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Protein Page:
KIF1B (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
KIF1B a member of the kinesin motor protein family. Motor for anterograde transport of mitochondria. May play a role in synaptic vesicle transport. Has a microtubule plus end-directed motility. Aberrant expression seen in neuroblastoma. Mutated in Charcot-Marie-Tooth disease. Note: This description may include information from UniProtKB.
Protein type: Microtubule binding protein; Motor protein
Cellular Component: microtubule; neuron projection; microtubule associated complex; cytoplasmic vesicle membrane; mitochondrion; cytoplasmic vesicle
Molecular Function: protein binding; kinesin binding; ATPase activity; phospholipid binding; microtubule motor activity; ATP binding
Biological Process: apoptosis; neuromuscular synaptic transmission; nerve-nerve synaptic transmission; cytoskeleton-dependent intracellular transport; anterograde axon cargo transport; microtubule-based movement; mitochondrion transport along microtubule
Reference #:  O60333 (UniProtKB)
Alt. Names/Synonyms: CMT2; CMT2A; CMT2A1; FLJ23699; HMSNII; KIAA0591; KIAA1448; KIF1B; kinesin family member 1B; kinesin superfamily protein KIF1B; Kinesin-like protein KIF1B; Klp; MGC134844; NBLST1
Gene Symbols: KIF1B
Molecular weight: 204,476 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
Select Structure to View Below

KIF1B
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 K7-a _MSGASVkVAVRVRP
0 1 S69 PEDPCFASQNRVYND
0 1 N71 DPCFASQNRVYNDIG
0 1 Y74 FASQNRVYNDIGKEM
0 4 K201-u DLMDAGNkARTVAAT
0 2 K243-u LSTEKVSkISLVDLA
0 1 T276 ANINKSLTTLGKVIS
0 1 K294 EVDNCTSKSKKKKKT
0 1 K367 INEDPNAKLVRELKE
0 1 K407 DYSGSGSKYLKDFQN
0 1 K410 GSGSKYLKDFQNNKH
0 2 T467-p IQERIMStPGGEEAI
0 4 S527-p GGTLGVFsPKKTPHL
0 1 K552-u ECLLYYIkDGITRVG
0 2 T647-p ARAEREKtPSAETPS
0 1 T652 EKtPSAETPSEPVDW
0 1 K690 QEMEILYKKEKEEAD
0 1 Y707-p LEQQRLDyEsKLQAL
0 1 S709-p QQRLDyEsKLQALQK
0 1 K784-u NAISVELkKKVQFQF
0 1 K1033 IRQSGTAKIsFDNEy
0 1 S1035-p QSGTAKIsFDNEyFN
0 8 Y1040-p KIsFDNEyFNQSDFS
0 2 S1054-p SSVAMTRsGLsLEEL
0 19 S1057-p AMTRsGLsLEELRIV
0 5 T1075-p GQSSEVItPPEEISR
0 6 K1089-u RINDLDLkSSTLLDG
0 3 K1156-u AFSTEPLkNNGRGsP
0 1 S1162-p LkNNGRGsPLAFYHV
0 1 K1228-u PPPMPLSkPVPATKL
0 2 T1241-p KLNTMSKtSLGQSMS
0 1 S1363 RFEAVWDSSLHNSLL
0 1 S1364 FEAVWDSSLHNSLLL
0 2 S1416-p YSRDAKIsPPRSLRS
0 1 S1420 AKIsPPRSLRSLFGS
0 1 S1427 SLRSLFGSGYSKsPD
0 1 Y1429 RSLFGSGYSKsPDsN
0 1 S1432-p FGSGYSKsPDsNRVT
