Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
JMJD2B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JMJD2B Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.11.-; Oxidoreductase; Demethylase
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: focal adhesion; cell junction; nucleus
Molecular Function: zinc ion binding; dioxygenase activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification
Reference #:  O94953 (UniProtKB)
Alt. Names/Synonyms: FLJ44906; JHDM3B; JmjC domain-containing histone demethylation protein 3B; JMJD2B; jumonji domain containing 2B; Jumonji domain-containing protein 2B; KDM4B; KIAA0876; lysine (K)-specific demethylase 4B; Lysine-specific demethylase 4B
Gene Symbols: KDM4B
Molecular weight: 121,897 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JMJD2B

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y31-p EFKDFNKyVAyIEsQ
0 2 Y34-p DFNKyVAyIEsQGAH
0 1 S37-p KyVAyIEsQGAHRAG
0 1 T305 IDYGKVATQCTCRKD
1 0 K337-ub YELWKQGkDLTVLDH
0 1 T345-p DLTVLDHtRPTALTs
0 1 S352-p tRPTALTsPELSSWS
0 2 S364-p SWSASRAsLKAKLLR
0 1 - gap
0 1 - gap
0 1 S373 KAKLLRRSHRKRSQP
0 1 K381-ac HRKRSQPkKPkPEDP
0 1 K384-ac RSQPkKPkPEDPKFP
0 3 F390 PkPEDPKFPGEGTAG
0 1 K409-ac EEAGGSVkEEAGPEV
0 2 L462 KKKSFGLLPPQLPPP
0 1 P467 GLLPPQLPPPPAHFP
0 1 S475 PPPAHFPSEEALWLP
1 0 K562-ub AQKGPTWkEPVsPME
0 5 S566-p PTWkEPVsPMELTGP
0 1 S579-p GPEDGAAsSGAGRME
0 1 K602-ac QAPSTFSkLKMEIKK
0 3 S622-p LGRPPTRsPLsVVKQ
0 1 S625-p PPTRsPLsVVKQEAs
0 3 S632-p sVVKQEAssDEEASP
0 3 S633-p VVKQEAssDEEASPF
0 1 S707-p EKEAPIAsLGKGCPA
0 1 S1039 KRVRSRLSLSTGAPQ
0 1 K1056-ub AFSGEEAkAAKRPRV
0 97 T1065-p AKRPRVGtPLAtEDS
0 7 T1069-p RVGtPLAtEDSGRSQ
0 2 Y1078-p DSGRSQDyVAFVESL
  mouse

► Hide Isoforms
 
Y31 EFRDFNRYVAYIESQ
Y34 DFNRYVAYIESQGAH
S37 RYVAYIESQGAHRAG
T305-p IDYGKVAtQCTCRKD
R337 YEQWKQGRDLTVLDH
T345 DLTVLDHTRPTALSS
S352 TRPTALSSPELSSWS
S364 SWSASRTSIKAKLLR
S375-p KLLRRQIsVKESRPW
T394-p EERRREPtRRPGPAs
S401-p tRRPGPAsHRRRSQP
K409 HRRRSQPKKSKPEES
K412 RSQPKKSKPEESRsP
S418-p SKPEESRsPGEATAG
R437 DEARGCSRGEAMPED
S485-p KKTPSPSsPPLLsAP
S490-p PSsPPLLsAPPALFP
T498-p APPALFPtEEVLRPP
- gap
- gap
- gap
K599 QGTTPFSKLKVEIKK
S619-p LGRPPTRsPLSVVKQ
S622 PPTRsPLSVVKQEAs
S629-p SVVKQEAssDEEAFL
S630-p VVKQEAssDEEAFLF
- gap
S1027-p KRVRSRLsLSTGTPQ
K1044 SFSGDDVKAAKRPRV
S1053-p AKRPRVAsVLATTTE
T1057 RVAsVLATTTEDTGR
Y1068 DTGRSPEYLSFMESL
  JMJD2B iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S83 LGRPPTRSPLSVVKQ
S86 PPTRSPLSVVKQEAs
S93-p SVVKQEAssDEGEDD
S94-p VVKQEAssDEGEDDV
- gap
S485 KRVRSRLSLSTGTPQ
K502 SFSGDDVKAAKRPRV
S511 AKRPRVASVLATTTE
T515 RVASVLATTTEDTGR
Y526 DTGRSPEYLSFMESL
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.