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Protein Page:
calpastatin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
calpastatin Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. Belongs to the protease inhibitor I27 (calpastatin) family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Inhibitor protein
Chromosomal Location of Human Ortholog: 5q15
Cellular Component: membrane; cytoplasm; cytosol
Molecular Function: protein binding; endopeptidase inhibitor activity; cysteine protease inhibitor activity
Reference #:  P20810 (UniProtKB)
Alt. Names/Synonyms: BS-17; Calpain inhibitor; Calpastatin; CAST; heart-type calpastatin; ICAL; MGC9402; Sperm BS-17 component
Gene Symbols: CAST
Molecular weight: 76,573 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

calpastatin

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 - gap
0 13 - gap
0 2 - gap
0 1 - gap
0 1 - gap
0 4 - gap
0 1 - gap
0 5 - gap
0 2 - gap
0 1 - gap
0 4 - gap
0 1 - gap
0 8 - gap
0 2 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 S41-p EPEKKSQsTKLSVVH
0 1 T42 PEKKSQsTKLSVVHE
0 1 K51-m1 LSVVHEKksQEGkPk
0 1 S52-p SVVHEKksQEGkPkE
0 1 K56-m1 EKksQEGkPkEHTEP
0 1 K58-m1 ksQEGkPkEHTEPKs
0 1 S65-p kEHTEPKsLPKQAsD
0 3 S71-p KsLPKQAsDTGSNDA
0 7 S87 NKKAVSRSAEQQPSE
0 1 P99 PSEKSTEPKTKPQDM
0 1 K123-ac GITAISGkPGDKKKE
0 10 S133-p DKKKEKKsLtPAVPV
0 10 T135-p KKEKKsLtPAVPVEs
0 19 V138 KKsLtPAVPVEsKPD
0 3 S142-p tPAVPVEsKPDKPSG
0 3 K143 PAVPVEsKPDKPSGK
0 2 D145 VPVEsKPDKPSGKSG
0 1 S148 EsKPDKPSGKSGMDA
0 2 T216 LAKKEGITGPPADSs
0 8 S222 ITGPPADSsKPIGPD
0 1 S223-p TGPPADSsKPIGPDD
0 3 P228 DSsKPIGPDDAIDAL
0 3 S236-p DDAIDALsSDFtCGs
0 2 T240-p DALsSDFtCGsPtAA
0 1 G242 LsSDFtCGsPtAAGk
0 17 S243-p sSDFtCGsPtAAGkK
0 5 T245-p DFtCGsPtAAGkKTE
0 2 K249-ac GsPtAAGkKTEKEES
0 1 K261 EESTEVLKAQSAGTV
0 1 S287-p KVEKDTMsDQALEAL
0 1 S295-p DQALEALsAsLGtRQ
0 2 S297-p ALEALsAsLGtRQAE
0 1 T300-p ALsAsLGtRQAEPEL
0 1 S311-p EPELDLRsIkEVDEA
