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Protein Page:
ARID1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ARID1A Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Defects in ARID1A are the cause of mental retardation autosomal dominant type 14 (MRD14). A disease characterized by multiple congenital anomalies and mental retardation. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD14 patients manifest developmental delay, abnormal corpus callosum, absent/hypoplastic fifth finger/toenails, sparse scalp hair, long eyelashes, and a coarse facial appearance with wide mouth, thick lips, and abnormal ears. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; DNA binding protein
Cellular Component: SWI/SNF complex; nuclear chromatin; nucleolus; nucleus
Molecular Function: ligand-dependent nuclear receptor binding; protein binding; DNA binding; nucleosome binding; transcription coactivator activity
Biological Process: estrogen receptor signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; nucleosome mobilization; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; chromatin remodeling; nucleosome disassembly; chromatin-mediated maintenance of transcription; glucocorticoid receptor signaling pathway; neural tube closure; androgen receptor signaling pathway; forebrain development; ATP-dependent chromatin remodeling
Reference #:  O14497 (UniProtKB)
Alt. Names/Synonyms: ARI1A; ARID domain-containing protein 1A; ARID1A; AT rich interactive domain 1A (SWI- like); AT rich interactive domain 1A (SWI-like); AT-rich interactive domain-containing protein 1A; B120; BAF250; BAF250A; BM029; brain protein 120; BRG1-associated factor 250; BRG1-associated factor 250a; C1orf4; chromatin remodeling factor p250; hELD; hOSA1; Osa homolog 1; OSA1; OSA1 nuclear protein; P270; SMARCF1; SWI-like protein; SWI/SNF complex protein p270; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
Gene Symbols: ARID1A
Molecular weight: 242,045 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ARID1A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S11-p QVAPAAAsSLGNPPP
0 1 S58-p KAAAGQEsEGPAVGP
0 5 K71-ac GPPQPLGkELQDGAE
0 2 S79-p ELQDGAEsNGGGGGG
0 3 Y229-p YPPPAPAyALSsPrG
0 11 S233-p APAyALSsPrGGTPG
0 3 R235-m1 AyALSsPrGGTPGSG
0 1 S280-p AMGGGGPsAAGGGtP
