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En-2 (human)

Overview En-2 Genetic variations in EN2 may be associated with susceptibility to autism. Belongs to the engrailed homeobox family. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: nucleus Molecular Function: sequence-specific DNA binding; transcription factor activity Biological Process: multicellular organismal development; midbrain development; neuron development; positive regulation of transcription from RNA polymerase II promoter; hindbrain development Reference #:  P19622 (UniProtKB) Alt. Names/Synonyms: EN2; engrailed homeobox 2; engrailed homolog 2; engrailed-2; HME2; Homeobox protein en-2; Homeobox protein engrailed-2; Hu-En-2 Gene Symbols: EN2 Molecular weight: 34,211 Da Basal Isoelectric point: 9.49  Predict pI for various phosphorylation states

Select Structure to View Below En-2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 131310 611016  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S232-p	RPSSGPRsRKPKKKN
0	1		S35-p	GSGGGGGssPGEADt
0	1		S36-p	SGGGGGssPGEADtG
0	1		T42-p	ssPGEADtGRRRALM
0	1		P176	KGGDPGGPLDGSLKA
0	1		S276	LTEQRRQSLAQELSL

	mouse
S223	RPSSGPRSRKPKKKN
S31	GGGSGGGSSPSDSDT
S32	GGSGGGSSPSDSDTG
T38	SSPSDSDTGRRRALM
S167-p	KPGDPGGsLDGVLKA
S267-p	LTEQRRQsLAQELSL

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