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Protein Page:
CDK7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDK7 a protein kinase of the CDK family. Forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). Activates the cyclin-associated kinases CDK1, -2, -4 and -6. An essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. Serves as a direct link between the regulation of transcription and the cell cycle. Phosphorylates and activates RNA polymerase II, allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CMGC; EC 2.7.11.22; Nuclear receptor co-regulator; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.23; CMGC group; CDK family; CDK/CDK7 subfamily; CDK7 subfamily
Cellular Component: nucleoplasm; holo TFIIH complex; mitochondrion; perinuclear region of cytoplasm; cytoplasm; nucleus
Molecular Function: protein C-terminus binding; RNA polymerase subunit kinase activity; DNA-dependent ATPase activity; protein binding; androgen receptor binding; cyclin-dependent protein kinase activity; transcription coactivator activity; ATP binding; protein kinase activity
Biological Process: transcription from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; mRNA capping; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA damage removal; cell cycle arrest; G2/M transition of mitotic cell cycle; ATP catabolic process; transcription initiation from RNA polymerase II promoter; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; DNA repair; termination of RNA polymerase I transcription; cell proliferation; nucleotide-excision repair; cell division; RNA elongation from RNA polymerase II promoter; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; gene expression; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; transcription initiation from RNA polymerase I promoter; G1/S transition of mitotic cell cycle
Reference #:  P50613 (UniProtKB)
Alt. Names/Synonyms: 39 kDa protein kinase; CAK; CAK1; CDK-activating kinase; CDK7; CDKN7; Cell division protein kinase 7; cyclin-dependent kinase 7; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; MO15; p39 Mo15; p39MO15; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; STK1; TFIIH basal transcription factor complex kinase subunit
Gene Symbols: CDK7
Molecular weight: 39,038 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDK7

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell cycle regulation: S164‑p
transcription, altered: S164‑p, T170‑p
enzymatic activity, induced: T170‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S7-p _MALDVKsRAKRYEK
0 1 K139-ub WILHRDLkPNNLLLD
0 1 K160-ub LADFGLAksFGsPNR
1 5 S161-p ADFGLAksFGsPNRA
3 42 S164-p GLAksFGsPNRAytH
0 1 Y169-p FGsPNRAytHQVVTR
3 121 T170-p GsPNRAytHQVVTRW
0 1 T287-p PCARITAtQALkMKY
0 1 K291-ub ITAtQALkMKYFSNR
0 3 S321-p VETLKEQsNPALAIk
0 1 K328-ub sNPALAIkRKRtEAL
0 1 T332-p LAIkRKRtEALEQGG
  mouse

 
S7 _MAVDVKSRAKRYEK
K139 WILHRDLKPNNLLLD
K160 LADFGLAKsFGsPNR
S161-p ADFGLAKsFGsPNRA
S164-p GLAKsFGsPNRAytH
Y169-p FGsPNRAytHQVVTR
T170-p GsPNRAytHQVVTRW
S287 PCTRTTASQALKTKY
K291 TTASQALKTKYFSNR
A321 VEALKEPANPTVATK
K328 ANPTVATKRKRAEAL
A332 VATKRKRAEALEQGI
  rat

 
- gap
K131 WILHRDLKPNNLLLD
K152 LADFGLAKSFGsPNW
S153 ADFGLAKSFGsPNWA
S156-p GLAKSFGsPNWAYtH
Y161 FGsPNWAYtHQVVTR
T162-p GsPNWAYtHQVVTRW
S279 PCTRITASQALRTKY
R283 ITASQALRTKYFSNR
S313 VEALKEQSNPAMATK
K320 SNPAMATKRKRAEAL
A324 MATKRKRAEALEQ__
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