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lamin A/C (human)

Overview lamin A/C nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. Cleaved by caspase-6 during apoptosis into a 40-45 kDa and a28 kDa fragment. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: nucleoplasm; nuclear lamina; nuclear matrix; perinuclear region of cytoplasm; cytoplasm; lamin filament; intermediate filament; nuclear envelope; nucleus Molecular Function: protein binding; structural molecule activity Biological Process: regulation of apoptosis; muscle development; unfolded protein response, activation of signaling protein activity; unfolded protein response; apoptosis; ventricular cardiac muscle cell development; sterol regulatory element binding protein nuclear translocation; spermatogenesis; regulation of cell migration; nuclear membrane organization and biogenesis; cell structure disassembly during apoptosis; establishment and/or maintenance of microtubule cytoskeleton polarity Reference #:  P02545 (UniProtKB) Alt. Names/Synonyms: 70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; HGPS; IDC; lamin A/C; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; PRO1; Renal carcinoma antigen NY-REN-32 Gene Symbols: LMNA Molecular weight: 74,139 Da Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states CST Pathways:  Death Receptor Signaling  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below lamin A/C 1IFR - A=435-552 (human) 1IVT - A=428-549 (human) 1X8Y - A=303-387 (human) 2XV5 - A/B=328-398 (human) 2YPT - H/F/I/G=661-664 (human) 3GEF - A/D/C/B=436-552 (human) 3V4Q - A=313-386 (human) 3V4W - A=313-386 (human) 3V5B - A=313-386 (human) 1UFG - A=406-546 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1IFR 1IVT 1X8Y 2XV5 2YPT 3GEF 3V4Q 3V4W 3V5B  |  Phospho3D  |  DISEASE 115200 150330 151660 159001 176670 181350 248370 277700 604929 605588 607554 607920 608056  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: T19‑p, S22‑p, S392‑p cytoskeletal reorganization: S22‑p, S525‑p activation: S22‑p, S390‑p, S392‑p, S652‑p, S657‑p intracellular localization: S22‑p, S390‑p, S392‑p, S403‑p, S404‑p, S652‑p, S657‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	2		T3-p	_____MEtPSQRRAt
