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Protein Page:
JMJD2B (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
JMJD2B Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Demethylase; EC 1.14.11.-
Cellular Component: nucleus
Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; zinc ion binding
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification
Reference #:  O94953 (UniProtKB)
Alt. Names/Synonyms: FLJ44906; JHDM3B; JmjC domain-containing histone demethylation protein 3B; JMJD2B; jumonji domain containing 2B; Jumonji domain-containing protein 2B; KDM4B; KIAA0876; lysine (K)-specific demethylase 4B; Lysine-specific demethylase 4B
Gene Symbols: KDM4B
Molecular weight: 121,897 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JMJD2B
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 Y31-p EFKDFNKyVAyIEsQ
0 2 Y34-p DFNKyVAyIEsQGAH
0 1 S37-p KyVAyIEsQGAHRAG
0 1 T305 IDYGKVATQCTCRKD
0 1 T345-p DLTVLDHtRPTALTs
0 1 S352-p tRPTALTsPELSSWS
0 2 S364-p SWSASRAsLKAKLLR
0 1 - gap
0 1 S373 KAKLLRRSHRKRSQP
0 1 K381-a HRKRSQPkKPkPEDP
0 1 K384-a RSQPkKPkPEDPKFP
0 3 F390 PkPEDPKFPGEGTAG
0 1 K409-a EEAGGSVkEEAGPEV
0 1 L462 KKKSFGLLPPQLPPP
0 1 P467 GLLPPQLPPPPAHFP
0 1 S475 PPPAHFPSEEALWLP
0 3 S566-p PTWKEPVsPMELTGP
0 1 S579-p GPEDGAAsSGAGRME
0 1 K602-a QAPSTFSkLKMEIKK
0 2 S622-p LGRPPTRsPLsVVKQ
0 1 S625-p PPTRsPLsVVKQEAs
0 3 S632-p sVVKQEAssDEEASP
0 3 S633-p VVKQEAssDEEASPF
0 1 S707-p EKEAPIAsLGKGCPA
0 1 S1039 KRVRSRLSLSTGAPQ
0 1 K1056-u AFSGEEAkAAKRPRV
0 86 T1065-p AKRPRVGtPLAtEDS
0 7 T1069-p RVGtPLAtEDSGRSQ
0 2 Y1078-p DSGRSQDyVAFVESL
  mouse

► Hide Isoforms 		 
Y31 EFRDFNRYVAYIESQ
Y34 DFNRYVAYIESQGAH
S37 RYVAYIESQGAHRAG
T305-p IDYGKVAtQCTCRKD
T345 DLTVLDHTRPTALSS
S352 TRPTALSSPELSSWS
S364 SWSASRTSIKAKLLR
S375-p KLLRRQIsVKESRPW
S401-p TRRPGPAsHRRRSQP
K409 HRRRSQPKKSKPEES
K412 RSQPKKSKPEESRsP
S418-p SKPEESRsPGEATAG
R437 DEARGCSRGEAMPED
S485-p KKTPSPSsPPLLsAP
S490-p PSsPPLLsAPPALFP
T498-p APPALFPtEEVLRPP
A574 HSAHAQLAPMELGPE
- gap
K599 QGTTPFSKLKVEIKK
S619 LGRPPTRSPLSVVKQ
S622 PPTRSPLSVVKQEAs
S629-p SVVKQEAssDEEAFL
S630-p VVKQEAssDEEAFLF
- gap
S1027-p KRVRSRLsLSTGTPQ
K1044 SFSGDDVKAAKRPRV
S1053 AKRPRVASVLATTTE
T1057 RVASVLATTTEDTGR
Y1068 DTGRSPEYLSFMESL
  JMJD2B iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
A45 HSAHAQLAPMELGPE
- gap
- gap
S83 LGRPPTRSPLSVVKQ
S86 PPTRSPLSVVKQEAs
S93-p SVVKQEAssDEGEDD
S94-p VVKQEAssDEGEDDV
- gap
S485 KRVRSRLSLSTGTPQ
K502 SFSGDDVKAAKRPRV
S511 AKRPRVASVLATTTE
T515 RVASVLATTTEDTGR
Y526 DTGRSPEYLSFMESL
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