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Protein Page:
Securin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Securin Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. Belongs to the securin family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein binding; cysteine protease inhibitor activity; SH3 domain binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; mitosis; regulation of transcription, DNA-dependent; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; spermatogenesis; mitotic cell cycle; DNA repair; chromosome organization and biogenesis; chromosome segregation
Reference #:  O95997 (UniProtKB)
Alt. Names/Synonyms: EAP1; Esp1-associated protein; ESP1-associated protein 1; hPTTG; MGC126883; MGC138276; pituitary tumor-transforming 1; Pituitary tumor-transforming gene 1 protein; PTTG; PTTG1; Securin; Tumor-transforming protein 1; TUTR1
Gene Symbols: PTTG1
Molecular weight: 22,024 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Securin

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y6-p __MATLIyVDkENGE
1 0 K9-ub ATLIyVDkENGEPGt
0 1 T16-p kENGEPGtRVVAKDG
0 2 S28-p KDGLKLGsGPsIKAL
1 3 S31-p LKLGsGPsIKALDGR
0 2 S39-p IKALDGRsQVstPRF
0 5 S42-p LDGRsQVstPRFGkT
0 11 T43-p DGRsQVstPRFGkTF
0 2 K48-ac VstPRFGkTFDAPPA
1 1 K48-ub VstPRFGkTFDAPPA
1 0 T66-p ATRKALGtVNRATEK
1 0 S87-p PLKQKQPsFsAKKMT
1 0 S89-p KQKQPsFsAKKMTEK
0 1 T97 AKKMTEKTVKAkSSV
0 1 K101-ub TEKTVKAkSSVPASD
0 1 S102 EKTVKAkSSVPASDD
0 18 Y111-p VPASDDAyPEIEKFF
1 29 S165-p LFQLGPPsPVKMPsP
0 1 S171-p PsPVKMPsPPWESNL
1 0 S183-p SNLLQSPssILSTLD
1 0 S184-p NLLQSPssILSTLDV
  mouse

 
F6 __MATLIFVDKDNEE
K9 ATLIFVDKDNEEPGR
R16 KDNEEPGRRLASKDG
T28 KDGLKLGTGVKALDG
- gap
L37 VKALDGKLQVSTPRV
S40 LDGKLQVSTPRVGKV
T41 DGKLQVSTPRVGKVF
K46 VSTPRVGKVFNAPAV
K46 VSTPRVGKVFNAPAV
T63 ASRKALGTVNRVAEK
T84 PLQPKQPTLTGKKIT
T86 QPKQPTLTGKKITEK
T95-p KKITEKStKTQsSVP
Q98 TEKStKTQsSVPAPD
S99-p EKStKTQsSVPAPDD
Y108 VPAPDDAYPEIEKFF
S162-p LLHLGPPsPLKTPFL
F168 PsPLKTPFLSWESDP
P180 SDPLYSPPSALSTLD
S181 DPLYSPPSALSTLDV
  rat

 
F6 __MATLIFVDKDNEE
K9 ATLIFVDKDNEEPGS
S16 KDNEEPGSRLASKDG
S28 KDGLKLGSGVKALDG
- gap
L37 VKALDGKLQVSTPRV
S40 LDGKLQVSTPRVGKV
T41 DGKLQVSTPRVGKVF
K46 VSTPRVGKVFGAPGL
K46 VSTPRVGKVFGAPGL
T63 ASRKALGTVNRVTEK
T84 PLQSKQPTLSVKKIT
S86 QSKQPTLSVKKITEK
T95 KKITEKSTKTQGSAP
Q98 TEKSTKTQGSAPAPD
S100 KSTKTQGSAPAPDDA
Y108 APAPDDAYPEIEKFF
S162-p LLHLDPPsPLQKPFL
F168 PsPLQKPFLPWESDP
P180 SDPLPSPPSALSALD
S181 DPLPSPPSALSALDV
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