1	0		S5	___MEtPSQRRAtRs
0	44		T10-p	tPSQRRAtRsGAQAs
0	27		S12-p	SQRRAtRsGAQAsst
0	9		S17-p	tRsGAQAsstPLsPt
0	9		S18-p	RsGAQAsstPLsPtR
1	64		T19-p	sGAQAsstPLsPtRI
5	163		S22-p	QAsstPLsPtRITRL
0	2		T24-p	sstPLsPtRITRLQE
0	5		K32-u	RITRLQEkEDLQELN
0	1		S51-p	VYIDRVRsLETENAG
0	1		T64-p	AGLRLRItEsEEVVs
0	2		S66-p	LRLRItEsEEVVsRE
0	1		S71-p	tEsEEVVsREVSGIk
0	3		K78-u	sREVSGIkAAyEAEL
0	2		Y81-p	VSGIkAAyEAELGDA
0	1		K90-u	AELGDARkTLDsVAk
0	1		S94-p	DARkTLDsVAkERAR
0	1		K97-a	kTLDsVAkERARLQL
0	7		K97-u	kTLDsVAkERARLQL
0	4		S107-p	ARLQLELskVREEFk
0	1		K108-a	RLQLELskVREEFkE
0	4		K108-u	RLQLELskVREEFkE
0	5		K114-a	skVREEFkELKARNT
0	3		K114-u	skVREEFkELKARNT
0	11		K135-u	IAAQARLkDLEALLN
0	9		K144-u	LEALLNSkEAALSTA
0	44		K155-a	LSTALSEkRTLEGEL
0	2		K155-u	LSTALSEkRTLEGEL
0	27		K171-u	DLRGQVAkLEAALGE
0	46		K180-a	EAALGEAkkQLQDEM
0	28		K180-u	EAALGEAkkQLQDEM
0	15		K181-u	AALGEAkkQLQDEML
1	0		T199	DAENRLQTMkEELDF
1	0		K201-s	ENRLQTMkEELDFQk
0	7		K201-u	ENRLQTMkEELDFQk
0	11		K208-u	kEELDFQkNIYsEEL
0	5		S212-p	DFQkNIYsEELRETK
0	1		K219	sEELRETKRRHEtRL
0	5		T224-p	ETKRRHEtRLVEIDN
0	4		K233-a	LVEIDNGkQREFESR
0	56		K233-u	LVEIDNGkQREFESR
0	3		K260-a	EDQVEQYkkELEkTY
0	2		K260-u	EDQVEQYkkELEkTY
0	31		K261-a	DQVEQYkkELEkTYS
0	20		K261-u	DQVEQYkkELEkTYS
0	3		K265-u	QYkkELEkTYSAkLD
0	26		K270-u	LEkTYSAkLDNARQs
0	1		K270-a	LEkTYSAkLDNARQs
0	3		S277-p	kLDNARQsAERNSNL
1	142		S301-p	QSRIRIDsLsAQLsQ
0	16		S303-p	RIRIDsLsAQLsQLQ
0	1		S307-p	DsLsAQLsQLQkQLA
0	1		K311-a	AQLsQLQkQLAAKEA
0	14		K311-u	AQLsQLQkQLAAKEA
0	1		K319	QLAAKEAKLRDLEDs
0	1		S326-p	KLRDLEDsLARERDT
0	55		K378-u	MEIHAYRkLLEGEEE
3	180		S390-p	EEERLRLsPsPtsQR
6	133		S392-p	ERLRLsPsPtsQRsR
0	44		T394-p	LRLsPsPtsQRsRGR
0	82		S395-p	RLsPsPtsQRsRGRA
0	25		S398-p	PsPtsQRsRGRAssH
1	83		S403-p	QRsRGRAssHssQtQ
2	111		S404-p	RsRGRAssHssQtQG
0	61		S406-p	RGRAssHssQtQGGG
1	127		S407-p	GRAssHssQtQGGGs
1	41		T409-p	AssHssQtQGGGsVt
0	18		S414-p	sQtQGGGsVtkkRkL
1	9		T416-p	tQGGGsVtkkRkLEs
0	89		K417-a	QGGGsVtkkRkLEst
0	11		K417-u	QGGGsVtkkRkLEst
0	19		K418-a	GGGsVtkkRkLEstE
0	5		K418-u	GGGsVtkkRkLEstE
1	0		K420-s	GsVtkkRkLEstEsR
