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YY1
a polycomb-group (Pc-G) protein essential for early mammalian development and the regulation of X-inactivation and certain imprinted genes. Required for the transactivation of TSIX by CTCF. The complex of CTCF-YY1-TSIX is a critical regulator of the X chromosome binary switch. Can function as an activator or a repressor depending on the presence of other proteins. For example it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor |
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Cellular Component: transcription factor complex; nuclear matrix; plasma membrane; PcG protein complex; nucleus
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Molecular Function: protein binding; DNA binding; four-way junction DNA binding; zinc ion binding; RNA binding; transcription coactivator activity; transcription factor activity; transcription corepressor activity
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Biological Process: regulation of transcription from RNA polymerase II promoter; anterior/posterior pattern formation; RNA localization; camera-type eye morphogenesis; transcription, DNA-dependent; spermatogenesis; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; response to DNA damage stimulus; chromosome organization and biogenesis; response to UV-C; double-strand break repair via homologous recombination
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Reference #:
P25490 (UniProtKB)
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| Alt. Names/Synonyms: DELTA; Delta transcription factor; INO80 complex subunit S; INO80S; NF-E1; Transcriptional repressor protein YY1; TYY1; UCRBP; Yin and yang 1; Yin and Yang 1 protein; yin yang 1; YIN-YANG-1; YY-1; YY1; YY1 transcription factor |
| Gene Symbols: YY1 |
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Molecular weight: 44,713 Da
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Basal Isoelectric point: 5.8
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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