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Protein Page:
SGTA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SGTA Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. Homooligomerize. Interacts with NS1 from parvovirus H-1, with Vpu and Gag from HIV-1. Interacts with SARS- CoV accessory protein 7a. Interacts with DNAJC5 and DNAJC5B. Ubiquitous. Belongs to the SGT family. Note: This description may include information from UniProtKB.
Protein type: Chaperone
Cellular Component: cytoplasm
Molecular Function: protein binding
Biological Process: viral reproduction
Reference #:  O43765 (UniProtKB)
Alt. Names/Synonyms: Alpha-SGT; alphaSGT; hSGT; protein containing three tetratricopeptide repeats; SGT; SGT1; SGTA; small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; Small glutamine-rich tetratricopeptide repeat-containing protein alpha; UBP; Vpu-binding protein
Gene Symbols: SGTA
Molecular weight: 34,063 Da
Basal Isoelectric point: 4.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SGTA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K4-ac ____MDNkKRLAyAI
0 5 Y9-p DNkKRLAyAIIQFLH
0 35 S77-p EMPQDLRsPARtPPs
0 56 T81-p DLRsPARtPPsEEDS
0 5 S84-p sPARtPPsEEDSAEA
0 1 K95-ub SAEAERLkTEGNEQM
0 3 K103 TEGNEQMKVENFEAA
0 3 K116-ub AAVHFYGkAIELNPA
0 32 K137-ub NRAAAYSkLGNyAGA
0 3 K137-ac NRAAAYSkLGNyAGA
0 3 Y141-p AYSkLGNyAGAVQDC
0 8 Y158-p AICIDPAyskAyGRM
0 1 S159-p ICIDPAyskAyGRMG
0 109 K160-ub CIDPAyskAyGRMGL
0 2 Y162-p DPAyskAyGRMGLAL
0 1 S171-p RMGLALSsLNKHVEA
0 1 K174 LALSsLNKHVEAVAY
0 1 K183-ub VEAVAYYkkALELDP
0 3 K184-ub EAVAYYkkALELDPD
0 4 K196-ub DPDNETYkSNLkIAE
0 69 K200-ub ETYkSNLkIAELkLR
0 9 K205-ub NLkIAELkLREAPSP
0 12 S297-p ELIEQLRsQIRsRtP
0 96 S301-p QLRsQIRsRtPsAsN
0 112 T303-p RsQIRsRtPsAsNDD
0 590 S305-p QIRsRtPsAsNDDQQ
0 138 S307-p RsRtPsAsNDDQQE_
8664 : Phospho-SGTA (Ser305) (D23E10) Rabbit mAb
  mouse

 
R4 ____MDNRKRLAYAI
Y9 DNRKRLAYAIIQFLH
A78 EMPQDPRAPDRtPPs
T82-p DPRAPDRtPPsEEDS
S85-p APDRtPPsEEDSAEA
K96 SAEAERLKTEGNEQM
K104-ub TEGNEQMkLENFEAA
K117 AAVHLYGKAIELNPA
K138-ub NRAAAYSkLGNYVGA
K138 NRAAAYSKLGNYVGA
Y142 AYSkLGNYVGAVQDC
Y159-p AIGIDPGySkAYGRM
S160 IGIDPGySkAYGRMG
K161-ub GIDPGySkAYGRMGL
Y163 DPGySkAYGRMGLAL
S172 RMGLALSSLNkHAEA
K175-ub LALSSLNkHAEAVAY
K184 AEAVAYYKkALELDP
K185-ub EAVAYYKkALELDPD
K197-ub DPDNDTYkSNLkIAE
K201-ub DTYkSNLkIAELkLR
K206-ub NLkIAELkLREAPSP
S298-p EFVEQIRsQVVRsRt
S303-p IRsQVVRsRtPsAsH
T305-p sQVVRsRtPsAsHEE
S307-p VVRsRtPsAsHEEQQ
S309-p RsRtPsAsHEEQQE_
  rat

 
R4 ____MDNRKRLAYAI
Y9 DNRKRLAYAIIQFLH
G77 EMPQDPRGPDRtPPS
T81-p DPRGPDRtPPSEEDS
S84 GPDRtPPSEEDSAEA
K95 SAEAERLKTEGNEQM
K103 TEGNEQMKLENFEAA
K116 AAVHLYGKAIELNPA
K137-ub NRAAAYSkLGNYVGA
K137 NRAAAYSKLGNYVGA
Y141 AYSkLGNYVGAVQDC
Y158 AIGIDPGYSkAYGRM
S159 IGIDPGYSkAYGRMG
K160-ub GIDPGYSkAYGRMGL
Y162 DPGYSkAYGRMGLAL
S171 RMGLALSSLNKHAEA
K174 LALSSLNKHAEAVAY
K183 AEAVAYYKKALELDP
K184 EAVAYYKKALELDPD
K196 DPDNDTYKSNLkIAE
K200-ub DTYKSNLkIAELKLR
K205 NLkIAELKLREAPSP
S297 EFVEQIRSQVVRsRt
S302-p IRSQVVRsRtPsASH
T304-p SQVVRsRtPsASHEE
S306-p VVRsRtPsASHEEQQ
S308 RsRtPsASHEEQQE_
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