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CDK2 (human)

Overview CDK2 a protein kinase of the CDK family. An important component of the cell cycle machinery. Activity of CDK2 is maximal during S phase and G2. Cdk2/cyclin E kinase activity is important for the G1 to S transition and phosphorylates the Rb protein. In S-phase, active cdk2/cyclin A complexes predominate and phosphorylate E2F, and the active cdk2 complex persists in the nucleus through G2. Part of the Rb pathway disregulated in most tumors. Target of several candidate cancer drugs. However, inhibition does not always prevent cancer cell growth, possibly due to CDK redundancy. Inhibitors: BMS-265246, BMS-265246-01, R-roscovitine (CYC200, CYC202), SU9516, R547, L868276 Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.22; CMGC group; CDK family; CDK1 subfamily; CDK/CDK1 subfamily Cellular Component: Cajal body; centrosome; chromosome, telomeric region; X chromosome; condensed chromosome; cytosol; Y chromosome; nucleoplasm; transcription factor complex; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; nucleus; endosome Molecular Function: cyclin binding; protein binding; cyclin-dependent protein kinase activity; metal ion binding; histone kinase activity; ATP binding Biological Process: G1 DNA damage checkpoint; mitosis; meiosis; M/G1 transition of mitotic cell cycle; positive regulation of transcription, DNA-dependent; histone phosphorylation; DNA repair; G2 phase of mitotic cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cell proliferation; Ras protein signal transduction; mitotic cell cycle; S phase of mitotic cell cycle; DNA replication; G2/M transition of mitotic cell cycle; blood coagulation; centrosome duplication; cell cycle checkpoint; potassium ion transport; G1/S transition of mitotic cell cycle; positive regulation of DNA replication initiation Reference #:  P24941 (UniProtKB) Alt. Names/Synonyms: cdc2-related protein kinase; CDK2; cell devision kinase 2; Cell division protein kinase 2; cyclin-dependent kinase 2; p33 protein kinase; p33(CDK2) Gene Symbols: CDK2 Molecular weight: 33,930 Da Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CDK2 1AQ1 - A=1-298 (human) 1B38 - A=1-298 (human) 1B39 - A=1-298 (human) 1BUH - A=1-298 (human) 1CKP - A=1-298 (human) 1DI8 - A=1-298 (human) 1DM2 - A=1-298 (human) 1E1V - A=1-298 (human) 1E1X - A=1-298 (human) 1E9H - A/C=1-296 (human) 1F5Q - A/C=1-298 (human) 1FIN - A/C=1-298 (human) 1FQ1 - B=1-298 (human) 1FVT - A=1-298 (human) 1FVV - A/C=1-298 (human) 1G5S - A=1-298 (human) 1GIH - A=1-298 (human) 1GII - A=1-298 (human) 1GIJ - A=1-298 (human) 1GY3 - A/C=1-298 (human) 1GZ8 - A=1-298 (human) 1H00 - A=1-298 (human) 1H01 - A=1-298 (human) 1H07 - A=1-298 (human) 