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Protein Page:
REL (mouse)

Overview
REL a proto-oncogenic transcription factor of the nuclear factor-kappaB (NFkB) group. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. May play a role in differentiation and lymphopoiesis. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: transcription factor complex; cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 biosynthetic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; cytokine production; positive regulation of transcription from RNA polymerase II promoter
Reference #:  P15307 (UniProtKB)
Alt. Names/Synonyms: c-Rel; C-Rel proto-oncogene protein; OTTMUSP00000005467; Proto-oncogene c-Rel; Rel; reticuloendotheliosis oncogene
Gene Symbols: Rel
Molecular weight: 64,960 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

REL

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S3 _____MASSGYNPYV
0 1 Y6 __MASSGYNPYVEII
0 4 Y47 STDNNRTYPSVQIMN
0 1 Y88 GKDCRDGYYEAEFGP
0 1 Y89 KDCRDGYYEAEFGPE
0 1 Y176 PIVSNPIYDNRAPNT
0 1 F327 GSTGEGRFIKKESNL
0 1 P356 GVPGQAEPYYSSCGS
0 3 Y357 VPGQAEPYYSSCGSI
0 1 A406 NTLSTFSAGTLSSNS
0 2 T408 LSTFSAGTLSSNSQG
0 1 S450-p RMETPSMsPTDLYSI
2 0 S464 ISDVNMLSTRPLSVM
2 0 T475 LSVMAPSTDGMGDTD
1 0 S495 SINLENPSCNARLGP
1 0 A498 LENPSCNARLGPRDL
1 0 S528 SSSSVFVSQSDAFDR
0 1 Y566 TFVQSSHYSVNTLQS
  human

 
S3-p _____MAsGAyNPYI
Y6-p __MAsGAyNPYIEII
Y47-p STDNNRTyPSIQIMN
Y88-p GKDCRDGyyEAEFGQ
Y89-p KDCRDGyyEAEFGQE
Y176-p PVVSNPIyDNRAPNT
Y359-p GSIGEGRyFKKEPNL
S386-p GVSSQAEsyYPSPGP
Y387-p VSSQAEsyYPSPGPI
T433-p NPLSSFStRtLPSNS
T435-p LSSFStRtLPSNSQG
S479 MEASSMPSADLYGIS
S492-p ISDPNMLsNCSVNMM
S503-p VNMMTTSsDSMGETD
S523-p SMNLENPsCNsVLDP
S526-p LENPsCNsVLDPRDL
S557-p SNTTVFVsQSDAFEG
Y597-p GFVQDSQySGIGSMQ
  rat

 
S3 _____ILSGGYNPYV
Y6 __ILSGGYNPYVEII
Y47 STDNNRTYPSIQIMN
Y88 GKDCRDGYYEAEFGP
Y89 KDCRDGYYEAEFGPE
Y176 PIVSNPIYDNRAPNT
F327 ESIGETRFIKKESNL
P356 GVPGQAEPYYSSSGS
Y357 VPGQAEPYYSSSGSI
A406 NTLSSFPAGQLSSNS
Q408 LSSFPAGQLSSNSQG
S450 RMETPSMSPTDLYSI
T464 ISDVNMLTNRPVSVM
T475 VSVMTSSTDGMGDTD
S495 SVNLENPSCNSRLDP
S498 LENPSCNSRLDPRDP
S529 SSSSVFVSQSDTFNR
Y567 NFAQSSQYSGIDALQ
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