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Protein Page:
lamin A/C (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
lamin A/C nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. Cleaved by caspase-6 during apoptosis into a 40-45 kDa and a28 kDa fragment. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: nucleoplasm; nuclear lamina; perinuclear region of cytoplasm; cytoplasm; nucleolus; lamin filament; intermediate filament; nuclear speck; nuclear envelope; cytosol; nucleus
Molecular Function: protein binding; structural molecule activity
Biological Process: muscle development; mitotic nuclear envelope reassembly; unfolded protein response; apoptosis; ventricular cardiac muscle cell development; mitotic nuclear envelope disassembly; regulation of cell migration; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; sterol regulatory element binding protein nuclear translocation; mitotic cell cycle; establishment and/or maintenance of microtubule cytoskeleton polarity; cell structure disassembly during apoptosis
Reference #:  P02545 (UniProtKB)
Alt. Names/Synonyms: 70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; HGPS; IDC; lamin A/C; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; PRO1; Renal carcinoma antigen NY-REN-32
Gene Symbols: LMNA
Molecular weight: 74,139 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

lamin A/C

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: T19‑p, S22‑p, S392‑p
cytoskeletal reorganization: S22‑p, S525‑p
activity, induced: S22‑p, S390‑p, S392‑p, S652‑p, S657‑p
intracellular localization: S22‑p, S390‑p, S392‑p, S403‑p, S404‑p, S628‑p, S652‑p, S657‑p
molecular association, regulation: S22‑p, S392‑p, S628‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 4 T3-p _____MEtPsQRRAt
1 1 S5-p ___MEtPsQRRAtRs
0 46 T10-p tPsQRRAtRsGAQAs
0 34 S12-p sQRRAtRsGAQAsst
0 12 S17-p tRsGAQAsstPLsPt
0 13 S18-p RsGAQAsstPLsPtR
2 72 T19-p sGAQAsstPLsPtRI
8 171 S22-p QAsstPLsPtRItRL
0 4 T24-p sstPLsPtRItRLQE
0 3 T27-p PLsPtRItRLQEkED
0 1 K32 RItRLQEKEDLQELN
0 5 K32-ub RItRLQEkEDLQELN
0 1 K32-sc RItRLQEkEDLQELN
0 3 S51-p VYIDRVRsLETENAG
0 1 T64-p AGLRLRItEsEEVVs
0 4 S66-p LRLRItEsEEVVsRE
0 3 S71-p tEsEEVVsREVSGIk
0 3 K78-ub sREVSGIkAAyEAEL
