Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ataxin-7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ataxin-7 Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization. Defects in ATXN7 are the cause of spinocerebellar ataxia type 7 (SCA7); also known as olivopontocerebellar atrophy III (OPCA III or OPCA3) or olivopontocerebellar atrophy with retinal degeneration. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA7 belongs to the autosomal dominant cerebellar ataxias type II (ADCA II) which are characterized by cerebellar ataxia with retinal degeneration and pigmentary macular dystrophy. Belongs to the ataxin-7 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Transcription regulation
Chromosomal Location of Human Ortholog: 3p21.1-p12
Cellular Component: microtubule cytoskeleton; nuclear matrix; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; chromatin binding
Biological Process: cell death; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; visual perception; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; microtubule cytoskeleton organization and biogenesis; nuclear organization and biogenesis; histone deubiquitination
Reference #:  O15265 (UniProtKB)
Alt. Names/Synonyms: ADCAII; ataxin 7; Ataxin-7; ATX7; ATXN7; FLJ17787; OPCA3; SCA7; Spinocerebellar ataxia type 7 protein
Gene Symbols: ATXN7
Molecular weight: 95,451 Da
Basal Isoelectric point: 9.89  Predict pI for various phosphorylation states
Select Structure to View Below

ataxin-7

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S69-p DGGPGAAstSAAAMA
0 1 T70-p GGPGAAstSAAAMAT
0 1 S86-p GERRPLPsPEVMLGQ
0 2 S115-p DGTELDEsFKEFGKN
0 1 S216-p GGVLSASsSSsKLLK
0 2 S219-p LSASsSSsKLLKSPK
1 0 K257-ac RIMTPSVkVEKIHPK
1 0 K257-sm RIMTPSVkVEKIHPK
0 1 S302-p IPKPTLPsPGQILNG
0 1 S492-p EPASRLSsEEGEGDD
0 1 R531-m1 FGSRQIGrGYYVFDS
0 1 S649-p QSRQVSSssssPSTP
0 1 S650-p SRQVSSssssPSTPS
0 1 S651-p RQVSSssssPSTPSG
0 1 S652-p QVSSssssPSTPSGL
0 1 S660-p PSTPSGLsSVPssPM
0 1 S664-p SGLsSVPssPMSRKP
0 1 S665-p GLsSVPssPMSRKPQ
0 1 S703-p SSSTSGGsGKKRKNS
0 2 S720-p LLVHSSSsSSSSSSS
0 2 S783-p GRGPPTGsPAEsIKR
0 1 S787-p PTGsPAEsIKRMSVM
0 2 S840-p IGKKRKCsPSSssIN
0 1 S844-p RKCsPSSssINNsSS
0 1 S845-p KCsPSSssINNsSSK
0 2 S849-p SSssINNsSSKPtKV
0 1 T854-p NNsSSKPtKVAKVPA
0 1 - gap
0 2 - gap
  ataxin-7 iso2  
S69 DGGPGAASTSAAAMA
T70 GGPGAASTSAAAMAT
S86 GERRPLPSPEVMLGQ
S115 DGTELDESFKEFGKN
S216 GGVLSASSSSSKLLK
S219 LSASSSSSKLLKSPK
K257 RIMTPSVKVEKIHPK
K257 RIMTPSVKVEKIHPK
S302 IPKPTLPSPGQILNG
S492 EPASRLSSEEGEGDD
R531 FGSRQIGRGYYVFDS
S649 QSRQVSSSSSSPSTP
S650 SRQVSSSSSSPSTPS
S651 RQVSSSSSSPSTPSG
S652 QVSSSSSSPSTPSGL
S660 PSTPSGLSSVPSSPM
S664 SGLSSVPSSPMSRKP
S665 GLSSVPSSPMSRKPQ
S703 SSSTSGGSGKKRKNS
S720 LLVHSSSSSSSSSSS
S783 GRGPPTGSPAESIKR
S787 PTGSPAESIKRMSVM
S840 IGKKRKCSPSSSSIN
S844 RKCSPSSSSINNSSS
S845 KCSPSSSSINNSSSK
S849 SSSSINNSSSKPTKV
T854 NNSSSKPTKVAKVPA
S902-p RTGISATsPQsPDLK
S905-p ISATsPQsPDLKSKG
  mouse

 
T56 DGGTGDTTTSAAAMA
T57 GGTGDTTTSAAAMAT
S73 GERRPLPSPEAMLGQ
S102 DGTELDESFKEFGKN
S202 SGGVLCASSSSKLLR
S205 VLCASSSSKLLRLPK
K243 RVMTPSVKVEKMHPK
K243 RVMTPSVKVEKMHPK
S288 IPKPTLPSPGQILNG
S471 EPASRLSSEEGEGDD
R510 FGSRQIGRGYYVFDS
S628 QSRQVSASSSPPSTP
S629 SRQVSASSSPPSTPS
S630 RQVSASSSPPSTPSG
P631 QVSASSSPPSTPSGL
S639 PSTPSGLSSVPSSPL
S643 SGLSSVPSSPLSRKP
S644 GLSSVPSSPLSRKPQ
S682 SSSTSGGSGKKRKNS
S700 LVPSSSSSSSSSSSS
S763 GRGPAGVSSAEPIKR
P767 AGVSSAEPIKRMSVM
S815 IGKKRKCSPGSSTVG
S819 RKCSPGSSTVGNSGS
T820 KCSPGSSTVGNSGSK
S824 GSSTVGNSGSKPTKV
T829 GNSGSKPTKVAKLPA
- gap
- gap
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.