDkItPENLP
0 3 T134-p RyPEDkItPENLPQI
0 4 K146-a PQILLQLkRRRtEEG
0 23 K146-u PQILLQLkRRRtEEG
1 43 T150-p LQLkRRRtEEGPtLs
0 3 T155-p RRtEEGPtLsyGRDG
0 5 S157-p tEEGPtLsyGRDGRs
0 12 Y158-p EEGPtLsyGRDGRsA
0 4 S164-p syGRDGRsAtREPPy
0 1 T166-p GRDGRsAtREPPyRV
0 46 Y171-p sAtREPPyRVPRDDW
0 337 S188-p KRHFRRDsFDDRGPs
1 39 S195-p sFDDRGPsLNPVLDy
0 32 Y202-p sLNPVLDyDHGsRsQ
0 14 S206-p VLDyDHGsRsQEsGy
0 22 S208-p DyDHGsRsQEsGyyD
0 7 S211-p HGsRsQEsGyyDRMD
0 60 Y213-p sRsQEsGyyDRMDyE
0 149 Y214-p RsQEsGyyDRMDyED
0 220 Y219-p GyyDRMDyEDDRLRD
0 144 S234-p GERCRDDsFFGEtsH
0 2 T239-p DDsFFGEtsHNyHKF
0 2 S240-p DsFFGEtsHNyHKFD
0 28 Y243-p FGEtsHNyHKFDsEy
0 25 S248-p HNyHKFDsEyERMGR
0 48 Y250-p yHKFDsEyERMGRGP
0 1 S264-p PGPLQERsLFEKKRG
0 1 S275-p KKRGAPPssNIEDFH
0 1 S276-p KRGAPPssNIEDFHG
0 1 T443 EAFIEMATTEDAQAA
0 1 T444 AFIEMATTEDAQAAV
0 1 Y453 DAQAAVDYYTTTPAL
0 1 Y454 AQAAVDYYTTTPALV
0 1 T455 QAAVDYYTTTPALVF
0 1 T456 AAVDYYTTTPALVFG
0 1 T457 AVDYYTTTPALVFGK
0 1 S471 KPVRVHLSQkYKRIK
0 2 K473-a VRVHLSQkYKRIKKP
0 2 K473-u VRVHLSQkYKRIKKP
0 2 K483-u RIKKPEGkPDQkFDQ
0 3 K487-u PEGkPDQkFDQkQEL
0 40 K491-u PDQkFDQkQELGRVI
0 2 S501-p LGRVIHLsNLPHsGy
0 1 S506-p HLsNLPHsGysDsAV
0 1 Y508-p sNLPHsGysDsAVLk
0 1 S509-p NLPHsGysDsAVLkL
0 1 S511-p PHsGysDsAVLkLAE
0 16 K515-u ysDsAVLkLAEPyGk
0 2 Y520-p VLkLAEPyGkIkNyI
0 1 K522-a kLAEPyGkIkNyILM
0 55 K522-u kLAEPyGkIkNyILM
0 7 K524-u AEPyGkIkNyILMRM
0 1 Y526-p PyGkIkNyILMRMks
0 13 K532-u NyILMRMksQAFIEM
0 37 S533-p yILMRMksQAFIEME
0 8 K555-u MVDHCLKkALWFQGR
0 10 K565-u WFQGRCVkVDLSEkY
0 3 K571-a VkVDLSEkYkKLVLR
0 2 K573-a VDLSEkYkKLVLRIP
0 24 S596-p KDKSRKRsysPDGKE
0 8 Y597-p DKSRKRsysPDGKEs
0 58 S598-p KSRKRsysPDGKEsP
0 40 S604-p ysPDGKEsPsDKKSk
0 14 S606-p PDGKEsPsDKKSkTD
0 1 K611-u sPsDKKSkTDGsQkT
0 7 S615-p KKSkTDGsQkTEsSt
0 8 K617-a SkTDGsQkTEsStEG
0 5 S620-p DGsQkTEsStEGkEQ
0 1 T622-p sQkTEsStEGkEQEE
0 4 K625-a TEsStEGkEQEEKSG
0 1 K625-u TEsStEGkEQEEKSG
0 1 S631 GkEQEEKSGEDGEKD
0 1 T639-p GEDGEKDtKDDQtEQ
0 1 T644-p KDtKDDQtEQEPNML
0 3 S654-p EPNMLLEsEDELLVD
