Home

CCND3 (human)

Overview CCND3 Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/p27Kip1, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/p27Kip1 required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either p21Cip1 or CDKN2A. Belongs to the cyclin family. Cyclin D subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation; Nuclear receptor co-regulator; Activator protein Cellular Component: membrane; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; nucleus Molecular Function: protein binding; cyclin-dependent protein kinase activity; protein kinase binding Biological Process: T cell proliferation; positive regulation of cyclin-dependent protein kinase activity; cell division; positive regulation of protein amino acid phosphorylation; signal transduction Reference #:  P30281 (UniProtKB) Alt. Names/Synonyms: CCND3; cyclin D3; D3-type cyclin; G1/S-specific cyclin D3; G1/S-specific cyclin-D3 Gene Symbols: CCND3 Molecular weight: 32,520 Da Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CCND3

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
protein degradation: T283‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T9-p	ELLCCEGtRHAPRAG
0	1		T261-p	SLREASQtSssPAPK
0	1		S263-p	REASQtSssPAPKAP
0	2		S264-p	EASQtSssPAPKAPR
0	1		S274	PKAPRGSSSQGPsQt
0	5		S279-p	GSSSQGPsQtstPTD
0	1		T281-p	SSQGPsQtstPTDVT
0	1		S282-p	SQGPsQtstPTDVTA
5	7		T283-p	QGPsQtstPTDVTAI

	mouse
T9	ELLCCEGTRHAPRAG
T261	SLREAAQTAPsPVPK
P263	REAAQTAPsPVPKAP
S264-p	EAAQTAPsPVPKAPR
S274-p	PKAPRGSsSQGPSQT
S279	GSsSQGPSQTStPTD
T281	sSQGPSQTStPTDVT
S282	SQGPSQTStPTDVTA
T283-p	QGPSQTStPTDVTAI

	rat
T9	ELLCCEGTRLAPRAG
T262	SLREAAQTAPSPVPK
P264	REAAQTAPSPVPKAP
S265	EAAQTAPSPVPKAPG
S275	PKAPGGSSSQGPSQT
S280	GSSSQGPSQTSTPTD
T282	SSQGPSQTSTPTDVT
S283	SQGPSQTSTPTDVTA
T284	QGPSQTSTPTDVTAI

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.