0 1 S1435-p GYSKsPDsNRVTGIY
0 12 S1454-p CKMSDTGsPGMQRRR
0 122 S1487-p GWRPRGDsLILEHQW
0 1 K1584 REKELATKCLQLLTH
0 2 T1592-p CLQLLTHtFNREFsQ
0 1 S1598-p HtFNREFsQVHGSVS
0 1 S1605 sQVHGSVSDCKLsDI
0 1 S1610-p SVSDCKLsDIsPIGR
0 3 S1613-p DCKLsDIsPIGRDPs
0 4 S1620-p sPIGRDPsESSFSSA
0 1 S1632-p SSATLTPsSTCPSLV
0 1 S1641-p TCPSLVDsRSNsLDQ
0 2 S1645-p LVDsRSNsLDQKtPE
0 4 T1650-p SNsLDQKtPEANsRA
0 1 S1655-p QKtPEANsRAsSPCP
0 2 S1658-p PEANsRAsSPCPEFE
0 1 S1659 EANsRAsSPCPEFEQ
0 1 K1720-a PLYSNWAkHFVVVRR
0 5 - gap
0 5 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 7 - gap
0 52 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 12 - gap
0 62 - gap
11993 : Phospho-KIF1B (Ser1487) Antibody
  KIF1B iso3  
K7 _MSGASVKVAVRVRP
S69 PEDPCFASQNRVYND
N71 DPCFASQNRVYNDIG
Y74 FASQNRVYNDIGKEM
K201 DLMDAGNKARTVAAT
K243 LSTEKVSKISLVDLA
T276-p ANINKSLtTLGKVIS
- gap
K361 INEDPNAKLVRELKE
- gap
- gap
T421 IQERIMSTPGGEEAI
S481 GGTLGVFSPKKTPHL
K506 ECLLYYIKDGITRVG
T601-p ARAEREKtPSAETPS
T606 EKtPSAETPSEPVDW
K644 QEMEILYKKEKEEAD
- gap
- gap
- gap
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- gap
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S663-p QQRLDADsDsGDDSD
S665-p RLDADsDsGDDSDKR
S724-p IPQRRRLsKDSKWVT
S733-p DSKWVTIsDLKIQAV
K930-u RQEQIRFkNLQQQEI
K939-u LQQQEITkQLRRQNV
S1051-p PPQLRWRsNsLNNGQ
S1053-p QLRWRsNsLNNGQPK
S1099-p HIHQHRQsyCNYNTG
Y1100-p IHQHRQsyCNYNTGG
T1121-p ATSYQKQtDKPSHCS
S1125 QKQtDKPSHCSQFVt
T1132-p SHCSQFVtPPRMRRQ
S1141-p PRMRRQFsAPNLKAG
  mouse

► Hide Isoforms 		 
K7 _MSGASVKVAVRVRP
S69 PEDPCFASQNRVYND
N71 DPCFASQNRVYNDIG
Y74 FASQNRVYNDIGKEM
K201-u DLMDAGNkARTVAAT
K243 LSTEKVSKISLVDLA
T276 ANINKSLTTLGKVIS
K294-u EVDNCTSkSKKKKKT
K367-u INEDPNAkLVRELKE
K407-u DYSGSGGkYLkDFQN
K410-u GSGGkYLkDFQNNKH
T467 IQERIMSTPGGEEAI
S527-p GGTLGVFsPKKTPHL
K552 ECLLYYIKDGITRVG
T647-p ARAEREKtPSAEtPS
T652-p EKtPSAEtPSEPVDW
K690-a QEMEILYkKEKEEAD
Y707 LEQQRLDYESKLQAL
S709 QQRLDYESKLQALQR
K784 NAISVELKKKVQFQF
K1033-u IRQSGTAkISFDNEY
S1035 QSGTAkISFDNEYFN
Y1040 kISFDNEYFNQSDFS
S1054-p SSAAMTRsGLsLEEL
S1057-p AMTRsGLsLEELRIV
S1075-p GQSSEVIsPPEEVNR
K1089-u RMNDLDLkSGTLLDG
K1156 AFSTEPLKNNGRGSP
S1162 LKNNGRGSPLGFYHV
K1228 PPPMPLSKPVPATKL
T1241 KLNTMNKTTLGQSMS
S1363-p RFEAVWDssLHNSLL
S1364-p FEAVWDssLHNSLLL
S1416-p YSRDAKIsPPRsLRN
S1420-p AKIsPPRsLRNLFGs
S1427-p sLRNLFGsGySKSPD
Y1429-p RNLFGsGySKSPDSN
S1432 FGsGySKSPDSNRVT
S1435 GySKSPDSNRVTGIY
S1454-p CKMADTGsPGMQRRR
S1487-p GWRPRGDsLILEHQW
K1584-u REKELATkCLQLLTH
