GTPase-activating protein for RHOA and CDC42. Interacts with NYAP1, NYAP2 and MYO16. Binds to the C-terminus of PTK2/FAK1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAPs; Motility/polarity/chemotaxis; GAPs, Rac/Rho
Molecular Function: protein binding; Rho GTPase activator activity; phospholipid binding
Biological Process: nervous system development; regulation of small GTPase mediated signal transduction; plasma membrane organization and biogenesis; small GTPase mediated signal transduction; actin cytoskeleton organization and biogenesis; positive regulation of Rho GTPase activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.