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Protein Page:
CASP6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CASP6 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Activation is suppressed by phosphorylation at Ser-257. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.4.22.59; EC 3.4.22.-; Apoptosis
Cellular Component: nucleoplasm; cytosol
Molecular Function: identical protein binding; protein binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: epithelial cell differentiation; apoptosis; proteolysis; cell structure disassembly during apoptosis
Reference #:  P55212 (UniProtKB)
Alt. Names/Synonyms: Apoptotic protease Mch-2; CASP-6; CASP6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6; Caspase-6 subunit p11; Caspase-6 subunit p18; MCH2
Gene Symbols: CASP6
Molecular weight: 33,310 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CASP6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K36-ac EMFDPAEkYKMDHRR
0 1 S79-p DNLTRRFsDLGFEVK
0 1 K144-ub QTLTGLFkGDKCHSL
3 0 S257-p TLVNRKVsQRRVDFC
0 1 K273-ac DPSAIGKkQVPCFAS
0 1 K284-ac CFASMLTkkLHFFPK
0 1 K285-ac FASMLTkkLHFFPKS
  mouse

 
Q19 EVFDPAEQYKMDHKR
S62-p DNLTRRFsDLGFEVK
K127 QTLTGLFKGDKCQSL
S239 TLVNRKVSQRRVDFC
K255 DPDAIGKKQVPCFAS
K266 CFASMLTKKLHFCPK
K267 FASMLTKKLHFCPKP
  rat

 
Q19 EVLDPAEQYKMDHKR
S62 DNPTRRFSELGFEVK
K127 QTLTGLFKGDKCQSL
S240 TLVNRKVSQRRVDFC
K256 DPGAIGKKQVPCFAS
K267 CFASMLTKKLHFCPK
K268 FASMLTKKLHFCPKP
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