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Protein Page:
JunB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JunB Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. Binds DNA as an homodimer or as an heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains). By growth factors. Belongs to the bZIP family. Jun subfamily. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Cellular Component: nucleoplasm; nucleolus; chromatin; nucleus
Molecular Function: protein binding; DNA binding; double-stranded DNA binding; transcription coactivator activity; transcription factor activity; transcription corepressor activity
Biological Process: response to drug; response to light stimulus; response to peptide hormone stimulus; transcription initiation from RNA polymerase II promoter; response to cAMP; transcription, DNA-dependent; regulation of cell cycle; embryonic process involved in female pregnancy; osteoclast differentiation; decidualization; cellular response to hormone stimulus; trophectodermal cell differentiation; osteoblast differentiation; regulation of transcription from RNA polymerase II promoter; osteoblast proliferation; response to mechanical stimulus; transforming growth factor beta receptor signaling pathway; response to cytokine stimulus; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; positive regulation of cell differentiation; vasculogenesis; response to corticosterone stimulus
Reference #:  P17275 (UniProtKB)
Alt. Names/Synonyms: activator protein 1; AP-1; jun B proto-oncogene; JUNB; Transcription factor jun-B
Gene Symbols: JUNB
Molecular weight: 35,879 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JunB

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S79‑p, T102‑p, T104‑p
activity, induced: S79‑p, T102‑p, T104‑p
molecular association, regulation: T102‑p, T104‑p
protein degradation: S251‑p, T255‑p, S259‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 4 A23 TATGYGRAPGGLSLH
0 1 K36-ac LHDYKLLkPSLAVNL
0 1 K36-ub LHDYKLLkPSLAVNL
0 4 Y47-p AVNLADPyRsLKAPG
0 1 S49-p NLADPyRsLKAPGAR
0 2 Y68-p EGGGGGSyFSGQGSD
2 1 S79-p QGSDTGAsLKLASSE
0 1 T100 PNSNGVITTtPtPPG
0 1 T101 NSNGVITTtPtPPGQ
1 3 T102-p SNGVITTtPtPPGQy
1 5 T104-p GVITTtPtPPGQyFy
0 3 Y109-p tPtPPGQyFyPRGGG
0 2 Y111-p tPPGQyFyPRGGGsG
0 4 S117-p FyPRGGGsGGGAGGA
0 1 T129-p GGAGGGVtEEQEGFA
1 0 T153 LHKMNHVTPPNVSLG
1 0 S189 YTNLSSYSPASASSG
0 1 S237 LGLGRGAStFkEEPQ
0 1 T238-p GLGRGAStFkEEPQT
1 0 K240 GRGAStFKEEPQTVP
0 2 K240-ac GRGAStFkEEPQTVP
0 1 K240-ub GRGAStFkEEPQTVP
1 27 S251-p QTVPEARsRDAtPPV
1 39 T255-p EARsRDAtPPVsPIN
2 45 S259-p RDAtPPVsPINMEDQ
1 0 K270 MEDQERIKVERKRLR
0 1 T302 RLEDKVKTLKAENAG
1 0 K304 EDKVKTLKAENAGLS
0 1 S312-p AENAGLSsTAGLLRE
0 1 K325-ub REQVAQLkQKVMtHV
0 1 T330-p QLkQKVMtHVSNGCQ
8053 : Phospho-JunB (Thr102/Thr104) (D3C6) Rabbit mAb
8053 : Phospho-JunB (Thr102/Thr104) (D3C6) Rabbit mAb
  mouse

 
S23-p AAAGYGRsPGSLSLH
K36 LHDYKLLKPTLALNL
K36 LHDYKLLKPTLALNL
Y47 ALNLADPYRGLKGPG
G49 NLADPYRGLKGPGAR
Y68 EGSGAGSYFSGQGSD
S79 QGSDTGASLKLASTE
T100-p PNSNGVItttPtPPG
T101-p NSNGVItttPtPPGQ
T102-p SNGVItttPtPPGQY
T104-p GVItttPtPPGQYFY
Y109 tPtPPGQYFYPRGGG
Y111 tPPGQYFYPRGGGSG
S117 FYPRGGGSGGGTGGG
T126 GGTGGGVTEEQEGFA
T150 LHKMNHVTPPNVSLG
S186 YTNLSSYSPASAPSG
S234-p LGLSRGAsAFkEEPQ
A235 GLSRGAsAFkEEPQT
K237-sm SRGAsAFkEEPQTVP
K237 SRGAsAFKEEPQTVP
K237 SRGAsAFKEEPQTVP
S248-p QTVPEARsRDAtPPV
T252-p EARsRDAtPPVsPIN
S256-p RDAtPPVsPINMEDQ
K267-sm MEDQERIkVERKRLR
T299-p RLEDKVKtLkAENAG
K301-sm EDKVKtLkAENAGLS
S309 AENAGLSSAAGLLRE
K322 REQVAQLKQKVMTHV
T327 QLKQKVMTHVSNGCQ
8053 : Phospho-JunB (Thr102/Thr104) (D3C6) Rabbit mAb
8053 : Phospho-JunB (Thr102/Thr104) (D3C6) Rabbit mAb
  rat

 
S23-p AAAGYGRsPGSLSLH
K36 LHDYKLLKPTLALNL
K36 LHDYKLLKPTLALNL
Y47 ALNLADPYRGLKGPG
G49 NLADPYRGLKGPGAR
Y68 EGSGAGSYFSGQGSD
S79 QGSDTGASLKLASTE
T100 PNSNGVITTTPTPPG
T101 NSNGVITTTPTPPGQ
T102 SNGVITTTPTPPGQY
T104 GVITTTPTPPGQYFY
Y109 TPTPPGQYFYPRGGG
Y111 TPPGQYFYPRGGGSG
S117 FYPRGGGSGGGTGGG
T126 GGTGGGVTEEQEGFA
T150-p LHKMNHVtPPNVSLG
S186-p YTNLSSYsPASAPSG
S234 LGLSRGASAFKEEPQ
A235 GLSRGASAFKEEPQT
K237 SRGASAFKEEPQTVP
K237 SRGASAFKEEPQTVP
K237 SRGASAFKEEPQTVP
S248 QTVPEARSRDAtPPV
T252-p EARSRDAtPPVsPIN
S256-p RDAtPPVsPINMEDQ
K267 MEDQERIKVERKRLR
T299 RLEDKVKTLKAENAG
K301 EDKVKTLKAENAGLS
S309 AENAGLSSAAGLLRE
K322 REQVAQLKQKVMTHV
T327 QLKQKVMTHVSNGCQ
8053 : Phospho-JunB (Thr102/Thr104) (D3C6) Rabbit mAb
8053 : Phospho-JunB (Thr102/Thr104) (D3C6) Rabbit mAb
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