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Protein Page:
ARHGAP26 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ARHGAP26 GTPase-activating protein for RHOA and CDC42. Interacts with NYAP1, NYAP2 and MYO16. Binds to the C-terminus of PTK2/FAK1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAPs; Motility/polarity/chemotaxis; GAPs, Rac/Rho
Cellular Component: cytoskeleton; focal adhesion; cytosol
Molecular Function: protein binding; Rho GTPase activator activity; phospholipid binding; cytoskeletal adaptor activity; SH3 domain binding
Biological Process: nervous system development; regulation of small GTPase mediated signal transduction; filopodium formation; small GTPase mediated signal transduction; actin cytoskeleton organization and biogenesis; positive regulation of Rho GTPase activity
Reference #:  Q9UNA1 (UniProtKB)
Alt. Names/Synonyms: ARHGAP26; FLJ42530; GRAF; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); KIAA0621; Oligophrenin-1-like protein; OPHN1L; OPHN1L1; RHG26; Rho GTPase activating protein 26; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26
Gene Symbols: ARHGAP26
Molecular weight: 92,235 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ARHGAP26

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K118-u VLITPLEkFRKEQIG
0 3 K128-a KEQIGAAkEAKKKYD
0 1 K310-u FDQKSGGkGGEDESV
0 8 Y371-p MDGREPVyNSNKDSQ
0 1 R394 SIGFSIIRKCIHAVE
0 1 T402-p KCIHAVEtRGINEQG
0 2 K454-u KTITSALkTYLRMLP
0 1 S584 TNAQLHLSRKKSsDS
0 2 S588 LHLSRKKSsDSKPPS
0 1 S589-p HLSRKKSsDSKPPSC
0 1 T602 SCSERPLTLFHTVQS
1 1 S685 PMFSAPSSPMPTSST
  ARHGAP26 iso2  
K118 VLITPLEKFRKEQIG
K128 KEQIGAAKEAKKKYD
K310 FDQKSGGKGGEDESV
Y371 MDGREPVYNSNKDSQ
R394 SIGFSIIRKCIHAVE
T402 KCIHAVETRGINEQG
K454 KTITSALKTYLRMLP
S584 TNAQLHLSRKKSSDS
S588 LHLSRKKSSDSKPPS
S589 HLSRKKSSDSKPPSC
T602 SCSERPLTLFHTVQS
S685-p PMFSAPSsPMPTSST
  mouse

 
K118 VLITPLEKFRKEQIG
R128 KEQIGAAREAKKKYD
K310 FDQKSGGKGGEDESV
Y371-p MDGREPVyNSNRDSQ
R394-m2 SIGFSIIrKCIHAVE
T402 KCIHAVETRGINEQG
K454-u KTVTSALkTYLRMLP
S584-p TNAQLHLsRKKsSDS
S588-p LHLsRKKsSDSKPPS
S589 HLsRKKsSDSKPPSC
T602-p SCSKRPLtLFHAVPS
S685 PMFSAPSSPMPTSST
  rat

 
K118 VLITPLEKFRKEQIG
R128 KEQIGAAREAKKKYD
K310 FDQKSGGKGGEDESV
Y371 MDGREPVYNSNKDSQ
R394 SIGFSIIRKCIHAVE
T402 KCIHAVETRGINEQG
K454 KTVTSALKTYLRMLP
S584 TNAQLHLSRKKSSDS
S588 LHLSRKKSSDSKPPS
S589 HLSRKKSSDSKPPSC
T602 SCSERPLTLFHAVPS
S685 PMFSAPSSPMPTSST
  chicken

 
- gap
- gap
K118 FDQKSGGKGGEDEAV
Y179 MDGREPVYNSNKDNQ
K202 SIGFSIIKKCIHAVE
T210 KCIHAVETRGINEQG
K262 KTITSALKTYLRMLP
S392 SNSQLLLSRKKSTDS
S396 LLLSRKKSTDSKPPS
T397 LLSRKKSTDSKPPSC
T410 SCSERPLTLFHTAQP
S494-p PMFSAPSsPMPTSST
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