a protein kinase of the CDK family. Catalytic subunit of the conserved protein complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions. Mitotic cyclins stably associate with this protein and function as regulatory subunits. Its activity is controlled by cyclin availability and phosphorylation through the cell cycle. Activated in many cancers including colon, liver and breast. The T isoform, which lacks a regulatory region, is expressed in breast cancer. Inhibition in cancer cells may drive cells into apoptosis. May also drive cell migration. Inhibitors: BMS-265246, BMS-265246-01. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 18.104.22.168; Protein kinase, Ser/Thr (non-receptor); Cell cycle regulation; Motility/polarity/chemotaxis; EC 22.214.171.124; Protein kinase, CMGC; CMGC group; CDK family; CDK1 subfamily; CDK/CDK1 subfamily
Molecular Function: RNA polymerase subunit kinase activity; protein serine/threonine kinase activity; protein binding; cyclin-dependent protein kinase activity; Hsp70 protein binding; ATP binding; protein kinase activity
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of Schwann cell differentiation; activation of MAPK activity; apoptosis; regulation of embryonic development; centrosome cycle; mitotic nuclear envelope disassembly; epithelial cell differentiation; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; DNA replication; G2/M transition of mitotic cell cycle; mitosis; cell migration; organelle organization and biogenesis; peptidyl-threonine phosphorylation; microtubule cytoskeleton organization and biogenesis; pronuclear fusion; DNA repair; G1/S-specific transcription in mitotic cell cycle; peptidyl-serine phosphorylation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; mitotic cell cycle G2/M transition DNA damage checkpoint; mitotic cell cycle; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
Alt. Names/Synonyms: CDC2; CDC28A; CDK1; cell cycle controller CDC2; Cell division control protein 2 homolog; cell division cycle 2; cell division cycle 2, G1 to S and G2 to M; Cyclin-dependent kinase 1; DKFZp686L20222; MGC111195; p34 protein kinase; P34CDC2
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.