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Protein Page:
PIK3CD (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIK3CD Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity. Belongs to the PI3/PI4-kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; Kinase, lipid; Motility/polarity/chemotaxis
Cellular Component: cytoplasm; plasma membrane; phosphoinositide 3-kinase complex
Molecular Function: transferase activity; protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; phosphotransferase activity, alcohol group as acceptor; phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding
Biological Process: cell surface receptor linked signal transduction; phosphoinositide-mediated signaling; B cell activation; B cell homeostasis; phosphoinositide phosphorylation; immune system process; innate immune response; chemotaxis; inflammatory response; cell differentiation; phosphorylation
Reference #:  O35904 (UniProtKB)
Alt. Names/Synonyms: 2410099E07Rik; 2610208K16Rik; AW545373; catalytic phosphatidylinositol 3-kinase delta; p100 delta; p110delta; phosphatidylinositol 3-kinase catalytic delta polypeptide; phosphatidylinositol 3-kinase catalytic subunit delta; phosphatidylinositol 3-kinase p110 delta; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphoinositide 3 kinase P110delta; PI3-kinase subunit delta; PI3K-delta; Pik3cd; PK3CD; PtdIns-3-kinase subunit delta; PtdIns-3-kinase subunit p110-delta
Gene Symbols: Pik3cd
Molecular weight: 119,712 Da
Basal Isoelectric point: 7.03  Predict pI for various phosphorylation states
Select Structure to View Below

PIK3CD

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K46 NANLSTIKQVLWHRA
0 1 K210-ac FTFQVSTkDMPLALM
0 1 S312 PIPAKKPSSVSLWSL
0 1 S315 AKKPSSVSLWSLEQP
0 2 S406-p EKAKKARsTKKKSKK
0 1 S411 ARsTKKKSKKADCPI
0 6 Y440 KTGERCLYMWPSVPD
0 50 Y484-p EVAPHPVyFPALEKI
0 15 F485 VAPHPVyFPALEKIL
0 3 S519-p EILERRGsGELyEHE
1 301 Y523-p RRGsGELyEHEKDLV
0 1 K532 HEKDLVWKMRHEVQE
0 1 K840 IANIQLNKSNMAATA
0 1 T934 ERVPFILTyDFVHVI
1 73 Y935-p RVPFILTyDFVHVIQ
0 2 K998-ub SKDIQYLkDSLALGK
2 3 S1038-p NWLAHNVsKDNRQ__
  human

 
K46-ub NANLSTIkQLLWHRA
K210 FTFQVSTKDVPLALM
S312-p PIPAKKPsSVsLWSL
S315-p AKKPsSVsLWSLEQP
S406-p EKAKKARsTKKKsKK
S411-p ARsTKKKsKKADCPI
Y440-p KTGERCLyMWPSVPD
Y484-p EVAPHPVyyPALEKI
Y485-p VAPHPVyyPALEKIL
S520-p EILERRGsGELyEHE
Y524-p RRGsGELyEHEKDLV
K533-ub HEKDLVWkLRHEVQE
K841-ub IANIQLNkSNMAATA
T935-p ERVPFILtyDFVHVI
Y936-p RVPFILtyDFVHVIQ
K999-ub SKDIQYLkDSLALGK
S1039-p NWLAHNVsKDNRQ__
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