Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PPPM1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PPPM1A a Ser/Thr protein phosphatase of the PP2C family. Inhibits the activation of p38 and JNK kinase cascades induced by environmental stresses. Can also dephosphorylate cyclin-dependent kinases and may play a role in cell cycle control. Overexpression of this phosphatase activates the expression of p53, leading to G2/M cell cycle arrest and apoptosis. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)
Cellular Component: nucleoplasm; neuron projection; membrane; voltage-gated calcium channel complex; nucleus; cytosol
Molecular Function: protein C-terminus binding; protein binding; signal transducer activity; calmodulin-dependent protein phosphatase activity; manganese ion binding; magnesium ion binding; protein serine/threonine phosphatase activity
Biological Process: transcription initiation from RNA polymerase II promoter; N-terminal protein myristoylation; Wnt receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of NF-kappaB import into nucleus; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; dephosphorylation; transforming growth factor beta receptor signaling pathway; insulin receptor signaling pathway; gene expression; negative regulation of transforming growth factor beta receptor signaling pathway; cell cycle arrest; positive regulation of Wnt receptor signaling pathway
Reference #:  P35813 (UniProtKB)
Alt. Names/Synonyms: FLJ42306; MGC9201; phosphatase 2C alpha; PP2C-alpha; PP2CA; PP2Calpha; PPM1A; PPPM1A; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; protein phosphatase 2C alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; protein phosphatase, Mg2+/Mn2+ dependent, 1A
Gene Symbols: PPM1A
Molecular weight: 42,448 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PPPM1A

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K98 APSVENVKNGIRTGF
0 2 S135 TAVGVLISPQHTYFI
0 2 S216 GPTEQLVSPEPEVHD
0 1 S285-p KGSRDNMsVILICFP
0 1 K310 KKEAELDKyLECRVE
0 1 Y311-p KEAELDKyLECRVEE
0 1 K322 RVEEIIKKQGEGVPD
0 9 Y362-p RNVIEAVyNRLNPYK
0 2 T373-p NPYKNDDtDsTsTDD
1 2 S375-p YKNDDtDsTsTDDMW
1 3 S377-p NDDtDsTsTDDMW__
0 2 T378 DDtDsTsTDDMW___
  PPPM1A iso2  
K98 APSVENVKNGIRTGF
S135 TAVGVLISPQHTYFI
S216 GPTEQLVSPEPEVHD
S285 KGSRDNMSVILICFP
K310 KKEAELDKYLECRVE
Y311 KEAELDKYLECRVEG
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
K98-ub APSVENVkNGIRTGF
S135-p TAVGVLIsPQHTYFI
S216-p GPTEQLVsPEPEVHD
S285 KGSRDNMSVILICFP
K310-ac KKEAELDkYLESRVE
Y311 KEAELDkYLESRVEE
K322-ub RVEEIIKkQVEGVPD
Y362 RNVIEAVYNRLNPYK
T373-p NPYKNDDtDsAstDD
S375-p YKNDDtDsAstDDMW
S377-p NDDtDsAstDDMW__
T378-p DDtDsAstDDMW___
  rat

 
K98 APSVENVKNGIRTGF
S135 TAVGVLISPQHTYFI
S216 GPTEQLVSPEPEVHD
S285 KGSRDNMSVILICFP
K310 KKEAELDKYLENRVE
Y311 KEAELDKYLENRVEE
K322 RVEEIIKKQGEGVPD
Y362 RNVIEAVYNRLNPYK
T373 NPYKNDDTDSASTDD
S375 YKNDDTDSASTDDMW
S377 NDDTDSASTDDMW__
T378 DDTDSASTDDMW___
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.