Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Nuclear receptor co-regulator; Methyltransferase; Apoptosis; EC 188.8.131.52
Cellular Component: nucleoplasm; nucleus
Molecular Function: methyltransferase activity; methylated-DNA-[protein]-cysteine S-methyltransferase activity; DNA binding; calcium ion binding; DNA-methyltransferase activity
Biological Process: response to drug; DNA dealkylation; positive regulation of DNA repair; response to ethanol; response to folic acid; response to toxin; DNA methylation; regulation of caspase activity; DNA repair; DNA ligation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.