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PGRMC1 (human)

Overview PGRMC1 Receptor for progesterone. Widely expressed, with highest expression in liver and kidney. Belongs to the cytochrome b5 family. MAPR subfamily. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Receptor, misc. Cellular Component: endoplasmic reticulum membrane; cell surface; endoplasmic reticulum; integral to membrane; nucleolus; nucleus Molecular Function: protein binding; heme binding; steroid binding Reference #:  O00264 (UniProtKB) Alt. Names/Synonyms: HPR6.6; Membrane-associated progesterone receptor component 1; mPR; PGRC1; PGRMC; PGRMC1; progesterone binding protein; progesterone receptor membrane component 1 Gene Symbols: PGRMC1 Molecular weight: 21,671 Da Basal Isoelectric point: 4.56  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PGRMC1

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	Sites Implicated In
apoptosis, altered: S57‑p, S181‑p apoptosis, induced: S181‑p cell cycle regulation: S181‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	9		S54-p	RGDQPAAsGDsDDDE
1	26		S57-p	QPAAsGDsDDDEPPP
0	9		T74-p	RLKRRDFtPAELRRF
0	3		K96-a	ILMAINGkVFDVtkG
0	2		K96-u	ILMAINGkVFDVtkG
0	1		T101-p	NGkVFDVtkGRkFYG
0	2		K102-u	GkVFDVtkGRkFYGP
0	8		K105-u	FDVtkGRkFYGPEGP
0	46		Y113-p	FYGPEGPyGVFAGRD
0	2		K132-u	LATFCLDkEALKDEy
0	4		Y139-p	kEALKDEyDDLsDLT
0	1		S143-p	KDEyDDLsDLTAAQQ
0	1		K163	WESQFTFKYHHVGKL
0	1		K169	FKYHHVGKLLkEGEE
0	2		K172-u	HHVGKLLkEGEEPtV
0	8		T178-p	LkEGEEPtVysDEEE
0	30		Y180-p	EGEEPtVysDEEEPK
2	197		S181-p	GEEPtVysDEEEPKD
0	6		S190-p	EEEPKDEsARKND__
0	1		N194	KDEsARKND______

	mouse
S54	RGDQPGASGDNDDDE
N57	QPGASGDNDDDEPPP
T74-p	RLKRRDFtPAELRRF
K96	ILMAINGKVFDVTkG
K96-u	ILMAINGkVFDVTkG
T101	NGkVFDVTkGRkFYG
K102-u	GkVFDVTkGRkFYGP
K105-u	FDVTkGRkFYGPEGP
Y113	FYGPEGPYGVFAGRD
K132-u	LATFCLDkEALKDEy
Y139-p	kEALKDEyDDLSDLT
S143	KDEyDDLSDLTPAQQ
K163-u	WDSQFTFkYHHVGkL
K169-u	FkYHHVGkLLkEGEE
K172-u	HHVGkLLkEGEEPtV
T178-p	LkEGEEPtVysDDEE
Y180-p	EGEEPtVysDDEEPK
S181-p	GEEPtVysDDEEPKD
T190-p	DEEPKDEtARKNE__
N194	KDEtARKNE______

	rat
S54	RGDQPGASGDNDDDE
N57	QPGASGDNDDDEPPP
T74	RLKPRDFTPAELRRY
K96	ILMAINGKVFDVTKG
K96	ILMAINGKVFDVTKG
T101	NGKVFDVTKGRKFYG
K102	GKVFDVTKGRKFYGP
K105	FDVTKGRKFYGPEGP
Y113	FYGPEGPYGVFAGRD
K132	LATFCLDKEALKDEY
Y139	KEALKDEYDDLSDLT
S143	KDEYDDLSDLTPAQQ
K163	WDSQFTFKYHHVGKL
K169	FKYHHVGKLLKEGEE
K172	HHVGKLLKEGEEPtV
T178-p	LKEGEEPtVysDDEE
Y180-p	EGEEPtVysDDEEPK
S181-p	GEEPtVysDDEEPKD
A190	DEEPKDEAARKsD__
S194-p	KDEAARKsD______

	pig
S54	RGDQPAASDSDDDEP
S56	DQPAASDSDDDEPPP
T73	RLKRRDFTPAELRRF
K95	ILMAINGKVFDVTKG
K95	ILMAINGKVFDVTKG
T100	NGKVFDVTKGRKFYG
K101	GKVFDVTKGRKFYGP
K104	FDVTKGRKFYGPEGP
Y112	FYGPEGPYGVFAGRD
K131	LATFCLDKEALKDEY
Y138	KEALKDEYDDLSDLT
S142	KDEYDDLSDLTPAQQ
K162	WDSQFTFKYHHVGKL
K168	FKYHHVGKLLKEGEE
K171	HHVGKLLKEGEEPTV
T177	LKEGEEPTVYsDEEE
Y179	EGEEPTVYsDEEEPK
S180-p	GEEPTVYsDEEEPKD
S189	EEEPKDESARKND__
N193	KDESARKND______

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