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Protein Page:
CAMK2A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CAMK2A a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.17; CAMK group; CAMK2 family
Cellular Component: presynaptic membrane; nucleoplasm; plasma membrane; cell junction; cytosol; nucleus
Molecular Function: calmodulin binding; glutamate receptor binding; protein binding; calmodulin-dependent protein kinase activity; kinase activity; ATP binding
Biological Process: synaptic transmission; cytokine and chemokine mediated signaling pathway; calcium ion transport; protein amino acid autophosphorylation; regulation of neurotransmitter secretion; protein amino acid phosphorylation; G1/S transition of mitotic cell cycle; activation of NF-kappaB transcription factor; regulation of neuronal synaptic plasticity
Reference #:  Q9UQM7 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CaM-kinase II alpha chain; CaMK-II alpha subunit; CaMK-II subunit alpha; CAMK2A; CAMKA; CaMKII; CaMKIINalpha; KCC2A; KIAA0968
Gene Symbols: CAMK2A
Molecular weight: 54,088 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CAMK2A

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell growth, altered: T286‑p
cytoskeletal reorganization: T253‑p
enzymatic activity, induced: T286‑p
intracellular localization: T286‑p, T305‑p, T306‑p
molecular association, regulation: T286‑p
protein conformation: T286‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 T10 TITCTRFTEEYQLFE
0 15 Y13 CTRFTEEYQLFEELG
0 11 K21 QLFEELGKGAFSVVR
0 4 S25 ELGKGAFSVVRRCVK
0 8 K32 SVVRRCVKVLAGQEY
0 29 Y39 KVLAGQEYAAKIINT
0 1 K42 AGQEYAAKIINTKKL
0 7 K42 AGQEYAAKIINTKKL
0 1 K47 AAKIINTKKLSARDH
0 7 K47 AAKIINTKKLSARDH
0 7 K48 AKIINTKKLSARDHQ
0 10 K68 ARICRLLKHPNIVRL
0 1 S80 VRLHDSISEEGHHYL
0 8 K137 GVVHRDLKPENLLLA
0 1 K146 ENLLLASKLKGAAVK
0 9 K146 ENLLLASKLKGAAVK
0 7 K148 LLLASKLKGAAVKLA
0 2 K153 KLKGAAVKLADFGLA
1 1 R220 FWDEDQHRLYQQIkA
0 3 K226-ac HRLYQQIkAGAyDFP
0 18 K226-ub HRLYQQIkAGAyDFP
0 28 Y230-p QQIkAGAyDFPsPEW
0 11 S234-p AGAyDFPsPEWDTVT
0 10 K245 DTVTPEAKDLINKML
0 22 K250 EAKDLINKMLtINPS
7 5 T253-p DLINKMLtINPSkRI
0 1 T253 DLINKMLTINPSkRI
0 2 S257 KMLtINPSkRITAAE
