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PPPM1A (human)

Overview PPPM1A a Ser/Thr protein phosphatase of the PP2C family. Inhibits the activation of p38 and JNK kinase cascades induced by environmental stresses. Can also dephosphorylate cyclin-dependent kinases and may play a role in cell cycle control. Overexpression of this phosphatase activates the expression of p53, leading to G2/M cell cycle arrest and apoptosis. Note: This description may include information from UniProtKB. Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis Cellular Component: nucleoplasm; neuron projection; voltage-gated calcium channel complex; cytosol; nucleus Molecular Function: protein C-terminus binding; protein binding; signal transducer activity; calmodulin-dependent protein phosphatase activity; manganese ion binding; magnesium ion binding; protein serine/threonine phosphatase activity Biological Process: transcription initiation from RNA polymerase II promoter; Wnt receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; dephosphorylation; transforming growth factor beta receptor signaling pathway; insulin receptor signaling pathway; gene expression; negative regulation of transforming growth factor beta receptor signaling pathway; cell cycle arrest; positive regulation of Wnt receptor signaling pathway Reference #:  P35813 (UniProtKB) Alt. Names/Synonyms: FLJ42306; MGC9201; phosphatase 2C alpha; PP2C-alpha; PP2CA; PP2Calpha; PPM1A; PPPM1A; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; protein phosphatase 2C alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; protein phosphatase, Mg2+/Mn2+ dependent, 1A Gene Symbols: PPM1A Molecular weight: 42,448 Da Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PPPM1A 1A6Q - A=1-382 (human) 3FXJ - A=1-382 (human) 3FXK - A=1-382 (human) 3FXL - A=1-382 (human) 3FXM - A=1-382 (human) 3FXO - A=1-382 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K98	APSVENVKNGIRTGF
0	2		S135	TAVGVLISPQHTYFI
0	2		S216	GPTEQLVSPEPEVHD
0	1		S285-p	KGSRDNMsVILICFP
0	1		Y311-p	KEAELDKyLECRVEE
0	1		K322	RVEEIIKKQGEGVPD
0	9		Y362-p	RNVIEAVyNRLNPYK
0	2		T373-p	NPYKNDDtDsTstDD
1	2		S375-p	YKNDDtDsTstDDMW
1	2		S377-p	NDDtDsTstDDMW__
0	2		T378-p	DDtDsTstDDMW___

	PPPM1A iso2
K98	APSVENVKNGIRTGF
S135	TAVGVLISPQHTYFI
S216	GPTEQLVSPEPEVHD
S285	KGSRDNMSVILICFP
Y311	KEAELDKYLECRVEG
-	under review
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse
K98-u	APSVENVkNGIRTGF
S135-p	TAVGVLIsPQHTYFI
S216-p	GPTEQLVsPEPEVHD
S285	KGSRDNMSVILICFP
Y311	KEAELDKYLESRVEE
K322-u	RVEEIIKkQVEGVPD
Y362	RNVIEAVYNRLNPYK
T373-p	NPYKNDDtDsAstDD
S375-p	YKNDDtDsAstDDMW
S377-p	NDDtDsAstDDMW__
T378-p	DDtDsAstDDMW___

	rat
K98	APSVENVKNGIRTGF
S135	TAVGVLISPQHTYFI
S216	GPTEQLVSPEPEVHD
S285	KGSRDNMSVILICFP
Y311	KEAELDKYLENRVEE
K322	RVEEIIKKQGEGVPD
Y362	RNVIEAVYNRLNPYK
T373	NPYKNDDTDSASTDD
S375	YKNDDTDSASTDDMW
S377	NDDTDSASTDDMW__
T378	DDTDSASTDDMW___

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