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hnRNP A2/B1 (human)

Overview hnRNP A2/B1 Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with IGF2BP1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: RNA splicing; RNA binding protein Cellular Component: nucleoplasm; spliceosome; cytoplasm; nucleolus; nucleus; ribonucleoprotein complex Molecular Function: protein binding; single-stranded telomeric DNA binding; RNA binding; nucleotide binding Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA processing; RNA transport Reference #:  P22626 (UniProtKB) Alt. Names/Synonyms: DKFZp779B0244; FLJ22720; heterogeneous nuclear ribonucleoprotein A2/B1; heterogeneous nuclear ribonucleoprotein B1; Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1; hnRNP A2/B1; HNRNPA2; HNRNPA2B1; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; nuclear ribonucleoprotein particle A2 protein; RNPA2; ROA2; SNRPB1 Gene Symbols: HNRNPA2B1 Molecular weight: 37,430 Da Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below hnRNP A2/B1 1X4B - A=1-103 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K3-a	_____MEkTLEtVPL
0	1		T7-p	_MEkTLEtVPLERKK
0	25		K22-u	REKEQFRkLFIGGLs
0	4		S29-p	kLFIGGLsFETTEES
0	4		Y40-p	TEESLRNyyEQWGkL
0	3		Y41-p	EESLRNyyEQWGkLT
0	4		K46-a	NyyEQWGkLTDCVVM
0	58		K46-u	NyyEQWGkLTDCVVM
0	155		K59-a	VMRDPASkRSRGFGF
0	44		K59-u	VMRDPASkRSRGFGF
0	2		S70-p	GFGFVTFssMAEVdA
0	4		S71-p	FGFVTFssMAEVdAA
0	1		D76-ca	FssMAEVdAAMAARP
0	7		S85-p	AMAARPHsIDGRVVE
0	1		K94-a	DGRVVEPkRAVAREE
0	2		K94-u	DGRVVEPkRAVAREE
0	2		S102-p	RAVAREEsGkPGAHV
0	2		K104-a	VAREEsGkPGAHVTV
0	41		K104-u	VAREEsGkPGAHVTV
0	10		K112-a	PGAHVTVkkLFVGGI
0	54		K112-u	PGAHVTVkkLFVGGI
0	7		K113-u	GAHVTVkkLFVGGIk
0	1		K120-a	kLFVGGIkEDTEEHH
0	3		K120-u	kLFVGGIkEDTEEHH
0	35		K137-u	DYFEEYGkIDTIEII
0	1		S149-p	EIITDRQsGKKrGFG
0	1		K152	TDRQsGKKrGFGFVt
0	1		R153-m2	DRQsGKKrGFGFVtF
0	3		T159-p	KrGFGFVtFDDHDPV
0	4		K168-a	DDHDPVDkIVLQkyH