0 3 T286-p PsAAGGGtPQPTATP
0 4 S301-p TLNQLLTsPSSARGY
0 1 S304 QLLTsPSSARGYQGY
0 1 Y316-p QGYPGGDySGGPQDG
1 61 S363-p RSHHAPMsPGssGGG
0 8 S366-p HAPMsPGssGGGGQP
0 3 S367-p APMsPGssGGGGQPL
0 14 T377-p GGQPLARtPQPssPM
0 3 S381-p LARtPQPssPMDQMG
0 12 S382-p ARtPQPssPMDQMGK
0 1 R391-m2 MDQMGKMrPQPYGGT
0 4 R429-m2 YGSQTPQrYPMTMQG
0 1 Y592-p QQSQQTAySQQRFPP
0 25 S604-p FPPPQELsQDsFGSQ
0 4 S607-p PQELsQDsFGSQASS
0 1 S631-p GQEDMNLsLQsRPSS
0 1 S634-p DMNLsLQsRPSSLPD
1 63 S696-p LPGIRGPsPsPVGsP
0 21 S698-p GIRGPsPsPVGsPAs
0 34 S702-p PsPsPVGsPAsVAQS
0 4 S705-p sPVGsPAsVAQSRSG
0 1 S709 sPAsVAQSRSGPLsP
0 2 S715-p QSRSGPLsPAAVPGN
0 2 S730-p QMPPRPPsGQSDSIM
0 3 R755-m2 QDRGYMQrNPQMPQy
0 4 Y762-p rNPQMPQySsPQPGs
0 30 S764-p PQMPQySsPQPGsAL
0 5 S769-p ySsPQPGsALsPRQP
0 45 S772-p PQPGsALsPRQPSGG
0 1 T894 PGGMNRKTQETAVAM
0 1 T897 MNRKTQETAVAMHVA
0 1 S907 AMHVAANSIQNRPPG
0 3 K997-ac KTESKSKkSSSSTTT
0 2 K1007-ac SSTTTNEkITKLYEL
0 7 Y1055-p PLDLYRLyVsVKEIG
0 7 S1057-p DLYRLyVsVKEIGGL
0 2 T1065-p VKEIGGLtQVNKNKK
0 1 S1087-p LNVGTSSsAASsLKK
0 1 S1091-p TSSsAASsLKKQYIQ
0 2 S1134-p QPKIQPPsPAGSGSM
0 3 S1167-p LKPPTPAstPHsQIP
0 3 T1168-p KPPTPAstPHsQIPP
0 3 S1171-p TPAstPHsQIPPLPG
0 4 S1182-p PLPGMSRsNsVGIQD
0 6 S1184-p PGMSRsNsVGIQDAF
0 1 S1195 QDAFNDGSDSTFQKR
0 1 T1198 FNDGSDSTFQKRNsM
0 1 S1204-p STFQKRNsMtPNPGY
0 4 T1206-p FQKRNsMtPNPGYQP
0 5 Y1233-p YEPNKDPyGsMRKAP
0 3 S1235-p PNKDPyGsMRKAPGS
0 4 R1276-m1 GNVAMGPrQHYPYGG
0 4 R1276-m2 GNVAMGPrQHYPYGG
0 1 R1287 PYGGPYDRVRTEPGI
0 1 Y1319-p SNPDSGMysPsRYPP
1 1 S1320-p NPDSGMysPsRYPPQ
1 1 S1322-p DSGMysPsRYPPQQQ
0 2 T1348-p NQFSTQGtPsGsPFP
0 2 S1350-p FSTQGtPsGsPFPsQ
0 3 S1352-p TQGtPsGsPFPsQQT
0 1 S1356-p PsGsPFPsQQTTMYQ
0 3 T1376-p YKRPMDGtyGPPAKR
0 9 Y1377-p KRPMDGtyGPPAKRH
0 15 Y1506-p QGRNDMTyNyANRQs
0 3 Y1508-p RNDMTyNyANRQstG
0 2 S1513-p yNyANRQstGSAPQG
0 1 T1514-p NyANRQstGSAPQGP
0 1 Y1523-p SAPQGPAyHGVNRTD
0 2 T1599-p PRPMENRtsPsKsPF
0 3 S1600-p RPMENRtsPsKsPFL
0 5 S1602-p MENRtsPsKsPFLHs
0 23 S1604-p NRtsPsKsPFLHsGM
0 1 S1609-p sKsPFLHsGMkMQKA
0 1 K1612-ac PFLHsGMkMQKAGPP
0 1 K1662-ub QRRRLTMkDIGTPEA
0 1 T1743-p VGDPGQRtLLDPGRF
0 3 S1751-p LLDPGRFsKVssPAP
0 1 S1754-p PGRFsKVssPAPMEG
0 8 S1755-p GRFsKVssPAPMEGG
0 3 M1759 KVssPAPMEGGEEEE
0 5 P1876 RPHAPCPPAPRKHVT
0 4 T1888-p HVTTAEGtPGtTDQE
0 2 T1891-p TAEGtPGtTDQEGPP