0 2 Y81-p VSGIkAAyEAELGDA
0 1 K90-ub AELGDARkTLDsVAk
0 3 S94-p DARkTLDsVAkERAR
0 2 K97-ac kTLDsVAkERARLQL
0 7 K97-ub kTLDsVAkERARLQL
0 1 K97-sc kTLDsVAkERARLQL
0 6 S107-p ARLQLELskVREEFk
0 2 K108-ac RLQLELskVREEFkE
0 4 K108-ub RLQLELskVREEFkE
0 1 K108-sc RLQLELskVREEFkE
0 5 K114-ac skVREEFkELKARNT
0 3 K114-ub skVREEFkELKARNT
0 1 K114-sc skVREEFkELKARNT
0 1 K135-ac IAAQARLkDLEALLN
0 11 K135-ub IAAQARLkDLEALLN
0 1 S143-p DLEALLNskEAALsT
0 1 K144-ac LEALLNskEAALsTA
0 9 K144-ub LEALLNskEAALsTA
0 1 S149-p NskEAALsTALsEkR
0 1 S153-p AALsTALsEkRTLEG
0 45 K155-ac LsTALsEkRTLEGEL
0 2 K155-ub LsTALsEkRTLEGEL
0 1 K155-sc LsTALsEkRTLEGEL
0 1 K171-ac DLRGQVAkLEAALGE
0 27 K171-ub DLRGQVAkLEAALGE
0 46 K180-ac EAALGEAkkQLQDEM
0 28 K180-ub EAALGEAkkQLQDEM
0 1 K180-sc EAALGEAkkQLQDEM
0 15 K181-ub AALGEAkkQLQDEML
1 0 T199 DAENRLQTMkEELDF
0 1 K201-ac ENRLQTMkEELDFQk
0 7 K201-ub ENRLQTMkEELDFQk
1 0 K201-sm ENRLQTMkEELDFQk
0 1 K201-sc ENRLQTMkEELDFQk
0 1 K208-ac kEELDFQkNIYsEEL
0 11 K208-ub kEELDFQkNIYsEEL
0 9 S212-p DFQkNIYsEELRETK
0 1 K219 sEELRETKRRHEtRL
0 5 T224-p ETKRRHEtRLVEIDN
0 4 K233-ac LVEIDNGkQREFESR
0 56 K233-ub LVEIDNGkQREFESR
0 3 K260-ac EDQVEQYkkELEkTY
0 2 K260-ub EDQVEQYkkELEkTY
0 1 K260-sc EDQVEQYkkELEkTY
0 31 K261-ac DQVEQYkkELEkTYS
0 20 K261-ub DQVEQYkkELEkTYS
0 1 K265 QYkkELEKTYSAkLD
0 3 K265-ub QYkkELEkTYSAkLD
0 1 K265-sc QYkkELEkTYSAkLD
0 26 K270-ub LEkTYSAkLDNARQs
0 2 K270-ac LEkTYSAkLDNARQs
0 6 S277-p kLDNARQsAERNSNL
0 1 S295-p AHEELQQsRIRIDsL
2 145 S301-p QsRIRIDsLsAQLsQ
0 17 S303-p RIRIDsLsAQLsQLQ
1 5 S307-p DsLsAQLsQLQkQLA
0 2 K311-ac AQLsQLQkQLAAkEA
0 14 K311-ub AQLsQLQkQLAAkEA
0 1 K316-sc LQkQLAAkEAKLRDL
0 1 K319 QLAAkEAKLRDLEDs
0 2 S326-p KLRDLEDsLARERDT
0 55 K378-ub MEIHAYRkLLEGEEE
0 2 K378-ac MEIHAYRkLLEGEEE
4 195 S390-p EEERLRLsPsPtsQR
7 144 S392-p ERLRLsPsPtsQRsR
0 48 T394-p LRLsPsPtsQRsRGR
0 89 S395-p RLsPsPtsQRsRGRA
0 28 S398-p PsPtsQRsRGRAssH
1 86 S403-p QRsRGRAssHssQtQ
3 123 S404-p RsRGRAssHssQtQG
0 66 S406-p RGRAssHssQtQGGG
1 140 S407-p GRAssHssQtQGGGs
1 43 T409-p AssHssQtQGGGsVt
0 27 S414-p sQtQGGGsVtkkRkL
1 12 T416-p tQGGGsVtkkRkLEs
0 89 K417-ac QGGGsVtkkRkLEst
0 11 K417-ub QGGGsVtkkRkLEst
0 19 K418-ac GGGsVtkkRkLEstE
0 5 K418-ub GGGsVtkkRkLEstE
2 0 K420-sm GsVtkkRkLEstEsR
0 2 K420-ub GsVtkkRkLEstEsR
