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Protein Page:
PVR (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PVR Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. Belongs to the nectin family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.; Immunoglobulin superfamily
Cellular Component: extracellular space; cell surface; cytoplasm; integral to membrane; plasma membrane
Molecular Function: viral receptor activity; protein binding; cell adhesion molecule binding; receptor activity
Biological Process: intercellular junction assembly and maintenance; regulation of immune response; cell-cell adhesion; cell migration; viral reproduction; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity
Reference #:  P15151 (UniProtKB)
Alt. Names/Synonyms: CD155; FLJ25946; HVED; NECL-5; NECL5; nectin-like 5; Nectin-like protein 5; Poliovirus receptor; PVR; PVS; TAGE4
Gene Symbols: PVR
Molecular weight: 45,303 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PVR

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y398‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K90-u GPSYSESkRLEFVAA
0 2 - gap
0 11 - gap
1 21 Y398-p SANGHVSySAVSREN
0 1 S399 ANGHVSySAVSRENS
0 8 A400 NGHVSySAVSRENSS
  mouse

 
E97 GPSISDPERVKFLVA
S388-p RHGRALQsNPsEREN
S391-p RALQsNPsERENVQy
Y398-p sERENVQyssVNGDC
S399-p ERENVQyssVNGDCR
S400-p RENVQyssVNGDCRL
  rat

 
E97 GPSISDPERVKFLVA
S385 RRGCGRQSRTLDREN
L388 CGRQSRTLDRENVRY
Y395 LDRENVRYSAANGVS
S396 DRENVRYSAANGVSV
A397 RENVRYSAANGVSVP
  cow

 
S94 GPSFHESSRLEFMAA
- gap
- gap
- gap
- gap
- gap
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