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Protein Page:
NFI-C (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NFI-C Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: nucleoplasm; nucleolus; nucleus
Molecular Function: double-stranded DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; DNA replication; odontogenesis of dentine-containing teeth
Reference #:  P08651 (UniProtKB)
Alt. Names/Synonyms: CCAAT-binding transcription factor; CCAAT-box-binding transcription factor; CTF; CTF5; MGC20153; NF-I; NF-I/C; NF1-C; NFI; NFI-C; NFIC; Nuclear factor 1 C-type; Nuclear factor 1/C; Nuclear factor I/C; nuclear factor I/C (CCAAT-binding transcription factor); TGGCA-binding protein
Gene Symbols: NFIC
Molecular weight: 55,675 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NFI-C

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 4 S4-p ____MYSsPLCLTQD
0 1 T9 YSsPLCLTQDEFHPF
0 3 S192-p RERDAEQsGsPRTGM
0 1 G193 ERDAEQsGsPRTGMG
0 14 S194-p RDAEQsGsPRTGMGS
0 2 T237-p ELIQVSRtPVVTGTG
0 2 T270-p ASTGLRRtLPSTsss
0 1 S275-p RRtLPSTsssGskRH
0 1 S276-p RtLPSTsssGskRHK
0 2 S277-p tLPSTsssGskRHKs
0 1 S279-p PSTsssGskRHKsGs
0 76 K280-ac STsssGskRHKsGsM
0 6 S284-p sGskRHKsGsMEEDV
0 2 S286-p skRHKsGsMEEDVDt
0 2 T293-p sMEEDVDtsPGGDyY
0 8 S294-p MEEDVDtsPGGDyYT
0 3 Y299-p DtsPGGDyYTsPssP
0 2 Y300 tsPGGDyYTsPssPt
0 2 T301 sPGGDyYTsPssPtS
0 3 S302-p PGGDyYTsPssPtSS
0 3 S304-p GDyYTsPssPtSSsR
0 11 S305-p DyYTsPssPtSSsRN
0 2 T307-p YTsPssPtSSsRNWt
0 1 S308 TsPssPtSSsRNWtE
0 1 S309 sPssPtSSsRNWtED
0 2 S310-p PssPtSSsRNWtEDM
0 1 T314-p tSSsRNWtEDMEGGI
0 6 S322-p EDMEGGIssPVKKtE
0 36 S323-p DMEGGIssPVKKtEM
0 2 T328-p IssPVKKtEMDKsPF
0 47 S333-p KKtEMDKsPFNsPsP
0 14 S337-p MDKsPFNsPsPQDsP
0 53 S339-p KsPFNsPsPQDsPRL
0 26 S343-p NsPsPQDsPRLSSFT
0 1 R365-m1 AVHSGIArsPHPSsA
0 1 R365-m2 AVHSGIArsPHPSsA
0 4 S366-p VHSGIArsPHPSsAL
0 1 S371-p ArsPHPSsALHFPTT
0 1 T378 sALHFPTTSILPQTA
0 1 R395-m2 YFPHTAIrYPPHLNP
0 2 S427-p QPGPLNGsGQLKMPS
0 1 S438-p KMPSHCLsAQMLAPP
0 1 R451-m1 PPPPGLPrLALPPAT
0 3 T472-p EGGATSPtsPsysPP
0 3 S473-p GGATSPtsPsysPPD
0 1 S475-p ATSPtsPsysPPDts
0 2 Y476-p TSPtsPsysPPDtsP
0 1 S477-p SPtsPsysPPDtsPA
0 1 T481-p PsysPPDtsPANRsF
0 2 S482-p sysPPDtsPANRsFV
0 4 S487-p DtsPANRsFVGLGPR
  NFI-C iso2  
- gap
- gap
S183 RERDAEQSGSPRTGM
G184 ERDAEQSGSPRTGMG
S185 RDAEQSGSPRTGMGS
T228 ELIQVSRTPVVTGTG
T261 ASTGLRRTLPSTSSS
S266 RRTLPSTSSSGSKRH
S267 RTLPSTSSSGSKRHK
S268 TLPSTSSSGSKRHKS
S270 PSTSSSGSKRHKSGS
K271 STSSSGSKRHKSGSM
S275 SGSKRHKSGSMEEDV
S277 SKRHKSGSMEEDVDT
T284 SMEEDVDTSPGGDYY
S285 MEEDVDTSPGGDYYT
Y290 DTSPGGDYYTSPSSP
Y291 TSPGGDYYTSPSSPT
T292 SPGGDYYTSPSSPTS