0	2		K420-u	GsVtkkRkLEstEsR
0	8		S423-p	tkkRkLEstEsRSsF
0	6		T424-p	kkRkLEstEsRSsFs
0	6		S426-p	RkLEstEsRSsFsQH
0	4		S429-p	EstEsRSsFsQHART
0	2		S431-p	tEsRSsFsQHARTSG
0	1		K450-a	EEVDEEGkFVRLRNk
0	2		K450-u	EEVDEEGkFVRLRNk
0	1		K457-u	kFVRLRNksNEDQsM
0	225		S458-p	FVRLRNksNEDQsMG
0	1		S463-p	NksNEDQsMGNWQIk
0	6		K470-a	sMGNWQIkRQNGDDP
0	2		K470-u	sMGNWQIkRQNGDDP
1	0		T480	NGDDPLLTYRFPPkF
0	1		K486-u	LTYRFPPkFTLKAGQ
0	1		T496	LKAGQVVTIWAAGAG
0	1		A500	QVVTIWAAGAGAtHS
0	2		T505-p	WAAGAGAtHSPPTDL
0	1		S507	AGAGAtHSPPTDLVW
0	1		T510	GAtHSPPTDLVWkAQ
0	1		K515-a	PPTDLVWkAQNTWGC
2	0		S525-p	NTWGCGNsLRTALIN
0	1		S533-p	LRTALINsTGEEVAM
0	16		S546-p	AMRKLVRsVtVVEDD
0	45		T548-p	RKLVRsVtVVEDDED
0	1		-	gap
0	1		-	gap
0	4		S568	LLHHHHGSHCSSSGD
0	6		S571	HHHGSHCSSSGDPAE
1	2		S573	HGSHCSSSGDPAEYN
0	1		S583-p	PAEYNLRsRtVLCGt
0	1		T585-p	EYNLRsRtVLCGtCG
0	2		T590-p	sRtVLCGtCGQPADk
0	1		K597-a	tCGQPADkASASGSG
0	1		K597-u	tCGQPADkASASGSG
0	1		S612-g	AQVGGPIssGSsAsS
0	2		S613-p	QVGGPIssGSsAsSV
0	2		S616-p	GPIssGSsAsSVTVT
0	2		S618-p	IssGSsAsSVTVTRS
0	1		S619	ssGSsAsSVTVTRSY
0	12		S628-p	TVTRSYRsVGGsGGG
0	15		S632-p	SYRsVGGsGGGsFGD
0	15		S636-p	VGGsGGGsFGDNLVt
0	1		T643-g	sFGDNLVtRSYLLGN
1	0		S651	RSYLLGNSsPRTQsP
1	7		S652-p	SYLLGNSsPRTQsPQ
1	0		S657-p	NSsPRTQsPQNCSIM

	lamin A/C iso2
T3	_____METPSQRRAt
S5	___METPSQRRAtRs
T10-p	TPSQRRAtRsGAQAS
S12-p	SQRRAtRsGAQASSt
S17	tRsGAQASStPLsPT
S18	RsGAQASStPLsPTR
T19-p	sGAQASStPLsPTRI
S22-p	QASStPLsPTRITRL
T24	SStPLsPTRITRLQE
K32	RITRLQEKEDLQELN
S51	VYIDRVRSLETENAG
T64	AGLRLRITESEEVVS
S66	LRLRITESEEVVSRE
S71	TESEEVVSREVSGIK
K78	SREVSGIKAAyEAEL
Y81-p	VSGIKAAyEAELGDA
K90	AELGDARKTLDSVAK
S94	DARKTLDSVAKERAR
K97	KTLDSVAKERARLQL
K97	KTLDSVAKERARLQL
S107	ARLQLELSKVREEFk
K108	RLQLELSKVREEFkE
K108	RLQLELSKVREEFkE
K114-a	SKVREEFkELKARNT
K114	SKVREEFKELKARNT
K135	IAAQARLKDLEALLN
K144	LEALLNSKEAALSTA
K155-a	LSTALSEkRTLEGEL
K155	LSTALSEKRTLEGEL
K171	DLRGQVAKLEAALGE
K180-a	EAALGEAkKQLQDEM
K180	EAALGEAKKQLQDEM
K181	AALGEAkKQLQDEML
T199	DAENRLQTMKEELDF
K201	ENRLQTMKEELDFQK
K201	ENRLQTMKEELDFQK
K208	KEELDFQKNIYSEEL
S212	DFQKNIYSEELRETK
K219	SEELRETKRRHETRL
T224	ETKRRHETRLVEIDN
K233	LVEIDNGKQREFESR
K233	LVEIDNGKQREFESR