0 4 K258 MLtINPSKRITAAEA
0 1 K258-m3 MLtINPSkRITAAEA
0 10 K258 MLtINPSKRITAAEA
0 10 K267 ITAAEALKHPWISHR
0 2 S272 ALKHPWISHRSTVAS
0 4 S275 HPWISHRSTVASCMH
0 2 T276 PWISHRSTVASCMHR
1 5 S279 SHRSTVASCMHRQEt
109 78 T286-p SCMHRQEtVDCLKKF
0 7 K291 QEtVDCLKKFNARRK
0 7 K292 EtVDCLKKFNARRKL
0 1 K298 KKFNARRKLkGAILt
0 5 K298 KKFNARRKLkGAILt
0 3 K300-m1 FNARRKLkGAILttM
0 7 K300 FNARRKLKGAILttM
18 4 T305-p KLkGAILttMLAtRN
13 8 T306-p LkGAILttMLAtRNF
1 5 T310-p ILttMLAtRNFsGGK
5 2 S314-p MLAtRNFsGGKsGGN
0 3 S318-p RNFsGGKsGGNKKSD
0 6 K322 GGKsGGNKKSDGVKE
0 6 K323 GKsGGNKKSDGVKES
0 10 K328 NKKSDGVKESsEstN
0 1 - gap
1 1 - gap
1 1 - gap
1 1 - gap
0 13 S330 KSDGVKESsEstNtt
0 14 S331-p SDGVKESsEstNttI
0 16 S333-p GVKESsEstNttIED
0 11 T334-p VKESsEstNttIEDE
0 13 T336-p ESsEstNttIEDEDT
0 20 T337-p SsEstNttIEDEDTK
0 1 T343 ttIEDEDTKVRKQEI
0 6 K344 tIEDEDTKVRKQEII
0 3 K347 DEDTKVRKQEIIKVT
0 5 K352 VRKQEIIKVTEQLIE
0 3 S404 FYFENLWSRNSKPVH
0 6 K408 NLWSRNSKPVHTTIL
0 1 T435 CIAYIRITQYLDAGG
0 8 Y437 AYIRITQYLDAGGIP
0 6 K461 VWHRRDGKWQIVHFH
0 1 S470 QIVHFHRSGAPSVLP
3356 : Phospho-CaMKII (Tyr231) Antibody
3361 : Phospho-CaMKII (Thr286) Antibody
  CAMK2A iso2  
T10 TITCTRFTEEYQLFE
Y13 CTRFTEEYQLFEELG
K21 QLFEELGKGAFSVVR
S25 ELGKGAFSVVRRCVK
K32 SVVRRCVKVLAGQEY
Y39 KVLAGQEYAAKIINT
K42 AGQEYAAKIINTKKL
K42 AGQEYAAKIINTKKL
K47 AAKIINTKKLSARDH
K47 AAKIINTKKLSARDH
K48 AKIINTKKLSARDHQ
K68 ARICRLLKHPNIVRL
S80 VRLHDSISEEGHHYL
K137 GVVHRDLKPENLLLA
K146 ENLLLASKLKGAAVK
K146 ENLLLASKLKGAAVK
K148 LLLASKLKGAAVKLA
K153 KLKGAAVKLADFGLA
R220 FWDEDQHRLYQQIKA
K226 HRLYQQIKAGAYDFP
K226 HRLYQQIKAGAYDFP
Y230 QQIKAGAYDFPSPEW
S234 AGAYDFPSPEWDTVT
K245 DTVTPEAKDLINKML
K250 EAKDLINKMLTINPS
T253 DLINKMLTINPSKRI
T253 DLINKMLTINPSKRI
S257 KMLTINPSKRITAAE
K258 MLTINPSKRITAAEA
K258 MLTINPSKRITAAEA
K258 MLTINPSKRITAAEA
K267 ITAAEALKHPWISHR
S272 ALKHPWISHRSTVAS
S275 HPWISHRSTVASCMH
T276 PWISHRSTVASCMHR
S279 SHRSTVASCMHRQEt
T286-p SCMHRQEtVDCLKKF
K291 QEtVDCLKKFNARRK
K292 EtVDCLKKFNARRKL
K298 KKFNARRKLKGAILT
K298 KKFNARRKLKGAILT
K300 FNARRKLKGAILTTM
K300 FNARRKLKGAILTTM
T305 KLKGAILTTMLATRN
T306 LKGAILTTMLATRNF
T310 ILTTMLATRNFSGGK
S314 MLATRNFSGGKSGGN
S318 RNFSGGKSGGNKkSD
K322 GGKSGGNKkSDGVKk
K323-ub GKSGGNKkSDGVKkR
