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Protein Page:
RYR1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RYR1 Calcium channel that controls communication between transverse-tubules and sarcoplasmic reticulum. Contraction of skeletal muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Can mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal development of muscle fibers, skeletal muscle, heart morphogenesis, and skin development and ossification during embryogenesis. Defects in RYR1 are the cause of malignant hyperthermia susceptibility type 1 (MHS1) and central core disease of muscle (CCD). CCD is an autosomal dominant congenital myopathy, but a severe autosomal recessive form also exists. Defects in RYR1 are the cause of multiminicore disease with external ophthalmoplegia (MMDO), congenital myopathy with fiber-type disproportion (CFTD). Defects in RYR1 may be a cause of Samaritan myopathy, a congenital myopathy with benign course. Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral
Cellular Component: I band; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; sarcoplasmic reticulum; integral to plasma membrane; cytoplasm; junctional membrane complex; T-tubule; plasma membrane; cell cortex
Molecular Function: calmodulin binding; voltage-gated calcium channel activity; protease binding; calcium-release channel activity; calcium channel activity; calcium ion binding; ryanodine-sensitive calcium-release channel activity
Biological Process: skin development; cytosolic calcium ion homeostasis; muscle contraction; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; skeletal muscle fiber development; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to caffeine
Reference #:  P21817 (UniProtKB)
Alt. Names/Synonyms: CCO; central core disease of muscle; MHS; MHS1; Ryanodine receptor 1; ryanodine receptor 1 (skeletal); ryanodine receptor type1; RYDR; RYR; RYR-1; RYR1; sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; SKRR; type 1-like ryanodine receptor
Gene Symbols: RYR1
Molecular weight: 565,176 Da
Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RYR1
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 K29 QCSATVLKEQLKLCL
0 2 Y245-p DDQRRLVyYEGGAVC
0 1 T675-p DEVTPFLtAQAtHLR
0 1 T679-p PFLtAQAtHLRVGWA
0 1 S781-p GLFFPVVsFSAGVKV
0 1 K900 GPVRDDNKRLHPCLV
0 1 Y1023-p RNPRLVPyRLLDEAT
0 1 K1348 WSEAENGKEGTAKEG
0 1 K1353 NGKEGTAKEGAPGGT
0 1 K1394 GFLFKAKKVAMMtQP
0 1 T1399-p AKKVAMMtQPPATPT
0 1 S1728-p SACRSRRsMLsEyIV
0 1 S1731-p RSRRsMLsEyIVPLT
0 1 Y1733-p RRsMLsEyIVPLTPE
0 1 K1860-a IFGDEDVkQILKMIE
0 1 Y1965-p LAAFAERyVDKLQAN
0 1 S1985 GLLIKAFSMTAAETA
0 3 K2069-u RLMSLLEkVRLVKKK
0 1 S2085-p EKPEEERsAEESKPR
0 1 S2345 AVFVNGESVEENANV
