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Protein Page:
XPG (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
XPG Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too. Defects in ERCC5 are the cause of xeroderma pigmentosum complementation group G (XP-G); also known as xeroderma pigmentosum VII (XP7). Xeroderma pigmentosum is an autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Some XP-G patients present features of Cockayne syndrome, including dwarfism, sensorineural deafness, microcephaly, mental retardation, pigmentary retinopathy, ataxia, decreased nerve conduction velocities. Belongs to the XPG/RAD2 endonuclease family. XPG subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.-.-; Deoxyribonuclease; DNA repair, damage
Cellular Component: nucleoplasm; intermediate filament cytoskeleton; DNA replication factor A complex; holo TFIIH complex; nucleolus; DNA-directed RNA polymerase II, holoenzyme; nucleus
Molecular Function: protein binding; protein homodimerization activity; endonuclease activity; metal ion binding; double-stranded DNA binding; protein N-terminus binding; bubble DNA binding; single-stranded DNA binding; endodeoxyribonuclease activity
Biological Process: nucleotide-excision repair, DNA incision, 3'-to lesion; UV protection; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA damage removal; DNA repair; DNA catabolic process, endonucleolytic; response to UV-C; negative regulation of apoptosis; response to UV
Reference #:  P28715 (UniProtKB)
Alt. Names/Synonyms: COFS3; DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; ERCC5; ERCM2; excision repair cross-complementing rodent repair deficiency, complementation group 5; excision repair protein; UVDR; xeroderma pigmentosum complementation group G protein; Xeroderma pigmentosum group G-complementing protein; xeroderma pigmentosum, complementation group G; XPG; XPG-complementing protein; XPGC
Gene Symbols: ERCC5
Molecular weight: 133,108 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
Select Structure to View Below

XPG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K8-ac MGVQGLWkLLECSGR
0 3 K64-ub TLFHRLCkLLFFRIR
0 1 S100-p QRKDLASsDSRKTTE
0 9 S156-p LQEEEKHssEEEDEK
0 9 S157-p QEEEKHssEEEDEKE
0 1 K209 HEILTDMKEFTKRRR
0 5 T217-p EFTKRRRtLFEAMPE