0 10 S423-p tkkRkLEstEsRSsF
0 7 T424-p kkRkLEstEsRSsFs
0 9 S426-p RkLEstEsRSsFsQH
0 5 S429-p EstEsRSsFsQHART
0 2 S431-p tEsRSsFsQHARTSG
0 2 K450-ac EEVDEEGkFVRLRNk
0 2 K450-ub EEVDEEGkFVRLRNk
0 1 K457-ub kFVRLRNksNEDQsM
0 232 S458-p FVRLRNksNEDQsMG
0 4 S463-p NksNEDQsMGNWQIk
0 7 K470-ac sMGNWQIkRQNGDDP
0 2 K470-ub sMGNWQIkRQNGDDP
0 1 K470-sc sMGNWQIkRQNGDDP
1 0 T480 NGDDPLLTYRFPPkF
1 0 K486-sm LTYRFPPkFTLKAGQ
0 1 K486-ub LTYRFPPkFTLKAGQ
0 1 T496 LKAGQVVTIWAAGAG
0 1 A500 QVVTIWAAGAGAtHS
0 2 T505-p WAAGAGAtHSPPtDL
0 1 S507 AGAGAtHSPPtDLVW
0 2 T510-p GAtHSPPtDLVWkAQ
0 1 K515-ac PPtDLVWkAQNTWGC
2 0 S525-p NTWGCGNsLRTALIN
0 3 S533-p LRTALINsTGEEVAM
0 16 S546-p AMRKLVRsVtVVEDD
0 44 T548-p RKLVRsVtVVEDDED
0 1 - gap
0 1 - gap
0 6 S568 LLHHHHGSHCSSSGD
0 9 S571 HHHGSHCSSSGDPAE
1 3 S573 HGSHCSSSGDPAEYN
0 1 S583-p PAEYNLRsRtVLCGt
0 3 T585-p EYNLRsRtVLCGtCG
0 3 T590-p sRtVLCGtCGQPADk
0 1 K597-ac tCGQPADkAsASGsG
0 1 K597-ub tCGQPADkAsASGsG
0 2 S599-p GQPADkAsASGsGAQ
0 1 S603-p DkAsASGsGAQVGGP
0 2 S612-p AQVGGPIssGssAss
0 1 S612-gl AQVGGPIssGssAss
0 4 S613-p QVGGPIssGssAssV
0 1 S615-p GGPIssGssAssVTV
0 5 S616-p GPIssGssAssVTVT
0 3 S618-p IssGssAssVTVTRs
0 4 S619-p ssGssAssVTVTRsY
0 1 S625-p ssVTVTRsYRsVGGs
0 18 S628-p TVTRsYRsVGGsGGG
0 20 S632-p sYRsVGGsGGGsFGD
1 21 S636-p VGGsGGGsFGDNLVt
0 2 T643-p sFGDNLVtrSYLLGN
0 1 T643-gl sFGDNLVtrSYLLGN
0 1 R644-m1 FGDNLVtrSYLLGNs
0 1 S645 GDNLVtrSYLLGNss
0 1 Y646 DNLVtrSYLLGNssP
1 1 S651-p rSYLLGNssPRTQsP
1 12 S652-p SYLLGNssPRTQsPQ
1 0 S657-p NssPRTQsPQNCSIM
2026 : Phospho-Lamin A/C (Ser22) Antibody
13448 : Phospho-Lamin A/C (Ser22) (D2B2E) XP(R) Rabbit mAb
  lamin A/C iso2  
T3 _____METPSQRRAt
S5 ___METPSQRRAtRs
T10-p TPSQRRAtRsGAQAS
S12-p SQRRAtRsGAQASSt
S17 tRsGAQASStPLsPT
S18 RsGAQASStPLsPTR
T19-p sGAQASStPLsPTRI
S22-p QASStPLsPTRITRL
T24 SStPLsPTRITRLQE
T27 PLsPTRITRLQEKED
K32 RITRLQEKEDLQELN
K32 RITRLQEKEDLQELN
K32 RITRLQEKEDLQELN
S51 VYIDRVRSLETENAG
T64 AGLRLRITESEEVVS
S66 LRLRITESEEVVSRE
S71 TESEEVVSREVSGIK
K78 SREVSGIKAAyEAEL
Y81-p VSGIKAAyEAELGDA
K90 AELGDARKTLDSVAK
S94 DARKTLDSVAKERAR
K97 KTLDSVAKERARLQL
K97 KTLDSVAKERARLQL
K97 KTLDSVAKERARLQL
S107 ARLQLELSKVREEFk
K108 RLQLELSKVREEFkE
K108 RLQLELSKVREEFkE
K108 RLQLELSKVREEFkE
K114-ac SKVREEFkELKARNT
K114 SKVREEFKELKARNT
