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Protein Page:
ANKRD3 (human)

Overview
ANKRD3 a TKL protein kinase of the RIPK family. Activates NFkappaB when overexpressed in cell lines and is required for keratinocyte differentiation in vivo. Appears to activate NFkappaB in both a kinase-dependent as well as a kinase-independent manner. Contains 10 ANK repeats. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; EC 2.7.11.1; Kinase, protein; TKL group; RIPK family
Cellular Component: membrane; cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: morphogenesis of an epithelium; protein amino acid phosphorylation; activation of NF-kappaB transcription factor
Reference #:  P57078 (UniProtKB)
Alt. Names/Synonyms: ANKK2; ANKRD3; ankyrin repeat domain 3; Ankyrin repeat domain-containing protein 3; DIK; MGC129992; MGC129993; PKC-delta-interacting protein kinase; PKK; receptor-interacting serine-threonine kinase 4; Receptor-interacting serine/threonine-protein kinase 4; RIP4; RIPK4; serine/threonine-protein kinase ANKRD3
Gene Symbols: RIPK4
Molecular weight: 91,611 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ANKRD3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T184 SMDGLFGTIAYLPPE
0 1 S415-p SKLPSSGsGKRLsGV
0 1 S420-p SGsGKRLsGVSSVDs
0 1 S427-p sGVSSVDsAFSSRGS
0 8 S438-p SRGSLSLsFEREPsT
0 2 S444-p LsFEREPsTSDLGTT
0 1 S520-p NLSNRRGstPLHMAV
0 1 T521-p LSNRRGstPLHMAVE
0 1 S544-p LLLARKIsVNAKDED
  mouse

 
T184-p SMDGLFGtIAYLPPE
S369 CKLPSSSSGKRLSGV
S374 SSSGKRLSGVSSVDS
S381 SGVSSVDSAFSSRGS
S392 SRGSLSLSFEREAST
S398 LSFEREASTGDLGPT
S474 NLTNRKGSTPLHMAV
T475 LTNRKGSTPLHMAVE
S498 LLLARKTSVNAKDED
  rat

 
T184 SMDGLFGTIAYLPPE
S369 CKLPSSSSGKRLSGV
S374 SSSGKRLSGVSSVDS
S381 SGVSSVDSAFSSRGS
S392 SRGSLSLSFEREAST
S398 LSFEREASTGDLGPT
S474 NLTNKKGSTPLHMAV
T475 LTNKKGSTPLHMAVE
S498 LLLARKTSVNAKDED
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