1H08 - A=1-298 (human) 1H0U - A=1-298 (human) 1H0V - A=1-298 (human) 1H0W - A=1-298 (human) 1H1P - A/C=1-298 (human) 1H1Q - A/C=1-298 (human) 1H1R - A/C=1-298 (human) 1H1S - A/C=1-298 (human) 1H24 - A/C=1-298 (human) 1H25 - A/C=1-298 (human) 1H26 - A/C=1-298 (human) 1H27 - A/C=1-298 (human) 1H28 - A/C=1-298 (human) 1HCK - A=1-298 (human) 1HCL - A=1-298 (human) 1JST - A/C=1-298 (human) 1JSU - A=1-298 (human) 1JSV - A=1-298 (human) 1JVP - P=1-298 (human) 1KE5 - A=1-298 (human) 1KE6 - A=1-298 (human) 1KE7 - A=1-298 (human) 1KE8 - A=1-298 (human) 1KE9 - A=1-298 (human) 1OGU - A/C=1-298 (human) 1OI9 - A/C=1-298 (human) 1OIQ - A=1-298 (human) 1OIR - A=1-298 (human) 1OIT - A=1-298 (human) 1OIU - A/C=1-298 (human) 1OIY - A/C=1-298 (human) 1OKV - A/C=1-298 (human) 1OKW - A/C=1-298 (human) 1OL1 - A/C=1-298 (human) 1OL2 - A/C=1-298 (human) 1P2A - A=1-298 (human) 1P5E - A/C=1-298 (human) 1PF8 - A=1-298 (human) 1PKD - A/C=1-296 (human) 1PW2 - A=1-298 (human) 1PXI - A=1-298 (human) 1PXJ - A=1-298 (human) 1PXK - A=1-298 (human) 1PXL - A=1-298 (human) 1PXM - A=1-298 (human) 1PXN - A=1-298 (human) 1PXO - A=1-298 (human) 1PXP - A=1-298 (human) 1PYE - A=1-298 (human) 1QMZ - A/C=1-298 (human) 1R78 - A=1-298 (human) 1URC - A/C=1-298 (human) 1URW - A=1-298 (human) 1V1K - A=1-298 (human) 1VYW - A/C=1-298 (human) 1VYZ - A=1-298 (human) 1W0X - C=1-298 (human) 1W8C - A=1-298 (human) 1W98 - A=1-297 (human) 1WCC - A=1-298 (human) 1Y8Y - A=1-298 (human) 1Y91 - A=1-298 (human) 1YKR - A=1-298 (human) 2A0C - X=1-298 (human) 2A4L - A=1-298 (human) 2B52 - A=1-298 (human) 2B53 - A=1-298 (human) 2B54 - A=1-298 (human) 2B55 - A=1-298 (human) 2BHE - A=1-298 (human) 2BHH - A=1-298 (human) 2BKZ - A/C=1-298 (human) 2BPM - A/C=1-298 (human) 2BTR - A=1-298 (human) 2BTS - A=1-298 (human) 2C4G - A/C=1-298 (human) 2C5N - A/C=1-298 (human) 2C5O - A/C=1-298 (human) 2C5P - A/C=1-298 (human) 2C5V - A/C=1-298 (human) 2C5X - A/C=1-298 (human) 2C5Y - A=1-298 (human) 2C68 - A=1-298 (human) 2C69 - A=1-298 (human) 2C6I - A=1-298 (human) 2C6K - A=1-298 (human) 2C6L - A=1-298 (human) 2C6M - A=1-298 (human) 2C6O - A=1-298 (human) 2C6T - A/C=1-298 (human) 2CCH - A/C=1-298 (human) 2CCI - A/C=1-298 (human) 2CJM - A/C=1-298 (human) 2CLX - A=1-298 (human) 2DS1 - A=1-298 (human) 2DUV - A=1-298 (human) 2EXM - A=1-298 (human) 2FVD - A=1-298 (human) 2G9X - A/C=1-298 (human) 2HIC - A=1-298 (human) 2I40 - A/C=1-298 (human) 2IW6 - A/C=1-298 (human) 2IW8 - A/C=1-298 (human) 2IW9 - A/C=1-298 (human) 2J9M - A=1-298 (human) 2JGZ - A=1-288 (human) 2R3F - A=1-298 (human) 2R3G - A=1-298 (human) 2R3H - A=1-298 (human) 2R3I - A=1-298 (human) 2R3J - A=1-298 (human) 2R3K - A=1-298 (human) 2R3L - A=1-298 (human) 2R3M - A=1-298 (human) 2R3N - A=1-298 (human) 2R3O - A=1-298 (human) 2R3P - A=1-298 (human) 2R3Q - A=1-298 (human) 2R3R - A=1-298 (human) 2R64 - A=1-298 (human) 2UUE - A/C=1-298 (human) 2UZB - A/C=1-298 (human) 2UZD - A/C=1-298 (human) 2UZE - A/C=1-298 (human) 2UZL - A/C=1-298 (human) 2UZN - A=1-298 (human) 2UZO - A=1-298 (human) 2V0D - A=1-298 (human) 2V22 - A/C=1-298 (human) 2VTA - A=1-298 (human) 2VTH - A=1-298 (human) 2VTI - A=1-298 (human) 2VTJ - A=1-298 (human) 2VTL - A=1-298 (human) 2VTM - A=1-298 (human) 2VTN - A=1-298 (human) 2VTO - A=1-298 (human) 2VTP - A=1-298 (human) 2VTQ - A=1-298 (human) 2VTR - A=1-298 (human) 2VTS - A=1-298 (human) 2VTT - A=1-298 (human) 2VU3 - A=1-298 (human) 2VV9 - A=1-298 (human) 2W05 - A=1-298 (human) 2W06 - A=1-298 (human) 2W17 - A=1-298 (human) 2W1H - A=1-298 (human) 2WEV - A/C=1-298 (human) 2WFY - A/C=1-298 (human) 2WHB - A/C=1-298 (human) 2WIH - A/C=1-298 (human) 2WIP - A/C=1-298 (human) 2WMA - A/C=1-298 (human) 2WMB - A/C=1-298 (human) 2WPA - A/C=1-298 (human) 2WXV - A/C=1-298 (human) 2X1N - A/C=1-298 (human) 2XMY - A=1-298 (human) 2XNB - A=1-298 (human) 3BHT - A/C=1-298 (human) 3BHU - A/C=1-298 (human) 3BHV - A/C=1-298 (human) 3DDP - A/C=1-298 (human) 3DDQ - A/C=1-298 (human) 3DOG - A/C=1-298 (human) 3EID - A/C=1-298 (human) 3EJ1 - A/C=1-298 (human) 3EOC - A/C=1-298 (human) 3EZR - A=1-298 (human) 3EZV - A=1-298 (human) 3F5X - A/C=1-298 (human) 3FZ1 - A=1-298 (human) 3IG7 - A=1-298 (human) 3IGG - A=1-298 (human) 3LE6 - A=1-298 (human) 3LFN - A=1-298 (human) 3LFQ - A=1-298 (human) 3LFS - A=1-298 (human) 3MY5 - A/C=1-298 (human) 3NS9 - A=1-298 (human) 3PJ8 - A=1-298 (human) 3PXF - A=1-298 (human) 3PXQ - A=1-298 (human) 3PXR - A=1-298 (human) 3PXY - A=1-298 (human) 3PXZ - A=1-298 (human) 3PY0 - A=1-298 (human) 3PY1 - A=1-298 (human) 3QHR - A/C=1-296 (human) 3QHW - A/C=1-296 (human) 3QL8 - A=1-298 (human) 3QQF - A=1-298 (human) 3QQG - A=1-298 (human) 3QQH - A=1-298 (human) 3QQJ - A=1-298 (human) 3QQK - A=1-298 (human) 3QQL - A=1-298 (human) 3QRT - A=1-298 (human) 3QRU - A=1-298 (human) 3QTQ - A=1-298 (human) 3QTR - A=1-298 (human) 3QTS - A=1-298 (human) 3QTU - A=1-298 (human) 3QTW - A=1-298 (human) 3QTX - A=1-298 (human) 3QTZ - A=1-298 (human) 3QU0 - A=1-298 (human) 3QWJ - A=1-298 (human) 3QWK - A=1-298 (human) 3QX2 - A=1-298 (human) 3QX4 - A=1-298 (human) 3QXO - A=1-298 (human) 3QXP - A=1-298 (human) 3QZF - A=1-298 (human) 3QZG - A=1-298 (human) 3QZH - A=1-298 (human) 3QZI - A=1-298 (human) 3R1Q - A=1-298 (human) 3R1S - A=1-298 (human) 3R1Y - A=1-298 (human) 3R28 - A=1-298 (human) 3R6X - A=1-298 (human) 3R71 - A=1-298 (human) 3R73 - A=1-298 (human) 3R7E - A=1-298 (human) 3R7I - A=1-298 (human) 3R7U - A=1-298 (human) 3R7V - A=1-298 (human) 3R7Y - A=1-298 (human) 3R83 - A=1-298 (human) 3R8L - A=1-298 (human) 3R8M - A=1-298 (human) 3R8P - A=1-298 (human) 3R8U - A=1-298 (human) 3R8V - A=1-298 (human) 3R8Z - A=1-298 (human) 3R9D - A=1-298 (human) 3R9H - A=1-298 (human) 3R9N - A=1-298 (human) 3R9O - A=1-298 (human) 3RAH - A=1-298 (human) 3RAI - A=1-298 (human) 3RAK - A=1-298 (human) 3RAL - A=1-298 (human) 3RJC - A=1-298 (human) 3RK5 - A=1-298 (human) 3RK7 - A=1-298 (human) 3RK9 - A=1-298 (human) 3RKB - A=1-298 (human) 3RM6 - A=1-298 (human) 3RM7 - A=1-298 (human) 3RMF - A=1-298 (human) 3RNI - A=1-298 (human) 3ROY - A=1-298 (human) 3RPO - A=1-298 (human) 3RPR - A=1-298 (human) 3RPV - A=1-298 (human) 3RPY - A=1-298 (human) 3RZB - A=1-298 (human) 3S00 - A=1-298 (human) 3S0O - A=1-298 (human) 3S1H - A=1-298 (human) 3S2P - A=1-298 (human) 3SQQ - A=1-298 (human) 3SW4 - A=1-298 (human) 3SW7 - A=1-298 (human) 3TI1 - A=1-298 (human) 3TIY - A=1-298 (human) 3TIZ - A=1-298 (human) 3TNW - A/C=1-298 (human) 3UNJ - A=1-298 (human) 3UNK - A=1-298 (human) 4ACM - A=1-298 (human) 4BCK - D/B=171-432 (human) 4BCM - D/B=171-432 (human) 4BCN - B=171-432 D=171-431 (human) 4BCO - A/C=1-298 (human) 4BCP - D/B=171-432 (human) 4BCQ - A/C=1-298 (human) 4EOI - D/B=175-432 (human) 4EOJ - D/B=175-432 (human) 4EOK - D/B=175-432 (human) 4EOL - D/B=175-432 (human) 4EOM - D/B=175-432 (human) 4EON - D/B=175-432 (human) 4EOO - D/B=175-432 (human) 4EOP - D/B=175-432 (human) 4EOQ - D/B=175-432 (human) 4EOR - D/B=175-432 (human) 4EOS - D/B=175-432 (human) 4ERW - A=1-298 (human) 4EZ3 - A=1-298 (human) 4EZ7 - A=1-298 (human) 4GCJ - A=1-298 (human) 4I3Z - A/C=1-296 (human) 4II5 - A/C=1-298 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H07 1H08 1H0U 1H0V 1H0W 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1OGU 1OI9 1OIQ 1OIR 1OIT 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P2A 1P5E 1PF8 1PKD 1PW2 1PXI 1PXJ 1PXK 1PXL 1PXM 1PXN 1PXO 1PXP 1PYE 1QMZ 1R78 1URC 1URW 1V1K 1VYW 1VYZ 1W0X 1W8C 1W98 1WCC 1Y8Y 1Y91 1YKR 2A0C 2A4L 2B52 2B53 2B54 2B55 2BHE 2BHH 2BKZ 2BPM 2BTR 2BTS 2C4G 2C5N 2C5O 2C5P 2C5V 2C5X 2C5Y 2C68 2C69 2C6I 2C6K 2C6L 2C6M 2C6O 2C6T 2CCH 2CCI 2CJM 2CLX 2DS1 2DUV 2EXM 2FVD 2G9X 2HIC 2I40 2IW6 2IW8 2IW9 2J9M 2JGZ 2R3F 2R3G 2R3H 2R3I 2R3J 2R3K 2R3L 2R3M 2R3N 2R3O 2R3P 2R3Q 2R3R 2R64 2UUE 2UZB 2UZD 2UZE 2UZL 2UZN 2UZO 2V0D 2V22 2VTA 2VTH 2VTI 2VTJ 2VTL 2VTM 2VTN 2VTO 2VTP 2VTQ 2VTR 2VTS 2VTT 2VU3 2VV9 2W05 2W06 2W17 2W1H 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 2XMY 2XNB 3BHT 3BHU 3BHV 3DDP 3DDQ 3DOG 3EID 3EJ1 3EOC 3EZR 3EZV 3F5X 3FZ1 3IG7 3IGG 3LE6 3LFN 3LFQ 3LFS 3MY5 3NS9 3PJ8 3PXF 3PXQ 3PXR 3PXY 3PXZ 3PY0 3PY1 3QHR 3QHW 3QL8 3QQF 3QQG 3QQH 3QQJ 3QQK 3QQL 3QRT 3QRU 3QTQ 3QTR 3QTS 3QTU 3QTW 3QTX 3QTZ 3QU0 3QWJ 3QWK 3QX2 3QX4 3QXO 3QXP 3QZF 3QZG 3QZH 3QZI 3R1Q 3R1S 3R1Y 3R28 3R6X 3R71 3R73 3R7E 3R7I 3R7U 