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Protein Page:
Oct1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Oct1 a ubiquitous transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. Phosphorylation apparently inhibits its interaction with DNA. Four splice variant isoforms have been described. Isoform 2 is lymphocyte specific. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleoplasm; transcription factor complex; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase III promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; olfactory placode formation
Reference #:  P14859 (UniProtKB)
Alt. Names/Synonyms: NF-A1; Oct-1; OCT1; Octamer-binding protein 1; Octamer-binding transcription factor 1; Octamer-binding transcription factor-1; OTF-1; OTF1; PO2F1; POU class 2 homeobox 1; POU domain, class 2, transcription factor 1; POU2F1
Gene Symbols: POU2F1
Molecular weight: 76,472 Da
Basal Isoelectric point: 6.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Oct1
Protein Structure Not Found.


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Sites Implicated In
inhibition: S385‑p
molecular association, regulation: S385‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 - gap
1 0 S78-p QSKSNEEsGDsQQPs
1 0 S81-p SNEEsGDsQQPsQPs
1 0 S85-p sGDsQQPsQPsQQPs
1 0 S88-p sQQPsQPsQQPsVQA
1 0 S92-p sQPsQQPsVQAAIPQ
1 0 T100-p VQAAIPQtQLMLAGG
1 0 S141-p AAAVQQHsAsQQHsA
1 0 S143-p AVQQHsAsQQHsAAG
1 0 S147-p HsAsQQHsAAGATIS
1 0 T162-p ASAATPMtQIPLsQP
1 0 S167-p PMtQIPLsQPIQIAQ
1 0 T226-p LQAQNLLtQLPQQsQ
1 0 S232-p LtQLPQQsQANLLQS
0 2 T259-p PTRTIAAtPIQTLPQ
0 8 S267-p PIQTLPQsQstPkRI
1 4 S269-p QTLPQsQstPkRIDt
1 29 T270-p TLPQsQstPkRIDtP
0 2 K272-a PQsQstPkRIDtPsL
0 11 T276-p stPkRIDtPsLEEPs
0 9 S278-p PkRIDtPsLEEPsDL
0 2 S283-p tPsLEEPsDLEELEQ
0 1 K293 EELEQFAKTFKQRRI
0 5 S335-p RFEALNLsFKNMCKL
0 1 S364-p SSDSSLSsPSALNSP
0 1 S366 DSSLSsPSALNSPGI
1 3 S385-p RRRKKRTsIETNIRV
0 2 T445-p NPPSSGGtsssPIKA
0 2 S446-p PPSSGGtsssPIKAI
0 2 S447-p PSSGGtsssPIKAIF
0 9 S448-p SSGGtsssPIKAIFP
0 1 S486 SPVLPLTSAAVTNLS
0 1 S502 TGTSDTTSNNTATVI
0 1 S510 NNTATVISTAPPASS
  mouse

► Hide Isoforms 		 
- gap
S78 QSKSSEESGDSQQSS
S81 SSEESGDSQQSSQPS
S85 SGDSQQSSQPSSQPP
S88 SQQSSQPSSQPPSVQ
S93 QPSSQPPSVQSAIPQ
T101 VQSAIPQTQLMLAGG
S142 AAAVQQHSASQQHSA
S144 AVQQHSASQQHSAAG
S148 HSASQQHSAAGATIS
T163 ASAATPMTQIPLSQP
S168 PMTQIPLSQPIQIAQ
T227 LQAQNLLTQLPQQSQ
S233 LTQLPQQSQANLLQP
A260 PTRTIAAASVQTLPQ
S268 SVQTLPQSQStPKRI
S270 QTLPQSQStPKRIDt
T271-p TLPQSQStPKRIDtP
K273 PQSQStPKRIDtPsL
T277-p StPKRIDtPsLEEPS
S279-p PKRIDtPsLEEPSDL
S284 tPsLEEPSDLEELEQ
K294-u EELEQFAkTFKQRRI
S336 RFEALNLSFKNMCKL
S365-p SSDSTASsPsALNSP
S367-p DSTASsPsALNSPGL
S388 RRRKKRTSIETNIRV
T448 NPPSSGGTSSsPIKA
S449 PPSSGGTSSsPIKAI
S450 PSSGGTSSsPIKAIF
S451-p SSGGTSSsPIKAIFP
S489 NPVLPLTSAAVTNLS
S529 AGTTDSTSNNNTATV
S538 NNTATVISTAPPASS
  Oct1 iso2  
- gap
S78 QSKSSEESGDSQQSS
S81 SSEESGDSQQSSQPS
S85 SGDSQQSSQPSSQPP
S88 SQQSSQPSSQPPSVQ
S93 QPSSQPPSVQSAIPQ
T101 VQSAIPQTQLMLAGG
S142 AAAVQQHSASQQHSA
S144 AVQQHSASQQHSAAG
S148 HSASQQHSAAGATIS
T163 ASAATPMTQIPLSQP
S168 PMTQIPLSQPIQIAQ
T227 LQAQNLLTQLPQQSQ
S233 LTQLPQQSQANLLQP
A260 PTRTIAAASVQTLPQ
S268 SVQTLPQSQSTPKRI
S270 QTLPQSQSTPKRIDT
T271 TLPQSQSTPKRIDTP
K273 PQSQSTPKRIDTPSL
T277 STPKRIDTPSLEEPS
S279 PKRIDTPSLEEPSDL
S284 TPSLEEPSDLEELEQ
K294 EELEQFAKTFKQRRI
S336 RFEALNLSFKNMCKL
S365 SSDSTASSPSALNSP
S367 DSTASSPSALNSPGL
S388 RRRKKRTSIETNIRV
T448 NPPSSGGTSSSPIKA
S449 PPSSGGTSSSPIKAI
S450 PSSGGTSSSPIKAIF
S451 SSGGTSSSPIKAIFP
S489-p NPVLPLTsAAVTNLS
S505-p TGTTDSTsNNNTATV
S514-p NNTATVIsTAPPASS
  Oct1 iso12  
S8-p MADGGAAsQDESSAA
S100 QSKSSEESGDSQQSS
S103 SSEESGDSQQSSQPS
S107 SGDSQQSSQPSSQPP
S110 SQQSSQPSSQPPSVQ
S115 QPSSQPPSVQSAIPQ
T123 VQSAIPQTQLMLAGG
S164 AAAVQQHSASQQHSA
S166 AVQQHSASQQHSAAG
S170 HSASQQHSAAGATIS
T185 ASAATPMTQIPLSQP
S190 PMTQIPLSQPIQIAQ
T249 LQAQNLLTQLPQQSQ
S255 LTQLPQQSQANLLQP
A282 PTRTIAAASVQTLPQ
S290 SVQTLPQSQSTPKRI
S292 QTLPQSQSTPKRIDT
T293 TLPQSQSTPKRIDTP
K295 PQSQSTPKRIDTPSL
T299 STPKRIDTPSLEEPS
S301 PKRIDTPSLEEPSDL
S306 TPSLEEPSDLEELEQ
K316 EELEQFAKTFKQRRI
S358 RFEALNLSFKNMCKL
S387 SSDSTASSPSALNSP
S389 DSTASSPSALNSPGL
S410 RRRKKRTSIETNIRV
T470 NPPSSGGTSSSPIKA
S471 PPSSGGTSSSPIKAI
S472 PSSGGTSSSPIKAIF
S473 SSGGTSSSPIKAIFP
S511 NPVLPLTSAAVTNLS
S551 AGTTDSTSNNNTATV
S560 NNTATVISTAPPASS
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