Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Ferritin-H (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Ferritin-H Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Belongs to the ferritin family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.16.3.1; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll
Cellular Component: ferritin complex; cytosol; nucleus
Molecular Function: ferroxidase activity; protein binding; ferric iron binding; iron ion binding
Biological Process: negative regulation of cell proliferation; negative regulation of fibroblast proliferation; cellular iron ion homeostasis; immune response; post-Golgi vesicle-mediated transport; transmembrane transport; iron ion transport; intracellular sequestering of iron ion
Reference #:  P02794 (UniProtKB)
Alt. Names/Synonyms: apoferritin; Cell proliferation-inducing gene 15 protein; Ferritin H subunit; Ferritin heavy chain; ferritin, heavy polypeptide 1; FHC; FRIH; FTH; FTH1; FTHL6; MGC104426; PIG15; placenta immunoregulatory factor; PLIF; proliferation-inducing protein 15
Gene Symbols: FTH1
Molecular weight: 21,226 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Ferritin-H

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
cell motility, altered: S179‑p
intracellular localization: S179‑p
molecular association, regulation: S179‑p
phosphorylation: S179‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S5 ___MTTASTSQVRQN
0 1 S96-p PDCDDWEsGLNAMEC
0 1 T136 HLCDFIETHYLNEQV
0 2 Y138 CDFIETHYLNEQVKA
0 1 K147-ub NEQVKAIkELGDHVT
0 6 T175-p EYLFDKHtLGDsDNE
1 20 S179-p DKHtLGDsDNEs___
0 7 S183-p LGDsDNEs_______
  mouse

 
S5-p ___MTTAsPSQVRQN
S96 PDRDDWESGLNAMEC
T136-p HLCDFIEtYyLSEQV
Y138-p CDFIEtYyLSEQVKS
K147 SEQVKSIKELGDHVT
T175 EYLFDKHTLGHGDES
G179 DKHTLGHGDES____
S182 TLGHGDES_______
  rat

 
S5-p ___MTTAsPSQVRQN
S96 PDRDDWESGLNAMRC
T136 HLCDFIETHYLNEQV
Y138 CDFIETHYLNEQVKS
K147 NEQVKSIKELGDHVT
T175 EYLFDKHTLGHGDES
G179 DKHTLGHGDES____
S182 TLGHGDES_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.