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Protein Page:
En-2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
En-2 Genetic variations in EN2 may be associated with susceptibility to autism. Belongs to the engrailed homeobox family. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: membrane; nucleus
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: multicellular organismal development; midbrain development; neuron development; positive regulation of transcription from RNA polymerase II promoter; hindbrain development
Reference #:  P19622 (UniProtKB)
Alt. Names/Synonyms: EN2; engrailed homeobox 2; engrailed homolog 2; engrailed-2; HME2; Homeobox protein en-2; Homeobox protein engrailed-2; Hu-En-2
Gene Symbols: EN2
Molecular weight: 34,211 Da
Basal Isoelectric point: 9.49  Predict pI for various phosphorylation states
Select Structure to View Below

En-2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S35-p GSGGGGGssPGEADt
0 1 S36-p SGGGGGssPGEADtG
0 1 T42-p ssPGEADtGRRRALM
0 1 P176 KGGDPGGPLDGSLKA
0 1 S232-p RPSSGPRsRKPKKKN
0 1 K245-m2 KNPNKEDkRPRTAFT
0 1 S276 LTEQRRQSLAQELSL
  mouse

 
S31 GGGSGGGSSPSDSDT
S32 GGSGGGSSPSDSDTG
T38 SSPSDSDTGRRRALM
S167-p KPGDPGGsLDGVLKA
S223 RPSSGPRSRKPKKKN
K236 KNPNKEDKRPRTAFT
S267-p LTEQRRQsLAQELSL
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