0 13 Y289-p VSEDTSHyILIKGIQ
0 7 S307-p VAEVDSEsLPSSSKM
0 2 S318-p SSKMHGMsFDVKSSP
0 2 T331-p SPCEKLKtEKEPDAt
0 14 T338-p tEKEPDAtPPsPRtL
0 22 S341-p EPDAtPPsPRtLLAM
0 1 T344-p AtPPsPRtLLAMQAA
0 7 S355-p MQAALLGsssEEELE
0 7 S356-p QAALLGsssEEELEs
0 7 S357-p AALLGsssEEELEsE
0 3 S363-p ssEEELEsENRRQAR
0 9 S382-p PAAVDEGsIsPRTLs
0 47 S384-p AVDEGsIsPRTLsAI
0 1 S389-p sIsPRTLsAIKRALD
0 2 K402-ub LDDDEDVkVCAGDDV
0 8 S423-p AEEMRINssTENsDE
0 3 S424-p EEMRINssTENsDEG
0 3 S428-p INssTENsDEGLKVR
0 3 K438-ac GLKVRDGkGIPFTAT
0 5 S448 PFTATLASSSVNSAE
0 1 S450 TATLASSSVNSAEEH
0 1 S477-p SVPKEQMsLVHVGTE
0 1 T523-p LPNGRELtPAsPTCT
0 15 S526-p GRELtPAsPTCTNSV
0 1 S558-p PYESKFDssLLssDD
0 4 S559-p YESKFDssLLssDDE
0 11 S562-p KFDssLLssDDEtKC
0 15 S563-p FDssLLssDDEtKCK
0 3 T567-p LLssDDEtKCKPNsA
0 1 S573-p EtKCKPNsASEVIGP
0 2 S662-p IEVQSVIsDEELQAE
0 2 S678-p PETSKPPsEQGEEEL
0 2 S699-p EAPAESEsLLRDNSE
0 2 N704 SEsLLRDNSERDDVD
0 4 S705 EsLLRDNSERDDVDG
0 1 S724-p AEKDAEDsLHEWQDI
0 1 K913 RPNPHDTKVKKKLRT
0 3 S1069-p NTLEESSsLKRKRLS
0 1 S1129-p PKTSASDsQNsVKEA
0 1 S1132-p SASDsQNsVKEAPVk
0 2 A1136 sQNsVKEAPVkNGGA
0 1 K1139-ac sVKEAPVkNGGATtS
0 1 T1145-p VkNGGATtSsssDsD
0 1 S1147-p NGGATtSsssDsDDD
0 1 S1148-p GGATtSsssDsDDDG
0 1 S1149-p GATtSsssDsDDDGG
0 1 S1151-p TtSsssDsDDDGGKE
  mouse

► Hide Isoforms
 
K8 MGVQGLWKLLECSGH
K64 TLFHRLCKLLFFRIR
I100 QRKDSASIDSRKTTE
S156-p LPEEEKHssEEEDEK
S157-p PEEEKHssEEEDEKQ
K209-ub HEILTDMkEFTKRRR
T217 EFTKRRRTLFEAMPE
Y289 VSEDTSHYILIKGIQ
S307 VMDVDSESLPSSSNV
S318 SSNVHSVSSNLKSSP
P331 SPHEKVKPEREPEAA
A338 PEREPEAAPPsPRTL
S341-p EPEAAPPsPRTLLAI
T344 AAPPsPRTLLAIQAA
S355-p IQAAMLGsssEDEPE
S356-p QAAMLGsssEDEPES
S357-p AAMLGsssEDEPESR
S363 ssEDEPESREGRQSK
S382 GATADAGSIsPRTCA
S384-p TADAGSIsPRTCAAI
A389 SIsPRTCAAIQKALD
K402 LDDDNDEKVSGSSDD
S418 AEKMLLGSGLEQEEH
G419 EKMLLGSGLEQEEHA
E423 LGSGLEQEEHADETA
G434 DETAERGGGVPFDTA
T444-p PFDTAPLtPsVTEVK
S446-p DTAPLtPsVTEVKEC
S485 DTPKETVSLARAVKE
T531 VLSEREPTLAPPTTR
P534 EREPTLAPPTTRTHS
S567-p PLETKCNssRLssDD
S568-p LETKCNssRLssDDE
S571-p KCNssRLssDDETEG
S572-p CNssRLssDDETEGG
T576 RLssDDETEGGQNPA
P582 ETEGGQNPAPKACST
S662 IEVQSVVSNSELQTE
S678 SEASTHLSEKDAEEP
C699 GTSRDTECLLQDssD
S704-p TECLLQDssDIEAME
S705-p ECLLQDssDIEAMEG
M723 ADIDAEDMPNEWQDI
K912-ub AENPYDTkVKKKLRK
V1060 PYKKETSVPKRRRPS
V1114 SKISCSDVPDLVRDP
