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Protein Page:
CDK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDK2 a protein kinase of the CDK family. An important component of the cell cycle machinery. Activity of CDK2 is maximal during S phase and G2. Cdk2/cyclin E kinase activity is important for the G1 to S transition and phosphorylates the Rb protein. In S-phase, active cdk2/cyclin A complexes predominate and phosphorylate E2F, and the active cdk2 complex persists in the nucleus through G2. Part of the Rb pathway disregulated in most tumors. Target of several candidate cancer drugs. However, inhibition does not always prevent cancer cell growth, possibly due to CDK redundancy. Inhibitors: BMS-265246, BMS-265246-01, R-roscovitine (CYC200, CYC202), SU9516, R547, L868276 Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; CMGC group; CDK family; CDK/CDK1 subfamily; CDK1 subfamily
Cellular Component: Y chromosome; nucleoplasm; Cajal body; centrosome; chromosome, telomeric region; transcription factor complex; X chromosome; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; condensed chromosome; nucleus; cytosol; endosome
Molecular Function: cyclin binding; protein binding; cyclin-dependent protein kinase activity; metal ion binding; histone kinase activity; ATP binding
Biological Process: G1 DNA damage checkpoint; mitosis; meiosis; histone phosphorylation; positive regulation of transcription, DNA-dependent; DNA repair; G2 phase of mitotic cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cell proliferation; Ras protein signal transduction; mitotic cell cycle; DNA replication; blood coagulation; G2/M transition of mitotic cell cycle; centrosome duplication; potassium ion transport; positive regulation of DNA replication initiation; G1/S transition of mitotic cell cycle
Reference #:  P24941 (UniProtKB)
Alt. Names/Synonyms: cdc2-related protein kinase; CDK2; cell devision kinase 2; Cell division protein kinase 2; cyclin-dependent kinase 2; p33 protein kinase; p33(CDK2)
Gene Symbols: CDK2
Molecular weight: 33,930 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDK2

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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1AQ1
1B38
1B39
1BUH
1CKP
1DI8
1DM2
1E1V
1E1X
1E9H
1F5Q
1FIN
1FQ1
1FVT
1FVV
1G5S
1GIH
1GII
1GIJ
1GY3
1GZ8
1H00
1H01
1H07
1H08
1H0U
1H0V
1H0W
1H1P
1H1Q
1H1R
1H1S
1H24
1H25
1H26
1H27
1H28
1HCK
1HCL
1JST
1JSU
1JSV
1JVP
1KE5
1KE6
1KE7
1KE8
1KE9
1OGU
1OI9
1OIQ
1OIR
1OIT
1OIU
1OIY
1OKV
1OKW
1OL1
1OL2
1P2A
1P5E
1PF8
1PKD
1PW2
1PXI
1PXJ
1PXK
1PXL
1PXM
1PXN
1PXO
1PXP
1PYE
1QMZ
1R78
1URC
1URW
1V1K
1VYW
1VYZ
1W0X
1W8C
1W98
1WCC
1Y8Y
1Y91
1YKR
2A0C
2A4L
2B52
2B53
2B54
2B55
2BHE
2BHH
2BKZ
2BPM
2BTR
2BTS
2C4G
2C5N
2C5O
2C5P
2C5V
2C5X
2C5Y
2C68
2C69
2C6I
2C6K
2C6L
2C6M
2C6O
2C6T
2CCH
2CCI
2CJM
2CLX
2DS1
2DUV
2EXM
2FVD
2G9X
2HIC
2I40
2IW6
2IW8
2IW9
2J9M
2JGZ
2R3F
2R3G
2R3H
2R3I
2R3J
2R3K
2R3L
2R3M
2R3N
2R3O
2R3P
2R3Q
2R3R
2R64
2UUE
2UZB
2UZD
2UZE
2UZL
2UZN
2UZO
2V0D
2V22
2VTA
2VTH
2VTI
2VTJ
2VTL
2VTM
2VTN
2VTO
2VTP
2VTQ
2VTR
2VTS
2VTT
2VU3
2VV9
2W05
2W06
2W17
2W1H
2WEV
2WFY
2WHB
2WIH
2WIP
2WMA
2WMB
2WPA
2WXV
2X1N
2XMY
2XNB
3BHT
3BHU
3BHV
3DDP
3DDQ
3DOG
3EID
3EJ1
3EOC
3EZR
3EZV
3F5X
3FZ1
3IG7
3IGG
3LE6
3LFN
3LFQ
3LFS
3MY5
3NS9
3PJ8
3PXF
3PXQ
3PXR
3PXY
3PXZ
3PY0
3PY1
3QHR
3QHW
3QL8
3QQF
3QQG
3QQH
3QQJ
3QQK
3QQL
3QRT
3QRU
3QTQ
3QTR
3QTS
3QTU
3QTW
3QTX
3QTZ
3QU0
3QWJ
3QWK
3QX2
3QX4
3QXO
3QXP
3QZF
3QZG
3QZH
3QZI
3R1Q
3R1S
3R1Y
3R28
3R6X
3R71
3R73
3R7E
3R7I
3R7U
3R7V
3R7Y
3R83
3R8L
3R8M
3R8P
3R8U
3R8V
3R8Z
3R9D
3R9H
3R9N
3R9O
3RAH
3RAI
3RAK
3RAL
3RJC
3RK5
3RK7
3RK9
3RKB
3RM6
3RM7
3RMF
3RNI
3ROY
3RPO
3RPR
3RPV
3RPY
3RZB
3S00
3S0O
3S1H
3S2P
3SQQ
3SW4
3SW7
3TI1
3TIY
3TIZ
3TNW
3ULI
3UNJ
3UNK
3WBL
4ACM
4BCK
4BCM
4BCN
4BCO
4BCP
4BCQ
4BGH
4BZD
4CFN
4CFW
4EK3
4EK4
4EK5
4EK6
4EK8
4EOI
4EOJ
4EOK
4EOL
4EOM
4EON
4EOO
4EOP
4EOQ
4EOR
4EOS
4ERW
4EZ3
4EZ7
4FKG
4FKI
4FKJ
4FKL
4FKO
4FKP
4FKQ
4FKR
4FKS
4FKT
4FKU
4FKV
4FKW
4FX3
4GCJ
4I3Z
4II5
4KD1
4LYN
4NJ3
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Sites Implicated In
apoptosis, induced: T39‑p
cell cycle regulation: T14‑p, Y15‑p, T39‑p, T160‑p
chromatin organization, altered: T160‑p
activity, induced: T160‑p
enzymatic activity, induced: T160‑p
enzymatic activity, inhibited: T14‑p, Y15‑p
intracellular localization: T39‑p
protein conformation: T14‑p, Y15‑p, T160‑p
protein stabilization: T14‑p, Y15‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K6-ac __MENFQkVEKIGEG
9 1512 T14-p VEKIGEGtyGVVykA
27 3863 Y15-p EKIGEGtyGVVykAR
0 1744 Y19-p EGtyGVVykARNkLT
0 1 K20-ub GtyGVVykARNkLTG
0 1 K24-ub VVykARNkLTGEVVA
1 0 K33-sm TGEVVALkKIRLDtE
0 1 K33-ub TGEVVALkKIRLDtE
1 1 T39-p LkKIRLDtETEGVPs
1 2 S46-p tETEGVPsTAIREIS
0 1 K56-ub IREISLLkELNHPNI
0 2 K129-ub RVLHRDLkPQNLLIN
0 1 T137-p PQNLLINtEGAIkLA
0 1 K142-ub INtEGAIkLADFGLA
0 23 T158-p AFGVPVRtytHEVVt
0 12 Y159-p FGVPVRtytHEVVtL
36 255 T160-p GVPVRtytHEVVtLW
1 3 T165-p tytHEVVtLWyRAPE
1 0 Y168-p HEVVtLWyRAPEILL
0 1 - gap
0 1 K237-ub VTSMPDYkPSFPKWA
0 1 K250-ub WARQDFSkVVPPLDE
0 1 S261 PLDEDGRSLLSQMLH
0 1 Y269 LLSQMLHYDPNkRIS
0 1 K273-ub MLHYDPNkRISAkAA
0 2 K278-ub PNkRISAkAALAHPF
0 1 K291-ub PFFQDVTkPVPHLRL
2561 : Phospho-CDK2 (Thr160) Antibody
  mouse