0 1 K313-ac ELDLRsIkEVDEAKA
0 5 Y339-p DETIPSEyRLKPATD
0 5 P362 EPEEKPKPRsEsELI
0 29 S364-p EEKPKPRsEsELIDE
0 6 S366-p KPKPRsEsELIDELs
0 6 S373-p sELIDELsEDFDRsE
0 3 S379-p LsEDFDRsECKEKPS
0 1 K384 DRsECKEKPSKPtEK
0 1 T389-p KEKPSKPtEKTEESK
0 1 K391 KPSKPtEKTEESKAA
0 1 - gap
0 1 - gap
0 1 - gap
0 10 - gap
0 1 S414-p VCRTSMCsIQSAPPE
0 1 K426 PPEPATLKGTVPDDA
0 6 S440-p AVEALADsLGkKEAD
0 2 K443-ac ALADsLGkKEADPED
0 3 Y481-p EETIPPDyRLEEVKD
0 2 S499-p KPLLPKEskEQLPPM
0 1 K500-ac PLLPKEskEQLPPMs
0 1 S507-p kEQLPPMsEDFLLDA
0 1 S516-p DFLLDALsEDFSGPQ
0 2 S526-p FSGPQNAssLkFEDA
0 1 S527-p SGPQNAssLkFEDAk
0 1 K529-ac PQNAssLkFEDAkLA
0 1 K534-ub sLkFEDAkLAAAISE
0 1 T546-p ISEVVSQtPASTTQA
0 1 T560-p AGAPPRDtsQsDKDL
0 1 S561-p GAPPRDtsQsDKDLD
0 1 S563-p PPRDtsQsDKDLDDA
0 1 K573-ac DLDDALDkLsDsLGQ
0 10 S575-p DDALDkLsDsLGQRQ
0 6 S577-p ALDkLsDsLGQRQPD
0 1 K598 MEDKVKEKAKAEHRD
0 1 K606 AKAEHRDKLGERDDt
0 2 T613-p KLGERDDtIPPEyRH
0 2 Y618-p DDtIPPEyRHLLDDN
0 2 K629-ac LDDNGQDkPVKPPTK
0 1 T635 DkPVKPPTKKSEDSK
0 4 S655-p QDPIDALsGDLDsCP
0 1 S660-p ALsGDLDsCPStTET
0 1 T664-p DLDsCPStTETsQNt
0 1 S668-p CPStTETsQNtAKDK
0 1 T671-p tTETsQNtAKDKCKk
0 2 K678-ub tAKDKCKkAASSSkA
0 1 K684-ac KkAASSSkAPkNGGk
0 1 K687-ac ASSSkAPkNGGkAKD
0 1 K687 ASSSkAPKNGGkAKD
0 1 K691-ac kAPkNGGkAKDSAKT
0 1 K691 kAPkNGGKAKDSAKT
  calpastatin iso5  
S2-p ______MsQPGQKPA
S11-p PGQKPAAsPRPRRAA
S34-p VSEKTSEsPSKPGEK
K48 KKGSDEKKAAsLGss
K48-m1 KKGSDEKkAAsLGss
S51-p SDEKkAAsLGssQSs
S54-p KkAAsLGssQSsRty
S55-p kAAsLGssQSsRtyA
S58-p sLGssQSsRtyAGGT
T60-p GssQSsRtyAGGTAs
Y61-p ssQSsRtyAGGTAsA
S67-p tyAGGTAsATKVSAS
S81 SSGATSKSSsMNPtE
S83-p GATSKSSsMNPtEtK
N85 TSKSSsMNPtEtKAV
P86 SKSSsMNPtEtKAVK
T87-p KSSsMNPtEtKAVKT
T89-p SsMNPtEtKAVKTEP
S102 EPEKKSQSTKLSVVH
T103 PEKKSQSTKLSVVHE
K112 LSVVHEKKSQEGKPK
S113 SVVHEKKSQEGKPKE
K117 EKKSQEGKPKEHTEP
K119 KSQEGKPKEHTEPKS
S126 KEHTEPKSLPKQASD
S132 KSLPKQASDTGSNDA
S148 NKKAVSRSAEQQPSE
P160 PSEKSTEPKTKPQDM
