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CCNE2 (human)

Overview CCNE2 Essential for the control of the cell cycle at the late G1 and early S phase. Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively. According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor- derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. Belongs to the cyclin family. Cyclin E subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Activator protein; Cell cycle regulation Cellular Component: nucleoplasm; cytosol Molecular Function: protein binding; cyclin-dependent protein kinase regulator activity; protein kinase binding Biological Process: DNA replication initiation; cell division; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; cell cycle checkpoint; G1/S transition of mitotic cell cycle Reference #:  O96020 (UniProtKB) Alt. Names/Synonyms: CCNE2; CYCE2; cyclin E2; G1/S-specific cyclin E2; G1/S-specific cyclin-E2 Gene Symbols: CCNE2 Molecular weight: 46,757 Da Basal Isoelectric point: 7.95  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CCNE2

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	Sites Implicated In
protein degradation: T74‑p, T392‑p, S396‑p ubiquitination: T74‑p, T392‑p, S396‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T19-p	QQPQPSQtEsPQEAQ
0	8		S21-p	PQPSQtEsPQEAQII
0	1		K31-u	EAQIIQAkKRKTTQD
0	2		S67-p	PVLSGGIsPCIIIEt
1	2		T74-p	sPCIIIEtPHKEIGT
0	1		S337	PFVNVVKSTSPVKLK
0	5		S383-p	FRKGGQLsPVCNGGI
2	5		T392-p	VCNGGIMtPPKsTEK
1	0		S396-p	GIMtPPKsTEKPPGK

	mouse
P19	QHAQPNQPDsPQETQ
S21-p	AQPNQPDsPQETQII
K31	ETQIIQAKKRKTAQD
S67	PVLSGGISPCIIIET
T74	SPCIIIETPHKEIGT
S337-p	PFVSVVKsVSPVKLK
S383-p	YRKGGQLsPVCNGGI
T392-p	VCNGGIMtPPKSTEK
S396	GIMtPPKSTEKPPGK

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