a protein kinase of the STE11 family. Phosphorylates and activates two different subgroups of MAP kinase kinases, MKK4/SEK1 and MKK3/MKK6, which in turn activate stress-activated protein kinase (JNK) and p38 subgroups of MAP kinases, respectively. Overexpression induces apoptotic cell death. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, STE; Kinase, protein; EC 188.8.131.52; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family
Cellular Component: endoplasmic reticulum
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; MAP kinase kinase kinase activity; magnesium ion binding; caspase activator activity; protein phosphatase binding; protein kinase binding; ATP binding; protein kinase activity
Biological Process: caspase activation; hydrogen peroxide-mediated programmed cell death; activation of MAPKK activity; positive regulation of apoptosis; virus-host interaction; MAPKKK cascade; JNK cascade; positive regulation of caspase activity; innate immune response; induction of apoptosis by oxidative stress; activation of JNK activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.