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TAF172 (human)

Overview TAF172 Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner. Associates with TBP to form B-TFIID. Binds DRAP1. Belongs to the SNF2/RAD54 helicase family. Note: This description may include information from UniProtKB. Protein type: EC 3.6.1.-; Helicase; Transcription initiation complex; EC 3.6.4.- Cellular Component: nucleus Molecular Function: DNA binding; transcription factor activity; helicase activity; ATP binding Biological Process: negative regulation of transcription, DNA-dependent Reference #:  O14981 (UniProtKB) Alt. Names/Synonyms: ATP-dependent helicase BTAF1; B-TFIID transcription factor-associated 170 kDa subunit; BTAF1; BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae); KIAA0940; MGC138406; MOT1; TAF(II)170; TAF-172; TAF172; TAFII170; TATA-binding protein-associated factor 172; TBP-associated factor 172 Gene Symbols: BTAF1 Molecular weight: 206,887 Da Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TAF172

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S234	AVETNEKSNDsTDGE
0	1		S224-p	KLFAKQRsRDAVETN
0	2		S237-p	TNEKSNDsTDGEPEE
0	1		T238	NEKSNDsTDGEPEEK
0	1		S257-p	ANVVINQsANDsKVL
0	1		S261-p	INQsANDsKVLIDNI
0	17		Y415-p	GGLLGIKyALAVRQD
0	1		K430-u	VINTLLPkVLTRIIE
0	1		K641-a	AKEKTGGkVRQGQSQ
0	1		T884-p	IIKPLMEtIKKEENT
0	1		S925	KIIKNLCSSLCVDPY
0	1		S926	IIKNLCSSLCVDPYL
0	3		Y974-p	HRGIITLyRHQKAAF
0	1		Y1256-p	DGKKLENyKIPVPIN
0	2		Y1359-p	EYLNPLHyTGPPTER
0	1		Y1465-p	ERQFAARyGKPILAs
0	2		S1472-p	yGKPILAsRDARSSS
0	1		S1538-p	LYEDFAKsRAKCDVD
0	1		T1756-p	VNVYRLItRGTLEEK
0	1		K1769-a	EKIMGLQkFKMNIAN
0	1		S1784-p	TVISQENsSLQSMGT
0	1		T1799-p	DQLLDLFtLDKDGKA
0	1		T1811-p	GKAEKADtsTSGKAS
0	1		S1812-p	KAEKADtsTSGKASM

	mouse
S233-p	AVETNEKsNDstDGE
S223-p	KLFAKQRsRDAVETN
S236-p	TNEKsNDstDGEPEE
T237-p	NEKsNDstDGEPEEK
T256	ANVVINQTASDSKVL
S260	INQTASDSKVLIDNV
Y414-p	GGLLGIKyALAVRQD
K429	VINTLLPKVLTRIIE
K640	AKEKTGGKVRQGQIQ
T883	IIKPLMETIKKEENT
S924	KVIKNLCSSLCVDPY
S925	VIKNLCSSLCVDPYL
Y973	HRGIITLYRHQKAAF
Y1255	DGKKLENYKIPVPIN
Y1358	EYLNPLHYTGPPTER
Y1464	ERQFAARYGKPILAS
S1471	YGKPILASRDARSSS
S1537	LYEDFAKSRAKCDVD
T1755	VNVYRLITRGTLEEK
K1768	EKIMGLQKFKMNIAN
S1783	TVISQENSSLQSMGT
T1798	DQLLDLFTLDKDGKA
S1810	GKAEKADSSTSGKAS
S1811	KAEKADSSTSGKASM

	rat
S240	AVETNEKSNDSTDGE
S230	KLFAKQRSRDAVETN
S243	TNEKSNDSTDGEPEE
T244	NEKSNDSTDGEPEEK
T263	ANVVINQTASDAKVL
A267	INQTASDAKVLIDNV
Y421-p	GGLLGIKyALAVRQD
K436	VINTLLPKVLTRIIE
K647	TKEKTGGKVRQGQMQ
T890	IIKPLMETIKKEENT
S931-p	KVIKNLCssLCVDPY
S932-p	VIKNLCssLCVDPYL
Y980	HRGIITLYRHQKAAF
Y1262	DGKKLENYKIPVPIN
Y1365	EYLNPLHYTGPPTER
Y1471	ERQFAARYGKPILAS
S1478	YGKPILASRDARSSS
S1544	LYEDFAKSRAKCDVD
T1762	VNVYRLITRGTLEEK
K1775	EKIMGLQKFKMNIAN
S1790	TVISQENSSLQSMGT
T1805	DQLLDLFTLDKDGKA
S1817	GKAEKADSSTSGKAS
S1818	KAEKADSSTSGKASM

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