K328 NKkSDGVKkRKsssS
K329-ub KkSDGVKkRKsssSV
S332-p DGVKkRKsssSVQLM
S333-p GVKkRKsssSVQLME
S334-p VKkRKsssSVQLMES
S341 sSVQLMESSEsTNTT
S342 SVQLMESSEsTNTTI
S344-p QLMESSEsTNTTIED
T345 LMESSEsTNTTIEDE
T347 ESSEsTNTTIEDEDT
T348 SSEsTNTTIEDEDTK
T354 TTIEDEDTKVRKQEI
K355 TIEDEDTKVRKQEII
K358 DEDTKVRKQEIIKVT
K363 VRKQEIIKVTEQLIE
S415 FYFENLWSRNSKPVH
K419 NLWSRNSKPVHTTIL
T446 CIAYIRITQYLDAGG
Y448 AYIRITQYLDAGGIP
K472 VWHRRDGKWQIVHFH
S481 QIVHFHRSGAPSVLP
3356 : Phospho-CaMKII (Tyr231) Antibody
  mouse

► Hide Isoforms
 
T10-p TITCTRFtEEyQLFE
Y13-p CTRFtEEyQLFEELG
K21-ub QLFEELGkGAFsVVR
S25-p ELGkGAFsVVRRCVk
K32-ub sVVRRCVkVLAGQEy
Y39-p kVLAGQEyAAkIINT
K42-ac AGQEyAAkIINTkkL
K42-ub AGQEyAAkIINTkkL
K47-ac AAkIINTkkLSARDH
K47-ub AAkIINTkkLSARDH
K48-ub AkIINTkkLSARDHQ
K68-ub ARICRLLkHPNIVRL
S80 VRLHDSISEEGHHYL
K137-ub GVVHRDLkPENLLLA
K146 ENLLLASKLkGAAVK
K146-ub ENLLLASkLkGAAVK
K148-ub LLLASkLkGAAVKLA
K153 kLkGAAVKLADFGLA
R220 FWDEDQHRLYQQIkA
K226 HRLYQQIKAGAyDFP
K226-ub HRLYQQIkAGAyDFP
Y230-p QQIkAGAyDFPsPEW
S234-p AGAyDFPsPEWDTVT
K245-ub DTVTPEAkDLINkML
K250-ub EAkDLINkMLtINPs
T253-p DLINkMLtINPskRI
T253-gl DLINkMLtINPskRI
S257-p kMLtINPskRITAAE
K258-ac MLtINPskRITAAEA
K258 MLtINPsKRITAAEA
K258-ub MLtINPskRITAAEA
K267-ub ITAAEALkHPWIsHR
S272-p ALkHPWIsHRstVAs
S275-p HPWIsHRstVAsCMH
T276-p PWIsHRstVAsCMHR
S279-p sHRstVAsCMHRQEt
T286-p sCMHRQEtVDCLkkF
K291-ub QEtVDCLkkFNARRk
K292-ub EtVDCLkkFNARRkL
K298-m1 kkFNARRkLkGAILt
K298 kkFNARRKLkGAILt
K300-m1 FNARRkLkGAILttM
K300-ub FNARRkLkGAILttM
T305-p kLkGAILttMLAtRN
T306-p LkGAILttMLAtRNF
T310-p ILttMLAtRNFsGGK
S314-p MLAtRNFsGGKsGGN
S318-p RNFsGGKsGGNKKND
K322 GGKsGGNKKNDGVkE
K323 GKsGGNKKNDGVkEs
K328-ub NKKNDGVkEssEstN
- gap
- gap
- gap
- gap
S330-p KNDGVkEssEstNtt
S331-p NDGVkEssEstNttI
S333-p GVkEssEstNttIED
T334-p VkEssEstNttIEDE
T336-p EssEstNttIEDEDt
T337-p ssEstNttIEDEDtk
T343-p ttIEDEDtkVRKQEI
K344-ub tIEDEDtkVRKQEII
K347 DEDtkVRKQEIIKVT
K352 VRKQEIIKVTEQLIE
S404-p FYFENLWsRNSKPVH
K408 NLWsRNSKPVHTTIL
T435 CIAYIRITQYLDAGG
Y437 AYIRITQYLDAGGIP
K461 VWHRRDGKWQIVHFH
S470-p QIVHFHRsGAPSVLP
3356 : Phospho-CaMKII (Tyr231) Antibody
3361 : Phospho-CaMKII (Thr286) Antibody
  CAMK2A iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S29 LSSTGGKSGGNKKND