0 6 K1905-ac PPDGPPEkRITATMD
0 1 S1920-p DMLSTRSsTLtEDGA
0 1 T1923-p STRSsTLtEDGAKsS
0 2 S1929-p LtEDGAKsSEAIKES
0 18 S1944-p SKFPFGIsPAQsHRN
0 1 S1948-p FGIsPAQsHRNIKIL
0 1 K2146-ub PPFSRLEkLYSTMVR
  mouse

 
S11 QVAPAAASSLGNPPP
S56 KAAAGQESEGPAVGP
K69 GPPQPLGKELQDGAE
S77 ELQDGAESNGGGGGG
Y230 YPPPPQAYALSsPRG
S234-p PQAYALSsPRGGTPG
R236 AYALSsPRGGTPGSG
S281 AMGGGGPSAAGGGTP
T287 PSAAGGGTPQPTATP
S302-p TLNQLLTsPSsARGY
S305-p QLLTsPSsARGYQGY
Y317 QGYPGGDYGGGPQDG
S365-p RSHHAPMsPGsSGGG
S368-p HAPMsPGsSGGGGQP
S369 APMsPGsSGGGGQPL
T379 GGQPLARTPQSSsPM
S383 LARTPQSSsPMDQMG
S384-p ARTPQSSsPMDQMGK
R393 MDQMGKMRPQPYGGT
R431-m2 YGSQTPQrYPMTMQG
Y593 QQSQQTAYSQQRFPP
S605-p FPPPQELsQDSFGSQ
S608 PQELsQDSFGSQASS
S632 GQEDMNLSLQSRPSS
S635 DMNLSLQSRPSSLPD
S697-p LPGIRGPsPsPVGsP
S699-p GIRGPsPsPVGsPAs
S703-p PsPsPVGsPAsVAQs
S706-p sPVGsPAsVAQsRSG
S710-p sPAsVAQsRSGPLsP
S716-p QsRSGPLsPAAVPGN
S731-p QMPPRPPsGQSDSIM
R756 QDRGYMQRNPQMPQy
Y763-p RNPQMPQyTsPQPGs
S765-p PQMPQyTsPQPGsAL
S770-p yTsPQPGsALsPRQP
S773-p PQPGsALsPRQPSGG
T895-p PGGMNRKtQEsAVAM
S898-p MNRKtQEsAVAMHVA
S908-p AMHVAANsIQNRPPG
K998 KTESKSKKSSSSTTT
K1008 SSTTTNEKITKLYEL
Y1056 PLDLYRLYVSVKEIG
S1058 DLYRLYVSVKEIGGL
T1066-p VKEIGGLtQVNKNKK
S1088 LNVGTSSSAASSLKK
S1092 TSSSAASSLKKQYIQ
S1135 QPKIQPPSPAGSGSM
S1168 LKPPTPASTPHSQIP
T1169 KPPTPASTPHSQIPP
S1172 TPASTPHSQIPPLPG
S1183-p PLPGMSRsNsVGIQD
S1185-p PGMSRsNsVGIQDAF
S1196-p QDAFPDGsDPtFQKR
T1199-p FPDGsDPtFQKRNSM
S1205 PtFQKRNSMtPNPGY
T1207-p FQKRNSMtPNPGYQP
Y1234 YEPNKDPYGSMRKAP
S1236 PNKDPYGSMRKAPGS
R1277-m1 GSVAMGPrQHYPYGG
R1277 GSVAMGPRQHYPYGG
R1288-m1 PYGGPYDrVRTEPGI
Y1320 STPDSGMYSPSRYPP
S1321 TPDSGMYSPSRYPPQ
S1323 DSGMYSPSRYPPQQQ
T1349 NQFSTQGTPSSSPFP
S1351 FSTQGTPSSSPFPSQ
S1353 TQGTPSSSPFPSQQT
S1357 PSSSPFPSQQTTMYQ
T1377 YKRPMDGTYGPPAKR
Y1378 KRPMDGTYGPPAKRH
Y1507 QGRNDMTYNYANRQN
Y1509 RNDMTYNYANRQNTG
N1514 YNYANRQNTGSATQG
T1515 NYANRQNTGSATQGP
Y1524 SATQGPAYHGVNRTD
T1600 PRPMENRTsPsKsPF
S1601-p RPMENRTsPsKsPFL
S1603-p MENRTsPsKsPFLHS
S1605-p NRTsPsKsPFLHSGM
S1610 sKsPFLHSGMKMQKA
K1613 PFLHSGMKMQKAGPP
K1663 QRRRLTMKDIGTPEA
T1744 VGDPGQRTLLDPGRF
T1752 LLDPGRFTKVYSPAH
Y1755 PGRFTKVYSPAHtEE
S1756 GRFTKVYSPAHtEEE
T1760-p KVYSPAHtEEEEEEH
T1874-p RPYVPCPtPPRKHLT
T1886-p HLTTVEGtPGtTEQE
T1889-p TVEGtPGtTEQEGPP
K1903 PPDGLPEKRITATMD
S1918 DMLSTRSSTLTDEGA
T1921 STRSSTLTDEGAKsA
