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Protein Page:
Tyk2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Tyk2 a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; JakA family
Cellular Component: cytoskeleton; membrane; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; type 1 angiotensin receptor binding; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; cytokine and chemokine mediated signaling pathway; protein amino acid phosphorylation
Reference #:  P29597 (UniProtKB)
Alt. Names/Synonyms: JTK1; Non-receptor tyrosine-protein kinase TYK2; TYK2; tyrosine kinase 2
Gene Symbols: TYK2
Molecular weight: 133,650 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Tyk2

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y1054‑p, Y1055‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T67-p IAHKVGItPPCFNLF
1 1448 Y292-p QAEGEPCyIRDSGVA
0 1 S339-p EVNKEEGssGSSGRN
0 1 S340-p VNKEEGssGSSGRNP
0 35 Y433-p LTADSSHyLCHEVAP
0 1 S491-p ILTVAQRsQAPDGMQ
0 9 S499-p QAPDGMQsLRLRKFP
0 3 S525 GWGRSFPSVRELGAA
0 2 S577-p SPRTLNLsQLSFHRV
0 1 Y604 QGTRTNVYEGRLRVE
0 1 S720-p VVAQQLAsALsYLEN
0 2 S723-p QQLAsALsYLENKNL
0 1 K728 ALsYLENKNLVHGNV
0 4 K756-ub EGTSPFIkLSDPGVG
0 32 Y827-p PSEKEHFyQRQHRLP
0 1 Y851-p LTSQCLTyEPTQRPS
0 3 S884-p VLTVNPDsPASDPTV
0 1 Y914 HFGKVSLYCYDPTND
0 1 S942 DCGPQHRSGWKQEID
6 61 Y1054-p AVPEGHEyyRVREDG
5 7 Y1055-p VPEGHEyyRVREDGD
0 1 Y1145-p DKCPCEVyHLMKNCW
9321 : Phospho-Tyk2 (Tyr1054/1055) Antibody
9321 : Phospho-Tyk2 (Tyr1054/1055) Antibody
  mouse

 
T68 IAHKVGITPPCLNLF
Y291-p QPERDPCyIQNSGQT
- gap
- gap
Y428-p LTADSSHyLCHEVAP
N486 ILTVAHRNPAXSNGP
G495 AXSNGPRGLRLRKFP
S521-p GWGRSFAsLGDLRLA
S573 HTRPLNLSQLSFHRV
Y600-p QGTRTNVyEGLLRVG
S713 VVAQQLASALSYLED
S716 QQLASALSYLEDkNL
K721-ac ALSYLEDkNLVHGNV
K749-ub EGTNPFIkLSDPGVG
Y820 PSEKERFYTKKHQLP
Y844 LTRQCLTYEPAQRPS
S877 TSAVNSDSPASDPTV
Y907-p HFGKVSLyCYDPTND
S935-p GCGPQLRsGWQREIE
Y1047-p AVPEGHEyyRVREDG
Y1048-p VPEGHEyyRVREDGD
Y1138 DRCPCEIYHLMKNCW
9321 : Phospho-Tyk2 (Tyr1054/1055) Antibody
9321 : Phospho-Tyk2 (Tyr1054/1055) Antibody
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