K114 SKVREEFKELKARNT
K135 IAAQARLKDLEALLN
K135 IAAQARLKDLEALLN
S143 DLEALLNSKEAALST
K144 LEALLNSKEAALSTA
K144 LEALLNSKEAALSTA
S149 NSKEAALSTALSEkR
S153 AALSTALSEkRTLEG
K155-ac LSTALSEkRTLEGEL
K155 LSTALSEKRTLEGEL
K155 LSTALSEKRTLEGEL
K171 DLRGQVAKLEAALGE
K171 DLRGQVAKLEAALGE
K180-ac EAALGEAkKQLQDEM
K180 EAALGEAKKQLQDEM
K180 EAALGEAKKQLQDEM
K181 AALGEAkKQLQDEML
T199 DAENRLQTMKEELDF
K201 ENRLQTMKEELDFQK
K201 ENRLQTMKEELDFQK
K201 ENRLQTMKEELDFQK
K201 ENRLQTMKEELDFQK
K208 KEELDFQKNIYSEEL
K208 KEELDFQKNIYSEEL
S212 DFQKNIYSEELRETK
K219 SEELRETKRRHETRL
T224 ETKRRHETRLVEIDN
K233 LVEIDNGKQREFESR
K233 LVEIDNGKQREFESR
K260 EDQVEQYKKELEKTY
K260 EDQVEQYKKELEKTY
K260 EDQVEQYKKELEKTY
K261 DQVEQYKKELEKTYS
K261 DQVEQYKKELEKTYS
K265 QYKKELEKTYSAKLD
K265 QYKKELEKTYSAKLD
K265 QYKKELEKTYSAKLD
K270 LEKTYSAKLDNARQS
K270 LEKTYSAKLDNARQS
S277 KLDNARQSAERNSNL
S295 AHEELQQSRIRIDsL
S301-p QSRIRIDsLsAQLSQ
S303-p RIRIDsLsAQLSQLQ
S307 DsLsAQLSQLQKQLA
K311 AQLSQLQKQLAAKEA
K311 AQLSQLQKQLAAKEA
K316 LQKQLAAKEAKLRDL
K319 QLAAKEAKLRDLEDS
S326 KLRDLEDSLARERDT
K378 MEIHAYRKLLEGEEE
K378 MEIHAYRKLLEGEEE
S390-p EEERLRLsPsPTsQR
S392-p ERLRLsPsPTsQRsR
T394 LRLsPsPTsQRsRGR
S395-p RLsPsPTsQRsRGRA
S398-p PsPTsQRsRGRAssH
S403-p QRsRGRAssHssQtQ
S404-p RsRGRAssHssQtQG
S406-p RGRAssHssQtQGGG
S407-p GRAssHssQtQGGGs
T409-p AssHssQtQGGGsVt
S414-p sQtQGGGsVtkkRKL
T416-p tQGGGsVtkkRKLES
K417-ac QGGGsVtkkRKLEST
K417 QGGGsVtKkRKLEST
K418-ac GGGsVtkkRKLESTE
K418 GGGsVtkKRKLESTE
K420 GsVtkkRKLESTESR
K420 GsVtkkRKLESTESR
S423 tkkRKLESTESRSSF
T424 kkRKLESTESRSSFS
S426 RKLESTESRSSFSQH
S429 ESTESRSSFSQHART
S431 TESRSSFSQHARTSG
K450 EEVDEEGKFVRLRNK
K450 EEVDEEGKFVRLRNK
K457 KFVRLRNKsNEDQSM
S458-p FVRLRNKsNEDQSMG
S463 NKsNEDQSMGNWQIk
K470-ac SMGNWQIkRQNGDDP
K470 SMGNWQIKRQNGDDP
K470 SMGNWQIKRQNGDDP
T480 NGDDPLLTYRFPPKF
K486 LTYRFPPKFTLKAGQ
K486 LTYRFPPKFTLKAGQ
T496 LKAGQVVTIWAAGAG
A500 QVVTIWAAGAGATHS
T505 WAAGAGATHSPPTDL
S507 AGAGATHSPPTDLVW
T510 GATHSPPTDLVWKAQ
K515 PPTDLVWKAQNTWGC
S525 NTWGCGNSLRTALIN
S533 LRTALINSTGEEVAM
S546-p AMRKLVRsVtVVEDD
T548-p RKLVRsVtVVEDDED
S568 LLHHHHVSGSRR___
S570 HHHHVSGSRR_____
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
T3-p _____MEtPsQRRAt
S5-p ___MEtPsQRRAtRs
T10-p tPsQRRAtRsGAQAs
S12-p sQRRAtRsGAQAsst
S17-p tRsGAQAsstPLsPt