 
K6 __MENFQKVEKIGEG
T14-p VEKIGEGtyGVVyKA
Y15-p EKIGEGtyGVVyKAK
Y19-p EGtyGVVyKAKNKLT
K20 GtyGVVyKAKNKLTG
K24 VVyKAKNKLTGEVVA
K33 TGEVVALKKIRLDtE
K33 TGEVVALKKIRLDtE
T39-p LKKIRLDtETEGVPS
S46 tETEGVPSTAIREIS
K56 IREISLLKELNHPNI
K129 RVLHRDLKPQNLLIN
A137 PQNLLINAEGSIKLA
K142 INAEGSIKLADFGLA
T158-p AFGVPVRtytHEVVT
Y159-p FGVPVRtytHEVVTL
T160-p GVPVRtytHEVVTLW
T165 tytHEVVTLWYRAPE
Y168 HEVVTLWYRAPEILL
S218-p HRRNGRHsLCPLCSY
K285 VTSMPDYKPSFPKWA
K298 WARQDFSKVVPPLDE
S309-p PLDEDGRsLLSQMLH
Y317-p LLSQMLHyDPNKRIS
K321 MLHyDPNKRISAKAA
K326 PNKRISAKAALAHPF
K339 PFFQDVTKPVPHLRL
2561 : Phospho-CDK2 (Thr160) Antibody
  rat

 
K6 __MENFQKVEKIGEG
T14-p VEKIGEGtyGVVyKA
Y15-p EKIGEGtyGVVyKAK
Y19-p EGtyGVVyKAKNKLT
K20 GtyGVVyKAKNKLTG
K24 VVyKAKNKLTGEVVA
K33 TGEVVALKKIRLDTE
K33 TGEVVALKKIRLDTE
T39 LKKIRLDTETEGVPS
S46 TETEGVPSTAIREIS
K56 IREISLLKELNHPNI
K129 RVLHRDLKPQNLLIN
A137 PQNLLINAEGSIKLA
K142 INAEGSIKLADFGLA
T158 AFGVPVRTYtHEVVT
Y159 FGVPVRTYtHEVVTL
T160-p GVPVRTYtHEVVTLW
T165 TYtHEVVTLWYRAPE
Y168 HEVVTLWYRAPEILL
- gap
K237 VTSMPDYKPSFPKWA
K250 WARQDFSKVVPPLDE
S261 PLDEDGRSLLSQMLH
Y269 LLSQMLHYDPNKRIS
K273 MLHYDPNKRISAKAA
K278 PNKRISAKAALAHPF
K291 PFFQDVTKPVPHLRL
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