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Protein Page:
REL (mouse)

Overview
REL a proto-oncogenic transcription factor of the nuclear factor-kappaB (NFkB) group. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. May play a role in differentiation and lymphopoiesis. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: transcription factor complex; cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 biosynthetic process; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; cytokine production
Reference #:  P15307 (UniProtKB)
Alt. Names/Synonyms: c-Rel; C-Rel proto-oncogene protein; OTTMUSP00000005467; Proto-oncogene c-Rel; Rel; reticuloendotheliosis oncogene
Gene Symbols: Rel
Molecular weight: 64,960 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

REL

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S3 _____MASSGYNPYV
0 1 Y6 __MASSGYNPYVEII
0 4 Y47 STDNNRTYPSVQIMN
0 1 Y88 GKDCRDGYYEAEFGP
0 1 Y89 KDCRDGYYEAEFGPE
0 1 Y176 PIVSNPIYDNRAPNT
0 1 F327 GSTGEGRFIKKESNL
0 1 P356 GVPGQAEPYYSSCGS
0 3 Y357 VPGQAEPYYSSCGSI
0 1 S450-p RMETPSMsPTDLYSI
2 0 S464 ISDVNMLSTRPLSVM
2 0 T475 LSVMAPSTDGMGDTD
1 0 S495 SINLENPSCNARLGP
1 0 A498 LENPSCNARLGPRDL
1 0 S528 SSSSVFVSQSDAFDR
0 1 Y566 TFVQSSHYSVNTLQS
  human

 
S3-p _____MAsGAyNPYI
Y6-p __MAsGAyNPYIEII
Y47-p STDNNRTyPSIQIMN
Y88-p GKDCRDGyyEAEFGQ
Y89-p KDCRDGyyEAEFGQE
Y176-p PVVSNPIyDNRAPNT
Y359-p GSIGEGRyFKKEPNL
S386-p GVSSQAEsyYPSPGP
Y387-p VSSQAEsyYPSPGPI
S479 MEASSMPSADLYGIS
S492-p ISDPNMLsNCSVNMM
S503-p VNMMTTSsDSMGETD
S523-p SMNLENPsCNsVLDP
S526-p LENPsCNsVLDPRDL
S557-p SNTTVFVsQSDAFEG
Y597-p GFVQDSQySGIGSMQ
  rat

 
S3 _____ILSGGYNPYV
Y6 __ILSGGYNPYVEII
Y47 STDNNRTYPSIQIMN
Y88 GKDCRDGYYEAEFGP
Y89 KDCRDGYYEAEFGPE
Y176 PIVSNPIYDNRAPNT
F327 ESIGETRFIKKESNL
P356 GVPGQAEPYYSSSGS
Y357 VPGQAEPYYSSSGSI
S450 RMETPSMSPTDLYSI
T464 ISDVNMLTNRPVSVM
T475 VSVMTSSTDGMGDTD
S495 SVNLENPSCNSRLDP
S498 LENPSCNSRLDPRDP
S529 SSSSVFVSQSDTFNR
Y567 NFAQSSQYSGIDALQ
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