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Protein Page:
RYR1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RYR1 Calcium channel that controls communication between transverse-tubules and sarcoplasmic reticulum. Contraction of skeletal muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Can mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal development of muscle fibers, skeletal muscle, heart morphogenesis, and skin development and ossification during embryogenesis. Defects in RYR1 are the cause of malignant hyperthermia susceptibility type 1 (MHS1) and central core disease of muscle (CCD). CCD is an autosomal dominant congenital myopathy, but a severe autosomal recessive form also exists. Defects in RYR1 are the cause of multiminicore disease with external ophthalmoplegia (MMDO), congenital myopathy with fiber-type disproportion (CFTD). Defects in RYR1 may be a cause of Samaritan myopathy, a congenital myopathy with benign course. Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter; Transporter, ion channel; Membrane protein, multi-pass; Channel, calcium
Cellular Component: I band; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; sarcoplasmic reticulum; integral to plasma membrane; junctional membrane complex; T-tubule; cytoplasm; plasma membrane; cell cortex
Molecular Function: calmodulin binding; voltage-gated calcium channel activity; protein binding; protease binding; calcium channel activity; calcium-release channel activity; calcium ion binding; ryanodine-sensitive calcium-release channel activity
Biological Process: skin development; cytosolic calcium ion homeostasis; muscle contraction; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; skeletal muscle fiber development; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; transmembrane transport; response to caffeine
Reference #:  P21817 (UniProtKB)
Alt. Names/Synonyms: CCO; central core disease of muscle; MHS; MHS1; Ryanodine receptor 1; ryanodine receptor 1 (skeletal); ryanodine receptor type1; RYDR; RYR; RYR-1; RYR1; sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; SKRR; type 1-like ryanodine receptor
Gene Symbols: RYR1
Molecular weight: 565,176 Da
Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RYR1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K29 QCSATVLKEQLKLCL
0 2 Y245-p DDQRRLVyYEGGAVC
0 1 S781-p GLFFPVVsFSAGVKV
0 1 K900 GPVRDDNKRLHPCLV
0 1 K1394 GFLFKAKKVAMMTQP
0 1 Y1965-p LAAFAERyVDKLQAN
0 3 K2069-u RLMSLLEkVRLVKKK
0 1 S2085-p EKPEEERsAEESKPR
0 1 S2345 AVFVNGESVEENANV
0 1 Y2426-p GHAIMSFyAALIDLL
0 1 K2638 PILNEFAKMPLKLLT
0 1 K2690 FDSLAHKKYDPELyR
0 1 Y2696-p KKYDPELyRMAMPCL
0 1 Y2719-p PDYVDASySSKAEKK
0 1 K2841 TEKKKTRKIsQSAQT
6 5 S2843-p KKKTRKIsQSAQTYD
0 1 K2942 YAVTRGLKDMELDSS
0 1 K2988 VSSGRVEKSPHEQEI
0 1 K3185 TKNTYVEKLRPALGE
0 1 K3336 IDEASWMKRLAVFAQ
0 5 S3489-p GDIQSGGsDQERtKK
0 4 T3494-p GGsDQERtKKKRRGD
0 1 S3668-p WILTEDHsFEDRMID
0 1 K3851 NAFERQNKAEGLGMV
0 2 T4330-p LTAREAAtAVAALLW
0 1 K4551 ELEVQRVKFLNYLSR
0 1 Y4864-p FNFFRKFyNKsEDED
0 1 S4867-p FRKFyNKsEDEDEPD
  mouse

 
K31-u QCSATVLkEQLKLCL
Y247 DDQRRLVYYEGGPVC
S783 GLFFPVVSFSAGIKV
K902-u GPVRDDNkRLHPCLV
K1396-u GFLFKAKkVAMMTQP
Y1966 LAAFAECYVDKMQGN
K2070 RLMSLLEKVKLVKKT
A2086 EKPEEEPAPEEHKPQ
S2346 AVFVNGESVEENANV
Y2427 GHAIMSFYAALIDLL
K2639-u PILNEFAkMPLKLLT
K2691-u FDSLAHKkYDQELYR
Y2697 KkYDQELYRIAMPCL
Y2720 PDYVDASYSSKTEKK
K2842-u TEKKKTRkIsQTAQT
S2844-p KKKTRkIsQTAQTYD
K2943-u YAVTRGLkDMELDTS
K2989-u VSSGRVEkSPHEQEI
K3186-u TRNPYVEkLRPALGE
K3337-u IDEASWMkRLAVFAQ
S3490 GDVQSGGSDQERTKK
T3495 GGSDQERTKKKRRGD
S3669 WILTEDHSFEDRMID
K3855-u NAFERQNkAEGLGMV
T4327 LTAREAATAVAALLW
K4548-u ELEVQRVkFLNYLSR
Y4861 FNFFRKFYNKSEDED
S4864 FRKFYNKSEDEDEPD
  rat

 
K31 QCSATVLKEQLKLCL
Y247 DDQRRLVYYEGGPVC
S783 GLFFPVVSFSAGIKV
K902 GPVRDDNKRLHPCLV
K1395 GFLFKAKKVAMMTQP
Y1964 LAAFAERYVDKLQSN
K2068-u RLMSLLEkVRLVKKK
A2084 EKPEEEPAAEEHKPQ
S2344-p AVFVNGEsVEENANV
Y2425 GHAIMSFYAALIDLL
K2635 PILNEFAKMPLKLLT
K2687 FDSLAHKKYDQELYR
Y2693 KKYDQELYRIAMPCL
Y2716 PDYVDASYSSKTEKK
K2838 TEKKKTRKISQTAQT
S2840 KKKTRKISQTAQTYD
K2939 YAVTRHGKDMELDTS
K2985 VSSGRVEKSPHEQEI
K3182 TRNPYVEKLRPALGE
K3333 IDEASWMKRLAVFAQ
S3488 GVVRSGGSDQERTKK
T3493 GGSDQERTKKKRRGD
S3667 WILTEDHSFEDRMID
Q3853 TLSQREGQEERVMKV
T4327 LTAREAATAVAVLLW
K4548 ELEVQRVKFLNYLSR
Y4861 FNFFRKFYNKSEDED
S4864 FRKFYNKSEDEDEPD
  rabbit

 
K30 QCSATVLKEQLKLCL
Y246 DDQRRLVYYEGGAVC
S782 GLFFPVVSFSAGVKV
K901 GPVRDDNKRLHPCLV
K1395 GFLFKAKKAAMMTQP
Y1965 LAAFAERYVDKLQAN
T2069 RLRSLLETVRLVKKK
P2085 EKPEEELPAEEKKPQ
S2345 AVFVNGESVEENANV
Y2426 GHAIMSFYAALIDLL
K2638 PILNEFAKMPLKLLT
K2690 FDSLAHKKYDQELYR
Y2696 KKYDQELYRMAMPCL
Y2719 PDYVDASYSSKAEKK
K2841 TEKKKTRKIsQTAQT
S2843-p KKKTRKIsQTAQTYD
K2942 YAVTRGLKDMELDTS
K2988 VSSGRVEKSPHEQEI
K3185 TKNTYVEKLRPALGE
K3336 IDEATWMKRLAVFAQ
S3489 GDAQSGGSDQERTKK
T3494 GGSDQERTKKKRRGD
S3668 WILTEDHSFEDRMID
K3852 NAFERQNKAEGLGMV
T4329 LTAREAATALAALLW
K4550 ELEVQRVKFLNYLSR
Y4863 FNFFRKFYNKSEDED
S4866 FRKFYNKSEDEDEPD
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