K184 GITAISGKPGDKKKE
S194 DKKKEKKSLTPAVPV
T196 KKEKKSLTPAVPVES
V199 KKSLTPAVPVESKPD
S203 TPAVPVESKPDKPSG
K204 PAVPVESKPDKPSGK
D206 VPVESKPDKPSGKSG
S209 ESKPDKPSGKSGMDA
- gap
- gap
- gap
P276 LLAKPIGPDDAIDAL
S284 DDAIDALSSDFTCGs
T288 DALSSDFTCGsPTAA
G290 LSSDFTCGsPTAAGK
S291-p SSDFTCGsPTAAGKK
T293 DFTCGsPTAAGKKTE
K297 GsPTAAGKKTEKEES
K309 EESTEVLKAQSAGTV
S335 KVEKDTMSDQALEAL
S343 DQALEALSASLGTRQ
S345 ALEALSASLGTRQAE
T348 ALSASLGTRQAEPEL
S359 EPELDLRSIKEVDEA
K361 ELDLRSIKEVDEAKA
Y387 DETIPSEYRLKPATD
P410 EPEEKPKPRSESELI
S412 EEKPKPRSESELIDE
S414 KPKPRSESELIDELS
S421 SELIDELSEDFDRSE
S427 LSEDFDRSECKEKPS
K432 DRSECKEKPSKPTEK
T437 KEKPSKPTEKTEESK
K439 KPSKPTEKTEESKAA
- gap
- gap
- gap
- gap
S462 VCRTSMCSIQSAPPE
K474 PPEPATLKGTVPDDA
S488 AVEALADSLGKKEAD
K491 ALADSLGKKEADPED
Y529 EETIPPDYRLEEVKD
S547 KPLLPKESKEQLPPM
K548 PLLPKESKEQLPPMS
S555 KEQLPPMSEDFLLDA
S564 DFLLDALSEDFSGPQ
S574 FSGPQNASSLKFEDA
S575 SGPQNASSLKFEDAK
K577 PQNASSLKFEDAKLA
K582 SLKFEDAKLAAAISE
T594 ISEVVSQTPASTTQA
T608 AGAPPRDTSQSDKDL
S609 GAPPRDTSQSDKDLD
S611 PPRDTSQSDKDLDDA
K621 DLDDALDKLSDSLGQ
S623 DDALDKLSDSLGQRQ
S625 ALDKLSDSLGQRQPD
K646 MEDKVKEKAKAEHRD
K654 AKAEHRDKLGERDDT
T661 KLGERDDTIPPEYRH
Y666 DDTIPPEYRHLLDDN
K677 LDDNGQDKPVKPPTK
T683 DKPVKPPTKKSEDSK
S703 QDPIDALSGDLDSCP
S708 ALSGDLDSCPSTTET
T712 DLDSCPSTTETSQNT
S716 CPSTTETSQNTAKDK
T719 TTETSQNTAKDKCKK
K726 TAKDKCKKAASSSKA
K732 KKAASSSKAPKNGGK
K735 ASSSKAPKNGGKAKD
K735 ASSSKAPKNGGKAKD
K739 KAPKNGGKAKDSAKT
K739 KAPKNGGKAKDSAKT
  calpastatin iso6  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S41 EPEKKSQSTKLSVVH
T42 PEKKSQSTKLSVVHE
K51 LSVVHEKKSQEGKPK
S52 SVVHEKKSQEGKPKE
K56 EKKSQEGKPKEHTEP
K58 KSQEGKPKEHTEPKS
S65 KEHTEPKSLPKQASD
S71 KSLPKQASDTGSNDA
S87 NKKAVSRSAEQQPSE
P99 PSEKSTEPKTKPQDM
K123 GITAISGKPGDKKKE
S133 DKKKEKKSLTPAVPV
T135 KKEKKSLTPAVPVES
V138 KKSLTPAVPVESKPD
S142 TPAVPVESKPDKPSG
K143 PAVPVESKPDKPSGK
D145 VPVESKPDKPSGKSG
S148 ESKPDKPSGKSGMDA