0	56		K168-u	DDHDPVDkIVLQkyH
0	3		K173-a	VDkIVLQkyHtINGH
0	42		K173-u	VDkIVLQkyHtINGH
0	14		Y174-p	DkIVLQkyHtINGHN
0	19		T176-p	IVLQkyHtINGHNAE
0	2		S189-p	AEVRKALsRQEMQEV
0	3		S201-p	QEVQSSRsGrGGNFG
0	54		R203-m1	VQSSRsGrGGNFGFG
0	5		R203-m2	VQSSRsGrGGNFGFG
0	11		S212-p	GNFGFGDsrGGGGNF
0	54		R213-m1	NFGFGDsrGGGGNFG
0	3		R213-m2	NFGFGDsrGGGGNFG
0	8		S225-p	NFGPGPGsNFrGGsD
0	48		R228-m1	PGPGsNFrGGsDGYG
0	2		S231-p	GsNFrGGsDGYGsGr
0	5		S236-p	GGsDGYGsGrGFGDG
0	38		R238-m1	sDGYGsGrGFGDGyN
0	63		Y244-p	GrGFGDGyNGyGGGP
0	48		Y247-p	FGDGyNGyGGGPGGG
0	56		S259-p	GGGNFGGsPGyGGGr
0	25		Y262-p	NFGGsPGyGGGrGGY
0	22		R266-m1	sPGyGGGrGGYGGGG
0	1		R266-m2	sPGyGGGrGGYGGGG
0	1		Y287-p	GGGYGGGyDNyGGGN
0	1		Y290-p	YGGGyDNyGGGNyGs
0	3		Y295-p	DNyGGGNyGsGNyND
0	3		S297-p	yGGGNyGsGNyNDFG
0	1		Y300-p	GNyGsGNyNDFGNyN
0	3		Y306-p	NyNDFGNyNQQPsNy
0	1		S311-p	GNyNQQPsNyGPMKS
0	3		Y313-p	yNQQPsNyGPMKSGN
0	1		S318	sNyGPMKSGNFGGsr
0	5		S324-p	KSGNFGGsrNMGGPy
0	19		R325-m1	SGNFGGsrNMGGPyG
0	314		Y331-p	srNMGGPyGGGNyGP
0	559		Y336-p	GPyGGGNyGPGGsGG
0	50		S341-p	GNyGPGGsGGsGGyG
0	98		S344-p	GPGGsGGsGGyGGrS
0	178		Y347-p	GsGGsGGyGGrSry_
0	17		R350-m1	GsGGyGGrSry____
0	4		R352-m1	GGyGGrSry______
0	3		Y353-p	GyGGrSry_______

	mouse ► Hide Isoforms
K3	_____MEKTLETVPL
T7	_MEKTLETVPLERKK
K22-u	REKEQFRkLFIGGLs
S29-p	kLFIGGLsFETTEES
Y40	TEESLRNYYEQWGkL
Y41	EESLRNYYEQWGkLT
K46	NYYEQWGKLTDCVVM
K46-u	NYYEQWGkLTDCVVM
K59-a	VMRDPASkRSRGFGF
K59-u	VMRDPASkRSRGFGF
S70	GFGFVTFSSMAEVDA
S71	FGFVTFSSMAEVDAA
D76	FSSMAEVDAAMAARP
S85-p	AMAARPHsIDGRVVE
K94	DGRVVEPKRAVAREE
K94	DGRVVEPKRAVAREE
S102-p	RAVAREEsGkPGAHV
K104	VAREEsGKPGAHVTV
K104-u	VAREEsGkPGAHVTV
K112-a	PGAHVTVkkLFVGGI
K112-u	PGAHVTVkkLFVGGI
K113-u	GAHVTVkkLFVGGIk
K120	kLFVGGIKEDTEEHH
K120-u	kLFVGGIkEDTEEHH
K137-u	DYFEEYGkIDTIEII
S149	EIITDRQSGKkRGFG
K152-u	TDRQSGKkRGFGFVT
R153	DRQSGKkRGFGFVTF
T159	kRGFGFVTFDDHDPV
K168	DDHDPVDKIVLQkyH
K168-u	DDHDPVDkIVLQkyH
K173	VDkIVLQKyHtINGH
K173-u	VDkIVLQkyHtINGH
