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Protein Page:
MPG (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MPG Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. Belongs to the DNA glycosylase MPG family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.2.2.21; Hydrolase
Cellular Component: nucleoplasm
Molecular Function: protein binding; DNA-3-methyladenine glycosylase I activity; damaged DNA binding
Biological Process: DNA dealkylation; base-excision repair, AP site formation; depurination; base-excision repair; DNA repair
Reference #:  P29372 (UniProtKB)
Alt. Names/Synonyms: 3' end of the Mid1 gene, localized 68 kb upstream the humanzeta globin gene on 16p; 3-alkyladenine DNA glycosylase; 3-methyladenine DNA glycosidase; 3MG; AAG; ADPG; alkyladenine DNA glycosylase; ANPG; APNG; CRA36.1; CRA36.1 (3-methyl-adenine DNA glycosylase); DNA-3-methyladenine glycosylase; MDG; MID1; MPG; N-methylpurine-DNA glycosylase; N-methylpurine-DNA glycosylase, MPG; PIG11; PIG16; proliferation-inducing protein 11; proliferation-inducing protein 16
Gene Symbols: MPG
Molecular weight: 32,869 Da
Basal Isoelectric point: 9.65  Predict pI for various phosphorylation states
Select Structure to View Below

MPG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T66-p ERCLGPPttPGPyRS
0 12 T67-p RCLGPPttPGPyRSI
0 2 Y71-p PPttPGPyRSIyFSs
0 15 Y75-p PGPyRSIyFSsPkGH
0 3 S78-p yRSIyFSsPkGHLTR
0 1 K80-u SIyFSsPkGHLTRLG
0 6 K229-u CQALAINkSFDQRDL
0 2 S252-p ERGPLEPsEPAVVAA
  mouse

 
S86 TPKERLLSTPGLRRS
T87 PKERLLSTPGLRRSI
R91 LLSTPGLRRSIYFSS
Y95 PGLRRSIYFSSPEDH
S98 RRSIYFSSPEDHSGR
E100 SIYFSSPEDHSGRLG
K249 CQALAIDKSFDQRDL
S272 EHGPLESSSPAVVVA
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