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Protein Page:
Snail1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Snail1 a protein of the C2H2-type zinc-finger family that regulates transcription. Involved in embryonic mesoderm formation. Plays a role in the epithelial to mesenchymal transition (EMT). EMT is characterized by decreased levels of the epithelial markers E-cadherin and alpha- and beta-catenin, and increased cellular migration and expression of the mesenchymal markers fibronectin, vimentin, N-cadherin and smooth muscle alpha-actin.E Snail binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription. NF-kappaB binds and regulates the snail promoter and is critical for EMT, and inhibition of NF-kappaB activity lowered snail levels and morphologically reversed the EMT. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; metal ion binding; kinase binding
Biological Process: osteoblast differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; cell migration; hair follicle morphogenesis; mesoderm formation; positive regulation of transcription, DNA-dependent; epithelial to mesenchymal transition; palate development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell migration
Reference #:  O95863 (UniProtKB)
Alt. Names/Synonyms: dJ710H13.1; Protein sna; Protein snail homolog 1; SLUGH2; SNA; SNAH; SNAI1; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail homolog 1 (Drosophila); Zinc finger protein SNAI1
Gene Symbols: SNAI1
Molecular weight: 29,083 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Snail1

Protein Structure Not Found.


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Sites Implicated In
carcinogenesis, altered: S11‑p
carcinogenesis, induced: T203‑p
cell cycle regulation: T203‑p
cell motility, altered: S96‑p, S100‑p, S107‑p, S111‑p, S115‑p, S119‑p, T203‑p
cell motility, induced: S112‑gl
transcription, altered: S11‑p, S92‑p, S96‑p, S100‑p, S104‑p, S107‑p, S111‑p, S115‑p, S119‑p, S246‑p
transcription, inhibited: S112‑gl
activity, induced: S104‑p, S107‑p
activity, inhibited: S11‑p, S92‑p
intracellular localization: S11‑p, S96‑p, S100‑p, S107‑p, S111‑p, S115‑p, S119‑p, T203‑p, S246‑p
molecular association, regulation: S11‑p, S92‑p
phosphorylation: S112‑gl
protein degradation: S11‑p, S92‑p, S96‑p, S100‑p, S104‑p, S107‑p
protein stabilization: S11‑p, S112‑gl, T203‑p
ubiquitination: S96‑p, S100‑p, S104‑p, S107‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
4 0 S11-p SFLVRKPsDPNRKPN
2 0 S82-p ASLRLQEsPRVAELT
0 1 S90-p PRVAELTsLsDEDsG
2 2 S92-p VAELTsLsDEDsGKG
4 0 S96-p TsLsDEDsGKGsQPP
3 0 S100-p DEDsGKGsQPPsPPs
4 0 S104-p GKGsQPPsPPsPAPs
5 0 S107-p sQPPsPPsPAPssFS
2 0 S111-p sPPsPAPssFSsTSV
1 1 S112-gl PPsPAPssFSsTSVs
2 0 S115-p PAPssFSsTSVsSLE
2 0 S119-p sFSsTSVsSLEAEAY
1 1 T203-p QGHVRTHtGEKPFSC
2 0 S246-p QACARTFsRMSLLHK
  mouse

 
S11 SFLVRKPSDPRRKPN
S82 ATLPLRESPKAVELT
S90 PKAVELTSLSDEDSG
S92 AVELTSLSDEDSGKS
S96 TSLSDEDSGKSSQPP
S100 DEDSGKSSQPPSPPS
S104 GKSSQPPSPPSPAPS
S107 SQPPSPPSPAPSSFS
S111 SPPSPAPSSFSSTSA
S112 PPSPAPSSFSSTSAS
S115 PAPSSFSSTSASSLE
S119 SFSSTSASSLEAEAF
T203 QGHVRTHTGEKPFSC
S246 QACARTFSRMSLLHK
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