K260	EDQVEQYKKELEKTY
K260	EDQVEQYKKELEKTY
K261	DQVEQYKKELEKTYS
K261	DQVEQYKKELEKTYS
K265	QYKKELEKTYSAKLD
K270	LEKTYSAKLDNARQS
K270	LEKTYSAKLDNARQS
S277	KLDNARQSAERNSNL
S301-p	QSRIRIDsLsAQLSQ
S303-p	RIRIDsLsAQLSQLQ
S307	DsLsAQLSQLQKQLA
K311	AQLSQLQKQLAAKEA
K311	AQLSQLQKQLAAKEA
K319	QLAAKEAKLRDLEDS
S326	KLRDLEDSLARERDT
K378	MEIHAYRKLLEGEEE
S390-p	EEERLRLsPsPTsQR
S392-p	ERLRLsPsPTsQRsR
T394	LRLsPsPTsQRsRGR
S395-p	RLsPsPTsQRsRGRA
S398-p	PsPTsQRsRGRAssH
S403-p	QRsRGRAssHssQtQ
S404-p	RsRGRAssHssQtQG
S406-p	RGRAssHssQtQGGG
S407-p	GRAssHssQtQGGGs
T409-p	AssHssQtQGGGsVt
S414-p	sQtQGGGsVtkkRKL
T416-p	tQGGGsVtkkRKLES
K417-a	QGGGsVtkkRKLEST
K417	QGGGsVtKkRKLEST
K418-a	GGGsVtkkRKLESTE
K418	GGGsVtkKRKLESTE
K420	GsVtkkRKLESTESR
K420	GsVtkkRKLESTESR
S423	tkkRKLESTESRSSF
T424	kkRKLESTESRSSFS
S426	RKLESTESRSSFSQH
S429	ESTESRSSFSQHART
S431	TESRSSFSQHARTSG
K450	EEVDEEGKFVRLRNK
K450	EEVDEEGKFVRLRNK
K457	KFVRLRNKsNEDQSM
S458-p	FVRLRNKsNEDQSMG
S463	NKsNEDQSMGNWQIk
K470-a	SMGNWQIkRQNGDDP
K470	SMGNWQIKRQNGDDP
T480	NGDDPLLTYRFPPKF
K486	LTYRFPPKFTLKAGQ
T496	LKAGQVVTIWAAGAG
A500	QVVTIWAAGAGATHS
T505	WAAGAGATHSPPTDL
S507	AGAGATHSPPTDLVW
T510	GATHSPPTDLVWKAQ
K515	PPTDLVWKAQNTWGC
S525	NTWGCGNSLRTALIN
S533	LRTALINSTGEEVAM
S546-p	AMRKLVRsVtVVEDD
T548-p	RKLVRsVtVVEDDED
S568	LLHHHHVSGSRR___
S570	HHHHVSGSRR_____
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse ► Hide Isoforms
T3-p	_____MEtPsQRRAt
S5-p	___MEtPsQRRAtRs
T10-p	tPsQRRAtRsGAQAs
S12-p	sQRRAtRsGAQAsst
S17-p	tRsGAQAsstPLsPT
S18-p	RsGAQAsstPLsPTR
T19-p	sGAQAsstPLsPTRI
S22-p	QAsstPLsPTRITRL
T24	sstPLsPTRITRLQE
K32-u	RITRLQEkEDLQELN
S51	VYIDRVRSLETENAG
T64	AGLRLRITESEEVVS
S66	LRLRITESEEVVSRE
S71	TESEEVVSREVSGIk
K78-u	SREVSGIkAAYEAEL
Y81	VSGIkAAYEAELGDA
K90	AELGDARKTLDSVAk
S94	DARKTLDSVAkERAR
K97	KTLDSVAKERARLQL
K97-u	KTLDSVAkERARLQL
S107-p	ARLQLELskVREEFk
K108	RLQLELsKVREEFkE
K108-u	RLQLELskVREEFkE
K114	skVREEFKELKARNT
K114-u	skVREEFkELKARNT
K135-u	LAAQARLkDLEALLN
K144-u	LEALLNSkEAALSTA
K155	LSTALSEKRTLEGEL
K155-u	LSTALSEkRTLEGEL
K171-u	DLRGQVAkLEAALGE
K180-a	EAALGEAkkQLQDEM
K180-u	EAALGEAkkQLQDEM
K181-u	AALGEAkkQLQDEML
T199-p	DAENRLQtLkEELDF
K201	ENRLQtLKEELDFQk
K201-u	ENRLQtLkEELDFQk
K208-u	kEELDFQkNIYsEEL