0 1 Y2426-p GHAIMSFyAALIDLL
0 1 S2459-p RIRAILRsLVPLEDL
0 1 T2543-p LDTATFStTEMALAL
0 1 S2594-p YRLSRGRsLtKAQRD
0 1 T2596-p LSRGRsLtKAQRDVI
0 1 K2638 PILNEFAKMPLKLLT
0 1 K2690 FDSLAHKKYDPELyR
0 1 Y2696-p KKYDPELyRMAMPCL
0 1 Y2719-p PDYVDASySSKAEKK
0 1 Y2761-p FINKFAEytHEKWAF
0 1 T2762-p INKFAEytHEKWAFD
0 1 K2841 TEKKKTRKIsQSAQt
6 5 S2843-p KKKTRKIsQSAQtYD
0 1 T2848-p KIsQSAQtYDPREGY
0 1 S2863-p NPQPPDLsAVTLsRE
0 1 S2868-p DLsAVTLsRELQAMA
0 1 Y2935-p KFLQMNGyAVTRGLK
0 1 K2942 yAVTRGLKDMELDSS
0 1 K2953-a LDSSSIEkRFAFGFL
0 1 K2988 VSSGRVEKSPHEQEI
0 1 K3082 LDARTVMKSGPEIVK
0 1 K3089 KSGPEIVKAGLRSFF
0 1 Y3131-p GVGQNLTyttVALLP
0 1 T3132-p VGQNLTyttVALLPV
0 1 T3133-p GQNLTyttVALLPVL
0 1 T3177-p CSIYSLGttKNTYVE
0 1 T3178-p SIYSLGttKNTYVEK
0 1 K3185 tKNTYVEKLRPALGE
0 1 K3336 IDEASWMKRLAVFAQ
0 5 S3489-p GDIQSGGsDQERtKK
0 4 T3494-p GGsDQERtKKKRRGD
0 1 S3668-p WILTEDHsFEDRMID
0 1 K3851 NAFERQNKAEGLGMV
0 1 T3918-p TINIIICtVDyLLRL
0 1 Y3921-p IIICtVDyLLRLQES
0 1 K4229-m1 NEGGEAEkMELFVSF
0 2 T4330-p LTAREAAtAVAALLW
0 1 K4524 PTPEPPKKQAPPSPP
0 1 K4534 PPSPPPKKEEAGGEF
0 1 K4551 ELEVQRVKFLNYLSR
0 1 Y4776 LMSIDVKYQIWKFGV
0 1 Y4864-p FNFFRKFyNKsEDED
0 1 S4867-p FRKFyNKsEDEDEPD
  mouse

 
K31-u QCSATVLkEQLKLCL
Y247 DDQRRLVYYEGGPVC
T677 DEVAPFLTAQATHLR
T681 PFLTAQATHLRVGWA
S783 GLFFPVVSFSAGIKV
K902-u GPVRDDNkRLHPCLV
Y1025 RNPRLVPYRLLDEAT
K1350-a WGEAEGGkDGTAkEG
K1355-a GGkDGTAkEGTPGGT
K1396-u GFLFKAKkVAMMTQP
T1401 AKkVAMMTQPPSTPA
S1730 SACRSRRSMLSEYIV
S1733 RSRRSMLSEYIVPLT
Y1735 RRSMLSEYIVPLTPE
K1862 VFSDEDVKQILKMIE
Y1966 LAAFAECYVDKMQGN
T1986-p GLLMKAFtMSAAETA
K2070 RLMSLLEKVKLVKKT
A2086 EKPEEEPAPEEHKPQ
S2346 AVFVNGESVEENANV
Y2427 GHAIMSFYAALIDLL
S2460 RIRAILRSLVPLDDL
T2544 LDTATFSTTEMALAL
S2595 YRLSRGRSLTKAQRD
T2597 LSRGRSLTKAQRDVI
K2639-u PILNEFAkMPLKLLT
K2691-u FDSLAHKkYDQELYR
Y2697 KkYDQELYRIAMPCL
Y2720 PDYVDASYSSKTEKK
Y2762 FINKFAEYTHEKWAF
T2763 INKFAEYTHEKWAFD
K2842-u TEKKKTRkIsQTAQT
S2844-p KKKTRkIsQTAQTYD
T2849 kIsQTAQTYDPREGY
S2864 NPQPPDLSVVTLSRE
S2869 DLSVVTLSRELQAMA
Y2936 KFLQMNGYAVTRGLk
K2943-u YAVTRGLkDMELDTS
K2954 LDTSSIEKRFAFGFL
K2989-u VSSGRVEkSPHEQEI
K3083-a LDARTVMkSGPEIVk
K3090-a kSGPEIVkAGLRSFF
Y3132 GVGQNLTYTTVALLP
T3133 VGQNLTYTTVALLPV
T3134 GQNLTYTTVALLPVL
T3178 CSIYSLGTTRNPYVE
T3179 SIYSLGTTRNPYVEk
K3186-u TRNPYVEkLRPALGE
K3337-u IDEASWMkRLAVFAQ
S3490 GDVQSGGSDQERTKK
T3495 GGSDQERTKKKRRGD
S3669 WILTEDHSFEDRMID
K3855-u NAFERQNkAEGLGMV
T3922 TINIIICTVDYLLRL
Y3925 IIICTVDYLLRLQES
K4233 NEGGESEKMEMFVSF
T4327 LTAREAATAVAALLW
K4518-u PPPEPPKkTPPPPPP
K4527-u PPPPPPKkEEAGGAG
K4548-u ELEVQRVkFLNYLSR
Y4773 IMSIDVKYQIWKFGV
Y4861 FNFFRKFYNKSEDED
S4864 FRKFYNKSEDEDEPD
  rat

 
K31 QCSATVLKEQLKLCL
Y247 DDQRRLVYYEGGPVC
T677 DEVAPFLTAQATHLR
T681 PFLTAQATHLRVGWA
S783 GLFFPVVSFSAGIKV
