Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Activation is suppressed by phosphorylation at Ser-257. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.4.22.-; EC 18.104.22.168; Apoptosis
Molecular Function: protein binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: lens development in camera-type eye; positive regulation of retinal cell programmed cell death; apoptosis; acute inflammatory response to non-antigenic stimulus; response to testosterone stimulus; proteolysis; response to organic nitrogen; response to estradiol stimulus; response to hydrogen peroxide; response to heat; response to cytokine stimulus; positive regulation of neuron apoptosis; induction of apoptosis; response to glucose stimulus; response to gamma radiation; response to iron ion; cell structure disassembly during apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.