S212-p	DFQkNIYsEELRETk
K219-u	sEELRETkRRHEtRL
T224-p	ETkRRHEtRLVEIDN
K233	LVEIDNGKQREFESR
K233-u	LVEIDNGkQREFESR
K260	EDQVEQYKkELEKTY
K260	EDQVEQYKkELEKTY
K261-a	DQVEQYKkELEKTYS
K261	DQVEQYKKELEKTYS
K265	QYKkELEKTYSAkLD
K270-u	LEKTYSAkLDNARQs
K270	LEKTYSAKLDNARQs
S277-p	kLDNARQsAERNSNL
S301-p	QSRIRIDsLsAQLSQ
S303-p	RIRIDsLsAQLSQLQ
S307	DsLsAQLSQLQkQLA
K311	AQLSQLQKQLAAKEA
K311-u	AQLSQLQkQLAAKEA
K319-u	QLAAKEAkLRDLEDs
S326-p	kLRDLEDsLARERDT
K378-u	MEIHAYRkLLEGEEE
S390-p	EEERLRLsPsPtsQR
S392-p	ERLRLsPsPtsQRsR
T394-p	LRLsPsPtsQRsRGR
S395-p	RLsPsPtsQRsRGRA
S398-p	PsPtsQRsRGRAssH
S403-p	QRsRGRAssHssQsQ
S404-p	RsRGRAssHssQsQG
S406-p	RGRAssHssQsQGGG
S407-p	GRAssHssQsQGGGs
S409-p	AssHssQsQGGGsVt
S414-p	sQsQGGGsVtkkRKL
T416-p	sQGGGsVtkkRKLEs
K417-a	QGGGsVtkkRKLEss
K417	QGGGsVtKkRKLEss
K418-a	GGGsVtkkRKLEssE
K418	GGGsVtkKRKLEssE
K420	GsVtkkRKLEssEsR
K420	GsVtkkRKLEssEsR
S423-p	tkkRKLEssEsRSSF
S424-p	kkRKLEssEsRSSFS
S426-p	RKLEssEsRSSFSQH
S429	EssEsRSSFSQHART
S431	sEsRSSFSQHARTSG
K450	EEVDEEGKFVRLRNK
K450-u	EEVDEEGkFVRLRNK
K457	kFVRLRNKsNEDQSM
S458-p	FVRLRNKsNEDQSMG
S463	NKsNEDQSMGNWQIR
R470	SMGNWQIRRQNGDDP
R470	SMGNWQIRRQNGDDP
T480-p	NGDDPLMtYRFPPKF
K486	MtYRFPPKFTLKAGQ
T496	LKAGQVVTIWASGAG
S500	QVVTIWASGAGATHS
T505	WASGAGATHSPPTDL
S507	SGAGATHSPPTDLVW
T510	GATHSPPTDLVWKAQ
K515	PPTDLVWKAQNTWGC
S525-p	NTWGCGSsLRTALIN
S533	LRTALINSTGEEVAM
S546-p	AMRKLVRsLtMVEDN
T548-p	RKLVRsLtMVEDNED
-	gap
-	gap
S570-p	LLHHHRGsHCsGsGD
S573-p	HHRGsHCsGsGDPAE
S575-p	RGsHCsGsGDPAEYN
S585	PAEYNLRSRTVLCGT
T587	EYNLRSRTVLCGTCG
T592	SRTVLCGTCGQPADK
K599	TCGQPADKAAGGAGA
K599	TCGQPADKAAGGAGA
S613	AQVGGSISsGSsAss
S614-p	QVGGSISsGSsAssV
S617-p	GSISsGSsAssVTVT
S619-p	ISsGSsAssVTVTRS
S620-p	SsGSsAssVTVTRSF
S629-p	TVTRSFRsVGGsGGG
S633-p	SFRsVGGsGGGsFGD
S637-p	VGGsGGGsFGDNLVT
T644	sFGDNLVTRSYLLGN
S652-p	RSYLLGNssPRSQSS
S653-p	SYLLGNssPRSQSSQ
S658	NssPRSQSSQNCSIM

	lamin A/C iso3
-	gap
-	gap
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-	gap
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-	gap
-	gap
-	gap
-	gap
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-	gap
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-	gap