T216 LAKKEGITGPPADSS
S222 ITGPPADSSKPIGPD
S223 TGPPADSSKPIGPDD
P228 DSSKPIGPDDAIDAL
S236 DDAIDALSSDFTCGS
T240 DALSSDFTCGSPTAA
G242 LSSDFTCGSPTAAGK
S243 SSDFTCGSPTAAGKK
T245 DFTCGSPTAAGKKTE
K249 GSPTAAGKKTEKEES
K261 EESTEVLKAQSAGTV
S287 KVEKDTMSDQALEAL
S295 DQALEALSASLGTRQ
S297 ALEALSASLGTRQAE
T300 ALSASLGTRQAEPEL
S311 EPELDLRSIKEVDEA
K313 ELDLRSIKEVDEAKA
Y339 DETIPSEYRLKPATD
P362 EPEEKPKPRSESELI
S364 EEKPKPRSESELIDE
S366 KPKPRSESELIDELS
S373 SELIDELSEDFDRSE
S379 LSEDFDRSECKEKPS
K384 DRSECKEKPSKPTEK
T389 KEKPSKPTEKTEESK
K391 KPSKPTEKTEESKAA
- gap
- gap
- gap
- gap
S414 VSRTSMCSIQSAPPE
K426 PPEPATLKGTVPDDA
S440 AVEALADSLGKKEAD
K443 ALADSLGKKEADPED
Y481 EETIPPDYRLEEVKD
S499 KPLLPKESKEQLPPM
K500 PLLPKESKEQLPPMS
S507 KEQLPPMSEDFLLDA
S516 DFLLDALSEDFSGPQ
S526 FSGPQNASSLKFEDA
S527 SGPQNASSLKFEDAK
K529 PQNASSLKFEDAKLA
K534 SLKFEDAKLAAAISE
T546 ISEVVSQTPASTTQA
T560 AGAPPRDTSQSDKDL
S561 GAPPRDTSQSDKDLD
S563 PPRDTSQSDKDLDDA
K573 DLDDALDKLSDSLGQ
S575 DDALDKLSDSLGQRQ
S577 ALDKLSDSLGQRQPD
K598 MEDKVKEKAKAEHRD
K606 AKAEHRDKLGERDDT
T613 KLGERDDTIPPEYRH
Y618 DDTIPPEYRHLLDDN
K629 LDDNGQDKPVKPPTK
T635 DKPVKPPTKKSEDSK
S655 QDPIDALSGDLDSCP
S660 ALSGDLDSCPSTTET
T664 DLDSCPSTTETSQNT
S668 CPSTTETSQNTAKDK
T671 TTETSQNTAKDKCKK
K678 TAKDKCKKAASSSKA
K684 KKAASSSKAPKNGGK
K687 ASSSKAPKNGGKAKD
K687 ASSSKAPKNGGKAKD
K691 KAPKNGGKAKDSAKT
K691 KAPKNGGKAKDSAKT
  mouse

► Hide Isoforms
 
S2 ______MSQPGPKPA
S11-p PGPKPAAsPRPSRGA
S34 VNEKNIGSSSKPGEK
K48-ac KKGSDEKkAASLGSs
K48 KKGSDEKKAASLGSs
S51 SDEKkAASLGSsQPs
S54 KkAASLGSsQPsRPH
S55-p kAASLGSsQPsRPHV
S58-p SLGSsQPsRPHVGEA
P60 GSsQPsRPHVGEAAT
H61 SsQPsRPHVGEAATA
T67 PHVGEAATATKVTAS
S81-p SSAATSKsPsMstTE
S83-p AATSKsPsMstTETK
S85-p TSKsPsMstTETKAI
T86-p SKsPsMstTETKAIP
T87 KsPsMstTETKAIPV
T89 PsMstTETKAIPVNK
S120 TESKKPQSsEQPVVH
S121-p ESKKPQSsEQPVVHE
K130 QPVVHEKKSKGGPKE
S131 PVVHEKKSKGGPKEG
G134 HEKKSKGGPKEGSEP
K136 KKSKGGPKEGSEPKN
N143 KEGSEPKNLPKHTSS
S149 KNLPKHTSSTGSKHA
S165-p KEKALSRsNEQMVSE
