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restin (human)

Overview restin Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin. Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3. Detected in dendritic cells. Highly expressed in the Reed-Sternberg cells of Hodgkin disease. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: microtubule cytoskeleton; kinetochore; ruffle; microtubule; centrosome; cytoplasmic vesicle membrane; cytoplasmic microtubule; cytoplasm; intermediate filament; cytosol; endosome Molecular Function: tubulin binding; microtubule plus-end binding; protein binding; protein homodimerization activity; nucleic acid binding; zinc ion binding; metal ion binding; microtubule binding Biological Process: M phase of mitotic cell cycle; mitosis; transport; positive regulation of microtubule polymerization; mitotic cell cycle; microtubule bundle formation; mitotic prometaphase Reference #:  P30622 (UniProtKB) Alt. Names/Synonyms: CAP-GLY domain containing linker protein 1; CAP-Gly domain-containing linker protein 1; CLIP; CLIP-170; CLIP1; CLIP170; CYLN1; cytoplasmic linker 1; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; MGC131604; Reed-Steinberg cell-expressed intermediate filament-associated protein; Reed-Sternberg intermediate filament-associated protein; Restin; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein); RSN Gene Symbols: CLIP1 Molecular weight: 162,246 Da Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below restin 2CP5 - A=1-128 (human) 2CP6 - A=181-340 (human) 2E3H - A=211-300 (human) 2E3I - A=56-141 (human) 2E4H - A=203-300 (human) 2HQH - E/F/G/H=1405-1427 (human) 2PZO - E/F/G/H=1388-1427 (human) 2QK0 - A=57-128 (human) 3E2U - H/F/G/E=1388-1427 (human) 3RDV - A/D/C/B=56-127 (human) 2CP7 - A=58-128 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2CP5 2CP6 2E3H 2E3I 2E4H 2HQH 2PZO 2QK0 3E2U 3RDV  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
intracellular localization: S195‑p phosphorylation: S195‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T25-p	PGSTALKtPTAVVAP
0	1		S43-p	TISSEKAsstPssET
0	1		S44-p	ISSEKAsstPssETQ
0	5		T45-p	SSEKAsstPssETQE
0	1		S47-p	EKAsstPssETQEEF
0	3		S48-p	KAsstPssETQEEFV
0	3		T140-p	EANGLQTtPAsRAts
0	2		S143-p	GLQTtPAsRAtsPLC
0	2		T146-p	TtPAsRAtsPLCTST
0	7		S147-p	tPAsRAtsPLCTSTA
0	1		S158-p	TSTASMVsSsPstPS
0	2		S160-p	TASMVsSsPstPSNI
0	1		S162-p	SMVsSsPstPSNIPQ
0	1		T163-p	MVsSsPstPSNIPQK
0	7		S172-p	SNIPQKPsQPAAKEP
0	2		S180-p	QPAAKEPsAtPPIsN
