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Sec24C (human)

Overview Sec24C Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. Interacts with SLC6A4. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24C is capable of forming heterodimers with SEC24A. Interacts with TMED2 and TMED10. Ubiquitous. Belongs to the SEC23/SEC24 family. SEC24 subfamily. Note: This description may include information from UniProtKB. Protein type: Motor protein Cellular Component: Golgi membrane; endoplasmic reticulum membrane; intracellular membrane-bound organelle; COPII vesicle coat; perinuclear region of cytoplasm; nucleolus; cytosol; nucleus Molecular Function: protein binding; zinc ion binding Biological Process: COPII coating of Golgi vesicle; intracellular protein transport; ER to Golgi vesicle-mediated transport; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; membrane organization and biogenesis Reference #:  P53992 (UniProtKB) Alt. Names/Synonyms: KIAA0079; Protein transport protein Sec24C; SC24C; SEC24 family, member C (S. cerevisiae); SEC24 related gene family, member C; SEC24-related protein C; SEC24C Gene Symbols: SEC24C Molecular weight: 118,325 Da Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Sec24C 3EH2 - A/C/B=329-1094 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	16		Y83-p	APCGQAAyGQFGQGD
0	1		S176-p	ASGSFPNsGLyGSYP
0	5		Y179-p	SFPNsGLyGSYPQGQ
0	6		T214-p	PSQASSFtPPAsGGP
0	2		S218-p	SSFtPPAsGGPrLPS
0	1		R222-m2	PPAsGGPrLPSMTGP
0	2		S294-p	GPARGPQsNyGGPyP
0	37		Y296-p	ARGPQsNyGGPyPAA
0	1		G298	GPQsNyGGPyPAAPT
0	11		Y300-p	QsNyGGPyPAAPTFG
0	1		K364	VTTNFLVKDQGNASP
0	1		T666-p	DDRKLINtDKEkTLF
0	2		K670-u	LINtDKEkTLFQPQT
0	1		K865	GVLNSPVKAVRDTLI
0	1		S888-p	CYRKNCAsPSSAGQL
0	2		K956-u	PRLLPLTkSPVESTT
0	1		K1048-u	AQRSRYMkLTVVKQE
0	1		K1057	TVVKQEDKMEMLFKH
0	1		K1087-a	DFLCHMHkEIRQLLS

	mouse
Y83	VPCGQTTYGQFGQGD
S176	ASGNFPNSGPYGSYP
Y179	NFPNSGPYGSYPQSQ
T214	PPLASSFTSPASGGP
S218	SSFTSPASGGPQMPS
Q222	SPASGGPQMPSMTGL
P296	GPARGPQPNYEsPyP
Y298	ARGPQPNYEsPyPGA
S300-p	GPQPNYEsPyPGAPT
Y302-p	QPNYEsPyPGAPTFG
K366-u	VTTNFLVkDQGNASP
T668	DDRKLINTDKEkTLF
K672-u	LINTDKEkTLFQPQT
K867-u	AVLNSPVkTVRDTLI
S890	CYRKNCASPSSAGQL
K958-u	PRLLPLTkSPLDSTA
K1050	AQRMRYMKLIVVKQE
K1059-u	IVVKQEDkLEMLFKH
K1089	DFLCHMHKEIRQLLS

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