S18-p RsGAQAsstPLsPtR
T19-p sGAQAsstPLsPtRI
S22-p QAsstPLsPtRItRL
T24-p sstPLsPtRItRLQE
T27-p PLsPtRItRLQEkED
K32-ac RItRLQEkEDLQELN
K32-ub RItRLQEkEDLQELN
K32 RItRLQEKEDLQELN
S51 VYIDRVRSLETENAG
T64 AGLRLRITESEEVVS
S66 LRLRITESEEVVSRE
S71 TESEEVVSREVSGIk
K78-ub SREVSGIkAAYEAEL
Y81 VSGIkAAYEAELGDA
K90 AELGDARKTLDSVAk
S94 DARKTLDSVAkERAR
K97-ac KTLDSVAkERARLQL
K97-ub KTLDSVAkERARLQL
K97 KTLDSVAKERARLQL
S107-p ARLQLELskVREEFk
K108-ac RLQLELskVREEFkE
K108-ub RLQLELskVREEFkE
K108 RLQLELsKVREEFkE
K114 skVREEFKELKARNT
K114-ub skVREEFkELKARNT
K114 skVREEFKELKARNT
K135 LAAQARLKDLEALLN
K135-ub LAAQARLkDLEALLN
S143 DLEALLNSkEAALST
K144-ac LEALLNSkEAALSTA
K144-ub LEALLNSkEAALSTA
S149 NSkEAALSTALSEkR
S153 AALSTALSEkRTLEG
K155 LSTALSEKRTLEGEL
K155-ub LSTALSEkRTLEGEL
K155 LSTALSEKRTLEGEL
K171-ac DLRGQVAkLEAALGE
K171-ub DLRGQVAkLEAALGE
K180-ac EAALGEAkkQLQDEM
K180-ub EAALGEAkkQLQDEM
K180 EAALGEAKkQLQDEM
K181-ub AALGEAkkQLQDEML
T199-p DAENRLQtLkEELDF
K201-ac ENRLQtLkEELDFQk
K201-ub ENRLQtLkEELDFQk
K201 ENRLQtLKEELDFQk
K201 ENRLQtLKEELDFQk
K208-ac kEELDFQkNIYsEEL
K208-ub kEELDFQkNIYsEEL
S212-p DFQkNIYsEELRETk
K219-ub sEELRETkRRHEtRL
T224-p ETkRRHEtRLVEIDN
K233 LVEIDNGKQREFESR
K233-ub LVEIDNGkQREFESR
K260 EDQVEQYKkELEkTY
K260 EDQVEQYKkELEkTY
K260 EDQVEQYKkELEkTY
K261-ac DQVEQYKkELEkTYS
K261 DQVEQYKKELEkTYS
K265-ac QYKkELEkTYSAkLD
K265 QYKkELEKTYSAkLD
K265 QYKkELEKTYSAkLD
K270-ub LEkTYSAkLDNARQs
K270-ac LEkTYSAkLDNARQs
S277-p kLDNARQsAERNSNL
S295 AHEELQQSRIRIDsL
S301-p QSRIRIDsLsAQLSQ
S303-p RIRIDsLsAQLSQLQ
S307 DsLsAQLSQLQkQLA
K311 AQLSQLQKQLAAKEA
K311-ub AQLSQLQkQLAAKEA
K316 LQkQLAAKEAkLRDL
K319-ub QLAAKEAkLRDLEDs
S326-p kLRDLEDsLARERDT
K378-ub MEIHAYRkLLEGEEE
K378-ac MEIHAYRkLLEGEEE
S390-p EEERLRLsPsPtsQR
S392-p ERLRLsPsPtsQRsR
T394-p LRLsPsPtsQRsRGR
S395-p RLsPsPtsQRsRGRA
S398-p PsPtsQRsRGRAssH
S403-p QRsRGRAssHssQsQ
S404-p RsRGRAssHssQsQG
S406-p RGRAssHssQsQGGG
S407-p GRAssHssQsQGGGs
S409-p AssHssQsQGGGsVt
S414-p sQsQGGGsVtkkRKL
T416-p sQGGGsVtkkRKLEs
K417-ac QGGGsVtkkRKLEss
K417 QGGGsVtKkRKLEss
K418-ac GGGsVtkkRKLEssE
K418 GGGsVtkKRKLEssE
K420 GsVtkkRKLEssEsR
K420 GsVtkkRKLEssEsR
S423-p tkkRKLEssEsRSSF
S424-p kkRKLEssEsRSSFS
S426-p RKLEssEsRSSFSQH
S429 EssEsRSSFSQHART
S431 sEsRSSFSQHARTSG
K450 EEVDEEGKFVRLRNK
