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NFI-C (human)

Overview NFI-C Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: nucleus Molecular Function: DNA binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; DNA replication Reference #:  P08651 (UniProtKB) Alt. Names/Synonyms: CCAAT-binding transcription factor; CCAAT-box-binding transcription factor; CTF; CTF5; MGC20153; NF-I; NF-I/C; NF1-C; NFI; NFI-C; NFIC; Nuclear factor 1 C-type; Nuclear factor 1/C; Nuclear factor I/C; nuclear factor I/C (CCAAT-binding transcription factor); TGGCA-binding protein Gene Symbols: NFIC Molecular weight: 55,675 Da Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NFI-C

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		S4-p	____MYSsPLCLTQD
0	1		T9	YSsPLCLTQDEFHPF
0	1		Y41-p	LQARKRKyFKKHEKR
0	1		Y179	AVKELDLYLAYFVRE
0	1		Y182	ELDLYLAYFVRERDA
0	1		S192	RERDAEQSGsPRTGM
0	7		S194-p	RDAEQSGsPRTGMGS
0	1		T237-p	ELIQVSRtPVVTGTG
0	1		T270-p	ASTGLRRtLPSTssS
0	1		S275-p	RRtLPSTssSGskRH
0	1		S276-p	RtLPSTssSGskRHK
0	1		S277	tLPSTssSGskRHKs
0	1		S279-p	PSTssSGskRHKsGS
0	76		K280-a	STssSGskRHKsGSM
0	3		S284-p	SGskRHKsGSMEEDV
0	1		S286	skRHKsGSMEEDVDT
0	1		T293	SMEEDVDTsPGGDYY
0	2		S294-p	MEEDVDTsPGGDYYT
0	2		Y299	DTsPGGDYYTSPssP
0	2		Y300	TsPGGDYYTSPssPT
0	2		T301	sPGGDYYTSPssPTS
0	2		S302	PGGDYYTSPssPTSS
0	2		S304-p	GDYYTSPssPTSSSR
0	6		S305-p	DYYTSPssPTSSSRN
0	1		T307	YTSPssPTSSSRNWt
0	1		S308	TSPssPTSSSRNWtE
0	1		S309	SPssPTSSSRNWtED
0	1		S310	PssPTSSSRNWtEDM
0	1		T314-p	TSSSRNWtEDMEGGI
0	4		S322-p	EDMEGGIssPVKKTE
0	23		S323-p	DMEGGIssPVKKTEM
0	30		S333-p	KKTEMDKsPFNsPsP
0	7		S337-p	MDKsPFNsPsPQDsP
0	36		S339-p	KsPFNsPsPQDsPRL
0	14		S343-p	NsPsPQDsPRLSSFT
0	2		S366-p	VHSGIARsPHPSSAL
0	1		T378	SALHFPTTSILPQTA
0	1		S427-p	QPGPLNGsGQLKMPS
0	2		T472-p	EGGATSPtsPSySPP
0	1		S473-p	GGATSPtsPSySPPD
0	1		Y476-p	TSPtsPSySPPDtsP
0	1		T481-p	PSySPPDtsPANRsF
0	1		S482-p	SySPPDtsPANRsFV
0	1		S487-p	DtsPANRsFVGLGPR

	mouse
S4-p	____MYSsPLCLtQD
T9-p	YSsPLCLtQDEFHPF
Y41	LQARKRKYFKKHEKR
Y179	AVKELDLYLAYFVRE
Y182	ELDLYLAYFVRERDA
S192-p	RERDAEQsSsPRTGV
S194-p	RDAEQsSsPRTGVGS
T237	ELIQVSRTPVVTGTG
T270	ASAGMRRTLPSTSss
S275	RRTLPSTSssGSkRH
S276-p	RTLPSTSssGSkRHK
S277-p	TLPSTSssGSkRHKs
S279	PSTSssGSkRHKsGs
K280-a	STSssGSkRHKsGsM
S284-p	sGSkRHKsGsMEEDV
S286-p	SkRHKsGsMEEDVDt
T293-p	sMEEDVDtsPGGDyy
S294-p	MEEDVDtsPGGDyyt
Y299-p	DtsPGGDyytsPNsP
Y300-p	tsPGGDyytsPNsPt
T301-p	sPGGDyytsPNsPts
S302-p	PGGDyytsPNsPtsS
N304	GDyytsPNsPtsSSR
S305-p	DyytsPNsPtsSSRN
T307-p	ytsPNsPtsSSRNWT
S308-p	tsPNsPtsSSRNWTE
S309	sPNsPtsSSRNWTED
S310	PNsPtsSSRNWTEDI
T314	tsSSRNWTEDIEGGI
S322-p	EDIEGGIssPVKKTE
S323-p	DIEGGIssPVKKTEM
S333-p	KKTEMDKsPFNsPsP
S337-p	MDKsPFNsPsPQDsP
S339-p	KsPFNsPsPQDsPRL
S343-p	NsPsPQDsPRLSSFT
S366-p	VHSGIARsPHPTSAL
T378-p	SALHFPAtPILPQTA
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	rat
S4	____MYSSPLCLTQD
T9	YSSPLCLTQDEFHPF
Y41	LQARKRKYFKKHEKR
Y179-p	AVKELDLyLAyFVRE
Y182-p	ELDLyLAyFVRERDA
S192	RERDAEQSSsPRTGV
S194-p	RDAEQSSsPRTGVGS
T237	ELIQVSRTPVVTGTG
T270	ASAGMRRTLPSTSSS
S275	RRTLPSTSSSGSKRH
S276	RTLPSTSSSGSKRHK
S277	TLPSTSSSGSKRHKS
S279	PSTSSSGSKRHKSGS
K280	STSSSGSKRHKSGSM
S284	SGSKRHKSGSMEEDV
S286	SKRHKSGSMEEDVDT
T293	SMEEDVDTSPGGDyy
S294	MEEDVDTSPGGDyyt
Y299-p	DTSPGGDyytsPNsP
Y300-p	TSPGGDyytsPNsPt
T301-p	SPGGDyytsPNsPts
S302-p	PGGDyytsPNsPtss
N304	GDyytsPNsPtsssR
S305-p	DyytsPNsPtsssRN
T307-p	ytsPNsPtsssRNWT
S308-p	tsPNsPtsssRNWTE
S309-p	sPNsPtsssRNWTED
S310-p	PNsPtsssRNWTEDM
T314	tsssRNWTEDMEGGI
S322	EDMEGGISsPVKKTE
S323-p	DMEGGISsPVKKTEM
S333-p	KKTEMDKsPFNSPsP
S337	MDKsPFNSPsPQDsP
S339-p	KsPFNSPsPQDsPRL
S343-p	NSPsPQDsPRLSSFT
S366	VHSGIARSPHPSSAL
T378	SALHFPATPILPQTA
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

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