binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway. Note: This description may include information from UniProtKB.
Protein type: Translation initiation; Translation
Chromosomal Location of Human Ortholog: 8p12
Cellular Component: protein complex; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: protein binding; translation repressor activity; eukaryotic initiation factor 4E binding
Biological Process: negative regulation of translational initiation; TOR signaling pathway; cellular protein metabolic process; response to ethanol; translation; translational initiation; insulin receptor signaling pathway; gene expression; positive regulation of mitotic cell cycle; negative regulation of protein complex assembly; lung development; G1/S transition of mitotic cell cycle
Alt. Names/Synonyms: 4E-BP1; 4EBP1; BP-1; eIF4E-binding protein 1; EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; MGC4316; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.