0	14		T182-p	AAKEPsAtPPIsNLT
0	3		S186-p	PsAtPPIsNLTKtAs
0	2		T191-p	PIsNLTKtAsEsIsN
0	4		S193-p	sNLTKtAsEsIsNLs
1	55		S195-p	LTKtAsEsIsNLsEA
0	4		S197-p	KtAsEsIsNLsEAGs
0	65		S200-p	sEsIsNLsEAGsIKK
0	34		S204-p	sNLsEAGsIKKGERE
0	1		Y262-p	GAVAGTRyFQCQPKy
0	1		Y269-p	yFQCQPKyGLFAPVH
0	1		T279-p	FAPVHKVtKIGFPst
0	3		S285-p	VtKIGFPsttPAKAK
0	2		T286-p	tKIGFPsttPAKAKA
1	3		T287-p	KIGFPsttPAKAKAN
1	4		S310-p	TSASLKRsPsASsLs
2	3		S312-p	ASLKRsPsASsLsSM
1	1		S314	LKRsPsASsLsSMsS
1	3		S315-p	KRsPsASsLsSMsSV
0	1		S317-p	sPsASsLsSMsSVAS
1	2		S320-p	ASsLsSMsSVASsVS
0	1		S324	sSMsSVASsVSsRPS
0	3		S325-p	SMsSVASsVSsRPSR
0	1		S327	sSVASsVSsRPSRtG
0	2		S328-p	SVASsVSsRPSRtGL
0	1		S331	SsVSsRPSRtGLLTE
0	1		T333-p	VSsRPSRtGLLTETS
1	23		S348-p	SRYARKIsGttALQE
0	2		T350-p	YARKIsGttALQEAL
0	3		T351-p	ARKIsGttALQEALK
0	1		T415	AKMDQLRTMVEAADR
0	1		S510-p	VATVSEKsRIMELEK
0	1		S607-p	KENESLKsKLEHANK
0	2		K719	AIRSKLDKAEDQHLV
0	1		T731	HLVEMEDTLNKLQEA
0	1		E770	TSQLKATEEKLLDLD
0	2		S783-p	LDALRKAssEGKsEM
0	2		S784-p	DALRKAssEGKsEMK
0	1		S788-p	KAssEGKsEMKKLRQ
0	1		S815-p	EIEKNAEsSKASSIT
0	2		T833-p	QGRELKLtNLQENLS
0	1		K921	EREEQLIKAKEKLEN
0	2		D957	ELRLKERDVEELQLK
0	1		K1007-a	EKKELERkLsDLEkK
0	1		S1009-p	KELERkLsDLEkKME
0	1		K1013-a	RkLsDLEkKMETSHN
0	1		S1066-p	KGAREENsGLLQELE
0	1		R1076	LQELEELRKQADKAK
0	1		T1087-p	DKAKAAQtAEDAMQI
0	1		T1125	KLQNELDTLKENNLK
0	1		S1169-p	KQAAAQKsQQLSALQ
0	2		S1230-p	DADEEKAsLQKsIsI
0	3		S1234-p	EKAsLQKsIsITsAL
0	5		S1236-p	AsLQKsIsITsALLT
0	1		S1239-p	QKsIsITsALLTEKD
0	1		T1243	sITsALLTEKDAELE
0	8		S1302-p	KENKRQLssssGNtD
0	2		S1303-p	ENKRQLssssGNtDT
0	4		S1304-p	NKRQLssssGNtDTQ
0	4		S1305-p	KRQLssssGNtDTQA
0	4		T1308-p	LssssGNtDTQADED
1	2		S1364-p	DDLNNYDsDDQEKQS

	mouse
T25	PGSTALKTPAAAAAP
S43	TIPSEKASGPPSSET
G44	IPSEKASGPPSSETQ
P45	PSEKASGPPSSETQE
S47	EKASGPPSSETQEEF
S48	KASGPPSSETQEEFV
A140	EANGLQAAPGRtAsP
-	gap
T144-p	LQAAPGRtAsPLSTA
S146-p	AAPGRtAsPLSTAAA
S157	TAAATMVSSSPATPS
S159	AATMVSSSPATPSNI
A161	TMVSSSPATPSNIPH
T162	MVSSSPATPSNIPHK
S171	SNIPHKPSQSTAKEP
S179	QSTAKEPSATPQISN
T181	TAKEPSATPQISNLT
S185	PSATPQISNLTKtAs
T190-p	QISNLTKtAsEsIsN
S192-p	SNLTKtAsEsIsNLs
S194-p	LTKtAsEsIsNLsEA
S196-p	KtAsEsIsNLsEAGs
S199-p	sEsIsNLsEAGsVKK
S203-p	sNLsEAGsVKKGERE
Y261	GAVAGTRYFQCQPKY
Y268	YFQCQPKYGLFAPVH
T278	FAPVHKVTKIGFPsT
S284-p	VTKIGFPsTtPAKAK
T285	TKIGFPsTtPAKAKA
T286-p	KIGFPsTtPAKAKAA
S309-p	TPASLKRsPsAssLs
S311-p	ASLKRsPsAssLsSM
S313-p	LKRsPsAssLsSMSS
S314-p	KRsPsAssLsSMSSV
S316-p	sPsAssLsSMSSVAs
S319	AssLsSMSSVAssVS
S323-p	sSMSSVAssVSSKPS
S324-p	SMSSVAssVSSKPSR
