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Protein Page:
PGRMC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PGRMC1 Receptor for progesterone. Widely expressed, with highest expression in liver and kidney. Belongs to the cytochrome b5 family. MAPR subfamily. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq22-q24
Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane; nucleolus
Molecular Function: protein binding; heme binding; steroid binding
Biological Process: axon guidance
Reference #:  O00264 (UniProtKB)
Alt. Names/Synonyms: HPR6.6; Membrane-associated progesterone receptor component 1; mPR; PGRC1; PGRMC; PGRMC1; progesterone binding protein; progesterone receptor membrane component 1
Gene Symbols: PGRMC1
Molecular weight: 21,671 Da
Basal Isoelectric point: 4.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PGRMC1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S57‑p, S181‑p
apoptosis, induced: S181‑p
cell cycle regulation: S181‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 15 S54-p RGDQPAAsGDsDDDE
1 39 S57-p QPAAsGDsDDDEPPP
0 14 T74-p RLKRRDFtPAELRRF
0 3 K96-ac ILMAINGkVFDVtkG
0 2 K96-ub ILMAINGkVFDVtkG
0 1 T101-p NGkVFDVtkGRkFyG
0 2 K102-ub GkVFDVtkGRkFyGP
0 8 K105-ub FDVtkGRkFyGPEGP
0 1 K105 FDVtkGRKFyGPEGP
0 4 Y107-p VtkGRkFyGPEGPyG
0 52 Y113-p FyGPEGPyGVFAGRD
0 2 K132-ub LATFCLDkEALKDEy
0 1 K136 CLDkEALKDEyDDLs
0 4 Y139-p kEALKDEyDDLsDLT
0 1 S143-p KDEyDDLsDLTAAQQ
0 1 T152-p LTAAQQEtLSDWESQ
0 1 K163 WESQFTFKYHHVGKL
0 1 K163 WESQFTFKYHHVGKL
0 1 K169 FKYHHVGKLLkEGEE
0 2 K172-ub HHVGKLLkEGEEPtV
0 13 T178-p LkEGEEPtVysDEEE
0 36 Y180-p EGEEPtVysDEEEPK
2 220 S181-p GEEPtVysDEEEPKD
0 11 S190-p EEEPKDEsARKND__
0 1 N194 KDEsARKND______
  mouse

 
S54-p RGDQPGAsGDNDDDE
N57 QPGAsGDNDDDEPPP
T74-p RLKRRDFtPAELRRF
K96 ILMAINGKVFDVTkG
K96-ub ILMAINGkVFDVTkG
T101 NGkVFDVTkGRkFYG
K102-ub GkVFDVTkGRkFYGP
K105-ub FDVTkGRkFYGPEGP
K105-sc FDVTkGRkFYGPEGP
Y107 VTkGRkFYGPEGPYG
Y113 FYGPEGPYGVFAGRD
K132-ub LATFCLDkEALkDEy
K136-ac CLDkEALkDEyDDLS
Y139-p kEALkDEyDDLSDLT
S143 kDEyDDLSDLTPAQQ
T152 LTPAQQETLSDWDSQ
K163-ac WDSQFTFkYHHVGkL
K163-ub WDSQFTFkYHHVGkL
K169-ub FkYHHVGkLLkEGEE
K172-ub HHVGkLLkEGEEPtV
T178-p LkEGEEPtVysDDEE
Y180-p EGEEPtVysDDEEPK
S181-p GEEPtVysDDEEPKD
T190-p DEEPKDEtARKNE__
N194 KDEtARKNE______
  rat

 
S54 RGDQPGASGDNDDDE
N57 QPGASGDNDDDEPPP
T74-p RLKPRDFtPAELRRY
K96 ILMAINGKVFDVTKG
K96 ILMAINGKVFDVTKG
T101 NGKVFDVTKGRKFYG
K102 GKVFDVTKGRKFYGP
K105 FDVTKGRKFYGPEGP
K105 FDVTKGRKFYGPEGP
Y107 VTKGRKFYGPEGPYG
Y113 FYGPEGPYGVFAGRD
K132 LATFCLDKEALKDEY
K136 CLDKEALKDEYDDLS
Y139 KEALKDEYDDLSDLT
S143 KDEYDDLSDLTPAQQ
T152 LTPAQQETLNDWDSQ
K163 WDSQFTFKYHHVGKL
K163 WDSQFTFKYHHVGKL
K169 FKYHHVGKLLKEGEE
K172 HHVGKLLKEGEEPtV
T178-p LKEGEEPtVysDDEE
Y180-p EGEEPtVysDDEEPK
S181-p GEEPtVysDDEEPKD
A190 DEEPKDEAARKsD__
S194-p KDEAARKsD______
  pig

 
S54 RGDQPAASDSDDDEP
S56 DQPAASDSDDDEPPP
T73 RLKRRDFTPAELRRF
K95 ILMAINGKVFDVTKG
K95 ILMAINGKVFDVTKG
T100 NGKVFDVTKGRKFYG
K101 GKVFDVTKGRKFYGP
K104 FDVTKGRKFYGPEGP
K104 FDVTKGRKFYGPEGP
Y106 VTKGRKFYGPEGPYG
Y112 FYGPEGPYGVFAGRD
K131 LATFCLDKEALKDEY
K135 CLDKEALKDEYDDLS
Y138 KEALKDEYDDLSDLT
S142 KDEYDDLSDLTPAQQ
T151 LTPAQQETLNDWDSQ
K162 WDSQFTFKYHHVGKL
K162 WDSQFTFKYHHVGKL
K168 FKYHHVGKLLKEGEE
K171 HHVGKLLKEGEEPTV
T177 LKEGEEPTVYsDEEE
Y179 EGEEPTVYsDEEEPK
S180-p GEEPTVYsDEEEPKD
S189 EEEPKDESARKND__
N193 KDESARKND______
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