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-	gap
-	gap
-	gap
-	gap
K23	LAAQARLKDLEALLN
K32	LEALLNSKEAALSTA
K43	LSTALSEKRTLEGEL
K43	LSTALSEKRTLEGEL
K59	DLRGQVAKLEAALGE
K68	EAALGEAKKQLQDEM
K68	EAALGEAKKQLQDEM
K69	AALGEAKKQLQDEML
T87	DAENRLQTLKEELDF
K89	ENRLQTLKEELDFQK
K89	ENRLQTLKEELDFQK
K96	KEELDFQKNIYSEEL
S100	DFQKNIYSEELRETK
K107	SEELRETKRRHETRL
T112	ETKRRHETRLVEIDN
K121	LVEIDNGKQREFESR
K121	LVEIDNGKQREFESR
K148	EDQVEQYKKELEKTY
K148	EDQVEQYKKELEKTY
K149	DQVEQYKKELEKTYS
K149	DQVEQYKKELEKTYS
K153	QYKKELEKTYSAKLD
K158	LEKTYSAKLDNARQS
K158	LEKTYSAKLDNARQS
S165	KLDNARQSAERNSNL
S189-p	QSRIRIDsLsAQLSQ
S191-p	RIRIDsLsAQLSQLQ
S195	DsLsAQLSQLQKQLA
K199	AQLSQLQKQLAAKEA
K199	AQLSQLQKQLAAKEA
K207	QLAAKEAKLRDLEDS
S214	KLRDLEDSLARERDT
K266	MEIHAYRKLLEGEEE
S278-p	EEERLRLsPsPtsQR
S280-p	ERLRLsPsPtsQRSR
T282-p	LRLsPsPtsQRSRGR
S283-p	RLsPsPtsQRSRGRA
S286	PsPtsQRSRGRASSH
S291	QRSRGRASSHSSQSQ
S292	RSRGRASSHSSQSQG
S294	RGRASSHSSQSQGGG
S295	GRASSHSSQSQGGGS
S297	ASSHSSQSQGGGSVT
S302	SQSQGGGSVTKKRKL
T304	SQGGGSVTKKRKLES
K305	QGGGSVTKKRKLESS
K305	QGGGSVTKKRKLESS
K306	GGGSVTKKRKLESSE
K306	GGGSVTKKRKLESSE
K308	GSVTKKRKLESSESR
K308	GSVTKKRKLESSESR
S311	TKKRKLESSESRSSF
S312	KKRKLESSESRSSFS
S314	RKLESSESRSSFSQH
S317	ESSESRSSFSQHART
S319	SESRSSFSQHARTSG
K338	EEVDEEGKFVRLRNK
K338	EEVDEEGKFVRLRNK
K345	KFVRLRNKsNEDQSM
S346-p	FVRLRNKsNEDQSMG
S351	NKsNEDQSMGNWQIR
R358	SMGNWQIRRQNGDDP
R358	SMGNWQIRRQNGDDP
T368	NGDDPLMTYRFPPKF
K374	MTYRFPPKFTLKAGQ
T384	LKAGQVVTIWASGAG
S388	QVVTIWASGAGATHS
T393	WASGAGATHSPPTDL
S395	SGAGATHSPPTDLVW
T398	GATHSPPTDLVWKAQ
K403	PPTDLVWKAQNTWGC
S413	NTWGCGSSLRTALIN
S421	LRTALINSTGEEVAM
S434-p	AMRKLVRsLtMVEDN
T436-p	RKLVRsLtMVEDNED
S458-p	LLHHHRVsGsRR___
S460-p	HHHRVsGsRR_____
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	rat
T3	_____METPSQRRPT
S5	___METPSQRRPTRS
T10	TPSQRRPTRSGAQAS
S12	SQRRPTRSGAQASST
S17	TRSGAQASSTPLsPT
S18	RSGAQASSTPLsPTR
T19	SGAQASSTPLsPTRI
S22-p	QASSTPLsPTRITRL
T24	SSTPLsPTRITRLQE
K32	RITRLQEKEDLQELN
S51	VYIDRVRSLETENAG
T64	AGLRLRITESEEVVS
S66	LRLRITESEEVVSRE
S71	TESEEVVSREVSGIK
K78	SREVSGIKAAYEAEL
Y81	VSGIKAAYEAELGDA
K90	AELGDARKTLDSVAK
S94	DARKTLDSVAKERAR
K97	KTLDSVAKERARLQL
K97	KTLDSVAKERARLQL
S107	ARLQLELSKVREEFK