0 4 S671-p EAAALLEsGssVGDE
0 5 S673-p AALLEsGssVGDEtd
0 3 S674-p ALLEsGssVGDEtdL
0 1 T679-p GssVGDEtdLANLGD
0 2 D680-ca ssVGDEtdLANLGDV
0 3 S689-p ANLGDVAsDGkKEPs
0 7 K692-a GDVAsDGkKEPsDKA
0 2 S696-p sDGkKEPsDKAVKKD
0 17 K711-a GSASAAAkkKLKKVD
0 11 K712-a SASAAAkkKLKKVDK
0 2 - gap
0 2 T741-p GIKNEENtEPGAEss
0 2 S747-p NtEPGAEssENADDP
0 1 S748-p tEPGAEssENADDPN
0 1 D763-ca KDTSENAdGQsDENk
0 12 S766-p SENAdGQsDENkDDy
0 1 K770-u dGQsDENkDDyTIPD
0 7 Y773-p sDENkDDyTIPDEYR
0 5 Y784-p DEYRIGPyQPNVPVG
0 2 Y802-p VIPKTGFyCKLCSLF
0 5 T811-p KLCSLFYtNEEVAKN
0 9 Y827-p HCSSLPHyQkLkKFL
0 14 K829-a SSLPHyQkLkKFLNk
0 5 K831-a LPHyQkLkKFLNkLA
0 3 K836-a kLkKFLNkLAEERRQ
0 30 K836-u kLkKFLNkLAEERRQ
  matrin 3 iso3  
K3 _____MSKSFQQSSL
S4 ____MSKSFQQSSLS
S8 MSKSFQQSSLSRDSQ
S9 SKSFQQSSLSRDSQG
S11 SFQQSSLSRDSQGHG
S14 QSSLSRDSQGHGRDL
S22 QGHGRDLSAAGIGLL
S41 QSLSMPASLGRMNQG
S54 QGTARLASLMNLGMS
R92 SIFNIGSRGPLPLSS
S99 RGPLPLSSQHRGDAD
S118 ILASFGLSARDLDEL
S126 ARDLDELSRYPEDKI
Y128 DLDELSRYPEDKITP
K132 LSRYPEDKITPENLP
T134 RYPEDKITPENLPQI
K146 PQILLQLKRRRtEEG
K146 PQILLQLKRRRtEEG
T150-p LQLKRRRtEEGPTLS
T155 RRtEEGPTLSYGRDG
S157 tEEGPTLSYGRDGRS
Y158 EEGPTLSYGRDGRSA
S164 SYGRDGRSATREPPY
T166 GRDGRSATREPPYRV
Y171 SATREPPYRVPRDDW
S188-p KRHFRRDsFDDRGPs
S195-p sFDDRGPsLNPVLDY
Y202 sLNPVLDYDHGSRsQ
S206 VLDYDHGSRsQESGY
S208-p DYDHGSRsQESGYYD
S211 HGSRsQESGYYDRMD
Y213 SRsQESGYYDRMDyE
Y214 RsQESGYYDRMDyED
Y219-p GYYDRMDyEDDRLRD
S234-p GERCRDDsFFGETSH
T239 DDsFFGETSHNYHKF
S240 DsFFGETSHNYHKFD
Y243 FGETSHNYHKFDSEY
S248 HNYHKFDSEYERMGR
Y250 YHKFDSEYERMGRGP
S264 PGPLQERSLFEKKRG
S275 KKRGAPPSSNIEDFH
S276 KRGAPPSSNIEDFHG
T443 EAFIEMATTEDAQAA
T444 AFIEMATTEDAQAAV
Y453 DAQAAVDYYTTTPAL
Y454 AQAAVDYYTTTPALV
T455 QAAVDYYTTTPALVF
T456 AAVDYYTTTPALVFG
T457 AVDYYTTTPALVFGK
S471 KPVRVHLSQKYKRIK
K473 VRVHLSQKYKRIKKP
K473 VRVHLSQKYKRIKKP
K483 RIKKPEGKPDQKFDQ
K487 PEGKPDQKFDQKQEL
K491 PDQKFDQKQELGRVI
S501 LGRVIHLSNLPHSGY
S506 HLSNLPHSGYSDSAV
Y508 SNLPHSGYSDSAVLK
S509 NLPHSGYSDSAVLKL
S511 PHSGYSDSAVLKLAE
K515 YSDSAVLKLAEPYGK