K450-ub EEVDEEGkFVRLRNK
K457 kFVRLRNKsNEDQsM
S458-p FVRLRNKsNEDQsMG
S463-p NKsNEDQsMGNWQIR
R470 sMGNWQIRRQNGDDP
R470 sMGNWQIRRQNGDDP
R470 sMGNWQIRRQNGDDP
T480-p NGDDPLMtYRFPPKF
K486 MtYRFPPKFTLKAGQ
K486 MtYRFPPKFTLKAGQ
T496 LKAGQVVTIWASGAG
S500 QVVTIWASGAGATHS
T505 WASGAGATHSPPTDL
S507 SGAGATHSPPTDLVW
T510 GATHSPPTDLVWKAQ
K515 PPTDLVWKAQNTWGC
S525-p NTWGCGSsLRTALIN
S533-p LRTALINsTGEEVAM
S546-p AMRKLVRsLtMVEDN
T548-p RKLVRsLtMVEDNED
- gap
- gap
S570-p LLHHHRGsHCsGsGD
S573-p HHRGsHCsGsGDPAE
S575-p RGsHCsGsGDPAEYN
S585 PAEYNLRSRtVLCGT
T587-p EYNLRSRtVLCGTCG
T592 SRtVLCGTCGQPADK
K599 TCGQPADKAAGGAGA
K599 TCGQPADKAAGGAGA
- gap
- gap
S613 AQVGGSISsGssAss
S613 AQVGGSISsGssAss
S614-p QVGGSISsGssAssV
S616-p GGSISsGssAssVTV
S617-p GSISsGssAssVTVT
S619-p ISsGssAssVTVTRS
S620-p SsGssAssVTVTRSF
S626 ssVTVTRSFRsVGGs
S629-p TVTRSFRsVGGsGGG
S633-p SFRsVGGsGGGsFGD
S637-p VGGsGGGsFGDNLVt
T644-p sFGDNLVtRsyLLGN
T644 sFGDNLVTRsyLLGN
R645 FGDNLVtRsyLLGNs
S646-p GDNLVtRsyLLGNss
Y647-p DNLVtRsyLLGNssP
S652-p RsyLLGNssPRSQSS
S653-p syLLGNssPRSQSSQ
S658 NssPRSQSSQNCSIM
2026 : Phospho-Lamin A/C (Ser22) Antibody
13448 : Phospho-Lamin A/C (Ser22) (D2B2E) XP(R) Rabbit mAb
  lamin A/C iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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K23 LAAQARLKDLEALLN
K23 LAAQARLKDLEALLN
S31 DLEALLNSKEAALST
K32 LEALLNSKEAALSTA
K32 LEALLNSKEAALSTA
S37 NSKEAALSTALSEKR
S41 AALSTALSEKRTLEG
K43 LSTALSEKRTLEGEL
K43 LSTALSEKRTLEGEL
K43 LSTALSEKRTLEGEL
K59 DLRGQVAKLEAALGE
K59 DLRGQVAKLEAALGE
K68 EAALGEAKKQLQDEM
K68 EAALGEAKKQLQDEM
K68 EAALGEAKKQLQDEM
K69 AALGEAKKQLQDEML
T87 DAENRLQTLKEELDF
K89 ENRLQTLKEELDFQK
K89 ENRLQTLKEELDFQK
K89 ENRLQTLKEELDFQK
K89 ENRLQTLKEELDFQK
K96 KEELDFQKNIYSEEL
K96 KEELDFQKNIYSEEL
S100 DFQKNIYSEELRETK
K107 SEELRETKRRHETRL
T112 ETKRRHETRLVEIDN
K121 LVEIDNGKQREFESR
K121 LVEIDNGKQREFESR
K148 EDQVEQYKKELEKTY
K148 EDQVEQYKKELEKTY
K148 EDQVEQYKKELEKTY
K149 DQVEQYKKELEKTYS
K149 DQVEQYKKELEKTYS
K153 QYKKELEKTYSAKLD
K153 QYKKELEKTYSAKLD
K153 QYKKELEKTYSAKLD
K158 LEKTYSAKLDNARQS
K158 LEKTYSAKLDNARQS
S165 KLDNARQSAERNSNL
S183 AHEELQQSRIRIDsL
S189-p QSRIRIDsLsAQLSQ
S191-p RIRIDsLsAQLSQLQ
S195 DsLsAQLSQLQKQLA
K199 AQLSQLQKQLAAKEA
K199 AQLSQLQKQLAAKEA
K204 LQKQLAAKEAKLRDL
K207 QLAAKEAKLRDLEDS