K33 GGKSGGNKKNDGVKK
K34 GKSGGNKKNDGVKKR
K39 NKKNDGVKKRKSSSS
K40 KKNDGVKKRKSSSSV
S43 DGVKKRKSSSSVQLM
S44 GVKKRKSSSSVQLME
S45 VKKRKSSSSVQLMES
S52 SSVQLMESSESTNTT
S53 SVQLMESSESTNTTI
S55 QLMESSESTNTTIED
T56 LMESSESTNTTIEDE
T58 ESSESTNTTIEDEDT
T59 SSESTNTTIEDEDTK
T65 TTIEDEDTKVRKQEI
K66 TIEDEDTKVRKQEII
K69 DEDTKVRKQEIIKVT
K74 VRKQEIIKVTEQLIE
S126 FYFENLWSRNSKPVH
K130 NLWSRNSKPVHTTIL
T157 CIAYIRITQYLDAGG
Y159 AYIRITQYLDAGGIP
K183 VWHRRDGKWQIVHFH
S192 QIVHFHRSGAPSVLP
  rat

 
T10 TITCTRFTEEyQLFE
Y13-p CTRFTEEyQLFEELG
K21-ub QLFEELGkGAFSVVR
S25 ELGkGAFSVVRRCVk
K32-ub SVVRRCVkVLAGQEy
Y39-p kVLAGQEyAAkIINT
K42-ac AGQEyAAkIINTkkL
K42-ub AGQEyAAkIINTkkL
K47 AAkIINTKkLSARDH
K47-ub AAkIINTkkLSARDH
K48-ub AkIINTkkLSARDHQ
K68-ub ARICRLLkHPNIVRL
S80-p VRLHDSIsEEGHHYL
K137-ub GVVHRDLkPENLLLA
K146-ac ENLLLASkLkGAAVk
K146-ub ENLLLASkLkGAAVk
K148-ub LLLASkLkGAAVkLA
K153-ub kLkGAAVkLADFGLA
R220-m2 FWDEDQHrLYQQIkA
K226-ac HrLYQQIkAGAyDFP
K226-ub HrLYQQIkAGAyDFP
Y230-p QQIkAGAyDFPsPEW
S234-p AGAyDFPsPEWDTVT
K245-ub DTVTPEAkDLINkML
K250-ub EAkDLINkMLtINPs
T253-p DLINkMLtINPskRI
T253 DLINkMLTINPskRI
S257-p kMLtINPskRITAAE
K258-ac MLtINPskRITAAEA
K258 MLtINPsKRITAAEA
K258-ub MLtINPskRITAAEA
K267-ub ITAAEALkHPWISHR
S272 ALkHPWISHRSTVAs
S275 HPWISHRSTVAsCMH
T276 PWISHRSTVAsCMHR
S279-p SHRSTVAsCMHRQEt
T286-p sCMHRQEtVDCLkkF
K291-ub QEtVDCLkkFNARRk
K292-ub EtVDCLkkFNARRkL
K298 kkFNARRKLkGAILt
K298-ub kkFNARRkLkGAILt
K300 FNARRkLKGAILttM
K300-ub FNARRkLkGAILttM
T305-p kLkGAILttMLAtRN
T306-p LkGAILttMLAtRNF
T310-p ILttMLAtRNFsGGK
S314-p MLAtRNFsGGKSGGN
S318 RNFsGGKSGGNkkND
K322-ub GGKSGGNkkNDGVkE
K323-ub GKSGGNkkNDGVkES
K328-ub NkkNDGVkESSEstN
- gap
- gap
- gap
- gap
S330 kNDGVkESSEstNTt
S331 NDGVkESSEstNTtI
S333-p GVkESSEstNTtIED
T334-p VkESSEstNTtIEDE
T336 ESSEstNTtIEDEDT
T337-p SSEstNTtIEDEDTk
T343 TtIEDEDTkVRkQEI
K344-ub tIEDEDTkVRkQEII
K347-ub DEDTkVRkQEIIkVT
K352-ub VRkQEIIkVTEQLIE
S404-p FYFENLWsRNSkPVH
K408-ub NLWsRNSkPVHTTIL
T435-p CIAYIRItQyLDAGG
Y437-p AYIRItQyLDAGGIP
K461-ub VWHRRDGkWQIVHFH
S470 QIVHFHRSGAPSVLP
3356 : Phospho-CaMKII (Tyr231) Antibody
3361 : Phospho-CaMKII (Thr286) Antibody
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