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TCF8 (human)

Overview TCF8 Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Interacts (via N-terminus) with SMARCA4/BRG1. Colocalizes with SMARCA4/BRG1 in E-cadherin- negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas. Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; C2H2-type zinc finger protein; DNA binding protein; Transcription, coactivator/corepressor Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription corepressor activity Biological Process: regulation of transcription from RNA polymerase II promoter; cell proliferation; transcription, DNA-dependent; immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent Reference #:  P37275 (UniProtKB) Alt. Names/Synonyms: AREB6; BZP; delta-crystallin enhancer binding factor 1; DELTAEF1; FECD6; MGC133261; Negative regulator of IL2; NIL-2-A zinc finger protein; NIL2A; TCF-8; TCF8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); ZEB1; ZFHEP; ZFHX1A; zinc finger E-box binding homeobox 1; Zinc finger E-box-binding homeobox 1; zinc finger homeodomain enhancer-binding protein Gene Symbols: ZEB1 Molecular weight: 124,074 Da Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TCF8 2E19 - A=583-642 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE 189909 609141  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S31-p	NTVVETNsDsDDEDK
0	2		S33-p	VVETNsDsDDEDKLH
0	1		S155-p	RQGTPEAsGHDENGt
0	1		T162-p	sGHDENGtPDAFSQL
0	3		S309-p	PRTGLKTsQCSsPsL
0	3		S313-p	LKTsQCSsPsLsAsP
0	4		S315-p	TsQCSsPsLsAsPGs
0	1		S317-p	QCSsPsLsAsPGsPt
0	2		S319-p	SsPsLsAsPGsPtRP
0	15		S322-p	sLsAsPGsPtRPQIR
0	3		T324-p	sAsPGsPtRPQIRQK
0	1		K504-u	PVATNSCkSEKLPED
0	1		S521-p	VKSEKDKsFEGGVND
0	1		S641-p	AGQISVQssEPSsPE
0	1		S642-p	GQISVQssEPSsPEP
0	2		S646-p	VQssEPSsPEPGKVN
0	5		S679-p	DSTVNLQsPLKMTNS
0	1		T684	LQsPLKMTNSPVLPV
0	2		N685	QsPLKMTNSPVLPVG
0	1		S686	sPLKMTNSPVLPVGS
0	2		S693	SPVLPVGSTTNGSRs
0	6		S700-p	STTNGSRsstPsPSP
0	4		S701-p	TTNGSRsstPsPSPL
0	3		T702-p	TNGSRsstPsPSPLN
0	2		P703	NGSRsstPsPSPLNL
0	8		S704-p	GSRsstPsPSPLNLS
0	1		S706	RsstPsPSPLNLSSS
0	1		S711	sPSPLNLSSSRNtQG
0	1		T716-p	NLSSSRNtQGYLYTA
0	14		S887-p	NVEDQNDsDstPPKK
0	3		S889-p	EDQNDsDstPPKKKM
0	5		T890-p	DQNDsDstPPKKKMR
0	1		S995-p	REAEERDstEQEEAG
0	1		T996-p	EAEERDstEQEEAGP
0	3		S1100-p	MKDDRAEsQASSLGQ

	mouse
S31-p	NTVVEANsDsDDEDK
S33-p	VVEANsDsDDEDKLH
S135	RQGTPEASSHDENGT
T142	SSHDENGTPDAFSQL
S289	PRSGLKTSQCSsPsL
S293-p	LKTSQCSsPsLSTsP
S295-p	TSQCSsPsLSTsPGs
S297	QCSsPsLSTsPGsPt
S299-p	SsPsLSTsPGsPtRP
S302-p	sLSTsPGsPtRPQIR
T304-p	STsPGsPtRPQIRQK
K484	PAPTNSCKSEKLPED
S501	VKSETDKSFEGARDD
S619-p	AGQIPGQsPDPPsPG
P620	GQIPGQsPDPPsPGT
S624-p	GQsPDPPsPGTGSVN
S657-p	EDSTRGQsPVKIRss
R662	GQsPVKIRssPVLPV
S663-p	QsPVKIRssPVLPVG
S664-p	sPVKIRssPVLPVGs
S671-p	sPVLPVGsAMNGSRs
S678-p	sAMNGSRsCtssPsP
C679	AMNGSRsCtssPsPL
T680-p	MNGSRsCtssPsPLN
S681-p	NGSRsCtssPsPLNL
S682-p	GSRsCtssPsPLNLC
S684-p	RsCtssPsPLNLCSA
C689	sPsPLNLCSARNPQG
P694	NLCSARNPQGYSCVA
S865-p	TVEDQNDsDSTPPKK
S867	EDQNDsDSTPPKKKT
T868	DQNDsDSTPPKKKTR
A973	RGAEDRDAMEQEDAG
M974	GAEDRDAMEQEDAGP
Q1086	TVEVGAAQQAGSLEQ

	rat
S31	NTVVEANSDSDDEDK
S33	VVEANSDSDDEDKLH
S135	RQGTPEASGHDDNGT
T142	SGHDDNGTPDAFSQL
S289	PRSGLKTSQCSSPSL
S293	LKTSQCSSPSLSTSP
S295	TSQCSSPSLSTSPGS
S297	QCSSPSLSTSPGSPT
S299	SSPSLSTSPGSPTRP
S302	SLSTSPGSPTRPQIR
T304	STSPGSPTRPQIRQK
K484	PAPPKSCKSEKSPED
S501	VKSEKDKSFDGAADE
S619	AGQIPGQSLEPPSPG
L620	GQIPGQSLEPPSPGP
S624	GQSLEPPSPGPGSGN
S657	EDSTRGQSPLKMtsS
T662-p	GQSPLKMtsSPVLPV
S663-p	QSPLKMtsSPVLPVG
S664	SPLKMtsSPVLPVGs
S671-p	SPVLPVGsAINGSRS
S678	sAINGSRSCTSSPSP
C679	AINGSRSCTSSPSPL
T680	INGSRSCTSSPSPLN
S681	NGSRSCTSSPSPLNL
S682	GSRSCTSSPSPLNLs
S684	RSCTSSPSPLNLsSA
S689-p	SPSPLNLsSARNPQG
P694	NLsSARNPQGYSCVS
S864	SVEDQNDSDCTPPKK
C866	EDQNDSDCTPPKKKT
T867	DQNDSDCTPPKKKTR
A972	RGAEDRDAMEQEDTG
M973	GAEDRDAMEQEDTGP
Q1084	AVEEEAAQQAGSFQQ

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