3R7V 3R7Y 3R83 3R8L 3R8M 3R8P 3R8U 3R8V 3R8Z 3R9D 3R9H 3R9N 3R9O 3RAH 3RAI 3RAK 3RAL 3RJC 3RK5 3RK7 3RK9 3RKB 3RM6 3RM7 3RMF 3RNI 3ROY 3RPO 3RPR 3RPV 3RPY 3RZB 3S00 3S0O 3S1H 3S2P 3SQQ 3SW4 3SW7 3TI1 3TIY 3TIZ 3TNW 3UNJ 3UNK 4ACM 4BCK 4BCM 4BCN 4BCO 4BCP 4BCQ 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4ERW 4EZ3 4EZ7 4GCJ 4I3Z 4II5  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, induced: T39‑p cell cycle regulation: T14‑p, Y15‑p, T39‑p, T160‑p, Y179‑p chromatin organization, altered: T160‑p activation: T160‑p enzymatic activity, induced: T160‑p, Y179‑p enzymatic activity, inhibited: T14‑p, Y15‑p intracellular localization: T39‑p protein conformation: T14‑p, Y15‑p, T160‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K6-a	__MENFQkVEKIGEG
8	1440		T14-p	VEKIGEGtyGVVykA
24	3866		Y15-p	EKIGEGtyGVVykAR
0	1740		Y19-p	EGtyGVVykARNkLT
0	1		K20-u	GtyGVVykARNkLTG
0	1		K24-u	VVykARNkLTGEVVA
1	0		K33-s	TGEVVALkKIRLDtE
0	1		K33-u	TGEVVALkKIRLDtE
1	1		T39-p	LkKIRLDtETEGVPs
1	2		S46-p	tETEGVPsTAIREIS
0	1		K56-u	IREISLLkELNHPNI
0	2		K129-u	RVLHRDLkPQNLLIN
0	1		T137-p	PQNLLINtEGAIkLA
0	1		K142-u	INtEGAIkLADFGLA
0	22		T158-p	AFGVPVRtytHEVVt
0	8		Y159-p	FGVPVRtytHEVVtL
35	237		T160-p	GVPVRtytHEVVtLW
1	3		T165-p	tytHEVVtLWyRAPE
1	0		Y168-p	HEVVtLWyRAPEILL
1	0		Y179-p	EILLGCKyYSTAVDI
0	1		-	gap
0	1		K237-u	VTSMPDYkPSFPKWA
0	1		K250-u	WARQDFSkVVPPLDE
0	1		S261	PLDEDGRSLLSQMLH
0	1		Y269	LLSQMLHYDPNkRIS
0	1		K273-u	MLHYDPNkRISAkAA
0	2		K278-u	PNkRISAkAALAHPF
0	1		K291-u	PFFQDVTkPVPHLRL

	mouse
K6	__MENFQKVEKIGEG
T14-p	VEKIGEGtyGVVyKA
Y15-p	EKIGEGtyGVVyKAK
Y19-p	EGtyGVVyKAKNKLT
K20	GtyGVVyKAKNKLTG
K24	VVyKAKNKLTGEVVA
K33	TGEVVALKKIRLDtE
K33	TGEVVALKKIRLDtE
T39-p	LKKIRLDtETEGVPS
S46	tETEGVPSTAIREIS
K56	IREISLLKELNHPNI
K129	RVLHRDLKPQNLLIN
A137	PQNLLINAEGSIKLA
K142	INAEGSIKLADFGLA
T158-p	AFGVPVRtytHEVVT
Y159-p	FGVPVRtytHEVVTL
T160-p	GVPVRtytHEVVTLW
T165	tytHEVVTLWYRAPE
Y168	HEVVTLWYRAPEILL
Y179	EILLGCKYYSTAVDI
S218-p	HRRNGRHsLCPLCSY
K285	VTSMPDYKPSFPKWA
K298	WARQDFSKVVPPLDE
S309-p	PLDEDGRsLLSQMLH
Y317-p	LLSQMLHyDPNKRIS
K321	MLHyDPNKRISAKAA
K326	PNKRISAKAALAHPF
K339	PFFQDVTKPVPHLRL

	rat
K6	__MENFQKVEKIGEG
T14-p	VEKIGEGtyGVVyKA
Y15-p	EKIGEGtyGVVyKAK
Y19-p	EGtyGVVyKAKNKLT
K20	GtyGVVyKAKNKLTG
K24	VVyKAKNKLTGEVVA
K33	TGEVVALKKIRLDTE
K33	TGEVVALKKIRLDTE
T39	LKKIRLDTETEGVPS
S46	TETEGVPSTAIREIS
K56	IREISLLKELNHPNI
K129	RVLHRDLKPQNLLIN
A137	PQNLLINAEGSIKLA
K142	INAEGSIKLADFGLA
T158	AFGVPVRTYtHEVVT
Y159	FGVPVRTYtHEVVTL
T160-p	GVPVRTYtHEVVTLW
T165	TYtHEVVTLWYRAPE
Y168	HEVVTLWYRAPEILL
Y179	EILLGCKYYSTAVDI
-	gap
K237	VTSMPDYKPSFPKWA
K250	WARQDFSKVVPPLDE
S261	PLDEDGRSLLSQMLH
Y269	LLSQMLHYDPNKRIS
K273	MLHYDPNKRISAKAA
K278	PNKRISAKAALAHPF
K291	PFFQDVTKPVPHLRL

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