Y520 VLKLAEPYGKIKNYI
K522 KLAEPYGKIKNYILM
K522 KLAEPYGKIKNYILM
K524 AEPYGKIKNYILMRM
Y526 PYGKIKNYILMRMKS
K532 NYILMRMKSQAFIEM
S533 YILMRMKSQAFIEME
K555 MVDHCLKKALWFQGR
K565 WFQGRCVKVDLSEKY
K571 VKVDLSEKYKKLVLR
K573 VDLSEKYKKLVLRIP
S596 KDKSRKRSYSPDGKE
Y597 DKSRKRSYSPDGKES
S598 KSRKRSYSPDGKESP
S604 YSPDGKESPSDKKSK
S606 PDGKESPSDKKSKTD
K611 SPSDKKSKTDGSQKT
S615 KKSKTDGSQKTESST
K617 SKTDGSQKTESSTEG
S620 DGSQKTESSTEGKEQ
T622 SQKTESSTEGKEQEE
K625 TESSTEGKEQEEKSG
K625 TESSTEGKEQEEKSG
S631 GKEQEEKSGEDGEKD
T639 GEDGEKDTKDDQTEQ
T644 KDTKDDQTEQEPNML
S654 EPNMLLESEDELLVD
S671 EAAALLESGSSVGDE
S673 AALLESGSSVGDETD
S674 ALLESGSSVGDETDL
T679 GSSVGDETDLANLGD
D680 SSVGDETDLANLGDV
S689 ANLGDVASDGKKEPS
K692 GDVASDGKKEPSDKA
S696 SDGKKEPSDKAVKKD
K711-a GSASAAAkkKLKKRR
K712-a SASAAAkkKLKKRRF
S722-p KKRRFPGsMEGFVTL
T789 GIKNEENTEPGAESS
S795 NTEPGAESSENADDP
S796 TEPGAESSENADDPN
D811 KDTSENADGQSDENK
S814 SENADGQSDENKDDY
K818 DGQSDENKDDYTIPD
Y821 SDENKDDYTIPDEYR
Y832 DEYRIGPYQPNVPVG
Y850 VIPKTGFYCKLCSLF
T859 KLCSLFYTNEEVAKN
Y875 HCSSLPHYQkLkKFL
K877-a SSLPHYQkLkKFLNK
K879-a LPHYQkLkKFLNKLA
K884 kLkKFLNKLAEERRQ
K884 kLkKFLNKLAEERRQ
  mouse

 
K3 _____MSKsFQQSsL
S4-p ____MSKsFQQSsLG
S8 MSKsFQQSsLGRDSQ
S9-p SKsFQQSsLGRDSQG
G11 sFQQSsLGRDSQGHG
S14 QSsLGRDSQGHGRDL
S22-p QGHGRDLsAAGIGLL
S41 QSLSMPASLGRMNQG
S54 QGTARLASLMNLGMS
R92 SIFNIGSRGPLPLSS
S99 RGPLPLSSQHRGDTD
S118 ILASFGLSARDLDEL
S126 ARDLDELSRYPEDkI
Y128 DLDELSRYPEDkITP
K132-u LSRYPEDkITPENLP
T134 RYPEDkITPENLPQI
K146 PQILLQLKRRRtEEG
K146-u PQILLQLkRRRtEEG
T150-p LQLkRRRtEEGPtLS
T155-p RRtEEGPtLSYGRDG
S157 tEEGPtLSYGRDGRS
Y158 EEGPtLSYGRDGRSA
S164 SYGRDGRSATREPPy
T166 GRDGRSATREPPyRV
Y171-p SATREPPyRVPRDDW
S188-p KRHFRRDsFDDRGPs
S195-p sFDDRGPsLNPVLDy
Y202-p sLNPVLDyDHGsRsQ
S206-p VLDyDHGsRsQEsGy
S208-p DyDHGsRsQEsGyyD
S211-p HGsRsQEsGyyDRMD
Y213-p sRsQEsGyyDRMDyE
Y214-p RsQEsGyyDRMDyED
Y219-p GyyDRMDyEDDRLRD
S234-p GERCRDDsFFGETSH
T239 DDsFFGETSHNYHKF
S240 DsFFGETSHNYHKFD
Y243 FGETSHNYHKFDSEY
S248 HNYHKFDSEYERMGR
Y250 YHKFDSEYERMGRGP
S264 PGPLQERSLFEKKRG
S275 KKRGAPPSSNIEDFH