S326	SSVAssVSSKPSRTG
S327	SVAssVSSKPSRTGL
S330	ssVSSKPSRTGLLTE
T332	VSSKPSRTGLLTETS
S347-p	SRYARKIsGttALQE
T349-p	YARKIsGttALQEAL
T350-p	ARKIsGttALQEALK
T414-p	AKMDQLRtMVEAADR
S463	VATVSEKSRIMELEK
S560	KENESLRSKLDHANK
S672-p	AVKARLDsAEDQHLV
T684-p	HLVEMEDtLNKLQEA
K723-u	TSQLSAVkEKLLDLD
N736	LDALRKANSEGKLEL
S737	DALRKANSEGKLELE
L741	KANSEGKLELETLRQ
S768	ETERNAESSKANSIT
T786	QEKELVLTGLQDSLN
K874-a	DREDQLVkAKEKLEN
S910-p	ELRLKERsVEELQLK
K960	EKKELEEKLLELEKK
L962	KELEEKLLELEKKME
K966	EKLLELEKKMETSYN
R1019	KAAQEANRDLMQDME
K1029-a	MQDMEELkTQADKAK
T1040	DKAKAAQTAEDAMQI
T1078-p	RLQNELDtLKENNLK
S1122	KQAAAQKSQQLSALQ
S1183-p	DADEEKAsLQKsIsL
S1187-p	EKAsLQKsIsLTSAL
S1189-p	AsLQKsIsLTSALLt
S1192	QKsIsLTSALLtEKD
T1196-p	sLTSALLtEKDAELE
S1255-p	KENKRQLsSSsGNtD
S1256	ENKRQLsSSsGNtDA
S1257	NKRQLsSSsGNtDAQ
S1258-p	KRQLsSSsGNtDAQA
T1261-p	LsSSsGNtDAQAEED
S1317-p	EDLNSYDsDDQEKQS

	rat
T25	PGSTALKTPAAAAAP
S43	TVPSEKASGPPSSET
G44	VPSEKASGPPSSETQ
P45	PSEKASGPPSSETQE
S47	EKASGPPSSETQEEF
S48	KASGPPSSETQEEFV
A140	EANGLQTAHARAASP
-	gap
A145	QTAHARAASPLSTAA
S146	TAHARAASPLSTAAA
S157	TAAATMVSSSPATPS
S159	AATMVSSSPATPSNI
A161	TMVSSSPATPSNIPQ
T162	MVSSSPATPSNIPQK
S171	SNIPQKPSQPVAKET
S179	QPVAKETSATPQISN
T181	VAKETSATPQISNLT
S185	TSATPQISNLTKTAs
T190	QISNLTKTAsEsIsN
S192-p	SNLTKTAsEsIsNLs
S194-p	LTKTAsEsIsNLsEA
S196-p	KTAsEsIsNLsEAGs
S199-p	sEsIsNLsEAGsVKK
S203-p	sNLsEAGsVKKGERE
Y261	GAVAGTRYFQCQPKY
Y268	YFQCQPKYGLFAPVH
T278	FAPVHKVTKIGFPST
S284	VTKIGFPSTtPAKAK
T285	TKIGFPSTtPAKAKA
T286-p	KIGFPSTtPAKAKAA
S309-p	TPASLKRsPsAssLS
S311-p	ASLKRsPsAssLSSM
S313-p	LKRsPsAssLSSMsS
S314-p	KRsPsAssLSSMsSV
S316	sPsAssLSSMsSVAs
S319-p	AssLSSMsSVAsSVs
S323-p	SSMsSVAsSVssKPs
S324	SMsSVAsSVssKPsR
S326-p	sSVAsSVssKPsRTG
S327-p	SVAsSVssKPsRTGL
S330-p	sSVssKPsRTGLLTE
T332	VssKPsRTGLLTETS
S347-p	SRYARKIsGTTALQE
T349	YARKIsGTTALQEAL
T350	ARKIsGTTALQEALK
T414	AKMDQLRTMVEAADR
S498	VATVSEKSRIMELEK
S595	KENESLRSKLDHANK
T707	AVKARLDTAEDQHLV
M719	HLVEMEEMLSKLQEA
-	under review
-	gap
-	gap
-	gap
-	gap
-	gap
K794	EREDQLVKAKEKLEN
S830	ELRLKERSVEELQLK
K880	EKKELENKLLELEKK
L882	KELENKLLELEKKME
K886	NKLLELEKKMETSHY
R939	KAAQEANRDLMQDME
K949	MQDMEELKSQADKAK
T960	DKAKAAQTAEDAMQI
T998	KLQSELDTLKENNLK
S1042	KQAAAQKSQQLSALQ
S1110	DADEEKASLQKSISL
S1114	EKASLQKSISLTSAL
S1116	ASLQKSISLTSALLT
S1119	QKSISLTSALLTEKD
T1123	SLTSALLTEKDAELE
S1182	KENKRQLSSSSGNTD
S1183	ENKRQLSSSSGNTDV
S1184	NKRQLSSSSGNTDVQ
S1185	KRQLSSSSGNTDVQT
T1188	LSSSSGNTDVQTEED
S1246-p	EDPNSYDsDDQEKQS

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