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SGTA (human)

Overview SGTA Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. Homooligomerize. Interacts with NS1 from parvovirus H-1, with Vpu and Gag from HIV-1. Interacts with SARS- CoV accessory protein 7a. Interacts with DNAJC5 and DNAJC5B. Ubiquitous. Belongs to the SGT family. Note: This description may include information from UniProtKB. Protein type: Chaperone Cellular Component: cytoplasm Molecular Function: protein binding Biological Process: virus-host interaction Reference #:  O43765 (UniProtKB) Alt. Names/Synonyms: Alpha-SGT; alphaSGT; hSGT; protein containing three tetratricopeptide repeats; SGT; SGT1; SGTA; small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; Small glutamine-rich tetratricopeptide repeat-containing protein alpha; UBP; Vpu-binding protein Gene Symbols: SGTA Molecular weight: 34,063 Da Basal Isoelectric point: 4.81  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SGTA 2VYI - A/B=84-210 (human) 4GOD - A/B=4-54 (human) 4GOE - A/B=4-54 (human) 4GOF - A/B=4-54 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2VYI 4GOD 4GOE 4GOF  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K4-a	____MDNkKRLAyAI
0	5		Y9-p	DNkKRLAyAIIQFLH
0	31		S77-p	EMPQDLRsPARtPPs
0	47		T81-p	DLRsPARtPPsEEDS
0	5		S84-p	sPARtPPsEEDSAEA
0	1		K95-u	SAEAERLkTEGNEQM
0	3		K103	TEGNEQMKVENFEAA
0	3		K116-u	AAVHFYGkAIELNPA
0	32		K137-u	NRAAAYSkLGNyAGA
0	3		K137-a	NRAAAYSkLGNyAGA
0	3		Y141-p	AYSkLGNyAGAVQDC
0	8		Y158-p	AICIDPAyskAyGRM
0	1		S159-p	ICIDPAyskAyGRMG
0	109		K160-u	CIDPAyskAyGRMGL
0	2		Y162-p	DPAyskAyGRMGLAL
0	1		K174	LALSSLNKHVEAVAY
0	1		Y181	KHVEAVAYYkkALEL
0	1		K183-u	VEAVAYYkkALELDP
0	3		K184-u	EAVAYYkkALELDPD
0	4		K196-u	DPDNETYkSNLkIAE
0	69		K200-u	ETYkSNLkIAELkLR
0	9		K205-u	NLkIAELkLREAPSP
0	11		S297-p	ELIEQLRsQIRsRtP
0	90		S301-p	QLRsQIRsRtPsAsN
0	109		T303-p	RsQIRsRtPsAsNDD
0	584		S305-p	QIRsRtPsAsNDDQQ
0	137		S307-p	RsRtPsAsNDDQQE_

	mouse
R4	____MDNRKRLAYAI
Y9	DNRKRLAYAIIQFLH
A78	EMPQDPRAPDRtPPs
T82-p	DPRAPDRtPPsEEDS
S85-p	APDRtPPsEEDSAEA
K96	SAEAERLKTEGNEQM
K104-u	TEGNEQMkLENFEAA
K117	AAVHLYGKAIELNPA
K138-u	NRAAAYSkLGNYVGA
K138	NRAAAYSKLGNYVGA
Y142	AYSkLGNYVGAVQDC
Y159-p	AIGIDPGySkAYGRM
S160	IGIDPGySkAYGRMG
K161-u	GIDPGySkAYGRMGL
Y163	DPGySkAYGRMGLAL
K175-u	LALSSLNkHAEAVAY
Y182	kHAEAVAYYKkALEL
K184	AEAVAYYKkALELDP
K185-u	EAVAYYKkALELDPD
K197-u	DPDNDTYkSNLkIAE
K201-u	DTYkSNLkIAELkLR
K206-u	NLkIAELkLREAPSP
S298-p	EFVEQIRsQVVRsRt
S303-p	IRsQVVRsRtPsAsH
T305-p	sQVVRsRtPsAsHEE
S307-p	VVRsRtPsAsHEEQQ
S309-p	RsRtPsAsHEEQQE_

	rat
R4	____MDNRKRLAYAI
Y9	DNRKRLAYAIIQFLH
G77	EMPQDPRGPDRtPPS
T81-p	DPRGPDRtPPSEEDS
S84	GPDRtPPSEEDSAEA
K95	SAEAERLKTEGNEQM
K103	TEGNEQMKLENFEAA
K116	AAVHLYGKAIELNPA
K137-u	NRAAAYSkLGNYVGA
K137	NRAAAYSKLGNYVGA
Y141	AYSkLGNYVGAVQDC
Y158	AIGIDPGYSkAYGRM
S159	IGIDPGYSkAYGRMG
K160-u	GIDPGYSkAYGRMGL
Y162	DPGYSkAYGRMGLAL
K174	LALSSLNKHAEAVAy
Y181-p	KHAEAVAyYKKALEL
K183	AEAVAyYKKALELDP
K184	EAVAyYKKALELDPD
K196	DPDNDTYKSNLkIAE
K200-u	DTYKSNLkIAELKLR
K205	NLkIAELKLREAPSP
S297	EFVEQIRSQVVRsRt
S302-p	IRSQVVRsRtPsASH
T304-p	SQVVRsRtPsASHEE
S306-p	VVRsRtPsASHEEQQ
S308	RsRtPsASHEEQQE_

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