K108	RLQLELSKVREEFKE
K108	RLQLELSKVREEFKE
K114	SKVREEFKELKARNT
K114	SKVREEFKELKARNT
K135	LAAQARLKDLEALLN
K144	LEALLNSKEAALSTA
K155	LSTALSEKRTLEGEL
K155	LSTALSEKRTLEGEL
K171	DLRGQVAKLEAALGE
K180	EAALGEAKKQLQDEM
K180	EAALGEAKKQLQDEM
K181	AALGEAKKQLQDEML
T199	DAENRLQTLKEELDF
K201	ENRLQTLKEELDFQK
K201	ENRLQTLKEELDFQK
K208	KEELDFQKNIYSEEL
S212	DFQKNIYSEELRETK
K219	SEELRETKRRHETRL
T224	ETKRRHETRLVEIDN
K233	LVEIDNGKQREFESR
K233	LVEIDNGKQREFESR
K260	EDQVEQYKKELEKTY
K260	EDQVEQYKKELEKTY
K261	DQVEQYKKELEKTYS
K261	DQVEQYKKELEKTYS
K265	QYKKELEKTYSAKLD
K270	LEKTYSAKLDNARQS
K270	LEKTYSAKLDNARQS
S277	KLDNARQSAERNSNL
S301-p	QSRIRIDsLSAQLSQ
S303	RIRIDsLSAQLSQLQ
S307	DsLSAQLSQLQKQLA
K311	AQLSQLQKQLAAKEA
K311	AQLSQLQKQLAAKEA
K319	QLAAKEAKLRDLEDS
S326	KLRDLEDSLARERDT
K378	MEIHAYRKLLEGEEE
S390-p	EEERLRLsPsPTsQR
S392-p	ERLRLsPsPTsQRSR
T394	LRLsPsPTsQRSRGR
S395-p	RLsPsPTsQRSRGRA
S398	PsPTsQRSRGRASsH
S403	QRSRGRASsHSSQSQ
S404-p	RSRGRASsHSSQSQG
S406	RGRASsHSSQSQGGG
S407	GRASsHSSQSQGGGS
S409	ASsHSSQSQGGGSVT
S414	SQSQGGGSVTKKRKL
T416	SQGGGSVTKKRKLES
K417	QGGGSVTKKRKLESS
K417	QGGGSVTKKRKLESS
K418	GGGSVTKKRKLESSE
K418	GGGSVTKKRKLESSE
K420	GSVTKKRKLESSESR
K420	GSVTKKRKLESSESR
S423	TKKRKLESSESRSSF
S424	KKRKLESSESRSSFS
S426	RKLESSESRSSFSQH
S429	ESSESRSSFSQHART
S431	SESRSSFSQHARTSG
K450	EEVDEEGKFVRLRNK
K450	EEVDEEGKFVRLRNK
K457	KFVRLRNKSNEDQSM
S458	FVRLRNKSNEDQSMG
S463	NKSNEDQSMGNWQIK
K470	SMGNWQIKRQNGDDP
K470	SMGNWQIKRQNGDDP
T480	NGDDPLMTYRFPPKF
K486	MTYRFPPKFTLKAGQ
T496-p	LKAGQVVtIWAsGAG
S500-p	QVVtIWAsGAGAtHs
T505-p	WAsGAGAtHsPPtDL
S507-p	sGAGAtHsPPtDLVW
T510-p	GAtHsPPtDLVWKAQ
K515	PPtDLVWKAQNTWGC
S525	NTWGCGTSLRTALIN
A533	LRTALINATGEEVAM
S546	AMRKLVRSLTMVEDN
T548	RKLVRSLTMVEDNDD
-	gap
-	gap
S570	LLHHHRGSHCSSSGD
S573	HHRGSHCSSSGDPAE
S575	RGSHCSSSGDPAEYN
S585	PAEYNLRSRTVLCGT
T587	EYNLRSRTVLCGTCG
T592	SRTVLCGTCGQPADK
K599	TCGQPADKAASGSGA
K599	TCGQPADKAASGSGA
S613	AQVGGSISSGSSASS
S614	QVGGSISSGSSASSV
S617	GSISSGSSASSVTVT
S619	ISSGSSASSVTVTRS
S620	SSGSSASSVTVTRSF
S629	TVTRSFRSVGGSGGG
S633	SFRSVGGSGGGSFGD
S637	VGGSGGGSFGDNLVT
T644	SFGDNLVTRSYLLGN
S652	RSYLLGNSSPRTQSS
S653	SYLLGNSSPRTQSSQ
S658	NSSPRTQSSQNCSIM

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