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Protein Page:
CCNE2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CCNE2 Essential for the control of the cell cycle at the late G1 and early S phase. Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively. According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor- derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. Belongs to the cyclin family. Cyclin E subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Activator protein; Cell cycle regulation
Cellular Component: nucleoplasm; cytosol
Molecular Function: protein binding; cyclin-dependent protein kinase regulator activity; protein kinase binding
Biological Process: DNA replication initiation; cell division; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; cell cycle checkpoint; G1/S transition of mitotic cell cycle
Reference #:  O96020 (UniProtKB)
Alt. Names/Synonyms: CCNE2; CYCE2; cyclin E2; G1/S-specific cyclin E2; G1/S-specific cyclin-E2
Gene Symbols: CCNE2
Molecular weight: 46,757 Da
Basal Isoelectric point: 7.95  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCNE2

Protein Structure Not Found.


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Sites Implicated In
protein degradation: T74‑p, T392‑p, S396‑p
ubiquitination: T74‑p, T392‑p, S396‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T19-p QQPQPSQtEsPQEAQ
0 12 S21-p PQPSQtEsPQEAQII
0 1 K31-ub EAQIIQAkKRKTTQD
0 3 S67-p PVLSGGIsPCIIIEt
1 2 T74-p sPCIIIEtPHKEIGT
0 1 S337 PFVNVVKSTSPVKLK
0 1 S339 VNVVKSTSPVKLKTF
0 6 S383-p FRKGGQLsPVCNGGI
2 7 T392-p VCNGGIMtPPKsTEK
1 0 S396-p GIMtPPKsTEKPPGK
  mouse

 
P19 QHAQPNQPDsPQETQ
S21-p AQPNQPDsPQETQII
K31 ETQIIQAKKRKTAQD
S67 PVLSGGISPCIIIET
T74 SPCIIIETPHKEIGT
S337-p PFVSVVKsVsPVKLK
S339-p VSVVKsVsPVKLKTF
S383-p YRKGGQLsPVCNGGI
T392-p VCNGGIMtPPKSTEK
S396 GIMtPPKSTEKPPGK
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