Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. Belongs to the DNA glycosylase MPG family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 18.104.22.168; Hydrolase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: nucleoplasm
Molecular Function: protein binding; alkylbase DNA N-glycosylase activity; DNA-3-methyladenine glycosylase I activity; damaged DNA binding
Biological Process: DNA dealkylation; base-excision repair, AP site formation; depurination; base-excision repair; DNA repair
Alt. Names/Synonyms: 3' end of the Mid1 gene, localized 68 kb upstream the humanzeta globin gene on 16p; 3-alkyladenine DNA glycosylase; 3-methyladenine DNA glycosidase; 3MG; AAG; ADPG; alkyladenine DNA glycosylase; ANPG; APNG; CRA36.1; CRA36.1 (3-methyl-adenine DNA glycosylase); DNA-3-methyladenine glycosylase; MDG; MID1; MPG; N-methylpurine-DNA glycosylase; N-methylpurine-DNA glycosylase, MPG; PIG11; PIG16; proliferation-inducing protein 11; proliferation-inducing protein 16
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.