L1117 SCSDVPDLVRDPPHG
P1121 VPDLVRDPPHGRQGC
G1124 LVRDPPHGRQGCVST
S1130 HGRQGCVSTSSSSED
S1132 RQGCVSTSSSSEDDE
S1133 QGCVSTSSSSEDDED
S1134 GCVSTSSSSEDDEDK
S1135 CVSTSSSSEDDEDKA
  XPG var1  
K8 MGVQGLWKLLECSGH
K64 TLFHRLCKLLFFRIR
I100 QRKDSASIDSRKTTE
S156 LPEEEKHSSEEEDEK
S157 PEEEKHSSEEEDEKQ
K209 HEILTDMKEFTKRRR
T217 EFTKRRRTLFEAMPE
Y289 VSEDTSHYILIKGIQ
S307 VMDVDSESLPSSSNV
S318 SSNVHSVSSNLKSSP
P331 SPHEKVKPEREPEAA
A338 PEREPEAAPPSPRTL
S341 EPEAAPPSPRTLLAI
T344 AAPPSPRTLLAIQAA
S355 IQAAMLGSSSEDEPE
S356 QAAMLGSSSEDEPES
S357 AAMLGSSSEDEPESR
S363 SSEDEPESREGRQSK
S382 GATADAGSISPRTCA
S384 TADAGSISPRTCAAI
A389 SISPRTCAAIQKALD
K402 LDDDNDEKVSGSSDD
S418 AEKMLLGSGLEQEEH
G419 EKMLLGSGLEQEEHA
E423 LGSGLEQEEHADETA
G434 DETAERGGGVPFDTA
T444 PFDTAPLTPSVTEVK
S446 DTAPLTPSVTEVKEC
S485 DTPKETVSLARAVKE
T531 VLSEREPTLAPPTTR
P534 EREPTLAPPTTRTHS
S567 PLETKCNSSRLSSDD
S568 LETKCNSSRLSSDDE
S571 KCNSSRLSSDDETEG
S572 CNSSRLSSDDETEGG
T576 RLSSDDETEGGQNPA
P582 ETEGGQNPAPKACST
S662 IEVQSVVSNSELQTE
S678 SEASTHLSEKDAEEP
C699 GTSRDTECLLQDSSD
S704 TECLLQDSSDIEAME
S705 ECLLQDSSDIEAMEG
M723 ADIDAEDMPNEWQDI
K912 AENPYDTKVKKKLRK
V1060 PYKKETSVPKRRRPS
V1114 SKISCSDVPDLVRDs
L1117 SCSDVPDLVRDsPHG
S1121-p VPDLVRDsPHGRQGC
G1124 LVRDsPHGRQGCVST
S1130 HGRQGCVSTSSSSED
S1132 RQGCVSTSSSSEDDE
S1133 QGCVSTSSSSEDDED
S1134 GCVSTSSSSEDDEDK
S1135 CVSTSSSSEDDEDKA
  rat

 
K8 MGVQGLWKLLECSGR
K64 TLFHRLCKLLFFRIR
I100 QKKDSASIDSRKTTE
S156 LQEEEKHSSEEEDEK
S157 QEEEKHSSEEEDEKQ
K209 HEILTDMKEFTKRRR
T217 EFTKRRRTLFEAMPE
Y289 VAEDTSHYILIKGIQ
S307 VVDVDLESLPSSSKE
S318 SSKEHSVSFNLKSSP
P331 SPYEKVKPESEPEAT
T338 PESEPEATPPSPRTL
S341 EPEATPPSPRTLHAI
T344 ATPPSPRTLHAIQVA
G355 IQVAMLGGSSEEEPE
S356 QVAMLGGSSEEEPES
S357 VAMLGGSSEEEPESG
S363 SSEEEPESGEGGQSK
S382 WATADAGSISPQTCA
S384 TADAGSISPQTCAAI
A389 SISPQTCAAIQRALD
R402 LDDDEEERMCASSDN
N418 AVEMLLGNGLKQEHA
G419 VEMLLGNGLKQEHAD
E423 LGNGLKQEHADEVVV
G433 DEVVVKGGGVPLDTA
L443 PLDTASLLPSVTEVE
S445 DTASLLPSVTEVEEC
S484 EVPKETVSPAHVVSE
T530 VLSERELTLAPPIRT
P533 ERELTLAPPIRTHSH
S565 PPKNTCNSSHLSSDD
S566 PKNTCNSSHLSSDDE
S569 TCNSSHLSSDDETEG
S570 CNSSHLSSDDETEGG
T574 HLSSDDETEGGQNPA
P580 ETEGGQNPASKAGST
S660 IEVQSVISNDELQIE
S676 SEISKHLSEKDAEEP
C697 GsPRNTECLLQDSSD
S702 TECLLQDSSDIKAMK
S703 ECLLQDSSDIKAMKE
- under review  
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