Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Securin (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Securin Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. Belongs to the securin family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein binding; cysteine protease inhibitor activity; SH3 domain binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; mitosis; regulation of transcription, DNA-dependent; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; spermatogenesis; mitotic cell cycle; DNA repair; chromosome organization and biogenesis; chromosome segregation
Reference #:  O95997 (UniProtKB)
Alt. Names/Synonyms: EAP1; Esp1-associated protein; ESP1-associated protein 1; hPTTG; MGC126883; MGC138276; pituitary tumor-transforming 1; Pituitary tumor-transforming gene 1 protein; PTTG; PTTG1; Securin; Tumor-transforming protein 1; TUTR1
Gene Symbols: PTTG1
Molecular weight: 22,024 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Securin

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K9-u ATLIYVDkENGEPGt
0 1 T16-p kENGEPGtRVVAKDG
0 1 S28-p KDGLKLGsGPSIKAL
0 2 S39-p IKALDGRsQVstPRF
0 5 S42-p LDGRsQVstPRFGkT
0 11 T43-p DGRsQVstPRFGkTF
0 2 K48-a VstPRFGkTFDAPPA
1 1 K48-u VstPRFGkTFDAPPA
0 1 V98 KKMTEKTVKAkSSVP
0 1 K101-u TEKTVKAkSSVPASD
0 1 S102 EKTVKAkSSVPASDD
0 18 Y111-p VPASDDAyPEIEKFF
1 25 S165-p LFQLGPPsPVKMPSP
1 0 S183-p SNLLQSPssILSTLD
1 0 S184-p NLLQSPssILSTLDV
  mouse

 
K9 ATLIFVDKDNEEPGR
R16 KDNEEPGRRLASKDG
T28 KDGLKLGTGVKALDG
L37 VKALDGKLQVSTPRV
S40 LDGKLQVSTPRVGKV
T41 DGKLQVSTPRVGKVF
K46 VSTPRVGKVFNAPAV
K46 VSTPRVGKVFNAPAV
T95-p KKITEKStKTQsSVP
Q98 TEKStKTQsSVPAPD
S99-p EKStKTQsSVPAPDD
Y108 VPAPDDAYPEIEKFF
S162-p LLHLGPPsPLKTPFL
P180 SDPLYSPPSALSTLD
S181 DPLYSPPSALSTLDV
  rat

 
K9 ATLIFVDKDNEEPGS
S16 KDNEEPGSRLASKDG
S28 KDGLKLGSGVKALDG
L37 VKALDGKLQVSTPRV
S40 LDGKLQVSTPRVGKV
T41 DGKLQVSTPRVGKVF
K46 VSTPRVGKVFGAPGL
K46 VSTPRVGKVFGAPGL
- under review  
- under review  
- under review  
Y108 APAPDDAYPEIEKFF
S162 LLHLDPPSPLQKPFL
P180 SDPLPSPPSALSALD
S181 DPLPSPPSALSALDV
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.