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mTOR
an atypical kinase belonging to the PIKK family of kinases. Is the catalytic subunit of two protein complexes, mTORC1 and mTORC2. mTORC1 activates S6K and inactivates 4E-BP1, up-regulating protein synthesis. mTORC1 contains Raptor, a positive regulatory subunit and scaffold for recruiting substrates, two negative regulators, PRAS40 and DEPTOR, and mLST8; it is a target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. mTORC2, a downstream effector of PI3K, is insensitive to rapamycin and activates Akt by phosphorylating a key activation site. mTORC2 contains regulatory subunits Rictor and mSIN1, PROTOR, mLST8, and the negative regulator DEPTOR. mTORC1 suppresses PI3K activity via a strong negative feedback loop that involves S6K1. Inhibiting mTORC1 ablates this negative feedback loop and potentiates PI3K signaling. Known inhibitors of mTOR include rapamycin, temsirolimus (CCI-779). Note: This description may include information from UniProtKB.
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| Protein type: Protein kinase, ATYPICAL; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Autophagy; Motility/polarity/chemotaxis; Kinase, protein; ATYPICAL group; PIKK family; FRAP subfamily |
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Cellular Component: PML body; endoplasmic reticulum membrane; lysosome; dendrite; endomembrane system; cytosol; Golgi membrane; mitochondrial outer membrane; membrane; cell soma; cytoplasm; TORC2 complex; phosphoinositide 3-kinase complex
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Molecular Function: protein domain specific binding; protein serine/threonine kinase activity; protein binding; ribosome binding; phosphoprotein binding; drug binding; kinase activity; ATP binding
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Biological Process: negative regulation of autophagy; TOR signaling pathway; positive regulation of translation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; regulation of glycogen biosynthetic process; negative regulation of cell size; signal transduction; protein amino acid phosphorylation; germ cell development; negative regulation of macroautophagy; cellular response to nutrient levels; positive regulation of stress fiber formation; regulation of carbohydrate utilization; protein catabolic process; cell growth; regulation of Rac GTPase activity; regulation of response to food; response to nutrient; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; peptidyl-threonine phosphorylation; positive regulation of lipid biosynthetic process; response to amino acid stimulus; negative regulation of NFAT protein import into nucleus; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; T cell costimulation; insulin receptor signaling pathway; ruffle organization and biogenesis; regulation of fatty acid beta-oxidation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; regulation of protein kinase activity; phosphorylation; growth
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Reference #:
P42345 (UniProtKB)
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| Alt. Names/Synonyms: FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FKBP12-rapamycin complex-associated protein 1; FLJ44809; FRAP; FRAP1; FRAP2; Mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); mTOR; RAFT1; rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; Rapamycin target protein 1; RAPT1; Serine/threonine-protein kinase mTOR |
| Gene Symbols: MTOR |
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Molecular weight: 288,892 Da
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Basal Isoelectric point: 6.73
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Angiogenesis
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Autophagy Signaling
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B Cell Receptor Signaling
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ErbB/HER Signaling
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Insulin Receptor Signaling
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Jak/Stat/IL-6 Signaling
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mTOR Signaling
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PI3K/Akt Signaling
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T Cell Receptor Signaling
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TGF-ß Signaling
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Translation: eIF4E and p70S6K
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Warburg Effect
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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