Y174-p	DkIVLQkyHtINGHN
T176-p	IVLQkyHtINGHNAE
S189	AEVRKALSRQEMQEV
S201-p	QEVQSSRsGrGGNFG
R203-m1	VQSSRsGrGGNFGFG
R203-m2	VQSSRsGrGGNFGFG
S212-p	GNFGFGDsrGGGGNF
R213-m1	NFGFGDsrGGGGNFG
R213-m2	NFGFGDsrGGGGNFG
S225-p	NFGPGPGsNFrGGSD
R228-m1	PGPGsNFrGGSDGYG
S231	GsNFrGGSDGYGSGr
S236	GGSDGYGSGrGFGDG
R238-m1	SDGYGSGrGFGDGYN
Y244	GrGFGDGYNGYGGGP
Y247	FGDGYNGYGGGPGGG
S259-p	GGGNFGGsPGYGGGr
Y262	NFGGsPGYGGGrGGY
R266-m1	sPGYGGGrGGYGGGG
R266	sPGYGGGRGGYGGGG
Y287	GGGYGGGYDNYGGGN
Y290	YGGGYDNYGGGNYGS
Y295	DNYGGGNYGSGSYND
S297	YGGGNYGSGSYNDFG
Y300	GNYGSGSYNDFGNYN
Y306	SYNDFGNYNQQPSNY
S311	GNYNQQPSNYGPMKS
Y313	YNQQPSNYGPMKSGN
S318	SNYGPMKSGNFGGsr
S324-p	KSGNFGGsrNMGGPy
R325-m1	SGNFGGsrNMGGPyG
Y331-p	srNMGGPyGGGNyGP
Y336-p	GPyGGGNyGPGGsGG
S341-p	GNyGPGGsGGsGGyG
S344-p	GPGGsGGsGGyGGrS
Y347-p	GsGGsGGyGGrSrY_
R350-m1	GsGGyGGrSrY____
R352-m1	GGyGGrSrY______
Y353	GyGGrSrY_______

	hnRNP A2/B1 iso3
-	gap
-	gap
K10	REKEQFRKLFIGGLS
S17	KLFIGGLSFETTEES
Y28	TEESLRNYYEQWGKL
Y29	EESLRNYYEQWGKLT
K34	NYYEQWGKLTDCVVM
K34	NYYEQWGKLTDCVVM
K47	VMRDPASKRSRGFGF
K47	VMRDPASKRSRGFGF
S58	GFGFVTFSSMAEVDA
S59	FGFVTFSSMAEVDAA
D64	FSSMAEVDAAMAARP
S73	AMAARPHSIDGRVVE
K82	DGRVVEPKRAVAREE
K82	DGRVVEPKRAVAREE
S90	RAVAREESGKPGAHV
K92	VAREESGKPGAHVTV
K92	VAREESGKPGAHVTV
K100	PGAHVTVKKLFVGGI
K100	PGAHVTVKKLFVGGI
K101	GAHVTVKKLFVGGIK
K108	KLFVGGIKEDTEEHH
K108	KLFVGGIKEDTEEHH
K125	DYFEEYGKIDTIEII
S137	EIITDRQSGKKRGFG
K140	TDRQSGKKRGFGFVT
R141	DRQSGKKRGFGFVTF
T147	KRGFGFVTFDDHDPV
K156	DDHDPVDKIVLQKYH
K156	DDHDPVDKIVLQKYH
K161	VDKIVLQKYHTINGH
K161	VDKIVLQKYHTINGH
Y162	DKIVLQKYHTINGHN
T164	IVLQKYHTINGHNAE
S177	AEVRKALSRQEMQEV
S189	QEVQSSRSGRGGNFG
R191	VQSSRSGRGGNFGFG
R191	VQSSRSGRGGNFGFG
S200	GNFGFGDSRGGGGNF
R201	NFGFGDSRGGGGNFG
R201	NFGFGDSRGGGGNFG
S213	NFGPGPGSNFRGGSD
R216	PGPGSNFRGGSDGYG
S219	GSNFRGGSDGYGSGR
S224	GGSDGYGSGRGFGDG
R226	SDGYGSGRGFGDGYN
Y232	GRGFGDGYNGYGGGP
Y235	FGDGYNGYGGGPGGN
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
Y243	GGGPGGNYGsGSYND
