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Protein Page:
ANKRD3 (human)

Overview
ANKRD3 a TKL protein kinase of the RIPK family. Activates NFkappaB when overexpressed in cell lines and is required for keratinocyte differentiation in vivo. Appears to activate NFkappaB in both a kinase-dependent as well as a kinase-independent manner. Contains 10 ANK repeats. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; TKL group; RIPK family
Cellular Component: membrane; cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: morphogenesis of an epithelium; protein amino acid phosphorylation; activation of NF-kappaB transcription factor
Reference #:  P57078 (UniProtKB)
Alt. Names/Synonyms: ANKK2; ANKRD3; ankyrin repeat domain 3; Ankyrin repeat domain-containing protein 3; DIK; MGC129992; MGC129993; PKC-delta-interacting protein kinase; PKK; receptor-interacting serine-threonine kinase 4; Receptor-interacting serine/threonine-protein kinase 4; RIP4; RIPK4; serine/threonine-protein kinase ANKRD3
Gene Symbols: RIPK4
Molecular weight: 91,611 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ANKRD3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T184 SMDGLFGTIAYLPPE
0 1 S415-p SKLPSSGsGKRLsGV
0 1 S420-p SGsGKRLsGVSSVDs
0 1 S427-p sGVSSVDsAFSSRGS
0 8 S438-p SRGSLSLsFEREPsT
0 2 S444-p LsFEREPsTSDLGTT
0 1 S520-p NLSNRRGstPLHMAV
0 1 T521-p LSNRRGstPLHMAVE
0 1 S544-p LLLARKIsVNAKDED
  mouse

 
T184-p SMDGLFGtIAYLPPE
S369 CKLPSSSSGKRLSGV
S374 SSSGKRLSGVSSVDS
S381 SGVSSVDSAFSSRGS
S392 SRGSLSLSFEREAST
S398 LSFEREASTGDLGPT
S474 NLTNRKGSTPLHMAV
T475 LTNRKGSTPLHMAVE
S498 LLLARKTSVNAKDED
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