S276 KRGAPPSSNIEDFHG
T443-p EAFIEMAttEDAQAA
T444-p AFIEMAttEDAQAAV
Y453-p DAQAAVDyytttPAL
Y454-p AQAAVDyytttPALV
T455-p QAAVDyytttPALVF
T456-p AAVDyytttPALVFG
T457-p AVDyytttPALVFGK
S471-p KPVRVHLsQKYKRIK
K473 VRVHLsQKYKRIKKP
K473 VRVHLsQKYKRIKKP
K483 RIKKPEGKPDQKFDQ
K487 PEGKPDQKFDQkQEL
K491-u PDQKFDQkQELGRVI
S501 LGRVIHLSNLPHSGY
S506 HLSNLPHSGYSDSAV
Y508 SNLPHSGYSDSAVLk
S509 NLPHSGYSDSAVLkL
S511 PHSGYSDSAVLkLAE
K515-u YSDSAVLkLAEPYGk
Y520 VLkLAEPYGkIKNYI
K522 kLAEPYGKIKNYILM
K522-u kLAEPYGkIKNYILM
K524 AEPYGkIKNYILMRM
Y526 PYGkIKNYILMRMKs
K532 NYILMRMKsQAFIEM
S533-p YILMRMKsQAFIEME
K555-u MVDHCLKkALWFQGR
K565 WFQGRCVKVDLSEKY
K571 VKVDLSEKYKKLVLR
K573 VDLSEKYKKLVLRIP
S596-p KDKSRKRsysPDGKE
Y597-p DKSRKRsysPDGKEs
S598-p KSRKRsysPDGKEsP
S604-p ysPDGKEsPsDKKSK
S606-p PDGKEsPsDKKSKTD
K611 sPsDKKSKTDAQKTE
A614 DKKSKTDAQKTEsPA
K616 KSKTDAQKTEsPAEG
S619-p TDAQKTEsPAEGKEQ
A621 AQKTEsPAEGKEQEE
K624 TEsPAEGKEQEEKsG
K624 TEsPAEGKEQEEKsG
S630-p GKEQEEKsGEDGEKD
T638 GEDGEKDTKDDQTEQ
T643 KDTKDDQTEQEPSML
S653 EPSMLLESEDELLVD
S670 EAAALLESGSSVGDE
S672 AALLESGSSVGDETD
S673 ALLESGSSVGDETDL
T678 GSSVGDETDLANLGD
D679 SSVGDETDLANLGDV
S688 ANLGDVSSDGKKEPS
K691 GDVSSDGKKEPSDKA
S695 SDGKKEPSDKAVKKD
K710 PSASATSKKKLKKVD
K711 SASATSKKKLKKVDK
- gap
T740 GIKNEENTEPGAESA
S746 NTEPGAESAENADDP
A747 TEPGAESAENADDPN
D762 KDTSENADGQNDENK
N765 SENADGQNDENKEDY
K769 DGQNDENKEDYTIPD
Y772 NDENKEDYTIPDEYR
Y783 DEYRIGPYQPNVPVG
Y801 VIPKTGFYCKLCSLF
T810 KLCSLFYTNEEVAKN
Y826 HCSSLPHYQKLKKFL
K828 SSLPHYQKLKKFLNk
K830 LPHYQKLKKFLNkLA
K835 KLKKFLNKLAEERRQ
K835-u KLKKFLNkLAEERRQ
  rat

 
K3 _____MSKSFQQSSL
S4 ____MSKSFQQSSLG
S8 MSKSFQQSSLGRDSQ
S9 SKSFQQSSLGRDSQG
G11 SFQQSSLGRDSQGHG
S14 QSSLGRDSQGHGRDL
S22 QGHGRDLSAAGIGLL
S41 QSLSMPASLGRMNQG
S54 QGTARLASLMNLGMS
R92 SIFNIGSRGPLPLSS
S99 RGPLPLSSQHRGDTD
S118 ILASFGLSARDLDEL
S126 ARDLDELSRYPEDKI
Y128 DLDELSRYPEDKITP
K132 LSRYPEDKITPENLP
T134 RYPEDKITPENLPQI
K146-a PQILLQLkRRRTEEG
K146 PQILLQLKRRRTEEG
T150 LQLkRRRTEEGPTLS
T155 RRTEEGPTLSYGRDG
S157 TEEGPTLSYGRDGRS
Y158 EEGPTLSYGRDGRSA