S214 KLRDLEDSLARERDT
K266 MEIHAYRKLLEGEEE
K266 MEIHAYRKLLEGEEE
S278-p EEERLRLsPsPtsQR
S280-p ERLRLsPsPtsQRSR
T282-p LRLsPsPtsQRSRGR
S283-p RLsPsPtsQRSRGRA
S286 PsPtsQRSRGRASSH
S291 QRSRGRASSHSSQSQ
S292 RSRGRASSHSSQSQG
S294 RGRASSHSSQSQGGG
S295 GRASSHSSQSQGGGS
S297 ASSHSSQSQGGGSVT
S302 SQSQGGGSVTKKRKL
T304 SQGGGSVTKKRKLES
K305 QGGGSVTKKRKLESS
K305 QGGGSVTKKRKLESS
K306 GGGSVTKKRKLESSE
K306 GGGSVTKKRKLESSE
K308 GSVTKKRKLESSESR
K308 GSVTKKRKLESSESR
S311 TKKRKLESSESRSSF
S312 KKRKLESSESRSSFS
S314 RKLESSESRSSFSQH
S317 ESSESRSSFSQHART
S319 SESRSSFSQHARTSG
K338 EEVDEEGKFVRLRNK
K338 EEVDEEGKFVRLRNK
K345 KFVRLRNKsNEDQSM
S346-p FVRLRNKsNEDQSMG
S351 NKsNEDQSMGNWQIR
R358 SMGNWQIRRQNGDDP
R358 SMGNWQIRRQNGDDP
R358 SMGNWQIRRQNGDDP
T368 NGDDPLMTYRFPPKF
K374 MTYRFPPKFTLKAGQ
K374 MTYRFPPKFTLKAGQ
T384 LKAGQVVTIWASGAG
S388 QVVTIWASGAGATHS
T393 WASGAGATHSPPTDL
S395 SGAGATHSPPTDLVW
T398 GATHSPPTDLVWKAQ
K403 PPTDLVWKAQNTWGC
S413 NTWGCGSSLRTALIN
S421 LRTALINSTGEEVAM
S434-p AMRKLVRsLtMVEDN
T436-p RKLVRsLtMVEDNED
S458-p LLHHHRVsGsRR___
S460-p HHHRVsGsRR_____
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
T3 _____METPSQRRPT
S5 ___METPSQRRPTRs
T10 TPSQRRPTRsGAQAS
S12-p SQRRPTRsGAQASSt
S17 TRsGAQASStPLsPT
S18 RsGAQASStPLsPTR
T19-p sGAQASStPLsPTRI
S22-p QASStPLsPTRITRL
T24 SStPLsPTRITRLQE
T27 PLsPTRITRLQEKED
K32 RITRLQEKEDLQELN
K32 RITRLQEKEDLQELN
K32 RITRLQEKEDLQELN
S51 VYIDRVRSLETENAG
T64 AGLRLRITEsEEVVS
S66-p LRLRITEsEEVVSRE
S71 TEsEEVVSREVSGIK
K78 SREVSGIKAAYEAEL
Y81 VSGIKAAYEAELGDA
K90 AELGDARKTLDSVAK
S94 DARKTLDSVAKERAR
K97 KTLDSVAKERARLQL
K97 KTLDSVAKERARLQL
K97 KTLDSVAKERARLQL
S107 ARLQLELSKVREEFK
K108 RLQLELSKVREEFKE
K108 RLQLELSKVREEFKE
K108 RLQLELSKVREEFKE
K114 SKVREEFKELKARNT
K114 SKVREEFKELKARNT
K114 SKVREEFKELKARNT
K135 LAAQARLKDLEALLN
K135 LAAQARLKDLEALLN
S143 DLEALLNSKEAALST
K144 LEALLNSKEAALSTA
K144 LEALLNSKEAALSTA
S149 NSKEAALSTALSEKR
S153 AALSTALSEKRTLEG
K155 LSTALSEKRTLEGEL
K155 LSTALSEKRTLEGEL
K155 LSTALSEKRTLEGEL
K171 DLRGQVAKLEAALGE
K171 DLRGQVAKLEAALGE
K180 EAALGEAKKQLQDEM
K180 EAALGEAKKQLQDEM
K180 EAALGEAKKQLQDEM
K181 AALGEAKKQLQDEML
T199 DAENRLQTLKEELDF
K201 ENRLQTLKEELDFQK
K201 ENRLQTLKEELDFQK
K201 ENRLQTLKEELDFQK
K201 ENRLQTLKEELDFQK
K208 KEELDFQKNIYsEEL
K208 KEELDFQKNIYsEEL
S212-p DFQKNIYsEELRETK