S245-p	GPGGNYGsGSYNDFG
Y248	GNYGsGSYNDFGNyN
Y254-p	SYNDFGNyNQQPSNY
S259	GNyNQQPSNYGPMKs
Y261	yNQQPSNYGPMKsGN
S266-p	SNYGPMKsGNFGGsR
S272-p	KsGNFGGsRNMGGPY
R273	sGNFGGsRNMGGPYG
Y279	sRNMGGPYGGGNYGP
Y284	GPYGGGNYGPGGSGG
S289	GNYGPGGSGGSGGYG
S292	GPGGSGGSGGYGGRS
Y295	GSGGSGGYGGRSRY_
R298	GSGGYGGRSRY____
R300	GGYGGRSRY______
Y301	GYGGRSRY_______

	rat
K3	_____MEKTLETVPL
T7	_MEKTLETVPLERKK
K22	REKEQFRKLFIGGLS
S29	KLFIGGLSFETTEES
Y40	TEESLRNYyEQWGKL
Y41-p	EESLRNYyEQWGKLT
K46	NYyEQWGKLTDCVVM
K46	NYyEQWGKLTDCVVM
K59	VMRDPASKRSRGFGF
K59	VMRDPASKRSRGFGF
S70	GFGFVTFSSMAEVDA
S71	FGFVTFSSMAEVDAA
D76	FSSMAEVDAAMAARP
S85	AMAARPHSIDGRVVE
K94	DGRVVEPKRAVAREE
K94	DGRVVEPKRAVAREE
S102	RAVAREESGKPGAHV
K104	VAREESGKPGAHVTV
K104	VAREESGKPGAHVTV
K112	PGAHVTVKKLFVGGI
K112	PGAHVTVKKLFVGGI
K113	GAHVTVKKLFVGGIK
K120	KLFVGGIKEDTEEHH
K120	KLFVGGIKEDTEEHH
K137	DYFEEYGKIDTIEII
S149	EIITDRQSGKKRGFG
K152	TDRQSGKKRGFGFVT
R153	DRQSGKKRGFGFVTF
T159	KRGFGFVTFDDHDPV
K168	DDHDPVDKIVLQKYH
K168	DDHDPVDKIVLQKYH
K173	VDKIVLQKYHtINGH
K173	VDKIVLQKYHtINGH
Y174	DKIVLQKYHtINGHN
T176-p	IVLQKYHtINGHNAE
S189	AEVRKALSRQEMQEV
S201	QEVQSSRSGrGGNFG
R203-m1	VQSSRSGrGGNFGFG
R203	VQSSRSGRGGNFGFG
S212	GNFGFGDSrGGGGNF
R213-m1	NFGFGDSrGGGGNFG
R213	NFGFGDSRGGGGNFG
S225	NFGPGPGSNFrGGSD
R228-m1	PGPGSNFrGGSDGYG
S231	GSNFrGGSDGYGSGr
S236	GGSDGYGSGrGFGDG
R238-m1	SDGYGSGrGFGDGYN
Y244	GrGFGDGYNGYGGGP
Y247	FGDGYNGYGGGPGGG
S259	GGGNFGGSPGYGGGr
Y262	NFGGSPGYGGGrGGY
R266-m1	SPGYGGGrGGYGGGG
R266	SPGYGGGRGGYGGGG
Y287	GGGYGGGYDNYGGGN
Y290	YGGGYDNYGGGNYGS
Y295	DNYGGGNYGSGNYND
S297	YGGGNYGSGNYNDFG
Y300	GNYGSGNYNDFGNYN
Y306	NYNDFGNYNQQPSNY
S311	GNYNQQPSNYGPMKS
Y313	YNQQPSNYGPMKSGN
S318	SNYGPMKSGNFGGSr
S324	KSGNFGGSrNMGGPY
R325-m1	SGNFGGSrNMGGPYG
Y331	SrNMGGPYGGGNYGP
Y336	GPYGGGNYGPGGSGG
S341	GNYGPGGSGGSGGyG
S344	GPGGSGGSGGyGGrS
Y347-p	GSGGSGGyGGrSrY_
R350-m1	GSGGyGGrSrY____
R352-m1	GGyGGrSrY______
Y353	GyGGrSrY_______

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