S164 SYGRDGRSATREPPY
T166 GRDGRSATREPPYRV
Y171 SATREPPYRVPRDDW
S188-p KRHFRRDsFDDRGPs
S195-p sFDDRGPsLNPVLDY
Y202 sLNPVLDYDHGSRSQ
S206 VLDYDHGSRSQESGY
S208 DYDHGSRSQESGYYD
S211 HGSRSQESGYYDRMD
Y213 SRSQESGYYDRMDYE
Y214 RSQESGYYDRMDYED
Y219 GYYDRMDYEDDRLRD
S234 GERCRDDSFFGETSH
T239 DDSFFGETSHNYHKF
S240 DSFFGETSHNYHKFD
Y243 FGETSHNYHKFDSEY
S248 HNYHKFDSEYERMGR
Y250 YHKFDSEYERMGRGP
S264 PGPLQERSLFEKKRG
S275 KKRGAPPSSNIEDFH
S276 KRGAPPSSNIEDFHG
T443 EAFIEMATTEDAQAA
T444 AFIEMATTEDAQAAV
Y453 DAQAAVDYYTTTPAL
Y454 AQAAVDYYTTTPALV
T455 QAAVDYYTTTPALVF
T456 AAVDYYTTTPALVFG
T457 AVDYYTTTPALVFGK
S471 KPVRVHLSQKYKRIK
K473 VRVHLSQKYKRIKKP
K473 VRVHLSQKYKRIKKP
K483 RIKKPEGKPDEKFDQ
K487 PEGKPDEKFDQKQEL
K491 PDEKFDQKQELGRVI
S501 LGRVIHLSNLPHSGY
S506 HLSNLPHSGYSDSAV
Y508 SNLPHSGYSDSAVLK
S509 NLPHSGYSDSAVLKL
S511 PHSGYSDSAVLKLAE
K515 YSDSAVLKLAEPYGK
Y520 VLKLAEPYGKIKNYI
K522 KLAEPYGKIKNYILM
K522 KLAEPYGKIKNYILM
K524 AEPYGKIKNYILMRM
Y526 PYGKIKNYILMRMKS
K532 NYILMRMKSQAFIEM
S533 YILMRMKSQAFIEME
K555 MVDHCLKKALWFQGR
K565 WFQGRCVKVDLSEKY
K571 VKVDLSEKYKKLVLR
K573 VDLSEKYKKLVLRIP
S596 KDKSRKRSYsPDGKE
Y597 DKSRKRSYsPDGKEs
S598-p KSRKRSYsPDGKEsP
S604-p YsPDGKEsPsDKKSK
S606-p PDGKEsPsDKKSKTD
K611 sPsDKKSKTDGAQKT
A615 KKSKTDGAQKTENPA
K617 SKTDGAQKTENPAEG
N620 DGAQKTENPAEGKEQ
A622 AQKTENPAEGKEQEE
K625 TENPAEGKEQEEKSG
K625 TENPAEGKEQEEKSG
S631 GKEQEEKSGEDGEKD
T639 GEDGEKDTKDDQTEQ
T644 KDTKDDQTEQEPSML
S654 EPSMLLESEDELLVD
S671 EAAALIESGSSVGDE
S673 AALIESGSSVGDETD
S674 ALIESGSSVGDETDL
T679 GSSVGDETDLANLGD
D680 SSVGDETDLANLGDV
S689 ANLGDVSSDGKKEPS
K692 GDVSSDGKKEPSDKA
S696 SDGKKEPSDKAVKKD
K709 KDASATSKKKLKKVD
K710 DASATSKKKLKKVDK
- gap
T739-p GIKNEENtEPGAEsA
S745-p NtEPGAEsAENADDP
A746 tEPGAEsAENADDPN
D761 KDASDNSDGQNDENK
N764 SDNSDGQNDENKEDY
K768 DGQNDENKEDYTIPD
Y771 NDENKEDYTIPDEYR
Y782-p DEYRIGPyQPNVPGG
Y800-p VIPKTGFyCKLCSLF
T809 KLCSLFYTNEEVAKN
Y825 HCSSLPHYQKLKKFL
K827 SSLPHYQKLKKFLNk
K829 LPHYQKLKKFLNkLA
K834 KLKKFLNKLAEERRQ
K834-u KLKKFLNkLAEERRQ
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