S177-p VSEKPSEsKTKFQDV
K204 TVATALDKVVGKKKE
P214 GKKKEQKPFtPAsPV
T216-p KKEQKPFtPAsPVQS
S219-p QKPFtPAsPVQStPs
S223 tPAsPVQStPsKPsD
T224-p PAsPVQStPsKPsDK
S226-p sPVQStPsKPsDKSG
S229-p QStPsKPsDKSGMDA
T297-p LEKNEGItQPLPDsP
S303-p ItQPLPDsPKPMGtD
P304 tQPLPDsPKPMGtDQ
T309-p DsPKPMGtDQAIDAL
S317-p DQAIDALsSDFtCss
T321-p DALsSDFtCssPtGK
S323-p LsSDFtCssPtGKQS
S324-p sSDFtCssPtGKQSE
T326-p DFtCssPtGKQSEKE
K328 tCssPtGKQSEKEKS
K341-ub KSTGEIFkAQSAGVT
N367 KVEEEVINDQALQAL
S375 DQALQALSDSLGTRQ
S377 ALQALSDSLGTRQPD
T380 ALSDSLGTRQPDPPS
S390 PDPPSHVSQAEQVKE
E393 PSHVSQAEQVKEAKA
Y419 EDTVPAEYRLKPAKD
S442-p EPEETSKsLsEsELI
S444-p EETSKsLsEsELIGE
S446-p TSKsLsEsELIGELS
S453 sELIGELSADFDRST
S459 LSADFDRSTYQDkPS
K464-ac DRSTYQDkPSTPAEk
A469 QDkPSTPAEkksNDt
K471-ac kPSTPAEkksNDtSQ
K472-ac PSTPAEkksNDtSQt
S473-p STPAEkksNDtSQtP
T476-p AEkksNDtSQtPPGE
T479-p ksNDtSQtPPGETVP
S492 VPRASMCSIRSAPPK
K504-ub PPKLASLkGVVPEDA
S518-p AVETLAGsLGTREAD
T521 TLAGsLGTREADPEH
Y559 EETVPPDYRLEEVKD
S577 KPLLPKESQEQLAPL
Q578 PLLPKESQEQLAPLS
S585 QEQLAPLSDDFLLDA
S594 DFLLDALSQDFSSPA
S604-p FSSPANIsSLEFEDA
S605 SSPANIsSLEFEDAK
E607 PANIsSLEFEDAKLS
K612 SLEFEDAKLSAAISE
T624 ISEVVSQTPAPSTHA
T638 AAAPLPGTEQKDKEL
E639 AAPLPGTEQKDKELD
K641 PLPGTEQKDKELDDA
E651 ELDDALDELSDSLGQ
S653 DDALDELSDSLGQRP
S655 ALDELSDSLGQRPPD
K676-ac LDDKVKEkIKPEHSE
K684-ac IKPEHSEkLGERDDT
T691 kLGERDDTIPPEYRH
Y696 DDTIPPEYRHLLDND
K707 LDNDGKDKPEKPPtK
T713-p DKPEKPPtKKTEKPD
S730-p RDPIDALsEDLDSCP
S735 ALsEDLDSCPSTTET
T739 DLDSCPSTTETSKNT
S743 CPSTTETSKNTAKGK
T746 TTETSKNTAKGKSKK
K753 TAKGKSKKTSSSKAS
K758 SKKTSSSKASKDGEK
K761 TSSSKASKDGEKTKD
K761 TSSSKASKDGEKTKD
K765 KASKDGEKTKDSSKK
K765 KASKDGEKTKDSSKK
  calpastatin iso3  
S2 ______MSQPGPKPA
S11 PGPKPAASPRPSRGA
S34 VNEKNIGSSSKPGEK
K48 KKGSDEKKAASLGSS
K48 KKGSDEKKAASLGSS
S51 SDEKKAASLGSSQPS
S54 KKAASLGSSQPSRPH
S55 KAASLGSSQPSRPHV
S58 SLGSSQPSRPHVGEA
P60 GSSQPSRPHVGEAAT
H61 SSQPSRPHVGEAATA
