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Protein Page:
ARHGAP26 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ARHGAP26 GTPase-activating protein for RHOA and CDC42. Interacts with NYAP1, NYAP2 and MYO16. Binds to the C-terminus of PTK2/FAK1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAPs; Motility/polarity/chemotaxis; GAPs, Rac/Rho
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: focal adhesion; cytoskeleton; cytosol
Molecular Function: protein binding; phospholipid binding
Biological Process: nervous system development; regulation of small GTPase mediated signal transduction; plasma membrane organization and biogenesis; small GTPase mediated signal transduction; actin cytoskeleton organization and biogenesis
Disease: Juvenile Myelomonocytic Leukemia
Reference #:  Q9UNA1 (UniProtKB)
Alt. Names/Synonyms: ARHGAP26; FLJ42530; GRAF; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); KIAA0621; Oligophrenin-1-like protein; OPHN1L; OPHN1L1; RHG26; Rho GTPase activating protein 26; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26
Gene Symbols: ARHGAP26
Molecular weight: 92,235 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ARHGAP26

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K118-ub VLITPLEkFRKEQIG
0 1 K121 TPLEkFRKEQIGAAk
0 3 K128-ac KEQIGAAkEAKKKYD
0 1 K310-ub FDQKSGGkGGEDESV
0 1 T327-p KSCTRRKtDSIEKRF
0 8 Y371-p MDGREPVyNsNKDSQ
0 1 S373-p GREPVyNsNKDSQSE
0 1 R394 SIGFSIIRKCIHAVE
0 1 T402-p KCIHAVEtRGINEQG
0 1 Y411 GINEQGLYRIVGVNS
0 2 K454-ub KTITSALkTyLRMLP
0 1 Y456-p ITSALkTyLRMLPGP
0 1 Y467-p LPGPLMMyQFQRSFI
0 1 T570-p NHEKIFNtVPDMPLT
0 1 S584 TNAQLHLSRKKSsDS
0 2 S588 LHLSRKKSsDSKPPS
0 1 S589-p HLSRKKSsDSKPPSC
0 1 S597-p DSKPPSCsERPLTLF
0 1 T602 SCsERPLTLFHTVQS
0 1 S684 WPMFSAPSSPMPTSS
1 1 S685 PMFSAPSSPMPTSST
  ARHGAP26 iso2  
K118 VLITPLEKFRKEQIG
K121 TPLEKFRKEQIGAAK
K128 KEQIGAAKEAKKKYD
K310 FDQKSGGKGGEDESV
T327 KSCTRRKTDSIEKRF
Y371 MDGREPVYNSNKDSQ
S373 GREPVYNSNKDSQSE
R394 SIGFSIIRKCIHAVE
T402 KCIHAVETRGINEQG
Y411 GINEQGLYRIVGVNS
K454 KTITSALKTYLRMLP
Y456 ITSALKTYLRMLPGP
Y467 LPGPLMMYQFQRSFI
T570 NHEKIFNTVPDMPLT
S584 TNAQLHLSRKKSSDS
S588 LHLSRKKSSDSKPPS
S589 HLSRKKSSDSKPPSC
S597 DSKPPSCSERPLTLF
T602 SCSERPLTLFHTVQS
S684-p WPMFSAPssPMPTSS
S685-p PMFSAPssPMPTSST
  mouse

 
K118 VLITPLEKFRKEQIG
K121 TPLEKFRKEQIGAAR
R128 KEQIGAAREAKKKYD
K310 FDQKSGGKGGEDESV
T327 KSCTRRKTDSIEKRF
Y371-p MDGREPVyNSNRDSQ
S373 GREPVyNSNRDSQSE
R394-m2 SIGFSIIrKCIHAVE
T402 KCIHAVETRGINEQG
Y411 GINEQGLYRIVGVNS
K454-ub KTVTSALkTYLRMLP
Y456 VTSALkTYLRMLPGP
Y467 LPGPLMMYQFQRSFI
T570 NHEKIFNTVPDVPLT
S584-p TNAQLHLsRKKsSDS
S588-p LHLsRKKsSDSKPPS
S589 HLsRKKsSDSKPPSC
S597 DSKPPSCSKRPLtLF
T602-p SCSKRPLtLFHAVPS
S684 WPMFSAPSSPMPTSS
S685 PMFSAPSSPMPTSST
  rat

 
K118 VLITPLEKFRkEQIG
K121-ac TPLEKFRkEQIGAAR
R128 kEQIGAAREAKKKYD
K310 FDQKSGGKGGEDESV
T327 KSCTRRKTDSIEKRF
Y371 MDGREPVYNSNKDSQ
S373 GREPVYNSNKDSQSE
R394 SIGFSIIRKCIHAVE
T402 KCIHAVETRGINEQG
Y411-p GINEQGLyRIVGVNS
K454 KTVTSALKTYLRMLP
Y456 VTSALKTYLRMLPGP
Y467 LPGPLMMYQFQRSFI
T570 NHEKIFNTVPDVPLT
S584 TNAQLHLSRKKSSDS
S588 LHLSRKKSSDSKPPS
S589 HLSRKKSSDSKPPSC
S597 DSKPPSCSERPLTLF
T602 SCSERPLTLFHAVPS
S684 WPMFSAPSSPMPTSS
S685 PMFSAPSSPMPTSST
  chicken

 
- gap
- under review  
- gap
K118 FDQKSGGKGGEDEAV
T135 KSCTRRKTDSIEKRF
Y179 MDGREPVYNSNKDNQ
S181 GREPVYNSNKDNQSE
K202 SIGFSIIKKCIHAVE
T210 KCIHAVETRGINEQG
Y219 GINEQGLYRIVGVNS
K262 KTITSALKTYLRMLP
Y264 ITSALKTYLRMLPGP
Y275 LPGPLMMYQFQRSFI
T378 NHEKIFNTVPETPPS
S392 SNSQLLLSRKKSTDS
S396 LLLSRKKSTDSKPPS
T397 LLSRKKSTDSKPPSC
S405 DSKPPSCSERPLTLF
T410 SCSERPLTLFHTAQP
S493 WPMFSAPSsPMPTSS
S494-p PMFSAPSsPMPTSST
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