S1927-p LTDEGAKsAEATKES
S1942-p SKFPFGIsPAQSHRN
S1946 FGIsPAQSHRNIKIL
K2144 PPFSRLEKLYSTMVR
  rat

 
S11 QVAPAAASSLGNPPP
S56 KAAAGQESEGPAVGP
K69-ac GPPQPLGkELQDGAE
S77 ELQDGAESNGGGGGG
Y226 YPPPPQAYALSSPRG
S230 PQAYALSSPRGGTPG
R232 AYALSSPRGGTPGSG
S276 AMGGGGPSAAGGGTP
T282 PSAAGGGTPQPTATP
S297 TLNQLLTSPSSARGY
S300 QLLTSPSSARGYQGY
Y312 QGYPGGDYGGGPQDG
S359-p RSHHAPMsPGssGGG
S362-p HAPMsPGssGGGGQP
S363-p APMsPGssGGGGQPL
T373 GGQPLARTPQSSSPM
S377 LARTPQSSSPMDQMG
S378 ARTPQSSSPMDQMGK
R387 MDQMGKMRPQPYGGT
R425 YGSQTPQRYPMTMQG
Y589 QQSQQTAYSQQRFPP
S601 FPPPQELSQDSFGSQ
S604 PQELSQDSFGSQASS
S628 GQEDMNLSLQSRPSS
S631 DMNLSLQSRPSSLPD
S693-p LPGIRGPsPsPVGsP
S695-p GIRGPsPsPVGsPAs
S699-p PsPsPVGsPAsVAQS
S702-p sPVGsPAsVAQSRSG
S706 sPAsVAQSRSGPLSP
S712 QSRSGPLSPAAVPGN
S727 QMPPRPPSGQSDSIM
R752 QDRGYMQRNPQMPQY
Y759 RNPQMPQYTsPQPGS
S761-p PQMPQYTsPQPGSAL
S766 YTsPQPGSALsPRQP
S769-p PQPGSALsPRQPSGG
T891 PGGMNRKTQESAVAM
S894 MNRKTQESAVAMHVA
S904 AMHVAANSIQNRPPG
K994 KTESKSKKSSSSTTT
K1004 SSTTTNEKITKLYEL
Y1052 PLDLYRLYVSVKEIG
S1054 DLYRLYVSVKEIGGL
T1062 VKEIGGLTQVNKNKK
S1084 LNVGTSSSAASSLKK
S1088 TSSSAASSLKKQYIQ
S1131 QPKIQPPSPAGSGSM
S1164 LKPPTPASTPHSQIP
T1165 KPPTPASTPHSQIPP
S1168 TPASTPHSQIPPLPG
S1179 PLPGMSRSNSVGIQD
S1181 PGMSRSNSVGIQDAF
S1192 QDAFPDGSEPTFQKR
T1195 FPDGSEPTFQKRNSM
S1201 PTFQKRNSMTPNPGY
T1203 FQKRNSMTPNPGYQP
Y1230 YEPNKDPYGGMRKAP
G1232 PNKDPYGGMRKAPGS
R1273 GNVAMGPRQHYPYGG
R1273 GNVAMGPRQHYPYGG
R1284 PYGGPYDRVRTEPGI
Y1316 STPDSGMYSPSRYPP
S1317 TPDSGMYSPSRYPPQ
S1319 DSGMYSPSRYPPQQQ
T1355 NQFSTQGTPSSSPFP
S1357 FSTQGTPSSSPFPSQ
S1359 TQGTPSSSPFPSQQT
S1363 PSSSPFPSQQTTMYQ
T1384 YKRPMDGTYGPPAKR
Y1385 KRPMDGTYGPPAKRH
Y1514 QGRNDMTYNYANRQN
Y1516 RNDMTYNYANRQNTG
N1521 YNYANRQNTGSAPQG
T1522 NYANRQNTGSAPQGP
Y1531 SAPQGPAYHGVNRTD
T1607 PRPMENRTSPSKSPF
S1608 RPMENRTSPSKSPFL
S1610 MENRTSPSKSPFLHS
S1612 NRTSPSKSPFLHSGM
S1617 SKSPFLHSGMkMQKA
K1620-ac PFLHSGMkMQKAGPP
K1670 QRRRLTMKDIGTPEA
T1751 VGDPGQRTLLDPGRL
T1759 LLDPGRLTKVSsPAP
S1762 PGRLTKVSsPAPtEE
S1763-p GRLTKVSsPAPtEEE
T1767-p KVSsPAPtEEEEEEE
V1882 RPCVPSPVPPRKHVT
T1894 HVTTVEGTPGTTEQE
T1897 TVEGTPGTTEQEGPP
K1911 PPDGLPEKRITATMD
S1926 DMLSTRSSTLTDEGT
T1929 STRSSTLTDEGTKST
S1935 LTDEGTKSTEANKES
S1950 SKFPFGISPAQSHRN
S1954 FGISPAQSHRNIKIL
K2152 PPFSRLEKLYSTMVR
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