K219 sEELRETKRRHETRL
T224 ETKRRHETRLVEIDN
K233 LVEIDNGKQREFESR
K233 LVEIDNGKQREFESR
K260 EDQVEQYKKELEKTY
K260 EDQVEQYKKELEKTY
K260 EDQVEQYKKELEKTY
K261 DQVEQYKKELEKTYS
K261 DQVEQYKKELEKTYS
K265 QYKKELEKTYSAKLD
K265 QYKKELEKTYSAKLD
K265 QYKKELEKTYSAKLD
K270 LEKTYSAKLDNARQs
K270 LEKTYSAKLDNARQs
S277-p KLDNARQsAERNSNL
S295 AHEELQQSRIRIDsL
S301-p QSRIRIDsLSAQLSQ
S303 RIRIDsLSAQLSQLQ
S307 DsLSAQLSQLQKQLA
K311 AQLSQLQKQLAAKEA
K311 AQLSQLQKQLAAKEA
K316 LQKQLAAKEAKLRDL
K319 QLAAKEAKLRDLEDS
S326 KLRDLEDSLARERDT
K378 MEIHAYRKLLEGEEE
K378 MEIHAYRKLLEGEEE
S390-p EEERLRLsPsPTsQR
S392-p ERLRLsPsPTsQRSR
T394 LRLsPsPTsQRSRGR
S395-p RLsPsPTsQRSRGRA
S398 PsPTsQRSRGRAssH
S403-p QRSRGRAssHssQSQ
S404-p RSRGRAssHssQSQG
S406-p RGRAssHssQSQGGG
S407-p GRAssHssQSQGGGs
S409 AssHssQSQGGGsVt
S414-p sQSQGGGsVtKKRKL
T416-p SQGGGsVtKKRKLES
K417 QGGGsVtKKRKLESS
K417 QGGGsVtKKRKLESS
K418 GGGsVtKKRKLESSE
K418 GGGsVtKKRKLESSE
K420 GsVtKKRKLESSESR
K420 GsVtKKRKLESSESR
S423 tKKRKLESSESRSSF
S424 KKRKLESSESRSSFS
S426 RKLESSESRSSFSQH
S429 ESSESRSSFSQHART
S431 SESRSSFSQHARTSG
K450 EEVDEEGKFVRLRNK
K450 EEVDEEGKFVRLRNK
K457 KFVRLRNKsNEDQSM
S458-p FVRLRNKsNEDQSMG
S463 NKsNEDQSMGNWQIK
K470 SMGNWQIKRQNGDDP
K470 SMGNWQIKRQNGDDP
K470 SMGNWQIKRQNGDDP
T480 NGDDPLMTYRFPPKF
K486 MTYRFPPKFTLKAGQ
K486 MTYRFPPKFTLKAGQ
T496-p LKAGQVVtIWAsGAG
S500-p QVVtIWAsGAGAtHs
T505-p WAsGAGAtHsPPtDL
S507-p sGAGAtHsPPtDLVW
T510-p GAtHsPPtDLVWKAQ
K515 PPtDLVWKAQNTWGC
S525 NTWGCGTSLRTALIN
- gap
S546 AMRKLVRSLTMVEDN
T548 RKLVRSLTMVEDNDD
- gap
- gap
S570 LLHHHRGSHCsSSGD
S573-p HHRGSHCsSSGDPAE
S575 RGSHCsSSGDPAEYN
S585 PAEYNLRSRTVLCGT
T587 EYNLRSRTVLCGTCG
T592 SRTVLCGTCGQPADK
K599 TCGQPADKAASGSGA
K599 TCGQPADKAASGSGA
- gap
- gap
S613 AQVGGSISSGSSASS
S613 AQVGGSISSGSSASS
S614 QVGGSISSGSSASSV
S616 GGSISSGSSASSVTV
S617 GSISSGSSASSVTVT
S619 ISSGSSASSVTVTRS
S620 SSGSSASSVTVTRSF
S626 SSVTVTRSFRSVGGs
S629 TVTRSFRSVGGsGGG
S633-p SFRSVGGsGGGsFGD
S637-p VGGsGGGsFGDNLVT
T644 sFGDNLVTRSYLLGN
T644 sFGDNLVTRSYLLGN
R645 FGDNLVTRSYLLGNS
S646 GDNLVTRSYLLGNSs
Y647 DNLVTRSYLLGNSsP
S652 RSYLLGNSsPRTQSS
S653-p SYLLGNSsPRTQSSQ
S658 NSsPRTQSSQNCSIM
2026 : Phospho-Lamin A/C (Ser22) Antibody
13448 : Phospho-Lamin A/C (Ser22) (D2B2E) XP(R) Rabbit mAb
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