S293 PGGDYYTSPSSPTSS
S295 GDYYTSPSSPTSSSR
S296 DYYTSPSSPTSSSRN
T298 YTSPSSPTSSSRNWT
S299 TSPSSPTSSSRNWTE
S300 SPSSPTSSSRNWTED
S301 PSSPTSSSRNWTEDM
T305 TSSSRNWTEDMEGGI
S313 EDMEGGISSPVKKTE
S314 DMEGGISSPVKKTEM
T319 ISSPVKKTEMDKSPF
S324 KKTEMDKSPFNSPSP
S328 MDKSPFNSPSPQDSP
S330 KSPFNSPSPQDSPRL
S334 NSPSPQDSPRLSSFT
R356-m1 AVHSGIArSPHPSSA
R356 AVHSGIARSPHPSSA
S357 VHSGIArSPHPSSAL
S362 ArSPHPSSALHFPTT
T369 SALHFPTTSILPQTA
R386 YFPHTAIRYPPHLNP
S418 QPGPLNGSGQLKMPS
S429 KMPSHCLSAQMLAPP
R442 PPPPGLPRLALPPAT
T463 EGGATSPTSPSYSPP
S464 GGATSPTSPSYSPPD
S466 ATSPTSPSYSPPDTS
Y467 TSPTSPSYSPPDTSP
S468 SPTSPSYSPPDTSPA
T472 PSYSPPDTSPANRSF
S473 SYSPPDTSPANRSFV
S478 DTSPANRSFVGLGPR
  mouse

 
S4-p ____MYSsPLCLtQD
T9-p YSsPLCLtQDEFHPF
S192-p RERDAEQsssPRTGV
S193-p ERDAEQsssPRTGVG
S194-p RDAEQsssPRTGVGS
T237 ELIQVSRTPVVTGTG
T270 ASAGMRRTLPSTSss
S275 RRTLPSTSssGSkRH
S276-p RTLPSTSssGSkRHK
S277-p TLPSTSssGSkRHKs
S279 PSTSssGSkRHKsGs
K280-ac STSssGSkRHKsGsM
S284-p sGSkRHKsGsMEEDV
S286-p SkRHKsGsMEEDVDt
T293-p sMEEDVDtsPGGDyy
S294-p MEEDVDtsPGGDyyt
Y299-p DtsPGGDyytsPNsP
Y300-p tsPGGDyytsPNsPt
T301-p sPGGDyytsPNsPts
S302-p PGGDyytsPNsPtsS
N304 GDyytsPNsPtsSSR
S305-p DyytsPNsPtsSSRN
T307-p ytsPNsPtsSSRNWT
S308-p tsPNsPtsSSRNWTE
S309 sPNsPtsSSRNWTED
S310 PNsPtsSSRNWTEDI
T314 tsSSRNWTEDIEGGI
S322-p EDIEGGIssPVKKtE
S323-p DIEGGIssPVKKtEM
T328-p IssPVKKtEMDKsPF
S333-p KKtEMDKsPFNsPsP
S337-p MDKsPFNsPsPQDsP
S339-p KsPFNsPsPQDsPRL
S343-p NsPsPQDsPRLSSFT
R365 AVHSGIARsPHPTSA
R365 AVHSGIARsPHPTSA
S366-p VHSGIARsPHPTSAL
S371 ARsPHPTSALHFPAt
T378-p SALHFPAtPILPQTA
R395 YFPHTAIRYPPHLNP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
S4 ____MYSSPLCLTQD
T9 YSSPLCLTQDEFHPF
S192 RERDAEQSSsPRTGV
S193 ERDAEQSSsPRTGVG
S194-p RDAEQSSsPRTGVGS
T237 ELIQVSRTPVVTGTG
T270 ASAGMRRTLPSTSSS
S275 RRTLPSTSSSGSKRH
S276 RTLPSTSSSGSKRHK
S277 TLPSTSSSGSKRHKS
S279 PSTSSSGSKRHKSGS
K280 STSSSGSKRHKSGSM
S284 SGSKRHKSGSMEEDV
S286 SKRHKSGSMEEDVDT
T293 SMEEDVDTsPGGDyy
S294-p MEEDVDTsPGGDyyt
Y299-p DTsPGGDyytsPNsP
Y300-p TsPGGDyytsPNsPt
T301-p sPGGDyytsPNsPts
S302-p PGGDyytsPNsPtss
N304 GDyytsPNsPtsssR
S305-p DyytsPNsPtsssRN
T307-p ytsPNsPtsssRNWT
S308-p tsPNsPtsssRNWTE
S309-p sPNsPtsssRNWTED
S310-p PNsPtsssRNWTEDM
T314 tsssRNWTEDMEGGI
S322 EDMEGGISsPVKKTE
S323-p DMEGGISsPVKKTEM
T328 ISsPVKKTEMDKsPF
S333-p KKTEMDKsPFNSPsP
S337 MDKsPFNSPsPQDsP
S339-p KsPFNSPsPQDsPRL
S343-p NSPsPQDsPRLSSFT
R365 AVHSGIARSPHPSSA
R365 AVHSGIARSPHPSSA
S366 VHSGIARSPHPSSAL
S371 ARSPHPSSALHFPAT
T378 SALHFPATPILPQTA
R395 YFPHTAIRYPPHLNP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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