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Protein Page:
NFI-C (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NFI-C Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nucleolus; nucleus
Molecular Function: double-stranded DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; DNA replication; odontogenesis of dentine-containing teeth
Reference #:  P08651 (UniProtKB)
Alt. Names/Synonyms: CCAAT-binding transcription factor; CCAAT-box-binding transcription factor; CTF; CTF5; MGC20153; NF-I; NF-I/C; NF1-C; NFI; NFI-C; NFIC; Nuclear factor 1 C-type; Nuclear factor 1/C; Nuclear factor I/C; nuclear factor I/C (CCAAT-binding transcription factor); TGGCA-binding protein
Gene Symbols: NFIC
Molecular weight: 55,675 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NFI-C

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 S4-p ____MYSsPLCLTQD
0 1 T9 YSsPLCLTQDEFHPF
0 2 S192-p RERDAEQsGsPRTGM
0 12 S194-p RDAEQsGsPRTGMGS
0 2 T237-p ELIQVSRtPVVTGTG
0 2 T270-p ASTGLRRtLPSTsss
0 1 S275-p RRtLPSTsssGskRH
0 1 S276-p RtLPSTsssGskRHK
0 2 S277-p tLPSTsssGskRHKs
0 1 S279-p PSTsssGskRHKsGs
0 76 K280-ac STsssGskRHKsGsM
0 6 S284-p sGskRHKsGsMEEDV
0 2 S286-p skRHKsGsMEEDVDt
0 2 T293-p sMEEDVDtsPGGDyY
0 5 S294-p MEEDVDtsPGGDyYT
0 3 Y299-p DtsPGGDyYTsPssP
0 2 Y300 tsPGGDyYTsPssPt
0 2 T301 sPGGDyYTsPssPtS
0 3 S302-p PGGDyYTsPssPtSS
0 3 S304-p GDyYTsPssPtSSsR
0 9 S305-p DyYTsPssPtSSsRN
0 2 T307-p YTsPssPtSSsRNWt
0 1 S308 TsPssPtSSsRNWtE
0 1 S309 sPssPtSSsRNWtED
0 2 S310-p PssPtSSsRNWtEDM
0 1 T314-p tSSsRNWtEDMEGGI
0 5 S322-p EDMEGGIssPVKKtE
0 30 S323-p DMEGGIssPVKKtEM
0 1 T328-p IssPVKKtEMDKsPF
0 41 S333-p KKtEMDKsPFNsPsP
0 14 S337-p MDKsPFNsPsPQDsP
0 47 S339-p KsPFNsPsPQDsPRL
0 22 S343-p NsPsPQDsPRLSSFT
0 1 R365-m1 AVHSGIArsPHPSsA
0 1 R365-m2 AVHSGIArsPHPSsA
0 4 S366-p VHSGIArsPHPSsAL
0 1 S371-p ArsPHPSsALHFPTT
0 1 T378 sALHFPTTSILPQTA
0 1 R395-m2 YFPHTAIrYPPHLNP
0 2 S427-p QPGPLNGsGQLKMPS
0 1 S438-p KMPSHCLsAQMLAPP
0 1 R451-m1 PPPPGLPrLALPPAT
0 3 T472-p EGGATSPtsPsysPP
0 3 S473-p GGATSPtsPsysPPD
0 1 S475-p ATSPtsPsysPPDts
0 2 Y476-p TSPtsPsysPPDtsP
0 1 S477-p SPtsPsysPPDtsPA
0 1 T481-p PsysPPDtsPANRsF
0 2 S482-p sysPPDtsPANRsFV
0 4 S487-p DtsPANRsFVGLGPR
  mouse

 
S4-p ____MYSsPLCLtQD
T9-p YSsPLCLtQDEFHPF
S192-p RERDAEQsSsPRTGV
S194-p RDAEQsSsPRTGVGS
T237 ELIQVSRTPVVTGTG
T270 ASAGMRRTLPSTSss
S275 RRTLPSTSssGSkRH
S276-p RTLPSTSssGSkRHK
S277-p TLPSTSssGSkRHKs
S279 PSTSssGSkRHKsGs
K280-ac STSssGSkRHKsGsM
S284-p sGSkRHKsGsMEEDV
S286-p SkRHKsGsMEEDVDt
T293-p sMEEDVDtsPGGDyy
S294-p MEEDVDtsPGGDyyt
Y299-p DtsPGGDyytsPNsP
Y300-p tsPGGDyytsPNsPt
T301-p sPGGDyytsPNsPts
S302-p PGGDyytsPNsPtsS
N304 GDyytsPNsPtsSSR
S305-p DyytsPNsPtsSSRN
T307-p ytsPNsPtsSSRNWT
S308-p tsPNsPtsSSRNWTE
S309 sPNsPtsSSRNWTED
S310 PNsPtsSSRNWTEDI
T314 tsSSRNWTEDIEGGI
S322-p EDIEGGIssPVKKtE
S323-p DIEGGIssPVKKtEM
T328-p IssPVKKtEMDKsPF
S333-p KKtEMDKsPFNsPsP
S337-p MDKsPFNsPsPQDsP
S339-p KsPFNsPsPQDsPRL
S343-p NsPsPQDsPRLSSFT
R365 AVHSGIARsPHPTSA
R365 AVHSGIARsPHPTSA
S366-p VHSGIARsPHPTSAL
S371 ARsPHPTSALHFPAt
T378-p SALHFPAtPILPQTA
R395 YFPHTAIRYPPHLNP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
S4 ____MYSSPLCLTQD
T9 YSSPLCLTQDEFHPF
S192 RERDAEQSSsPRTGV
S194-p RDAEQSSsPRTGVGS
T237 ELIQVSRTPVVTGTG
T270 ASAGMRRTLPSTSSS
S275 RRTLPSTSSSGSKRH
S276 RTLPSTSSSGSKRHK
S277 TLPSTSSSGSKRHKS
S279 PSTSSSGSKRHKSGS
K280 STSSSGSKRHKSGSM
S284 SGSKRHKSGSMEEDV
S286 SKRHKSGSMEEDVDT
T293 SMEEDVDTsPGGDyy
S294-p MEEDVDTsPGGDyyt
Y299-p DTsPGGDyytsPNsP
Y300-p TsPGGDyytsPNsPt
T301-p sPGGDyytsPNsPts
S302-p PGGDyytsPNsPtss
N304 GDyytsPNsPtsssR
S305-p DyytsPNsPtsssRN
T307-p ytsPNsPtsssRNWT
S308-p tsPNsPtsssRNWTE
S309-p sPNsPtsssRNWTED
S310-p PNsPtsssRNWTEDM
T314 tsssRNWTEDMEGGI
S322 EDMEGGISsPVKKTE
S323-p DMEGGISsPVKKTEM
T328 ISsPVKKTEMDKsPF
S333-p KKTEMDKsPFNSPsP
S337 MDKsPFNSPsPQDsP
S339-p KsPFNSPsPQDsPRL
S343-p NSPsPQDsPRLSSFT
R365 AVHSGIARSPHPSSA
R365 AVHSGIARSPHPSSA
S366 VHSGIARSPHPSSAL
S371 ARSPHPSSALHFPAT
T378 SALHFPATPILPQTA
R395 YFPHTAIRYPPHLNP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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