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Tyk2 (human)

Overview Tyk2 a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain. Note: This description may include information from UniProtKB. Protein type: Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Kinase, protein; Protein kinase, TK; TK group; JakA family Cellular Component: cytoskeleton; membrane; cytoplasm; cytosol; nucleus Molecular Function: growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding Biological Process: cytokine and chemokine mediated signaling pathway; protein kinase cascade; protein amino acid phosphorylation Reference #:  P29597 (UniProtKB) Alt. Names/Synonyms: JTK1; Non-receptor tyrosine-protein kinase TYK2; TYK2; tyrosine kinase 2 Gene Symbols: TYK2 Molecular weight: 133,650 Da Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Tyk2 3LXN - A=888-1182 (human) 3LXP - A=888-1182 (human) 3NYX - A=885-1176 (human) 3NZ0 - A=885-1176 (human) 3ZON - A=541-873 (human) 4E1Z - A=880-1170 (mouse) 4E20 - A=881-1170 (mouse)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3LXN 3LXP 3NYX 3NZ0 3ZON  |  ENZYME  |  Phospho3D  |  DISEASE 176941 611521  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: Y1054‑p, Y1055‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1442		Y292-p	QAEGEPCyIRDSGVA
0	1		S339-p	EVNKEEGssGSSGRN
0	1		S340-p	VNKEEGssGSSGRNP
0	35		Y433-p	LTADSSHyLCHEVAP
0	7		S499-p	QAPDGMQsLRLRKFP
0	3		S525	GWGRSFPSVRELGAA
0	1		S577-p	SPRTLNLsQLSFHRV
0	1		Y604	QGTRTNVYEGRLRVE
0	1		K728	ALSYLENKNLVHGNV
0	4		K756-u	EGTSPFIkLSDPGVG
0	32		Y827-p	PSEKEHFyQRQHRLP
0	1		Y851-p	LTSQCLTyEPTQRPS
0	2		S884-p	VLTVNPDsPASDPTV
0	1		Y914-p	HFGKVSLyCYDPTND
0	1		S942	DCGPQHRSGWKQEID
5	62		Y1054-p	AVPEGHEyyRVREDG
4	7		Y1055-p	VPEGHEyyRVREDGD
0	1		Y1145-p	DKCPCEVyHLMKNCW

	mouse
Y291-p	QPERDPCyIQNSGQT
-	gap
-	gap
Y428-p	LTADSSHyLCHEVAP
G495	AXSNGPRGLRLRKFP
S521-p	GWGRSFAsLGDLRLA
S573	HTRPLNLSQLSFHRV
Y600-p	QGTRTNVyEGLLRVG
K721-a	ALSYLEDkNLVHGNV
K749-u	EGTNPFIkLSDPGVG
Y820	PSEKERFYTKKHQLP
Y844	LTRQCLTYEPAQRPS
S877	TSAVNSDSPASDPTV
Y907-p	HFGKVSLyCYDPTND
S935-p	GCGPQLRsGWQREIE
Y1047-p	AVPEGHEyyRVREDG
Y1048-p	VPEGHEyyRVREDGD
Y1138	DRCPCEIYHLMKNCW

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