K902 GPVRDDNKRLHPCLV
Y1025 RNPRLVPYRLLDEAT
K1349 WGEAEAGKDGTAKEG
K1354 AGKDGTAKEGTPGGA
K1395 GFLFKAKKVAMMTQP
T1400 AKKVAMMTQPPSTPA
S1728 SACRSRRSMLSEYIV
S1731 RSRRSMLSEYIVPLT
Y1733 RRSMLSEYIVPLTEE
K1860 VFSDEDVKQILKMIE
Y1964 LAAFAERYVDKLQSN
T1984 GLLMKAFTMSAAETA
K2068-u RLMSLLEkVRLVKKK
A2084 EKPEEEPAAEEHKPQ
S2344-p AVFVNGEsVEENANV
Y2425 GHAIMSFYAALIDLL
S2458 RIRAILRSLVPLDDL
- gap
S2591 YRLSRGRSLTKAQRD
T2593 LSRGRSLTKAQRDVI
K2635 PILNEFAKMPLKLLT
K2687 FDSLAHKKYDQELYR
Y2693 KKYDQELYRIAMPCL
Y2716 PDYVDASYSSKTEKK
Y2758 FINKFAEYAHEKWAF
A2759 INKFAEYAHEKWAFD
K2838 TEKKKTRKISQTAQT
S2840 KKKTRKISQTAQTYD
T2845 KISQTAQTYDPREGY
S2860 NPQPPDLSVVTLSRE
S2865 DLSVVTLSRELQAMA
Y2932 KFLQMNGYAVTRHGK
K2939 YAVTRHGKDMELDTS
K2950 LDTSSIEKRFAFGFL
K2985 VSSGRVEKSPHEQEI
K3079 LDARTVMKSGPEIVK
K3086 KSGPEIVKAGLRSFF
Y3128 GVGQNLTYTTVALLP
T3129 VGQNLTYTTVALLPV
T3130 GQNLTYTTVALLPVL
T3174 CSIYSLGTTRNPYVE
T3175 SIYSLGTTRNPYVEK
K3182 TRNPYVEKLRPALGE
K3333 IDEASWMKRLAVFAQ
S3488 GVVRSGGSDQERTKK
T3493 GGSDQERTKKKRRGD
S3667 WILTEDHSFEDRMID
Q3853 TLSQREGQEERVMKV
T3922 TINIIICTVDYLLRL
Y3925 IIICTVDYLLRLQES
K4233 NEGGESEKMELFVSF
T4327 LTAREAATAVAVLLW
K4518 PPPEPPKKAPPPPPP
K4527 PPPPPPKKEEAGGAG
K4548 ELEVQRVKFLNYLSR
Y4773-p IMSIDVKyQIWKFGV
Y4861 FNFFRKFYNKSEDED
S4864 FRKFYNKSEDEDEPD
  rabbit

 
K30 QCSATVLKEQLKLCL
Y246 DDQRRLVYYEGGAVC
T676 DEVVPFLTAQATHLR
T680 PFLTAQATHLRVGWA
S782 GLFFPVVSFSAGVKV
K901 GPVRDDNKRLHPCLV
Y1024 RNPRLVPYRLLDEAT
K1349 WGEAEGGKEGTAKEG
K1354 GGKEGTAKEGTPGGT
K1395 GFLFKAKKAAMMTQP
T1400 AKKAAMMTQPPATPA
S1729 SACRSRRSMLSEYIV
S1732 RSRRSMLSEYIVPLT
Y1734 RRSMLSEYIVPLTPE
K1860 IFGDEDVKQILKMIE
Y1965 LAAFAERYVDKLQAN
T1985 ALLMRAFTMSAAETA
T2069 RLRSLLETVRLVKKK
P2085 EKPEEELPAEEKKPQ
S2345 AVFVNGESVEENANV
Y2426 GHAIMSFYAALIDLL
S2459 RIRAILRSLVPLDDL
T2543 LDTATFSTTEMALAL
S2594 YRLSRGRSLTKAQRD
T2596 LSRGRSLTKAQRDVI
K2638 PILNEFAKMPLKLLT
K2690 FDSLAHKKYDQELYR
Y2696 KKYDQELYRMAMPCL
Y2719 PDYVDASYSSKAEKK
Y2761 FINKFAEYTHEKWAF
T2762 INKFAEYTHEKWAFD
K2841 TEKKKTRKIsQTAQT
S2843-p KKKTRKIsQTAQTYD
T2848 KIsQTAQTYDPREGY
S2863 NPQPPDLSGVTLSRE
S2868 DLSGVTLSRELQAMA
Y2935 KFLQMNGYAVTRGLK
K2942 YAVTRGLKDMELDTS
K2953 LDTSSIEKRFAFGFL
K2988 VSSGRVEKSPHEQEI
K3082 LDARTVMKSGPEIVK
K3089 KSGPEIVKAGLRSFF
Y3131 GVGQNLTYTTVALLP
T3132 VGQNLTYTTVALLPV
T3133 GQNLTYTTVALLPVL
T3177 CSIYSLGTTKNTYVE
T3178 SIYSLGTTKNTYVEK
K3185 TKNTYVEKLRPALGE
K3336 IDEATWMKRLAVFAQ
S3489 GDAQSGGSDQERTKK
T3494 GGSDQERTKKKRRGD
S3668 WILTEDHSFEDRMID
K3852 NAFERQNKAEGLGMV
T3919 TINIIICTVDYLLRL
Y3922 IIICTVDYLLRLQES
K4230 NEGGEAEKMELFVSF
T4329 LTAREAATALAALLW
K4521 APPEPPKKAPPSPPA
K4530 PPSPPAKKEEAGGAG
K4550 ELEVQRVKFLNYLSR
Y4775 LMSIDVKYQIWKFGV
Y4863 FNFFRKFYNKSEDED
S4866 FRKFYNKSEDEDEPD
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