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Protein Page:
XPG (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
XPG Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too. Defects in ERCC5 are the cause of xeroderma pigmentosum complementation group G (XP-G); also known as xeroderma pigmentosum VII (XP7). Xeroderma pigmentosum is an autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Some XP-G patients present features of Cockayne syndrome, including dwarfism, sensorineural deafness, microcephaly, mental retardation, pigmentary retinopathy, ataxia, decreased nerve conduction velocities. Belongs to the XPG/RAD2 endonuclease family. XPG subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Deoxyribonuclease; EC 3.1.-.-; DNA repair, damage
Cellular Component: nucleoplasm; intermediate filament cytoskeleton; holo TFIIH complex; nucleolus; DNA-directed RNA polymerase II, holoenzyme; nucleus
Molecular Function: protein binding; protein homodimerization activity; endonuclease activity; metal ion binding; double-stranded DNA binding; protein N-terminus binding; bubble DNA binding; single-stranded DNA binding; endodeoxyribonuclease activity
Biological Process: nucleotide-excision repair, DNA incision, 3'-to lesion; UV protection; nucleotide-excision repair; multicellular organism growth; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA damage removal; determination of adult life span; DNA repair; DNA catabolic process, endonucleolytic; response to UV-C; negative regulation of apoptosis; response to UV
Reference #:  P28715 (UniProtKB)
Alt. Names/Synonyms: COFS3; DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; ERCC5; ERCM2; excision repair cross-complementing rodent repair deficiency, complementation group 5; excision repair protein; UVDR; xeroderma pigmentosum complementation group G protein; Xeroderma pigmentosum group G-complementing protein; xeroderma pigmentosum, complementation group G; XPG; XPG-complementing protein; XPGC
Gene Symbols: ERCC5
Molecular weight: 133,108 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
Select Structure to View Below

XPG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K8-a MGVQGLWkLLECSGR
0 3 K64-u TLFHRLCkLLFFRIR
0 1 S100-p QRKDLASsDSRKTTE
0 8 S156-p LQEEEKHssEEEDEK
0 8 S157-p QEEEKHssEEEDEKE
0 1 K209 HEILTDMKEFTKRRR
0 5 T217-p EFTKRRRtLFEAMPE
0 13 Y289-p VSEDTSHyILIKGIQ
0 7 S307-p VAEVDSEsLPSSSKM
0 1 S318-p SSKMHGMsFDVKSSP
0 12 T338-p TEKEPDAtPPsPRTL
0 19 S341-p EPDAtPPsPRTLLAM
0 6 S355-p MQAALLGsssEEELE
0 6 S356-p QAALLGsssEEELEs
0 6 S357-p AALLGsssEEELEsE
0 3 S363-p ssEEELEsENRRQAR
0 6 S382-p PAAVDEGsIsPRTLS
0 44 S384-p AVDEGsIsPRTLSAI
0 2 K402-u LDDDEDVkVCAGDDV
0 7 S423-p AEEMRINssTENsDE
0 2 S424-p EEMRINssTENsDEG
0 2 S428-p INssTENsDEGLKVR
0 3 K438-a GLKVRDGkGIPFTAT
0 4 S448 PFTATLASSSVNSAE
0 13 S526-p GRELTPAsPTCTNSV
0 1 S558-p PYESKFDssLLssDD
0 2 S559-p YESKFDssLLssDDE
0 9 S562-p KFDssLLssDDEtKC
0 11 S563-p FDssLLssDDEtKCK
0 3 T567-p LLssDDEtKCKPNSA
0 1 S699-p EAPAESEsLLRDNSE
0 2 N704 SEsLLRDNSERDDVD
0 3 S705 EsLLRDNSERDDVDG
0 1 K913 RPNPHDTKVKKKLRT
0 2 S1069-p NTLEESSsLKRKRLS
0 2 - gap
  mouse

