Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SEC24C (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SEC24C Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. Interacts with SLC6A4. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24C is capable of forming heterodimers with SEC24A. Interacts with TMED2 and TMED10. Ubiquitous. Belongs to the SEC23/SEC24 family. SEC24 subfamily. Note: This description may include information from UniProtKB.
Protein type: Motor protein
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; COPII vesicle coat; perinuclear region of cytoplasm; cytosol
Molecular Function: protein binding; zinc ion binding
Biological Process: COPII coating of Golgi vesicle; intracellular protein transport; ER to Golgi vesicle-mediated transport; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Reference #:  P53992 (UniProtKB)
Alt. Names/Synonyms: KIAA0079; Protein transport protein Sec24C; SC24C; SEC24 family, member C (S. cerevisiae); SEC24 related gene family, member C; SEC24-related protein C; SEC24C
Gene Symbols: SEC24C
Molecular weight: 118,325 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SEC24C

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 16 Y83-p APCGQAAyGQFGQGD
0 1 S176-p ASGSFPNsGLyGSYP
0 5 Y179-p SFPNsGLyGSYPQGQ
0 6 T214-p PSQASSFtPPAsGGP
0 2 S218-p SSFtPPAsGGPrLPS
0 1 R222-m2 PPAsGGPrLPSMTGP
0 2 S294-p GPARGPQsNyGGPyP
0 33 Y296-p ARGPQsNyGGPyPAA
0 1 G298 GPQsNyGGPyPAAPT
0 11 Y300-p QsNyGGPyPAAPTFG
0 1 S328-p LDPDAIPsPIQVIED
0 1 K364 VTTNFLVKDQGNASP
0 1 S529-p LLCEELKsLLDFLPR
0 1 T666-p DDRKLINtDKEkTLF
0 2 K670-ub LINtDKEkTLFQPQT
0 1 S773-p FFGAFYMsNTtDVEL
0 1 T776-p AFYMsNTtDVELAGL
0 1 S862-p AYRGVLNsPVKAVRD
0 1 K865 GVLNsPVKAVRDTLI
0 2 S888-p CYRKNCAsPSsAGQL
0 1 S891-p KNCAsPSsAGQLILP
0 2 K956-ub PRLLPLTkSPVESTT
0 1 K1048-ub AQRSRYMkLTVVKQE
0 1 K1057 TVVKQEDKMEMLFKH
0 1 K1087-ac DFLCHMHkEIRQLLS
  mouse

 
Y83 VPCGQTTYGQFGQGD
S176 ASGNFPNSGPYGSYP
Y179 NFPNSGPYGSYPQSQ
T214 PPLASSFTSPASGGP
S218 SSFTSPASGGPQMPS
Q222 SPASGGPQMPSMTGL
P296 GPARGPQPNYEsPyP
Y298 ARGPQPNYEsPyPGA
S300-p GPQPNYEsPyPGAPT
Y302-p QPNYEsPyPGAPTFG
S330 LDPDAIPSPIQVIED
K366-ub VTTNFLVkDQGNASP
S531 LLCEELKSLLDYLPR
T668 DDRKLINTDKEkTLF
K672-ub LINTDKEkTLFQPQT
S775 FFGAFYMSNTTDVEL
T778 AFYMSNTTDVELAGL
S864 AYRAVLNSPVkTVRD
K867-ub AVLNSPVkTVRDTLI
S890 CYRKNCASPSSAGQL
S893 KNCASPSSAGQLILP
K958-ub PRLLPLTkSPLDSTA
K1050 AQRMRYMKLIVVKQE
K1059-ub IVVKQEDkLEMLFKH
K1089 DFLCHMHKEIRQLLS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.