T67 PHVGEAATATKVTAS
S81 SSAATSKSPSMSTTE
S83 AATSKSPSMSTTETK
S85 TSKSPSMSTTETKAV
T86 SKSPSMSTTETKAVK
T87 KSPSMSTTETKAVKT
T89 PSMSTTETKAVKTES
S101 TESKKPQSSEQPVVH
S102 ESKKPQSSEQPVVHE
K111 QPVVHEKKSKGGPKE
S112 PVVHEKKSKGGPKEG
G115 HEKKSKGGPKEGSEP
K117 KKSKGGPKEGSEPKN
N124 KEGSEPKNLPKHTSS
S130 KNLPKHTSSTGSKHA
S146 KEKALSRSNEQMVSE
S158 VSEKPSESKTKFQDV
K185 TVATALDKVVGKKKE
P195 GKKKEQKPFTPASPV
T197 KKEQKPFTPASPVQS
S200 QKPFTPASPVQSTPS
S204 TPASPVQSTPSKPSD
T205 PASPVQSTPSKPSDK
S207 SPVQSTPSKPSDKSG
S210 QSTPSKPSDKSGMDA
T278 LEKNEGITQPLPDSP
S284 ITQPLPDSPKSTGEI
P285 TQPLPDSPKSTGEIF
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K293 KSTGEIFKAQSAGVT
N319 KVEEEVINDQALQAL
S327 DQALQALSDSLGTRQ
S329 ALQALSDSLGTRQPD
T332 ALSDSLGTRQPDPPS
S342 PDPPSHVSQAEQVKE
E345 PSHVSQAEQVKEAKA
Y371 EDTVPAEYRLKPAKD
S394 EPEETSKSLSESELI
S396 EETSKSLSESELIGE
S398 TSKSLSESELIGELS
S405 SELIGELSADFDRST
S411 LSADFDRSTYQDKPS
K416 DRSTYQDKPSTPAEK
A421 QDKPSTPAEKKSNDT
K423 KPSTPAEKKSNDTSQ
K424 PSTPAEKKSNDTSQT
S425 STPAEKKSNDTSQTP
T428 AEKKSNDTSQTPPGE
T431 KSNDTSQTPPGETVP
S444 VPRASMCSIRSAPPK
K456 PPKLASLKGVVPEDA
S470 AVETLAGSLGTREAD
T473 TLAGSLGTREADPEH
Y511 EETVPPDYRLEEVKD
S529 KPLLPKESQEQLAPL
Q530 PLLPKESQEQLAPLS
S537 QEQLAPLSDDFLLDA
S546 DFLLDALSQDFSSPA
S556 FSSPANISSLEFEDA
S557 SSPANISSLEFEDAK
E559 PANISSLEFEDAKLS
K564 SLEFEDAKLSAAISE
T576 ISEVVSQTPAPSTHA
T590 AAAPLPGTEQKDKEL
E591 AAPLPGTEQKDKELD
K593 PLPGTEQKDKELDDA
E603 ELDDALDELSDSLGQ
S605 DDALDELSDSLGQRP
S607 ALDELSDSLGQRPPD
K628 LDDKVKEKIKPEHSE
K636 IKPEHSEKLGERDDT
T643 KLGERDDTIPPEYRH
Y648 DDTIPPEYRHLLDND
K659 LDNDGKDKPEKPPTK
T665 DKPEKPPTKKTEKPD
S682 RDPIDALSEDLDSCP
S687 ALSEDLDSCPSTTET
T691 DLDSCPSTTETSKNT
S695 CPSTTETSKNTAKGK
T698 TTETSKNTAKGKSKK
K705 TAKGKSKKTSSSKAS
K710 SKKTSSSKASKDGEK
K713 TSSSKASKDGEKTKD
K713 TSSSKASKDGEKTKD
K717 KASKDGEKTKDSSKK
K717 KASKDGEKTKDSSKK
  rat

 
S2 ______MSRPGPKPA
S11 PGPKPAASSRPRRGA
S34 VNEKNIGSSSKPAEK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S57-p SSAATGTsPRMSTTG