► Hide Isoforms
 
K8 MGVQGLWKLLECSGH
K64 TLFHRLCKLLFFRIR
I100 QRKDSASIDSRKTTE
S156-p LPEEEKHssEEEDEK
S157-p PEEEKHssEEEDEKQ
K209-u HEILTDMkEFTKRRR
T217 EFTKRRRTLFEAMPE
Y289 VSEDTSHYILIKGIQ
S307 VMDVDSESLPSSSNV
S318 SSNVHSVSSNLKSSP
- gap
S341-p EPEAAPPsPRTLLAI
S355-p IQAAMLGsssEDEPE
S356-p QAAMLGsssEDEPES
S357-p AAMLGsssEDEPESR
S363 ssEDEPESREGRQSK
S382 GATADAGSIsPRTCA
S384-p TADAGSIsPRTCAAI
K402 LDDDNDEKVSGSSDD
S418 AEKMLLGSGLEQEEH
- gap
- gap
- gap
T444-p PFDTAPLtPSVTEVK
- gap
S567-p PLETKCNssRLssDD
S568-p LETKCNssRLssDDE
S571-p KCNssRLssDDETEG
S572-p CNssRLssDDETEGG
T576 RLssDDETEGGQNPA
- gap
S704-p TECLLQDssDIEAME
S705-p ECLLQDssDIEAMEG
K912-u AENPYDTkVKKKLRK
V1060 PYKKETSVPKRRRPS
- gap
  XPG var1  
K8 MGVQGLWKLLECSGH
K64 TLFHRLCKLLFFRIR
I100 QRKDSASIDSRKTTE
S156 LPEEEKHSSEEEDEK
S157 PEEEKHSSEEEDEKQ
K209 HEILTDMKEFTKRRR
T217 EFTKRRRTLFEAMPE
Y289 VSEDTSHYILIKGIQ
S307 VMDVDSESLPSSSNV
S318 SSNVHSVSSNLKSSP
- gap
S341 EPEAAPPSPRTLLAI
S355 IQAAMLGSSSEDEPE
S356 QAAMLGSSSEDEPES
S357 AAMLGSSSEDEPESR
S363 SSEDEPESREGRQSK
S382 GATADAGSISPRTCA
S384 TADAGSISPRTCAAI
K402 LDDDNDEKVSGSSDD
S418 AEKMLLGSGLEQEEH
- gap
- gap
- gap
T444 PFDTAPLTPSVTEVK
- gap
S567 PLETKCNSSRLSSDD
S568 LETKCNSSRLSSDDE
S571 KCNSSRLSSDDETEG
S572 CNSSRLSSDDETEGG
T576 RLSSDDETEGGQNPA
- gap
S704 TECLLQDSSDIEAME
S705 ECLLQDSSDIEAMEG
K912 AENPYDTKVKKKLRK
V1060 PYKKETSVPKRRRPS
S1121-p VPDLVRDsPHGRQGC
  rat

 
K8 MGVQGLWKLLECSGR
K64 TLFHRLCKLLFFRIR
I100 QKKDSASIDSRKTTE
S156 LQEEEKHSSEEEDEK
S157 QEEEKHSSEEEDEKQ
K209 HEILTDMKEFTKRRR
T217 EFTKRRRTLFEAMPE
Y289 VAEDTSHYILIKGIQ
S307 VVDVDLESLPSSSKE
S318 SSKEHSVSFNLKSSP
T338 PESEPEATPPSPRTL
S341 EPEATPPSPRTLHAI
G355 IQVAMLGGSSEEEPE
S356 QVAMLGGSSEEEPES
S357 VAMLGGSSEEEPESG
S363 SSEEEPESGEGGQSK
S382 WATADAGSISPQTCA
S384 TADAGSISPQTCAAI
R402 LDDDEEERMCASSDN
- under review  
- gap
- gap
- gap
- gap
- gap
S565 PPKNTCNSSHLSSDD
S566 PKNTCNSSHLSSDDE
S569 TCNSSHLSSDDETEG
S570 CNSSHLSSDDETEGG
T574 HLSSDDETEGGQNPA
- gap
S702 TECLLQDSSDIKAMK
S703 ECLLQDSSDIKAMKE
K849 ESGGTKLKITRRLQK
- gap
- gap
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