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Protein Page:
MGMT (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MGMT Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. Note: This description may include information from UniProtKB.
Protein type: Methyltransferase; DNA repair, damage; Apoptosis; Nuclear receptor co-regulator; EC 2.1.1.63
Chromosomal Location of Human Ortholog: 10q26
Cellular Component: nucleoplasm; membrane; nucleus
Molecular Function: methyltransferase activity; methylated-DNA-[protein]-cysteine S-methyltransferase activity; DNA binding; calcium ion binding; DNA-methyltransferase activity
Biological Process: response to drug; DNA dealkylation; response to ethanol; positive regulation of DNA repair; response to toxin; response to folic acid; DNA methylation; regulation of caspase activity; DNA repair; DNA ligation
Reference #:  P16455 (UniProtKB)
Alt. Names/Synonyms: 6-O-methylguanine-DNA methyltransferase; Methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-methylguanine-DNA methyltransferase
Gene Symbols: MGMT
Molecular weight: 21,646 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MGMT

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T10-p KDCEMKRttLDsPLG
0 1 T11-p DCEMKRttLDsPLGK
0 2 S14-p MKRttLDsPLGKLEL
0 5 K125-ub AALAGNPkAARAVGG
0 1 Y158-p SSGAVGNySGGLAVK
0 5 K178-ub HEGHRLGkPGLGGSS
0 1 - gap
1 0 - gap
0 10 S201-p GAGATSGsPPAGRN_
  mouse

 
S10 ETCKMKYSVLDSPLG
V11 TCKMKYSVLDSPLGK
S14 MKYSVLDSPLGKMEL
K129 AALAGNPKAARAVGG
Y162 SDGAIGHYSGGGQAV
Q183 HEGIPTGQPASKGLG
S199-p TGTWLKSsFESTSSE
S204 KSsFESTSSEPSGRN
S205 SsFESTSSEPSGRN_
  rat

 
T10 EICKMKYTVLDSPLG
V11 ICKMKYTVLDSPLGK
S14 MKYTVLDSPLGKIEL
K129 AALAGNPKAARAVGG
Y162 SDGAIGNYSGGGQTV
Q183 HEGIPTGQPASKGLG
S199 IGSWLKPSFESSsPK
S204-p KPSFESSsPKPSG__
- gap
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