R59 AATGTsPRMSTTGAK
S61 TGTsPRMSTTGAKAV
T62 GTsPRMSTTGAKAVK
T63 TsPRMSTTGAKAVKI
A65 PRMSTTGAKAVKIES
S77 IESEKSQSSEPPVIH
S78 ESEKSQSSEPPVIHE
K87 PPVIHEKKPKGKPKE
P88 PVIHEKKPKGKPKEG
K91 HEKKPKGKPKEGSEP
K93 KKPKGKPKEGSEPQT
T100 KEGSEPQTLPKHASD
S106 QTLPKHASDTGSKHA
S122-p KEKALSRsNEQIVSE
S134 VSEKSSESKTKFQDA
K161 TVATASDKVVVKKKE
S171-p VKKKEKKsLtPTLPM
T173-p KKEKKsLtPTLPMES
L176 KKsLtPTLPMESTLN
S180 tPTLPMESTLNKLSD
T181 PTLPMESTLNKLSDK
N183 LPMESTLNKLSDKSG
S186 ESTLNKLSDKSGVNA
T254 LEKNEAITGPLPDsP
S260-p ITGPLPDsPKPMGID
P261 TGPLPDsPKPMGIDH
I266 DsPKPMGIDHAIDAL
S274-p DHAIDALsSDFTCSs
T278 DALsSDFTCSsPTGK
S280 LsSDFTCSsPTGKQT
S281-p sSDFTCSsPTGKQTE
T283 DFTCSsPTGKQTEKE
K285 TCSsPTGKQTEKEKS
K298 KSTGESSKAQSAGVT
N324 KVEEEVMNDQALQAL
S332 DQALQALSDSLGTRQ
S334 ALQALSDSLGTRQPD
T337 ALSDSLGTRQPDPQS
R347 PDPQSHLRQAKQVKE
K350 QSHLRQAKQVKEAKA
Y376 EDTVPAEYRLKPAKD
C399 EPEETSKCLSESELI
S401 EETSKCLSESELIGE
S403 TSKCLSESELIGELS
S410 SELIGELSADFVQPT
P416 LSADFVQPTYQEKPS
K421 VQPTYQEKPSMPAAK
A426 QEKPSMPAAKIKKGV
K428 KPSMPAAKIKKGVVP
- gap
- gap
- gap
- gap
- gap
K431 MPAAKIKKGVVPDDA
S445 AVETLARSLGTRKED
T448 TLARSLGTRKEDPED
Y486-p EETIPPDyRLEIVKD
A504 KPLLPKEAEEQLPPL
E505 PLLPKEAEEQLPPLS
S512 EEQLPPLSDDFLLDA
S521 DFLLDALSQDFSSPA
L531 FSSPANILSLGFEDA
S532 SSPANILSLGFEDAK
G534 PANILSLGFEDAKLS
K539 SLGFEDAKLSAAVSE
V551 VSETVSQVPAPSNHT
T565 TAAPPPGTERRDKEL
E566 AAPPPGTERRDKELD
R568 PPPGTERRDKELDDA
E578 ELDDALDELsDsLGQ
S580-p DDALDELsDsLGQRQ
S582-p ALDELsDsLGQRQPD
K603 LDDKVKEKIKAEHSE
K611 IKAEHSEKLGERDDT
T618 KLGERDDTIPPEYRH
Y623 DDTIPPEYRHLLDND
K634 LDNDGKDKPEKPLTK
T640 DKPEKPLTKNTEKLG
S657-p QDPIDALsEDLDSCP
S662 ALsEDLDSCPPTTET
T666 DLDSCPPTTETSQNT
S670 CPPTTETSQNTTKEK
T673 TTETSQNTTKEKGKk
K680-ub TTKEKGKkTSSSKAS
K685 GKkTSSSKASkNEEk
K688 TSSSKASKNEEkTKD
K688-ub TSSSKASkNEEkTKD
K692 KASkNEEKTKDSSKK
K692-ub KASkNEEkTKDSSKK
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