T1592 CLQLLTHTFNREFSQ
S1598 HTFNREFSQVHGSIs
S1605-p SQVHGSIsDCKLSDI
S1610 SIsDCKLSDIsPIGR
S1613-p DCKLSDIsPIGRDPS
S1620 sPIGRDPSVSSFSSS
S1632 SSSTLTPSSTCPSLV
S1641 TCPSLVDSRSSsMDQ
S1645-p LVDSRSSsMDQKtPE
T1650-p SSsMDQKtPEANsRA
S1655-p QKtPEANsRAssPCQ
S1658-p PEANsRAssPCQEFE
S1659-p EANsRAssPCQEFEQ
K1720 PLSSNWAKHFVVVRR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
11993 : Phospho-KIF1B (Ser1487) Antibody
  KIF1B iso3  
K7 _MSGASVKVAVRVRP
S69 PEDPCFASQNRVYND
N71 DPCFASQNRVYNDIG
Y74 FASQNRVYNDIGKEM
K201 DLMDAGNKARTVAAT
K243 LSTEKVSKISLVDLA
T276 ANINKSLTTLGKVIS
- gap
K361 INEDPNAKLVRELKE
- gap
- gap
T421 IQERIMSTPGGEEAI
S481 GGTLGVFSPKKTPHL
K506 ECLLYYIKDGITRVG
T601 ARAEREKTPSAETPS
T606 EKTPSAETPSEPVDW
K644 QEMEILYKKEKEEAD
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S663-p QQRLDADsDsGDDSD
S665-p RLDADsDsGDDSDKR
S724 IPQRRRLSKDSKWVT
S733 DSKWVTISDLKIQAV
K930 RQEQIRFKNLQQQEI
K939 LQQQEITKQLRRQNV
S1048 PPQLRWRSNsLNNGQ
S1050-p QLRWRSNsLNNGQPK
P1096 HIHQHRQPYCNYNTG
Y1097 IHQHRQPYCNYNTGG
T1118 ASCCQKQTDKPsHCN
S1122-p QKQTDKPsHCNQFVt
T1129-p sHCNQFVtPPRMRRQ
S1138-p PRMRRQFsAPNLKAG
  rat

 
K7 _MSGASVKVAVRVRP
S69-p PEDPCFAsQsRVyND
S71-p DPCFAsQsRVyNDIG
Y74-p FAsQsRVyNDIGKEM
K201-u DLMDAGNkARTVAAT
K243 LSTEKVSKISLVDLA
T276 ANINKSLTTLGKVIS
K294 EVDNCTSKSKKKKKT
K367 INEDPNAKLVRELKE
K407 DYSGSGGKYLKDFQN
K410 GSGGKYLKDFQNNKH
T467 IQERIMSTPGGEEAI
S527 GGTLGVFSPKKTPHL
K552 ECLLYYIKDGITRVG
T647 ARAEREKTPSAETPS
T652 EKTPSAETPSEPVDW
K690 QEMEILYKREKEEAD
Y707 LEQQRLDYESKLQAL
S709 QQRLDYESKLQALQK
K784 NAISVELKKKVQFQF
K1033 IRQSGTAKISFDNEY
S1035 QSGTAKISFDNEYFN
Y1040 KISFDNEYFNQSDFP
S1054 PSAAMTRSGLsLEEL
S1057-p AMTRSGLsLEELRIV
S1075 GQSSEVISPPEEVNR
K1089 RMNDLDLKSGTLLDG
K1156 AFSTEPLKNNGRGSP
S1162 LKNNGRGSPLGFYHV
R1228 PPPMPLSRPVPATKL
T1241 KLNTMNKTSLGQSMS
S1363 RFEAVWDSSLHNSLL
S1364 FEAVWDSSLHNSLLL
S1416 YSRDAKISPPRSLRN
S1420 AKISPPRSLRNLFGS
S1427 SLRNLFGSGYSKSPD
Y1429 RNLFGSGYSKSPDSN
S1432 FGSGYSKSPDSNRVT
S1435 GYSKSPDSNRVTGIY
S1454-p CKMADTGsPGMQRRR
S1487-p GWRPRGDsLILEHQW
K1584 REKELATKCLQLLTH
T1592 CLQLLTHTFNREFSQ
S1598 HTFNREFSQVHGSIS
S1605 SQVHGSISDCKLSDI
S1610 SISDCKLSDISPIGR
S1613 DCKLSDISPIGRDPS
S1620 SPIGRDPSVSSFSSS
S1632 SSSTLTPSSTCPSLV
S1641 TCPSLVDSRSSSMDQ
S1645 LVDSRSSSMDQKTPE
T1650 SSSMDQKTPEANSRA
S1655 QKTPEANSRAsSPCQ
S1658-p PEANSRAsSPCQEFE
S1659 EANSRAsSPCQEFEQ
K1720 PLSSNWAKHFVVVRR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
11993 : Phospho-KIF1B (Ser1487) Antibody
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